PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Smurf2 Nkd2 19379695 biogrid,intact exp Smurf2 Rac1 19379695 biogrid,intact exp Smurf2 Pklr 19379695 biogrid exp Smurf2 Prok2 19379695 biogrid exp Smurf2 Tp53bp1 19379695 biogrid,intact exp Smurf2 Dvl1 19379695 biogrid,intact exp Smurf2 Tgfbr1 25885904 biogrid exp, ortho Smurf2 Irf3 mint exp, ortho Smurf2 Runx2 23969857 biogrid exp, ortho Smurf2 Skil 16959829 biogrid exp, ortho Smurf2 Dvl2 19379695 biogrid exp, ortho Smurf2 Smad1 20956305,23969857 biogrid exp, ortho Smurf2 Pard6a 19379695 biogrid,intact exp, ortho Smurf2 Smad7 25885904,15173588 biogrid exp, ortho Smurf2 Fbxl15 ortho Smurf2 G3bp2 ortho Smurf2 Mrps23 ortho Smurf2 Gng2 ortho Smurf2 Nkiras1 ortho Smurf2 Ilf2 ortho Smurf2 Rpl22 ortho Smurf2 Dcaf6 ortho Smurf2 Mrps7 ortho Smurf2 Hspb1 ortho Smurf2 Zbtb44 ortho Smurf2 Id1 ortho Smurf2 Diablo ortho Smurf2 Stambp ortho Smurf2 Strap ortho Smurf2 Rnf111 ortho Smurf2 Acbd3 ortho Smurf2 Prickle1 ortho Smurf2 Mrps22 ortho Smurf2 Rhoa ortho Smurf2 Efnb1 ortho Smurf2 Txnip ortho Smurf2 Ubc ortho Smurf2 Tcap ortho Smurf2 Rpl18a ortho Smurf2 Sqstm1 ortho Smurf2 Tenm2 ortho Smurf2 Nras ortho Smurf2 Epha1 ortho Smurf2 Protein Tmem139 ortho Smurf2 Gfm1 ortho Smurf2 Mrpl12 ortho Smurf2 Ncam1 ortho Smurf2 Fkbp4 ortho Smurf2 Nudt21 ortho Smurf2 Id3 ortho Smurf2 Fam175b ortho Smurf2 Ccar1 ortho Smurf2 Mrps31 ortho Smurf2 Aimp1 ortho Smurf2 Spta1 ortho Smurf2 Lmcd1 ortho Smurf2 Dgcr2 ortho Smurf2 Rps10 ortho Smurf2 Dnajc10 ortho Smurf2 Smad2 ortho Smurf2 Rab3b ortho Smurf2 Hist1h1c ortho Smurf2 Rras2 ortho Smurf2 Rap1b ortho Smurf2 Gmeb1 ortho Smurf2 Esf1 ortho Smurf2 Prickle2 ortho Smurf2 Acox3 ortho Smurf2 Mrpl41 ortho Smurf2 Ppid ortho Smurf2 Xrcc6 ortho Smurf2 Atp5b ortho Smurf2 Stau1 ortho Smurf2 Rps7 ortho Smurf2 Rps12 ortho Smurf2 Rlim ortho Smurf2 Cttn ortho Smurf2 Igf2bp1 ortho Smurf2 Traf4 ortho Smurf2 Mrpl2 ortho Smurf2 Rps20 ortho Smurf2 Set ortho Smurf2 Ndufa1 ortho Smurf2 Ran ortho Smurf2 Axin1 ortho Smurf2 Bmpr1b ortho Smurf2 Acta1 ortho Smurf2 Cuedc1 ortho Smurf2 Anapc5 ortho Smurf2 Nsun2 ortho Smurf2 Flnc ortho Smurf2 Ntn1 ortho Smurf2 Rbm14 ortho Smurf2 Runx3 ortho Smurf2 Klf5 ortho Smurf2 Nap1l1 ortho Smurf2 Rasl12 ortho Smurf2 Srsf4 ortho Smurf2 Protein Apold1 ortho Smurf2 Smad5 ortho Smurf2 Smad4 ortho Smurf2 Ybx1 ortho Smurf2 Eef1g ortho Smurf2 Grwd1 ortho Smurf2 Ing2 ortho Smurf2 Ube2l3 ortho Smurf2 Arhgef1 ortho Smurf2 Tnnt1 ortho Smurf2 Ccm2 ortho Smurf2 Tfpi2 ortho Smurf2 Dazap2 ortho Smurf2 Acta2 ortho Smurf2 Gsk3b ortho Smurf2 Hdlbp ortho Smurf2 Ash2l ortho Smurf2 Smurf1 ortho Smurf2 Canx ortho Smurf2 Rps15a ortho Smurf2 Rab17 ortho Smurf2 Rnf11 ortho Smurf2 Usp15 ortho Smurf2 Tnni3 ortho Smurf2 Srsf6 ortho Smurf2 Fhl2 ortho Smurf2 Smurf2 ortho Smurf2 Rpl35 ortho Smurf2 