PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus RFFL RFFL 23871895 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G CASP8 RFFL 15069192 intact exp GP GP G GP P GP GP GP GP GP GP G GP P GP P G GP GP GP P GP GP GP GP G RFFL OTUB2 22626734 biogrid exp P P P P P P P P GP EFCAB7 RFFL 26186194 biogrid exp G G G G G G P G G G G G G G G G G G G G G GP RFFL OTUB1 22626734 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G RFFL USP28 22626734 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G RFFL USP7 22626734 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G RFFL PRKD2 26186194 biogrid exp G GP G G GP GP G GP GP G GP G GP GP G GP GP GP G GP GP G GP GP GP GP GP G TP53 RFFL 17121812,18382127 biogrid exp G G G G G G G G G G G G G G G GP G G G GP G G G GP G G GP G RFFL ATXN3L 22626734 biogrid exp P P G GP P G P P P P P P P P P P P GP GP P P GP G RFFL RNF34 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2D1 RFFL 18450452 biogrid exp GP G G G GP GP G G GP G GP GP GP GP G G GP GP P G GP GP G GP G GP GP GP G SFN RFFL 18382127 hprd exp GP G G G G G G G G G G G GP G G G G GP G G GP G G G G G G G SHC1 RFFL 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G IQCE RFFL 26186194 biogrid exp GP GP G P GP G GP GP G GP P GP P G GP GP GP P G GP GP GP GP P GP GP G UBE2D2 RFFL 23871895 biogrid exp GP G G G GP GP G G GP G GP GP GP GP G G GP GP P G GP GP G GP G GP GP GP G ESPL1 RFFL 22626734 biogrid exp GP GP G G GP GP GP GP G GP GP GP GP G GP GP GP P G GP P GP GP GP GP GP GP G UBE2G2 RFFL 19690564 biogrid,intact exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP G P G GP GP G G GP GP GP GP G USP5 RFFL 22626734 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP G GP GP GP GP GP G UBE2D3 RFFL 22626734 biogrid exp GP G G G GP GP G G GP G GP GP GP GP G G GP GP P G GP GP G GP G GP GP GP G RIPK1 RFFL 18450452 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G NEFH RFFL 26186194 biogrid exp G G GP G P G G GP GP G GP G G ATXN3 RFFL 22626734 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G P GP GP P G GP GP GP GP GP GP GP GP G RFFL UCHL5 22626734 biogrid exp, ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G MDM2 RFFL 18382127, 23023127 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G RFFL STAM 22626734, 21836163 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP G GP G GP GP G RHOQ RFFL 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G LRP3 RFFL 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G RFFL CHMP6 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G RFFL TSG101 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G RFFL CHMP3 21836163 pred P P P P P P P P P P P P P P P P P P P P P P TRIM3 RFFL 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G P G GP GP GP GP GP G GP GP G RFFL EHD2 21836163 pred G G G G P G GP GP P GP GP G G GP GP G GP G G GP G GP G RFFL CHMP1A 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP G GP GP GP GP GP G PRKCQ RFFL 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G RFFL TMEM9 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G RFFL CHMP5 21836163 pred G GP G G G GP G GP GP G GP G G G G GP GP G P G GP GP G G GP G GP GP G SYT2 RFFL 21836163 pred P GP G G GP GP G GP GP G GP GP GP GP GP GP P G GP P GP GP P GP G STARD3NL RFFL 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G TRIM37 RFFL 23023127 pred GP GP G G G GP G G GP G GP G GP G G GP GP G P G GP GP GP G GP G GP GP G ANXA3 RFFL 21836163 pred GP P G G GP GP G GP GP G GP P GP P G GP GP P P G GP GP GP GP GP GP GP P G RFFL SLC9A7 21836163 pred P P P P P P P P P P P P P P P P P RFFL MARCH2 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP P P G GP GP GP GP GP GP GP GP G RAB4A RFFL 21836163 pred P P P P P P P P P P P P P P P P P P P P P P RFFL CHMP4C 21836163 pred GP GP P GP GP GP GP GP P G GP P P G GP GP GP P GP GP GP P G RFFL VPS4A 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G HGS RFFL 21836163 pred GP GP G G GP GP G GP GP G GP G GP G G GP GP GP P G GP GP GP GP GP G GP GP G RFFL FAF1 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G RFFL CHMP4B 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G P G GP GP G GP GP GP GP GP G RAB5A RFFL 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G