PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P22681 E9Q0N0 protein complementation assay 22158968 direct interaction X 2 E9Q0N0 O43597 affinity chromatography technology 24216759 physical association X 2 P42567-2 E9Q0N0 affinity chromatography technology 10064583 physical association X 2 P42567-2 E9Q0N0 affinity chromatography technology 10064583 physical association X 2 A6X8Z5 E9Q0N0 affinity chromatography technology 11744688 physical association X 2 A6X8Z5 E9Q0N0 affinity chromatography technology 11744688 physical association X 2 Q9QXV8 E9Q0N0 affinity chromatography technology 22158968 physical association X 2 Q9QXV8 E9Q0N0 pull down 22158968 direct interaction X 2 Q9QXV8 E9Q0N0 protein complementation assay 22158968 direct interaction X 2 P35235 E9Q0N0 affinity chromatography technology 24216759 physical association X 2 P35235 E9Q0N0 protein complementation assay 24216759 direct interaction X 2 P22682 E9Q0N0 affinity chromatography technology 21712076 physical association X 2 P22682 E9Q0N0 affinity chromatography technology 17875942 physical association X 2 P22682 E9Q0N0 affinity chromatography technology 16914641 physical association X 2 E9Q0N0 two hybrid 17875942 direct interaction X 2 E9Q0N0 affinity chromatography technology 17875942 physical association X 2 E9Q0N0 affinity chromatography technology 17875942 physical association X 2 E9Q0N0 P39053 affinity chromatography technology 21712076 physical association X 2 P10144 E9Q0N0 enzymatic study 16798735 direct interaction X 2

PPI - HINT Gene A Gene B PMID Method Quality ARHGAP31 ITSN1 21349274,21349274,21349274 0049,0096,0081 LC PIK3C2B ITSN1 17875942,17875942 0018,0004 LC AP2A2 ITSN1 20160082 0114 LC PTPN11 ITSN1 24216759,24216759 0004,0090 LC DNM1 ITSN1 10064583,10064583 0416,0018 LC DNM2 ITSN1 10064583 0018 LC EPS15 ITSN1 10064583,10064583,10064583,10064583 0004,0019,0416,0018 LC YWHAE ITSN1 16615898 0027 LC DAB2 ITSN1 22648170,22648170 0007,0416 LC EPS15L1 ITSN1 10064583 0018 LC EPN1 ITSN1 17380122 0018 LC YWHAB ITSN1 16635246 0029 LC PIK3AP1 ITSN1 15102471 0018 LC SPRY2 ITSN1 22158968,22158968,22158968 0004,0090,0096 LC ITSN1 ITSN1 20585582 0114 LC ARHGAP31 ITSN1 11744688,21349274,21349274,21349274 0004,0049,0096,0081 LC PIK3C2B ITSN1 17875942,17875942 0018,0004 LC CBL ITSN1 21712076,16914641,17875942,16914641 0004,0004,0004,0006 LC PTPN11 ITSN1 24216759,24216759 0004,0090 LC DNM1 ITSN1 21712076 0004 LC EPS15 ITSN1 10064583,10064583,10064583,10064583 0004,0019,0416,0018 LC ATP6V1A ITSN1 22707207 0006 LC DAB2 ITSN1 22648170,22648170 0007,0416 LC ARHGAP30 ITSN1 21349274 0096 LC INPPL1 ITSN1 18692052 0006 LC DENND1A ITSN1 17182770,17182770 0096,0006 LC SPRY2 ITSN1 22158968,22158968,22158968 0004,0090,0096 LC