Enah ortho Smurf2 Ldlrad4 ortho Smurf2 Dab2 ortho Smurf2 Smad3 ortho Smurf2 Socs6 ortho Smurf2 Ube2g1 ortho Smurf2 Rab22a ortho Smurf2 Rhod ortho Smurf2 Gnb2l1 ortho Smurf2 Yy1 ortho Smurf2 Tnfrsf1b ortho Smurf2 Mybpc3 ortho Smurf2 Flnb ortho Smurf2 Myoz1 ortho Smurf2 Rpl35a ortho Smurf2 Tgfbr2 ortho Smurf2 Rps11 ortho Smurf2 Echs1 ortho Smurf2 Tuba1b ortho Smurf2 Rnf14 ortho Smurf2 Rsl1d1 ortho Smurf2 Mylk2 ortho Smurf2 Trim28 ortho Smurf2 Srsf1 ortho Smurf2 Laptm5 ortho Smurf2 Nek6 ortho Smurf2 Smarca2 ortho Smurf2 H1 histone family, member X, Protein H1fx ortho Smurf2 Rps13 ortho Smurf2 Uxt ortho Smurf2 Traf2 ortho Smurf2 Wbp2 ortho Smurf2 Syncrip ortho Smurf2 Xrcc5 ortho Smurf2 Tnpo3 ortho Smurf2 Ythdf2 ortho Smurf2 Kctd12 ortho Smurf2 Tnni2 ortho Smurf2 Rab25 ortho Smurf2 Tfrc ortho Smurf2 Dhx9 ortho Smurf2 Mavs ortho Smurf2 Ube2d1 ortho Smurf2 Irf8 ortho Smurf2 Mrpl19 ortho Smurf2 Ube2d3 ortho Smurf2 Egfr ortho Smurf2 Snrnp70 ortho Smurf2 Rasd2 ortho Smurf2 Ttn ortho Smurf2 Rnf2 ortho Smurf2 Slc25a5 ortho Smurf2 Tssk4 ortho Smurf2 Ptch1 ortho Smurf2 Rab14 ortho Smurf2 Rab13 ortho Smurf2 Smad6 ortho Smurf2 Rif1 ortho Smurf2 Rps24 ortho Smurf2 Smap1 ortho Smurf2 Snrpd3 ortho Smurf2 Btrc ortho Smurf2 Lats1 ortho Smurf2 Eif3e ortho Smurf2 Hdgfrp3 ortho Smurf2 Rnf20 ortho Smurf2 Des ortho Smurf2 Sla2 ortho Smurf2 Arhgap5 ortho Smurf2 Rps27a ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants F6KD01 A2A5Z6 affinity chromatography technology 19379695 physical association X 2 A2A5Z6 affinity chromatography technology 19379695 physical association X 2 A2A5Z6 O75688-3 affinity chromatography technology 19379695 physical association X 2 A2A5Z6 P51141 affinity chromatography technology 19379695 physical association X 2 A2A5Z6 affinity chromatography technology 19379695 physical association X 2 A2A5Z6 affinity chromatography technology 19379695 physical association X 2 A2A5Z6 G3X925 affinity chromatography technology 19379695 physical association X 2 A2A5Z6 Q08775-9 affinity chromatography technology 23969857 physical association X 2 A2A5Z6 Q3TB81 affinity chromatography technology 16959829 physical association X 2 O14641 A2A5Z6 affinity chromatography technology 19379695 physical association X 2 P63001 A2A5Z6 affinity chromatography technology 19379695 physical association X 2 Q8VE28 A2A5Z6 affinity chromatography technology 19379695 physical association X 2 A2A5Z6 Q92997 affinity chromatography technology 19379695 physical association X 2 A2A5Z6 P70399 affinity chromatography technology 19379695 physical association X 2 A2A5Z6 Q60838 affinity chromatography technology 19379695 physical association X 2 A2A5Z6 Q60838 affinity chromatography technology 19379695 physical association X 2 A2A5Z6 G3X8R6 affinity chromatography technology 19379695 