iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Mmu-063130

Ensembl Protein ID

ENSMUSP00000017759.2

UniProt Accession

O70479; Q3TH85; Q3UGQ5; Q8BV61; Q8BZK5; BACD2_MOUSE

Genbank Protein ID

AAC78826.1; AAC78826.1; AAC78826.1; AAC78826.1; AAC78826.1; AAC78826.1; BAB23395.1; BAC28668.1; BAC37770.1; BAE28152.1; BAE40313.1; BAE40546.1; CAI25552.1; AAH03906.1

Protein Name

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2; BTB/POZ domain-containing protein TNFAIP1; Tumor necrosis factor, alpha-induced protein 1, endothelial

Genbank Nucleotide ID

AF061346; AF061341; AF061342; AF061343; AF061344; AF061345; AK004593; AK034305; AK079869; AK147809; AK168386; AK168704; AL591177; BC003906

Gene Name

Tnfaip1; Edp1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000017615.12	ENSMUST00000017759.8	ENSMUSP00000017759.2

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	4.40e-07	31.3	29	94

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 2    DvilvvggeeffahkivLaasSsvFyalflmele.esksklmveikdvqpevfrallkFlYtgklde 67
            v+l+vgg+ + ++   L+++  +++a+f++ +e  +++++ + i+ +  ++f ++l++l+ +++++
   Q: 29   YVQLNVGGSLYYTTVRALTRHDTMLKAMFSGRMEvLTDKEGWILID-RCGKHFGTILNYLRDDTITL 94
           599********************************9999******9.**************999876 PP

Organism

Mus musculus

Functional Description
(View)

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD2) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity (By similarity).

Protein Sequence
(Fasta)

MSGDTCLCPA SGAKPKISGF KGGGLGNKYV QLNVGGSLYY TTVRALTRHD TMLKAMFSGR 60
MEVLTDKEGW ILIDRCGKHF GTILNYLRDD TITLPQSRQE IQELMAEAKY YLIQGLVSTC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGATTTGTTC CCGAACCCGG AAGTAGAAGG AAGTCAAACG TCAAGTTTTC GACCCACTGC 60
TAGCTCGCGC GCTGTGCATG CCGGGTCTTG TAGTCTCTTT CCCGATCTGT AGGGTTGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR003131--T1-type_BTB

PROSITE

PS50097--BTB

Pfam

PF02214--BTB_2

SMART

SM00225--BTB

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005768--C:endosome
GO:0005730--C:nucleolus
GO:0017049--F:GTP-Rho binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0016477--P:cell migration
GO:0006260--P:DNA replication
GO:0009790--P:embryo development
GO:0006955--P:immune response
GO:0035024--P:negative regulation of Rho protein signal transduction
GO:0045740--P:positive regulation of DNA replication
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051260--P:protein homooligomerization
GO:0016567--P:protein ubiquitination
GO:0043149--P:stress fiber assembly

KEGG

mmu:21927

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001724	Ailuropoda melanoleuca	96.52	0.00e+00	641.00
IUUC-Apl-003702	Anas platyrhynchos	90.16	7.00e-168	582.00
IUUC-Aca-004408	Anolis carolinensis	81.65	2.00e-145	508.00
IUUC-Afl-008662	Aspergillus flavus	34.48	1.10e-01	30.80
IUUC-Afu-008834	Aspergillus fumigatus	32.50	1.00e+00	27.30
IUUC-Ang-009546	Aspergillus niger	30.51	2.20e-01	29.30
IUUC-Ame-010738	Astyanax mexicanus	76.04	7.00e-122	429.00
IUUC-Bta-013551	Bos taurus	95.25	2.00e-171	594.00
IUUC-Cja-019122	Callithrix jacchus	97.15	0.00e+00	644.00
IUUC-Cfa-020193	Canis familiaris	97.15	0.00e+00	643.00
IUUC-Cpo-022024	Cavia porcellus	96.84	0.00e+00	641.00
IUUC-Csa-024138	Chlorocebus sabaeus	97.15	0.00e+00	644.00
IUUC-Dno-029163	Dasypus novemcinctus	95.57	0.00e+00	638.00
IUUC-Dor-030970	Dipodomys ordii	97.47	0.00e+00	644.00
IUUC-Eca-034114	Equus caballus	96.52	0.00e+00	642.00
IUUC-Eeu-034709	Erinaceus europaeus	95.89	0.00e+00	631.00
IUUC-Fca-036397	Felis catus	96.20	7.00e-173	599.00
IUUC-Fal-037588	Ficedula albicollis	89.81	3.00e-168	583.00
IUUC-Gga-040445	Gallus gallus	89.81	2.00e-167	581.00
IUUC-Ggo-045312	Gorilla gorilla	97.15	0.00e+00	645.00
IUUC-Hsa-046091	Homo sapiens	97.15	0.00e+00	644.00
IUUC-Itr-048608	Ictidomys tridecemlineatus	97.15	0.00e+00	644.00
IUUC-Lch-049970	Latimeria chalumnae	88.40	5.00e-168	583.00
IUUC-Laf-054286	Loxodonta africana	94.62	0.00e+00	631.00
IUUC-Meu-056850	Macropus eugenii	86.83	3.00e-153	534.00
IUUC-Mga-060119	Meleagris gallopavo	92.56	2.00e-132	464.00
IUUC-Mdo-061847	Monodelphis domestica	92.79	1.00e-166	578.00
IUUC-Mpu-066060	Mustela putorius furo	97.47	0.00e+00	646.00
IUUC-Mlu-067951	Myotis lucifugus	96.20	0.00e+00	639.00
IUUC-Nle-069523	Nomascus leucogenys	97.15	0.00e+00	644.00
IUUC-Opr-070426	Ochotona princeps	95.57	0.00e+00	635.00
IUUC-Ont-072156	Oreochromis niloticus	68.90	1.00e-129	456.00
IUUC-Oan-073164	Ornithorhynchus anatinus	84.85	3.00e-73	266.00
IUUC-Ocu-074319	Oryctolagus cuniculus	96.52	0.00e+00	642.00
IUUC-Oga-088279	Otolemur garnettii	95.57	0.00e+00	639.00
IUUC-Oar-089368	Ovis aries	95.57	0.00e+00	637.00
IUUC-Ptr-091204	Pan troglodytes	96.84	1.00e-175	608.00
IUUC-Pan-092880	Papio anubis	97.14	0.00e+00	643.00
IUUC-Psi-093768	Pelodiscus sinensis	88.50	6.00e-166	576.00
IUUC-Pab-098414	Pongo abelii	95.57	0.00e+00	628.00
IUUC-Pca-100380	Procavia capensis	90.19	2.00e-171	594.00
IUUC-Pva-102366	Pteropus vampyrus	96.20	0.00e+00	639.00
IUUC-Pgr-103695	Puccinia graminis	23.12	1.20e-01	32.70
IUUC-Ptt-103935	Puccinia triticina	27.96	1.20e-01	30.40
IUUC-Rno-104902	Rattus norvegicus	98.42	0.00e+00	650.00
IUUC-Sha-106996	Sarcophilus harrisii	92.16	2.00e-166	578.00
IUUC-Ssc-116300	Sus scrofa	96.52	0.00e+00	640.00
IUUC-Tgu-116738	Taeniopygia guttata	89.17	5.00e-167	580.00
IUUC-Tru-117840	Takifugu rubripes	72.64	6.00e-116	410.00
IUUC-Tsy-119370	Tarsius syrichta	79.35	1.00e-109	389.00
IUUC-Tni-119857	Tetraodon nigroviridis	70.86	1.00e-129	455.00
IUUC-Tbe-127709	Tupaia belangeri	95.89	0.00e+00	635.00
IUUC-Ttr-129110	Tursiops truncatus	95.89	0.00e+00	639.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence