PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus TPM1 KLHL21 26186194 biogrid exp G GP G GP G GP G G G G G G GP G G G G G GP G G G G PLK1 KLHL21 23455478 biogrid exp P P G P G GP GP P P P GP GP GP GP GP G P G GP GP P GP ZBTB44 KLHL21 26186194 biogrid exp GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP G P G G GP GP G GP GP G AURKB KLHL21 19995937 biogrid exp P P G GP P P P GP P G P P GP GP P KLHL29 KLHL21 24778252 biogrid exp GP GP G GP G GP GP G GP GP G GP G GP GP G GP G P G G G GP G GP GP G COPS5 KLHL21 21145461 biogrid exp GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP G P G G GP GP G GP GP G KLHL13 KLHL21 19995937, 23023127 biogrid exp, pred GP G G G G GP GP G GP GP G G GP G G GP G G G GP GP GP GP G KLHL9 KLHL21 19995937, 23023127 biogrid exp, pred GP G G G G GP GP G GP GP G G G GP G G GP G G G GP GP G GP GP G CUL3 KLHL21 19995937,21145461, 25402006 biogrid exp, pred GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP G P G G GP GP G GP GP G RPGRIP1L KLHL21 ortho P P P P P P P P P P P G P G P P P GP G HSPA1A, HSPA1B KLHL21 25402006 pred P P P P P P P P P P P P P P P P P P EGF KLHL21 23023127 pred P P P GP P GP P P P G P P GP P G G GP GP P P ZBTB48 KLHL21 23023127 pred G GP G P P GP GP GP G GP G G P GP G P G G P G G G GP G ZBTB7C KLHL21 23023127 pred G GP G G P P P G G GP G G G GP GP TNFAIP1 KLHL21 23023127 pred G G G G G G GP G GP G G G G GP G G GP G G G G GP G GP G G BCL6 KLHL21 23023127 pred G G G G G G G G G G G GP G G G G G G P G G G G G G G G ZBTB16 KLHL21 23023127 pred G GP G GP G G GP G G G GP G G GP GP G GP G G G G GP G G GP G KLHL22 KLHL21 23023127 pred G GP G G G GP GP G GP G GP G G GP G G GP G P G G GP GP G GP GP G RASA1 KLHL21 23023127 pred GP G G GP G G G G G G G G G G GP G G G P G G G G G GP G G KBTBD4 KLHL21 23023127 pred GP GP GP G P G GP P P G GP GP G GP G P G G G GP G P GP SOCS3 KLHL21 23023127 pred GP GP G GP G GP GP G GP GP GP G G GP GP GP GP G P G G GP GP G GP GP G ZBTB7B KLHL21 23023127 pred GP GP P G GP G G G G GP G GP P G P G G G GP G GP P VHL KLHL21 23023127 pred G G G G G G G G GP GP GP G G G G G P G G G G G G G GP G KLHL38 KLHL21 23023127 pred P P P P P P P P P P P P P P P P P KLHL21 IPP 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q96CT2 Q9UJP4 affinity chromatography technology 24778252 physical association X 2 Q9UJP4 A0A024R475 affinity chromatography technology 21145461 physical association X 2 Q9UJP4 A0A024R475 affinity chromatography technology 19995937 physical association X 2 Q9UJP4 A0A024R475 affinity chromatography technology 19995937 physical association X 2 P0CG48 Q9UJP4 affinity chromatography technology 22053931 physical association X 2 P0CG48 Q9UJP4 affinity chromatography technology 22505724 physical association X 2 P0CG48 Q9UJP4 affinity chromatography technology 21963094 physical association X 2 P0CG48 Q9UJP4 affinity chromatography technology 25147182 physical association X 2 P0CG48 Q9UJP4 affinity chromatography technology 21987572 physical association X 2 P0CG48 Q9UJP4 affinity chromatography technology 21906983 physical association X 2 Q58EZ4 Q9UJP4 affinity chromatography technology 19995937 physical association X 2 Q58EZ4 Q9UJP4 affinity chromatography technology 19995937 physical association X 2 P53350 Q9UJP4 affinity chromatography technology 23455478 physical association X 2 P53350 Q9UJP4 affinity chromatography technology 23455478 physical association X 2 Q96HC9 Q9UJP4 affinity chromatography technology 19995937 physical association X 2 Q96HC9 Q9UJP4 affinity chromatography technology 19995937 physical association X 2 A0A024R7W9 Q9UJP4 affinity chromatography technology 21145461 physical association X 2 Q96GD4 Q9UJP4 affinity chromatography technology 19995937 physical association X 2 Q96GD4 Q9UJP4 pull down 19995937 direct interaction X 2 Q96GD4 Q9UJP4 enzymatic study 19995937 direct interaction X 2

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9UJP4 Q8NCP5 KLHL21 ZBTB44 0.126 26186194 Q9UJP4 P09493 KLHL21 TPM1 0.126 26186194 Q9UJP4 Q92905 KLHL21 COPS5 0.126 21145461 Q9UJP4 Q96CT2 KLHL21 KLHL29 0.126 24778252 Q9UJP4 Q96GD4 KLHL21 AURKB 0.623 19995937 Q9UJP4 Q96JM2 KLHL21 ZNF462 0.126 27705803 Q9UJP4 P53350 KLHL21 PLK1 0.376 23455478 Q9UJP4 Q13618 KLHL21 CUL3 0.454 19995937,21145461 Q9UJP4 Q9P2J3 KLHL21 KLHL9 0.21 19995937 Q9UJP4 Q9P2N7 KLHL21 KLHL13 0.21 19995937