MDM4 RFFL 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G RAB11A RFFL 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G PDCD6IP RFFL 21836163 pred G GP G G GP GP G GP GP G GP GP GP G G GP GP GP P G GP GP GP GP GP G GP GP G STAMBP RFFL 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P0CG48 Q8WZ73 affinity chromatography technology 21963094 physical association X 2 P0CG48 Q8WZ73 affinity chromatography technology 25147182 physical association X 2 Q8WZ73 C9JQV6 enzymatic study 22626734 direct interaction X 2 Q8WZ73 enzymatic study 22626734 direct interaction X 2 Q8WZ73 Q96RU2 enzymatic study 22626734 direct interaction X 2 Q8WZ73 Q14674 enzymatic study 22626734 direct interaction X 2 Q96DC9 Q8WZ73 enzymatic study 22626734 direct interaction X 2 Q93009 Q8WZ73 enzymatic study 22626734 direct interaction X 2 Q92783 Q8WZ73 enzymatic study 22626734 direct interaction X 2 A0A087WW00 Q8WZ73 pull down 18450452 direct interaction X 2 Q00987 Q8WZ73 affinity chromatography technology 18382127 physical association X 2 A0A024QZU0 Q8WZ73 enzymatic study 18450452 direct interaction X 2 A0A024QZU0 Q8WZ73 affinity chromatography technology 18450452 physical association X 2 A0A024QZU0 Q8WZ73 affinity chromatography technology 18450452 physical association X 2 Q9H3M9 Q8WZ73 enzymatic study 22626734 direct interaction X 2 Q8WZ73 Q96FW1 enzymatic study 22626734 direct interaction X 2 Q8WZ73 P61077-3 pull down 22626734 direct interaction X 2 Q8WZ73 P62837 pull down 23871895 direct interaction X 2 Q8WZ73 Q8WZ73 enzymatic study 23871895 direct interaction X 2 Q8WZ73 P60604-2 two hybrid 19690564 direct interaction X 2 Q8WZ73 P04637-7 affinity chromatography technology 17121812 physical association X 2 Q8WZ73 P04637-7 affinity chromatography technology 18382127 physical association X 2 P45974-2 Q8WZ73 enzymatic study 22626734 direct interaction X 2 Q8WZ73 in vivo 18382127 - C 4 Q8WZ73 in vivo 18382127 - C 4 Q8WZ73 in vivo 18382127 - C 4 Q8WZ73 in vivo 18382127 - C 4 Q8WZ73 in vivo 18382127 - X 2 Q8WZ73 in vivo 18382127 - X 2 Q8WZ73 in vivo 18382127 - C 3 Q8WZ73 in vivo 18382127 - C 3 Q8WZ73 in vivo 18382127 - C 3 P60604 Q8WZ73 two hybrid array 19690564 physical association X 2 Q14790 Q8WZ73 anti tag coimmunoprecipitation 15069192 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B MDM2 RFFL MI:0004(affinity chromatography technology)|MI:0493(in vivo)|MI:0493(in vivo) 18382127 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|-|- (biogrid)|MI:0468(hprd)|MI:0468(hprd) BIOGRID_166899|HPRD_40065|HPRD_40068 prey|-|- bait|-|- OTUB1 RFFL MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_222973 prey bait RFFL ATXN3L MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_222976 bait prey ATXN3 RFFL MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_222971 prey bait RFFL UCHL5 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_222974 bait prey ESPL1 RFFL MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_222978 prey bait STAM RFFL MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_222979 prey bait UBC RFFL MI:0004(affinity chromatography technology) 21963094 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_266170 bait prey USP28 RFFL MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_222977 prey bait USP7 RFFL MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_222972 prey bait UBE2D3 RFFL MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223063 prey bait CASP8 RFFL MI:0018(two hybrid) 15069192 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_76277 prey bait UBE2G2 RFFL MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102565|BIOGRID_123576 bait|bait prey|prey USP5 RFFL MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_222970 prey bait SFN RFFL MI:0493(in vivo) 18382127 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_33327 - - UBE2D2 RFFL MI:0415(enzymatic study) 23871895 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_283637 prey bait OTUB2 RFFL MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_222975 prey bait p53 RFFL MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0493(in vivo) 17121812,18382127 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|- (biogrid)|(biogrid)|MI:0468(hprd) BIOGRID_166900|BIOGRID_141349|HPRD_40065 prey|prey|- bait|bait|-

