iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Csv-026256

UUCD1 version

UUC-CiS-00370

Ensembl Protein ID

ENSCSAVP00000010155.1

UniProt Accession

H2YXU4; H2YXU4_CIOSA

Protein Name

Uncharacterized protein

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCSAVG00000005992.1	ENSCSAVT00000010278.1	ENSCSAVP00000010154.1
ENSCSAVG00000005992.1	ENSCSAVT00000010279.1	ENSCSAVP00000010155.1
ENSCSAVG00000005992.1	ENSCSAVT00000010280.1	ENSCSAVP00000010156.1
ENSCSAVG00000005992.1	ENSCSAVT00000010281.1	ENSCSAVP00000010157.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.00e-132	441.7	247	578

Active Site

Position(s)	Description	Evidence
547	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           +dl++rl++ f+gEegld+gGv+re+++l+s+e+ np+++lf+y  + ++tlq+np+s + np+h+ +F+f+Gr++++al++g+++d+
   Q: 247  YDLRRRLYIMFKGEEGLDYGGVAREWFFLVSHEVLNPMYCLFEYAGSTNYTLQINPASTI-NPDHMHYFRFVGRFIAMALYHGKFIDT 333
           799*******************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvv 178
            +s +fyk++l++kl+++d+e+vd+e+y+sl +i++n   +iee+gl+l f+++ e+lg++++ eLk+gG+++ Vt+eNkeeY++l++
   Q: 334  GFSLPFYKRMLNRKLTIKDIESVDEEFYNSLVWIRDN---NIEECGLELDFTMDFEVLGKIDTIELKEGGADMAVTEENKEEYIRLMI 418
           ***********************************99...9*********************************************** PP
   S: 179  eyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLq 266
           ++r+ +g+++q++ f +Gfnev+pl++l++F+e+elel++cG++e+dv+d++++t y++ yt++s+++ wFw+ ++e+++e+r+++Lq
   Q: 419  DWRFSRGVEKQTKGFLDGFNEVVPLQWLQYFDERELELMLCGMQEFDVDDWNRHTIYRN-YTRNSKQVVWFWQYIHEIDNEKRARLLQ 505
           *********************************************************99.**************************** PP
   S: 267  FvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Fv+g++r+P+gGfael     p++f+i+k +++++lP+s+TCfn+L+LP+Y+s+e+l+ekL++Aieet+gF++
   Q: 506  FVSGTCRIPVGGFAELLgsngPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLTMAIEETEGFGQ 578
           ****************99*****************************************************96 PP

Organism

Ciona savignyi

Protein Sequence
(Fasta)