physical association X 2 O35253 A2A5Z6 affinity chromatography technology 15173588 physical association X 2 P70340 A2A5Z6 affinity chromatography technology 23969857 physical association X 2 P70340 A2A5Z6 affinity chromatography technology 20956305 physical association X 2 Q15717 A2A5Z6 affinity chromatography technology 19379695 physical association X 2 A2A5Z6 anti tag coimmunoprecipitation 19379695 association C 3 A2A5Z6 anti tag coimmunoprecipitation 19379695 association C 3 A2A5Z6 anti tag coimmunoprecipitation 19379695 physical association C 3 A2A5Z6 tandem affinity purification 19379695 association C 3 A0A024R368 A2A5Z6 anti tag coimmunoprecipitation 19379695 physical association X 2 F6KD01 A2A5Z6 luminescence based mammalian interactome mapping 19379695 physical association X 2 A2A5Z6 Q9Y2G4 luminescence based mammalian interactome mapping 19379695 physical association X 2 A2A5Z6 O75688 luminescence based mammalian interactome mapping 19379695 physical association X 2 A2A5Z6 P51141 luminescence based mammalian interactome mapping 19379695 physical association X 2 O14641 A2A5Z6 luminescence based mammalian interactome mapping 19379695 physical association X 2 O14641 A2A5Z6 anti tag coimmunoprecipitation 19379695 physical association X 2 O14641 A2A5Z6 anti tag coimmunoprecipitation 19379695 physical association X 2 O14641 A2A5Z6 luminescence based mammalian interactome mapping 19379695 physical association X 2 O14641 A2A5Z6 anti tag coimmunoprecipitation 19379695 physical association X 2 P63001 A2A5Z6 luminescence based mammalian interactome mapping 19379695 physical association X 2 Q8VE28 A2A5Z6 luminescence based mammalian interactome mapping 19379695 physical association X 2 A2A5Z6 P70399 luminescence based mammalian interactome mapping 19379695 physical association X 2 A2A5Z6 Q92997 luminescence based mammalian interactome mapping 19379695 physical association X 2 A0A024R0W7 A2A5Z6 anti tag coimmunoprecipitation 19379695 physical association X 2 Q15717 A2A5Z6 luminescence based mammalian interactome mapping 19379695 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality SMURF2 DVL1 19379695,19379695 0004,0729 LC SMURF2 RAC1 19379695,19379695 0004,0729 LC SMURF2 TP53BP1 19379695,19379695 0004,0729 LC SMURF2 NKD2 19379695,19379695 0004,0729 LC SMURF2 SMAD7 15173588,25612247,25885904 0004,0004,0004 LC SMURF2 DVL1 19379695,19379695 0004,0729 LC SMURF2 PKLR 19379695 0004 LC SMURF2 RAC1 19379695,19379695 0004,0729 LC SMURF2 SMAD1 23969857,20956305 0004,0004 LC SMURF2 TP53BP1 19379695,19379695 0004,0729 LC SMURF2 RUNX2 23969857 0004 LC SMURF2 SKIL 16959829 0004 LC SMURF2 DVL2 19379695 0004 LC SMURF2 TGFBR1 25885904 0004 LC SMURF2 NKD2 19379695,19379695 0004,0729 LC SMURF2 PROK2 19379695 0004 LC SMURF2 PARD6A 19379695,19379695 0004,0007 LC