PPI - HINT Gene A Gene B PMID Method Quality EFCAB7 RFFL 26186194 0004 HT TP53 RFFL 17121812,18382127 0004,0004 LC NEFH RFFL 26186194 0004 HT SHC1 RFFL 26186194 0004 HT Q53GA5 RFFL 17121812,18382127 0004,0004 LC IQCE RFFL 26186194 0004 HT RFFL RNF34 26186194 0004 HT RFFL PRKD2 26186194 0004 HT EFCAB7 RFFL 26186194 0004 HT NEFH RFFL 26186194 0004 HT SHC1 RFFL 26186194 0004 HT IQCE RFFL 26186194 0004 HT RFFL RNF34 26186194 0004 HT RFFL PRKD2 26186194 0004 HT TP53 RFFL 17121812,18382127 0004,0004 LC Q53GA5 RFFL 17121812,18382127 0004,0004 LC USP5 RFFL 22626734 0415 HT ATXN3 RFFL 22626734 0415 HT UBE2G2 RFFL 19690564,19690564 0397,0018 HT RIPK1 RFFL 18450452,18450452 0004,0415 LC ESPL1 RFFL 22626734 0415 HT RFFL RFFL 23871895 0415 LC RFFL STAM 22626734 0415 HT RFFL USP7 22626734 0415 HT RFFL OTUB2 22626734 0415 HT RFFL OTUB1 22626734 0415 HT RFFL USP28 22626734 0415 HT RFFL ATXN3L 22626734 0415 HT RFFL UCHL5 22626734 0415 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8WZ73 P04637 RFFL TP53 0.376 17121812,18382127 Q9BZL6 Q8WZ73 PRKD2 RFFL 0.126 26186194 Q96RU2 Q8WZ73 USP28 RFFL 0.183 22626734 Q96FW1 Q8WZ73 OTUB1 RFFL 0.183 22626734 Q96DC9 Q8WZ73 OTUB2 RFFL 0.183 22626734 Q969K3 Q8WZ73 RNF34 RFFL 0.126 26186194 Q93009 Q8WZ73 USP7 RFFL 0.183 22626734 Q92783 Q8WZ73 STAM RFFL 0.183 22626734 Q8WZ73 Q8WZ73 RFFL RFFL 0.332 23871895 Q8WZ73 P45974 RFFL USP5 0.183 22626734 Q8WZ73 P29353 RFFL SHC1 0.126 26186194 Q8WZ73 A8K855 RFFL EFCAB7 0.126 26186194 Q8WZ73 P12036 RFFL NEFH 0.126 26186194 Q8WZ73 Q6IPM2 RFFL IQCE 0.126 26186194 Q8WZ73 P61077 RFFL UBE2D3 0.183 22626734 Q8WZ73 P54252 RFFL ATXN3 0.183 22626734 Q8WZ73 P60604 RFFL UBE2G2 0.376 19690564 Q8WZ73 Q14674 RFFL ESPL1 0.183 22626734 Q8WZ73 P62837 RFFL UBE2D2 0.309 23871895 Q8WZ73 Q00987 RFFL MDM2 0.21 18382127 Q9Y5K5 Q8WZ73 UCHL5 RFFL 0.183 22626734 Q9H3M9 Q8WZ73 ATXN3L RFFL 0.183 22626734 Q8WZ73 Q13546 RFFL RIPK1 0.569 18450452

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 EFCAB7 RFFL MI:0045 experimental interaction detection MI:0461 interaction database TP53 RFFL MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database UBB RFFL MI:0362 inference MI:1106 pathways database UBC RFFL MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database NEFH RFFL MI:0045 experimental interaction detection MI:0461 interaction database SHC1 RFFL MI:0045 experimental interaction detection MI:0461 interaction database USP5 RFFL MI:0045 experimental interaction detection MI:0461 interaction database UBE2D1 RFFL MI:0045 experimental interaction detection MI:0461 interaction database ATXN3 RFFL MI:0045 experimental interaction detection MI:0461 interaction database UBE2G2 RFFL MI:0045 experimental interaction detection MI:0461 interaction database UBE2D3 RFFL MI:0045 experimental interaction detection MI:0461 interaction database UBE2D2 RFFL MI:0045 experimental interaction detection MI:0461 interaction database RPS27A RFFL MI:0362 inference MI:1106 pathways database UBA52 RFFL MI:0362 inference MI:1106 pathways database MDM2 RFFL MI:0045 experimental interaction detection MI:0461 interaction database RIPK1 RFFL MI:0045 experimental interaction detection MI:0461 interaction database ESPL1 RFFL MI:0045 experimental interaction detection MI:0461 interaction database CASP8 RFFL MI:0045 experimental interaction detection MI:0461 interaction database IQCE RFFL MI:0045 experimental interaction detection MI:0461 interaction database RFFL STAM MI:0045 experimental interaction detection MI:0461 interaction database RFFL USP7 MI:0045 experimental interaction detection MI:0461 interaction database RFFL RNF34 MI:0045 experimental interaction detection MI:0461 interaction database RFFL OTUB2 MI:0045 experimental interaction detection MI:0461 interaction database RFFL OTUB1 MI:0045 experimental interaction detection MI:0461 interaction database RFFL USP28 MI:0045 experimental interaction detection MI:0461 interaction database RFFL PRKD2 MI:0045 experimental interaction detection MI:0461 interaction database RFFL ATXN3L MI:0045 experimental interaction detection MI:0461 interaction database RFFL UCHL5 MI:0045 experimental interaction detection MI:0461 interaction database