PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus VAC8 SNA4 18467557 biogrid,i2d,mint,intact exp SBP1 VAC8 23222640 biogrid exp VAC8 VAC8 22940862 biogrid exp VAC8 FMP41 16554755 biogrid,i2d,mint,intact exp VAC8 BUD32 14519092 biogrid,intact exp BLI1 VAC8 11283351 i2d,mint,intact,dip exp CDC28 VAC8 24374311 biogrid exp VAC8 RPN11 18757749 biogrid exp VAC8 NDL1 11283351 i2d,mint,intact,dip exp VAC8 IML1 18467557 biogrid,i2d,mint,intact exp VAC8 Uncharacterized protein YFR035C 16824055 biogrid exp DRS2 VAC8 16429126 intact exp VAC8 NCE102 16429126 intact exp COT1 VAC8 18467557 biogrid,i2d,mint,intact exp BEM1 VAC8 16854988 biogrid exp YCK3 VAC8 16301533 biogrid exp VAC8 PRR2 11283351 i2d,mint,intact,dip exp SNA3 VAC8 18467557 biogrid,i2d,mint,intact exp SSA2 VAC8 19536198 intact exp SSB1 VAC8 19536198 intact exp VAC8 CTF3 i2d exp VAC8 TAO3 16824055 biogrid exp VAC8 EAF1 16824055 biogrid exp VAC8 PFD1 19536198 intact exp VAC8 ATG1 22885598 biogrid,intact exp VAC8 TCO89 16824055 biogrid exp FBA1 VAC8 16429126 intact exp VAC8 HHT1, HHT2 22199229 biogrid exp Uncharacterized protein YEL043W VAC8 16824055 biogrid exp HXT1 VAC8 18467557 biogrid,i2d,mint,intact exp VAC8 ERF2 19416974 biogrid exp VAC8 VAB2 9813094,16824055,23547030,10888680 biogrid,i2d,intact,dip exp VAC8 RFC2 11805837 biogrid,mint,intact,dip exp VAC8 DPP1 18467557 biogrid,i2d,mint,intact exp VAC8 GTR1 18467557 biogrid,i2d,mint,intact exp VAC8 Uncharacterized protein YLR072W 25987606 biogrid exp VAC8 JJJ2 19536198 intact exp GCD7 VAC8 11805837 biogrid,mint,intact,dip exp VAC8 ATG13 15901835,10837477,16824055,10888680, 23023127 biogrid,i2d,intact,dip exp, pred NVJ1 VAC8 9813094,10888680, 23023127 biogrid,i2d,intact,dip exp, pred VAC8 VTI1 18541004,11406591, 23023127 biogrid exp, pred VAC8 MEH1 18467557,16301533, 23023127 biogrid,i2d,mint,intact exp, pred VAC8 PFA3 19416974,19453970,16186255,16301533, 23023127 biogrid exp, pred VMA7 VAC8 18467557, 23023127 biogrid,i2d,mint,intact exp, pred VAC8 PIB2 18467557, 23023127 mint,intact exp, pred VAC8 VAM3 11406591, 23023127 biogrid exp, pred YKT6 VAC8 15520806,14685280, 23023127 biogrid exp, pred VAC8 ACT1 9490720, 23023127 biogrid,i2d,dip exp, pred VAC17 VAC8 16824055,12594460, 23023127 biogrid exp, pred SWH1 VAC8 18467557, 23023127 biogrid,i2d,mint,intact exp, pred VAC8 JSN1 11283351, 23023127 biogrid,i2d,mint,intact,dip exp, pred SSA1 VAC8 19536198, 23023127 intact exp, pred FTH1 VAC8 18467557, 23023127 biogrid,i2d,mint,intact exp, pred PMC1 VAC8 18467557, 23023127 biogrid,i2d,mint,intact exp, pred VPS21 VAC8 23023127 pred MYO2 VAC8 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q06568 P39968 - 11283351 - X 2 P35727 P39968 - 11283351 - X 2 P40003 P39968 - 10888680 - X 2 P38881 P39968 - 10888680 - X 2 P39968 - 11805837 - C 7 P39968 - 11805837 - C 16 P39968 P60010 - 9490720 - X 2 Q06628 P39968 - 10888680 - X 2 Q12310 P39968 - 11283351 - X 2 P47135 P39968 - 11283351 - X 2 P39968 P39968 affinity chromatography technology 22940862 physical association X 2 Q06551 P39968 enzymatic study 19416974 direct interaction X 2 P39111 P39968 protein complementation assay 18467557 direct interaction X 2 P40348 P39968 affinity chromatography technology 11805837 physical association X 2 Q05521 P39968 protein complementation assay 18467557 direct interaction X 2 Q02205 P39968 biochemical 16301533 colocalization X 2 Q02205 P39968 protein complementation assay 18467557 direct interaction X 2 P0CG63 P39968 affinity chromatography technology 23749301 physical association X 2 P0CG63 P39968 affinity chromatography technology 23793018 physical association X 2 P0CG63 P39968 affinity chromatography technology 12872131 physical association X 2 P0CG63 P39968 affinity chromatography technology 21427232 physical association X 2 P0CG63 P39968 affinity chromatography technology 22106047 physical association X 2 P32618 P39968 two hybrid 16824055 direct interaction X 2 P32798 P39968 protein complementation assay 18467557 direct interaction X 2 Q04338 P39968 affinity chromatography technology 11406591 physical association X 2 Q04338 P39968 biochemical 18541004 colocalization X 2 P35845 P39968 protein complementation assay 18467557 direct interaction X 2 P40468 P39968 two hybrid 16824055 direct interaction X 2 Q07549 P39968 protein complementation assay 18467557 direct interaction X 2 P53889 P39968 affinity chromatography technology 16554755 physical association X 2 P32465 P39968 protein complementation assay 18467557 direct interaction X 2 Q08921 P39968 two hybrid 16824055 direct interaction X 2 P43608 P39968 two hybrid 16824055 direct interaction X 2 P14359 P39968 protein complementation assay 18467557 direct interaction X 2 P38929 P39968 protein complementation assay 18467557 direct interaction X 2 P40003 P39968 affinity chromatography technology 10888680 physical association X 2 P40003 P39968 two hybrid 16824055 direct interaction X 2 P32502 P39968 affinity chromatography technology 11805837 physical association X 2 P38881 P39968 affinity chromatography technology 10888680 physical association X 2 P38881 P39968 two hybrid 10888680 direct interaction X 2 P38310 P39968 protein complementation assay 18467557 direct interaction X 2 P39968 P60010 affinity chromatography technology 9490720 physical association X 2 P39968 P42836 enzymatic study 16186255 direct interaction X 2 P39968 P42836 imaging technique 16301533 colocalization X 2 P39968 P42836 enzymatic study 19416974 direct interaction X 2 P39968 P42836 biochemical 19453970 colocalization X 2 P39968 P42836 affinity chromatography technology 19453970 physical association X 2 P43588 P39968 affinity chromatography technology 18757749 physical association X 2 Q06337 P39968 two hybrid 16824055 direct interaction X 2 P39962 P39968 biochemical 16301533 colocalization X 2 Q12241 P39968 affinity chromatography technology 11406591 physical association X 2 Q12241 P39968 pull down 11406591 direct interaction X 2 P29366 P39968 biochemical 16854988 colocalization X 2 P36015 P39968 pull down 14685280 direct interaction X 2 P36015 P39968 pull down 14685280 direct interaction X 2 P36015 P39968 pull down 15520806 direct interaction X 2 P53104 P39968 affinity chromatography technology 22885598 physical association X 2 Q00582 P39968 protein complementation assay 18467557 direct interaction X 2 P25591 P39968 affinity chromatography technology 12594460 physical association X 2 P25591 P39968 two hybrid 16824055 direct interaction X 2 P47170 P39968 protein complementation assay 18467557 direct interaction X 2 Q06628 P39968 two hybrid 10837477 direct interaction X 2 Q06628 P39968 affinity chromatography technology 10837477 physical association X 2 Q06628 P39968 affinity chromatography technology 10888680 physical association X 2 Q06628 P39968 two hybrid 15901835 direct interaction X 2 Q06628 P39968 two hybrid 16824055 direct interaction X 2 P61830 P39968 affinity chromatography technology 22199229 physical association X 2 P61830 P39968 affinity chromatography technology 22199229 physical association X 2 P53323 P39968 two hybrid 14519092 direct interaction X 2 Q12207 P39968 affinity chromatography technology 17200106 physical association X 2 P47135 P39968 two hybrid 11283351 direct interaction X 2 P39968 anti tag coimmunoprecipitation 11805837 - C 16 P39968 anti tag coimmunoprecipitation 11805837 - C 16 P40348 P39968 anti tag coimmunoprecipitation 11805837 physical association X 2 Q06568 P39968 two hybrid pooling approach 11283351 physical association X 2 P35727 P39968 two hybrid pooling approach 11283351 physical association X 2 P40003 P39968 affinity chromatography technology 9813094 physical association X 2 P40003 P39968 two hybrid 9813094 physical association X 2 P32502 P39968 anti tag coimmunoprecipitation 11805837 physical association X 2 P38881 P39968 affinity chromatography technology 9813094 physical association X 2 P38881 P39968 two hybrid 9813094 physical association X 2 P39968 anti tag coimmunoprecipitation 11805837 - C 7 P39968 anti tag coimmunoprecipitation 11805837 - C 47 P39968 P60010 biochemical 9490720 physical association X 2 Q06628 P39968 two hybrid 10888680 physical association X 2 Q06628 P39968 coimmunoprecipitation 10888680 physical association X 2 Q06628 P39968 two hybrid 10837477 physical association X 2 Q06628 P39968 biochemical 10888680 physical association X 2 Q06628 P39968 coimmunoprecipitation 10837477 physical association X 2 Q12310 P39968 two hybrid pooling approach 11283351 physical association X 2 P47135 P39968 two hybrid pooling approach 11283351 physical association X 2 P39968 inferred by author 16429126 physical association C 10 P39968 anti tag coimmunoprecipitation 22885598 association C 3 P39968 tandem affinity purification 16429126 association C 9 P39968 tandem affinity purification 16429126 association C 29 P39968 anti tag coimmunoprecipitation 11805837 association C 16 P39111 P39968 dihydrofolate reductase reconstruction 18467557 physical association X 2 Q05521 P39968 dihydrofolate reductase reconstruction 18467557 physical association X 2 P11484 P39968 tandem affinity purification 19536198 association X 2 Q02205 P39968 dihydrofolate reductase reconstruction 18467557 physical association X 2 Q06568 P39968 two hybrid fragment pooling approach 11283351 physical association X 2 P32798 P39968 dihydrofolate reductase reconstruction 18467557 physical association X 2 P35845 P39968 dihydrofolate reductase reconstruction 18467557 physical association X 2 P35727 P39968 two hybrid fragment pooling approach 11283351 physical association X 2 Q07549 P39968 dihydrofolate reductase reconstruction 18467557 physical association X 2 P53889 P39968 inferred by author 16554755 association X 2 P53889 P39968 tandem affinity purification 16554755 physical association X 2 P32465 P39968 dihydrofolate reductase reconstruction 18467557 physical association X 2 P14359 P39968 dihydrofolate reductase reconstruction 18467557 physical association X 2 P10591 P39968 tandem affinity purification 19536198 association X 2 P38929 P39968 dihydrofolate reductase reconstruction 18467557 physical association X 2 P40003 P39968 pull down 10888680 physical association X 2 P40003 P39968 two hybrid 10888680 physical association X 2 P38881 P39968 two hybrid 10888680 physical association X 2 P38881 P39968 confocal microscopy 10888680 colocalization X 2 P38881 P39968 two hybrid 10888680 physical association X 2 P38881 P39968 pull down 10888680 physical association X 2 P39968 anti tag coimmunoprecipitation 11805837 association C 13 P39968 inferred by author 16429126 physical association C 7 P39968 inferred by author 16429126 physical association C 18 P10592 P39968 tandem affinity purification 19536198 association X 2 P38310 P39968 dihydrofolate reductase reconstruction 18467557 physical association X 2 P53191 P39968 dihydrofolate reductase reconstruction 18467557 physical association X 2 P46988 P39968 tandem affinity purification 19536198 association X 2 Q00582 P39968 dihydrofolate reductase reconstruction 18467557 physical association X 2 P47170 P39968 dihydrofolate reductase reconstruction 18467557 physical association X 2 Q06628 P39968 two hybrid 10837477 physical association X 2 Q06628 P39968 two hybrid 10837477 physical association X 2 Q06628 P39968 anti bait coimmunoprecipitation 10837477 physical association X 2 Q06628 P39968 two hybrid 10888680 physical association X 2 Q06628 P39968 pull down 10888680 physical association X 2 Q12310 P39968 two hybrid fragment pooling approach 11283351 physical association X 2 P53323 P39968 two hybrid 14519092 physical association X 2 P46997 P39968 tandem affinity purification 19536198 association X 2 P47135 P39968 two hybrid fragment pooling approach 11283351 physical association X 2 Q06568 P39968 two hybrid 11283351 - X 2 Q06697 P39968 interaction detection method 14764870 - X 2 P35727 P39968 two hybrid 11283351 - X 2 P40003 P39968 two hybrid 20346969 - X 2 P38881 P39968 two hybrid 20346969 - X 2 P39968 mass spectrometry studies of complexes 11805837 - C 8 P39968 mass spectrometry studies of complexes 11805837 - C 17 P39968 P60010 cosedimentation 9490720 - X 2 Q06628 P39968 two hybrid 20346969 - X 2 Q12310 P39968 two hybrid 11283351 - X 2 P47135 P39968 two hybrid 11283351 - X 2

PPI - HINT Gene A Gene B PMID Method Quality SNA3 VAC8 18467557,18467557 0111,0090 HT VAC17 VAC8 16824055 0018 LC BEM1 VAC8 16854988 0401 LC HXT1 VAC8 18467557,18467557 0111,0090 HT P32618 VAC8 16824055 0018 LC COT1 VAC8 18467557,18467557 0111,0090 HT BLI1 VAC8 11283351,11283351,11283351 0018,0399,0398 HT SWH1 VAC8 18467557,18467557 0111,0090 HT FTH1 VAC8 18467557,18467557 0111,0090 HT NVJ1 VAC8 20346969,10888680,9813094,10888680,10888680,9813094,10888680 0018,0096,0004,0663,0004,0018,0018 LC PMC1 VAC8 18467557,18467557 0111,0090 HT VMA7 VAC8 18467557,18467557 0111,0090 HT YCK3 VAC8 16301533 0401 LC VAC8 VAB2 20346969,10888680,9813094,10888680,9813094,16824055,10888680 0018,0096,0004,0004,0018,0018,0018 LC VAC8 TAO3 16824055 0018 LC VAC8 PFA3 19453970,19453970,16186255,19416974 0004,0401,0415,0415 LC VAC8 P43608 16824055 0018 LC VAC8 JSN1 11283351,11283351,11283351 0018,0399,0398 HT VAC8 IML1 18467557,18467557 0111,0090 HT VAC8 PIB2 18467557 0111 HT VAC8 BUD32 14519092 0018 LC VAC8 ACT1 9490720,9490720,9490720 0027,0004,0401 LC VAC8 GTR1 18467557,18467557 0111,0090 HT VAC8 MEH1 18467557,18467557,16301533 0090,0111,0401 HT,LC VAC8 VTI1 18541004 0401 LC VAC8 DPP1 18467557,18467557 0111,0090 HT VAC8 EAF1 16824055 0018 LC VAC8 ERF2 19416974 0415 LC VAC8 NDL1 11283351,11283351,11283351 0018,0399,0398 HT VAC8 ATG13 20346969,15901835,10888680,10837477,10837477,10837477,10888680,16824055,10888680,10888680,10888680,10837477 0018,0018,0096,0006,0004,0018,0004,0018,0401,0019,0018,0019 LC VAC8 SNA4 18467557,18467557 0111,0090 HT VAC8 TCO89 16824055 0018 LC VAC8 PRR2 11283351,11283351,11283351 0018,0399,0398 HT CDC28 VAC8 24374311 0004 LC UBI4 VAC8 22106047 0004 LC SSA1 VAC8 19536198 0676 HT SSA2 VAC8 19536198 0676 HT SSB1 VAC8 19536198 0676 HT FBA1 VAC8 16429126 0363 HT VAC17 VAC8 12594460 0004 LC BEM1 VAC8 16854988 0401 LC GCD7 VAC8 11805837,11805837 0004,0007 HT YKT6 VAC8 15520806,14685280 0096,0096 LC NVJ1 VAC8 10888680,9813094,10888680,10888680,9813094,10888680 0096,0004,0663,0004,0018,0018 LC DRS2 VAC8 16429126 0363 HT YCK3 VAC8 16301533 0401 LC VAC8 VAC8 22940862 0004 HT VAC8 VAB2 10888680,9813094,10888680,9813094,23547030,10888680 0096,0004,0004,0018,0004,0018 LC VAC8 RFC2 11805837,11805837 0004,0007 HT VAC8 PFA3 19453970,19453970,16301533 0004,0401,0428 LC VAC8 RPN11 18757749 0004 HT VAC8 PFD1 19536198 0676 HT VAC8 JJJ2 19536198 0676 HT VAC8 ATG1 22885598,22885598 0004,0007 LC VAC8 FMP41 16554755,16554755,16554755 0363,0676,0004 HT VAC8 ACT1 9490720,9490720,9490720 0027,0004,0401 LC VAC8 HHT1|HHT2 22199229 0004 HT VAC8 MEH1 16301533 0401 LC VAC8 VTI1 11406591,18541004 0004,0401 LC VAC8 ATG13 10888680,10837477,10837477,10837477,10888680,10888680,10888680,10888680,10837477 0096,0006,0004,0018,0004,0401,0019,0018,0019 LC VAC8 LAM6 25987606 0004 LC VAC8 NCE102 16429126,17200106 0676,0004 HT VAC8 VAM3 11406591,11406591 0004,0096 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P53323 P39968 BUD32 VAC8 0.309 14519092 Q12207 P39968 NCE102 VAC8 0.126 16429126 P39968 P0CS90 VAC8 SSC1 0.126 25792736 P39968 P10080 VAC8 SBP1 0.126 23222640 P39968 P00546 VAC8 CDC28 0.126 24374311 P39968 P10591 VAC8 SSA1 0.126 19536198 P39968 P10592 VAC8 SSA2 0.126 19536198 P39968 P11484 VAC8 SSB1 0.126 19536198 P39968 P14540 VAC8 FBA1 0.126 16429126 Q05521 P39968 DPP1 VAC8 0.286 18467557 Q07549 P39968 SNA4 VAC8 0.286 18467557 Q04338 P39968 VTI1 VAC8 0.309 11406591,18541004 P53104 P39968 ATG1 VAC8 0.376 22885598 P39968 P35845 VAC8 SWH1 0.286 18467557 P39968 P38310 VAC8 FTH1 0.286 18467557 P39968 P38881 VAC8 NVJ1 0.065 9813094 Q06628 P39968 ATG13 VAC8 0.454 10888680,10837477 P39968 P38929 VAC8 PMC1 0.286 18467557 P39968 P14359 VAC8 SNA3 0.286 18467557 P53889 P39968 FMP41 VAC8 0.236 16554755 P47170 P39968 IML1 VAC8 0.286 18467557 Q12241 P39968 VAM3 VAC8 0.454 11406591 P39968 P32465 VAC8 HXT1 0.286 18467557 P39968 P32502 VAC8 GCD7 0.236 11805837 P39968 P32798 VAC8 COT1 0.286 18467557 P39968 P39111 VAC8 VMA7 0.286 18467557 P39968 P39524 VAC8 DRS2 0.126 16429126 P39968 P35727 VAC8 BLI1 0.21 11283351 P39968 P36015 VAC8 YKT6 0.671 14685280,15520806 P39968 P39962 VAC8 YCK3 0.126 16301533 P42836 P39968 PFA3 VAC8 0.583 19453970,19416974,16301533 P46997 P39968 JJJ2 VAC8 0.126 19536198 P47135 P39968 JSN1 VAC8 0.354 11283351 P53191 P39968 PIB2 VAC8 0.126 18467557 P60010 P39968 ACT1 VAC8 0.033 9490720 Q00582 P39968 GTR1 VAC8 0.286 18467557 Q06568 P39968 NDL1 VAC8 0.236 11283351 Q12310 P39968 PRR2 VAC8 0.21 11283351 P40003 P39968 VAB2 VAC8 0.261 9813094,23547030 P40348 P39968 RFC2 VAC8 0.21 11805837 P46988 P39968 PFD1 VAC8 0.126 19536198 Q02205 P39968 MEH1 VAC8 0.376 18467557,16301533 Q06551 P39968 ERF2 VAC8 0.309 19416974 Q08001 P39968 Q08001 VAC8 0.126 25987606