MGRIYYVDHN TKTTTWERPE PLPSGWEKRL DGRNRIYYVD HNTRTTTWQR PTLQRVQNFT 60
DWRNQRENIQ NQRQAFNQRY MVAPGSGEAA APPPTPQPAQ PAPQPDDGLG VLPKGWERRV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAATGGTGTC GCTGGTAGGT TTGGTGTTCA GGTGTTGGGA CTGAAAAACA CTAAGAACGT 60
TATTAAAAGG GTCGCTGTAA GATAAGCTTG GGATAAGGCT AGGGAGCGTT ACCACATGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001213	Ailuropoda melanoleuca	71.97	0.00e+00	883.00
IUUC-Apl-003310	Anas platyrhynchos	73.36	0.00e+00	908.00
IUUC-Aca-005388	Anolis carolinensis	73.18	0.00e+00	902.00
IUUC-Ago-007742	Ashbya gossypii	46.94	3.00e-153	533.00
IUUC-Acl-008273	Aspergillus clavatus	44.48	2.00e-146	511.00
IUUC-Afl-008713	Aspergillus flavus	45.81	5.00e-151	526.00
IUUC-Afu-009103	Aspergillus fumigatus	46.63	4.00e-155	540.00
IUUC-Ani-009259	Aspergillus nidulans	46.32	7.00e-153	533.00
IUUC-Ang-009738	Aspergillus niger	45.82	2.00e-151	528.00
IUUC-Aor-010053	Aspergillus oryzae	50.67	1.00e-93	334.00
IUUC-Ate-010529	Aspergillus terreus	46.88	1.00e-154	538.00
IUUC-Ame-010601	Astyanax mexicanus	65.75	0.00e+00	837.00
IUUC-Bgr-012148	Blumeria graminis	45.50	9.00e-148	515.00
IUUC-Bta-012857	Bos taurus	73.36	0.00e+00	902.00
IUUC-Bci-013785	Botrytis cinerea	46.60	5.00e-151	526.00
IUUC-Cel-018299	Caenorhabditis elegans	63.86	0.00e+00	790.00
IUUC-Cja-019448	Callithrix jacchus	73.36	0.00e+00	905.00
IUUC-Cfa-020728	Canis familiaris	73.18	0.00e+00	904.00
IUUC-Cpo-021635	Cavia porcellus	71.60	0.00e+00	894.00
IUUC-Csa-023805	Chlorocebus sabaeus	73.10	0.00e+00	892.00
IUUC-Cho-024695	Choloepus hoffmanni	65.98	0.00e+00	837.00
IUUC-Cin-025212	Ciona intestinalis	92.59	0.00e+00	1044.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	46.26	3.00e-151	527.00
IUUC-Cne-026849	Cryptococcus neoformans	45.67	1.00e-151	528.00
IUUC-Dre-028245	Danio rerio	72.66	0.00e+00	919.00
IUUC-Dno-029618	Dasypus novemcinctus	73.01	0.00e+00	903.00
IUUC-Dor-030176	Dipodomys ordii	71.28	0.00e+00	881.00
IUUC-Dse-031241	Dothistroma septosporum	46.04	4.00e-150	523.00
IUUC-Dme-032041	Drosophila melanogaster	70.10	0.00e+00	852.00
IUUC-Ete-032779	Echinops telfairi	68.86	0.00e+00	835.00
IUUC-Eca-033313	Equus caballus	72.84	0.00e+00	894.00
IUUC-Eeu-035259	Erinaceus europaeus	65.05	0.00e+00	768.00
IUUC-Fca-035420	Felis catus	73.18	0.00e+00	905.00
IUUC-Fal-037335	Ficedula albicollis	73.36	0.00e+00	911.00
IUUC-Fox-037774	Fusarium oxysporum	46.78	1.00e-150	525.00
IUUC-Fso-038393	Fusarium solani	44.33	8.00e-144	502.00
IUUC-Gmo-038842	Gadus morhua	69.08	0.00e+00	839.00
IUUC-Ggr-040107	Gaeumannomyces graminis	46.18	1.00e-150	525.00
IUUC-Gga-040246	Gallus gallus	73.18	0.00e+00	909.00
IUUC-Gac-042211	Gasterosteus aculeatus	72.15	0.00e+00	918.00
IUUC-Ggo-045001	Gorilla gorilla	73.18	0.00e+00	901.00
IUUC-Hsa-046544	Homo sapiens	73.18	0.00e+00	904.00
IUUC-Itr-048860	Ictidomys tridecemlineatus	73.01	0.00e+00	903.00
IUUC-Kpa-049273	Komagataella pastoris	48.22	8.00e-159	552.00
IUUC-Lch-050398	Latimeria chalumnae	73.18	0.00e+00	903.00
IUUC-Loc-052116	Lepisosteus oculatus	72.98	0.00e+00	924.00
IUUC-Laf-053551	Loxodonta africana	72.84	0.00e+00	898.00
IUUC-Mcc-055655	Macaca mulatta	71.63	0.00e+00	892.00
IUUC-Meu-055953	Macropus eugenii	61.76	0.00e+00	741.00
IUUC-Mor-057097	Magnaporthe oryzae	45.61	3.00e-149	520.00
IUUC-Mpo-057442	Magnaporthe poae	48.88	2.00e-139	488.00
IUUC-Mla-058996	Melampsora laricipopulina	50.00	3.00e-144	504.00
IUUC-Mga-059986	Meleagris gallopavo	73.18	0.00e+00	909.00
IUUC-Mmr-060896	Microcebus murinus	71.80	0.00e+00	895.00
IUUC-Mdo-062536	Monodelphis domestica	70.76	0.00e+00	885.00
IUUC-Mmu-063202	Mus musculus	73.36	0.00e+00	901.00
IUUC-Mpu-065773	Mustela putorius furo	73.10	0.00e+00	901.00
IUUC-Mlu-067623	Myotis lucifugus	69.55	0.00e+00	856.00
IUUC-Nfi-068427	Neosartorya fischeri	46.63	9.00e-155	539.00
IUUC-Ncr-068918	Neurospora crassa	46.15	1.00e-149	521.00
IUUC-Nle-069188	Nomascus leucogenys	73.36	0.00e+00	905.00
IUUC-Opr-070965	Ochotona princeps	72.49	0.00e+00	885.00
IUUC-Ont-072226	Oreochromis niloticus	73.01	0.00e+00	928.00
IUUC-Oan-073497	Ornithorhynchus anatinus	73.36	0.00e+00	910.00
IUUC-Ocu-074271	Oryctolagus cuniculus	70.76	0.00e+00	885.00
IUUC-Ola-087438	Oryzias latipes	73.01	0.00e+00	924.00
IUUC-Oga-087922	Otolemur garnettii	73.28	0.00e+00	902.00
IUUC-Oar-089429	Ovis aries	73.18	0.00e+00	898.00
IUUC-Ptr-090484	Pan troglodytes	73.18	0.00e+00	903.00
IUUC-Pan-092117	Papio anubis	73.36	0.00e+00	905.00
IUUC-Psi-093338	Pelodiscus sinensis	73.36	0.00e+00	910.00
IUUC-Pma-094279	Petromyzon marinus	64.83	0.00e+00	735.00
IUUC-Pno-095118	Phaeosphaeria nodorum	46.09	8.00e-149	519.00
IUUC-Pfo-096171	Poecilia formosa	72.84	0.00e+00	925.00
IUUC-Pab-098654	Pongo abelii	71.97	0.00e+00	880.00
IUUC-Pca-100596	Procavia capensis	75.48	0.00e+00	777.00
IUUC-Pva-102811	Pteropus vampyrus	73.53	0.00e+00	899.00
IUUC-Pgr-103620	Puccinia graminis	48.98	1.00e-141	495.00
IUUC-Pte-104016	Pyrenophora teres	45.69	1.00e-147	515.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	45.69	1.00e-147	515.00
IUUC-Rno-106125	Rattus norvegicus	73.36	0.00e+00	902.00
IUUC-Sce-106289	Saccharomyces cerevisiae	46.94	3.00e-154	537.00
IUUC-Sha-107243	Sarcophilus harrisii	72.46	0.00e+00	895.00
IUUC-Sja-107786	Schizosaccharomyces japonicus	47.66	1.00e-148	518.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	46.34	4.00e-151	527.00
IUUC-Sar-113761	Sorex araneus	66.26	0.00e+00	832.00
IUUC-Sre-114929	Sporisorium reilianum	46.02	1.00e-149	522.00
IUUC-Ssc-115368	Sus scrofa	73.28	0.00e+00	898.00
IUUC-Tgu-117079	Taeniopygia guttata	73.36	0.00e+00	909.00
IUUC-Tru-118062	Takifugu rubripes	72.84	0.00e+00	926.00
IUUC-Tsy-119507	Tarsius syrichta	68.17	0.00e+00	822.00
IUUC-Tni-120151	Tetraodon nigroviridis	72.54	0.00e+00	912.00
IUUC-Tre-122203	Trichoderma reesei	45.90	6.00e-148	516.00
IUUC-Tvi-122595	Trichoderma virens	45.17	5.00e-149	520.00
IUUC-Tbe-127793	Tupaia belangeri	72.94	0.00e+00	746.00
IUUC-Ttr-128275	Tursiops truncatus	70.76	0.00e+00	883.00
IUUC-Uma-129332	Ustilago maydis	50.20	1.00e-136	479.00
IUUC-Vda-129753	Verticillium dahliae	45.69	2.00e-148	517.00
IUUC-Vpa-130103	Vicugna pacos	57.96	0.00e+00	696.00
IUUC-Xtr-132866	Xenopus tropicalis	68.91	0.00e+00	860.00
IUUC-Xma-133778	Xiphophorus maculatus	73.01	0.00e+00	927.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence