• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Details
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064096
UUCD1 version UUC-MuM-00020
Ensembl Protein ID ENSMUSP00000070728.5
UniProt Accession Q3ULA2; Q3U0Q4; Q571K6; Q9QUI5; Q9R1G7; Q9Z159; FBW1A_MOUSE
Genbank Protein ID AAD08701.1; AAD41025.1; AAD04181.1; AAD17755.1; AAL40929.1; AAL40929.1; AAL40929.1; AAL40929.1; AAL40929.1; AAL40929.1; AAL40929.1; AAL40929.1; AAL40929.1; AAL40929.1; AAL40929.1; AAL40929.1; AAL40929.1; BAE26547.1; BAE33798.1; BAD90368.1; EDL41951.1; AAH03989.1
Protein Name F-box/WD repeat-containing protein 1A; Beta-TrCP protein E3RS-IkappaB; Beta-transducin repeat-containing protein; E3RSIkappaB; F-box and WD repeats protein beta-TrCP; HOS; Ubiquitin ligase FWD1; pIkappaB-E3 receptor subunit
Genbank Nucleotide ID AF099932; AF110396; AF112979; AF081887; AF391190; AF391178; AF391179; AF391180; AF391181; AF391182; AF391183; AF391184; AF391185; AF391186; AF391187; AF391188; AF391189; AK145624; AK156660; AK220183; CH466534; BC003989
Gene Name Btrc; Fbw1; Fbxw1; Fwd1; Kiaa4123
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000025217.14 ENSMUST00000065601.11 ENSMUSP00000070728.5
ENSMUSG00000025217.14 ENSMUST00000111936.2 ENSMUSP00000107567.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box F-box 16611981; 15767683
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 16611981; 15767683; 17588513
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/SCF/F-box 0.00065 20.9 191 228
E3 adaptor/Cullin RING/DCX/DWD 3.90e-58 191.9 504 537
UBD/Beta-Prp 3.00e-68 231.3 418 582
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/SCF/F-box
   S: 109  eilveilklldkeellraarvcrrwqelasqkalwktv 146
           +i  +il++ld+++l++a++vc++w++++s+  lwk++
   Q: 191  HIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKL 228
           7899**************************9****987 PP
   

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclafsd.tllvsGsdDgtikvWDlrtgv 34
           gH++ v+c++f d +++vsG++Dg+ikvWDl    
   Q: 504  GHEELVRCIRF-DnKRIVSGAYDGKIKVWDLMAAL 537
           8**********.44****************97665 PP
   

   UBD/Beta-Prp
   S: 44   llrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleet 132
           l r l gh a+v+ v+f+++  ++v++s Drtikvw+ st++ v+tl+gh++ + +l++      +vsGs+d+tir+wd+e g cl+ +
   Q: 418  LRRVLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGACLR-V 501
           445579*************9..8**************************************..************************.* PP
   S: 133  lsghdgvvncvvvhpdgnllvsGslDrtvrlWdl.........ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdl 209
           l+gh+++v+c++++   + +vsG++D+++++Wdl         +   +lrtl + h ++v  l+fd+  +++vs s+d t+ +wd+
   Q: 502  LEGHEELVRCIRFDN--KRIVSGAYDGKIKVWDLmaaldprapAGTLCLRTLVE-HSGRVFRLQFDE--FQIVSSSHDDTILIWDF 582
           **************9..*************************877889****98.************..99**************7 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22'. SCF(BTRC) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (By similarity). SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2. May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3.
 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22'. SCF(BTRC) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (By similarity). SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2. May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3.
Protein Sequence
(Fasta)
MDPAEAVLQE KALKFMCSMP RSLWLGCSSL ADSMPSLRCL YNPGTGALTA FQNSSEREDC 60
NNGEPPRKII PEKNSLRQTY NSCARLCINQ ETVCLTSTAM KTENCVAKAK LANGTSSMIV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064096|E3,F-box;E3,WD_repeat;UBD,Beta-Prp|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGCGGGGGA AGGAAGAGGA GGCGGGATCC GGACGCTGCG TTGGCTGCGG CCTGGCACGA 60
AAGGGGCGGC CCCGGCGGAG AGCAGACCCA GTAGTCCGGG CGATTATGGA CCCGGCAGAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064096|E3,F-box;E3,WD_repeat;UBD,Beta-Prp|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0090--Biological rhythms
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
KW-0879--Wnt signaling pathway
Interpro

IPR021977--Beta-TrCP_D
IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12125--Beta-TrCP_D
PF12937--F-box-like
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM01028--Beta-TrCP_D
SM00256--FBOX
SM00320--WD40
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0008013--F:beta-catenin binding
GO:0045309--F:protein phosphorylated amino acid binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0060444--P:branching involved in mammary gland duct morphogenesis
GO:0071407--P:cellular response to organic cyclic compound
GO:0007623--P:circadian rhythm
GO:0033598--P:mammary gland epithelial cell proliferation
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0042753--P:positive regulation of circadian rhythm
GO:0045862--P:positive regulation of proteolysis
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0030163--P:protein catabolic process
GO:0006470--P:protein dephosphorylation
GO:0031648--P:protein destabilization
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0060828--P:regulation of canonical Wnt signaling pathway
GO:0051726--P:regulation of cell cycle
GO:0042752--P:regulation of circadian rhythm
GO:0043122--P:regulation of I-kappaB kinase/NF-kappaB signaling
GO:0061136--P:regulation of proteasomal protein catabolic process
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0016055--P:Wnt signaling pathway
KEGG mmu:12234
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001961 Ailuropoda melanoleuca 98.68 0.00e+00 1249.00
IUUC-Apl-003437 Anas platyrhynchos 97.80 0.00e+00 1015.00
IUUC-Aca-004410 Anolis carolinensis 91.72 0.00e+00 1195.00
IUUC-Acl-008355 Aspergillus clavatus 29.76 2.00e-50 194.00
IUUC-Afl-008580 Aspergillus flavus 27.92 4.00e-44 172.00
IUUC-Afu-008790 Aspergillus fumigatus 29.79 2.00e-38 154.00
IUUC-Ani-009324 Aspergillus nidulans 29.40 2.00e-48 187.00
IUUC-Aor-009916 Aspergillus oryzae 28.88 3.00e-47 183.00
IUUC-Ate-010492 Aspergillus terreus 29.53 1.00e-49 191.00
IUUC-Bgr-012194 Blumeria graminis 32.52 4.00e-54 206.00
IUUC-Bta-013453 Bos taurus 92.73 0.00e+00 1155.00
IUUC-Bci-013685 Botrytis cinerea 31.51 8.00e-55 208.00
IUUC-Cja-019121 Callithrix jacchus 94.05 0.00e+00 1176.00
IUUC-Cfa-020553 Canis familiaris 98.84 0.00e+00 1250.00
IUUC-Cpo-022126 Cavia porcellus 96.13 0.00e+00 1158.00
IUUC-Csa-023688 Chlorocebus sabaeus 98.68 0.00e+00 1249.00
IUUC-Cin-025188 Ciona intestinalis 80.71 0.00e+00 828.00
IUUC-Csv-026020 Ciona savignyi 76.34 0.00e+00 788.00
IUUC-Cgl-026429 Colletotrichum gloeosporioides 33.26 2.00e-60 227.00
IUUC-Dno-029484 Dasypus novemcinctus 92.73 0.00e+00 1157.00
IUUC-Dor-031010 Dipodomys ordii 92.52 0.00e+00 1097.00
IUUC-Dse-031287 Dothistroma septosporum 28.91 3.00e-52 200.00
IUUC-Dme-031885 Drosophila melanogaster 77.98 0.00e+00 817.00
IUUC-Ete-032978 Echinops telfairi 85.74 0.00e+00 1045.00
IUUC-Eca-033374 Equus caballus 97.81 0.00e+00 1213.00
IUUC-Eeu-034760 Erinaceus europaeus 77.52 0.00e+00 937.00
IUUC-Fca-035427 Felis catus 94.55 0.00e+00 1182.00
IUUC-Fal-037530 Ficedula albicollis 97.79 0.00e+00 1202.00
IUUC-Fox-037978 Fusarium oxysporum 33.77 7.00e-63 235.00
IUUC-Fso-038077 Fusarium solani 32.97 1.00e-57 218.00
IUUC-Ggr-039974 Gaeumannomyces graminis 32.30 3.00e-56 213.00
IUUC-Gga-041087 Gallus gallus 94.27 0.00e+00 1222.00
IUUC-Ggo-045369 Gorilla gorilla 98.19 0.00e+00 1139.00
IUUC-Hsa-045962 Homo sapiens 98.68 0.00e+00 1249.00
IUUC-Itr-047872 Ictidomys tridecemlineatus 98.90 0.00e+00 934.00
IUUC-Lch-050285 Latimeria chalumnae 88.98 0.00e+00 933.00
IUUC-Loc-052686 Lepisosteus oculatus 91.57 0.00e+00 1159.00
IUUC-Lma-053289 Leptosphaeria maculans 38.08 2.00e-47 184.00
IUUC-Laf-054022 Loxodonta africana 97.81 0.00e+00 1214.00
IUUC-Mcc-055782 Macaca mulatta 98.64 0.00e+00 1211.00
IUUC-Meu-056078 Macropus eugenii 83.84 0.00e+00 891.00
IUUC-Mor-057283 Magnaporthe oryzae 33.26 9.00e-59 221.00
IUUC-Mpo-057540 Magnaporthe poae 32.52 1.00e-56 215.00
IUUC-Mla-058989 Melampsora laricipopulina 40.57 9.00e-61 226.00
IUUC-Mga-059388 Meleagris gallopavo 96.50 0.00e+00 1209.00
IUUC-Mmr-060969 Microcebus murinus 98.84 0.00e+00 1250.00
IUUC-Mdo-063041 Monodelphis domestica 98.18 0.00e+00 1212.00
IUUC-Mpu-066875 Mustela putorius furo 98.73 0.00e+00 1140.00
IUUC-Mlu-067621 Myotis lucifugus 98.21 0.00e+00 1028.00
IUUC-Nfi-068263 Neosartorya fischeri 29.50 9.00e-50 191.00
IUUC-Ncr-068639 Neurospora crassa 34.54 1.00e-44 175.00
IUUC-Nle-069548 Nomascus leucogenys 98.51 0.00e+00 1248.00
IUUC-Opr-071194 Ochotona princeps 93.22 0.00e+00 1162.00
IUUC-Oan-072867 Ornithorhynchus anatinus 94.38 0.00e+00 1218.00
IUUC-Ocu-074246 Oryctolagus cuniculus 98.84 0.00e+00 1250.00
IUUC-Oga-088244 Otolemur garnettii 98.80 0.00e+00 1029.00
IUUC-Oar-089199 Ovis aries 98.23 0.00e+00 1039.00
IUUC-Ptr-090475 Pan troglodytes 78.88 0.00e+00 930.00
IUUC-Pan-092826 Papio anubis 98.68 0.00e+00 1249.00
IUUC-Psi-093485 Pelodiscus sinensis 94.61 0.00e+00 1169.00
IUUC-Pma-094315 Petromyzon marinus 79.71 0.00e+00 885.00
IUUC-Pab-097680 Pongo abelii 98.18 0.00e+00 1243.00
IUUC-Pca-100843 Procavia capensis 91.90 0.00e+00 1127.00
IUUC-Pva-102793 Pteropus vampyrus 88.76 0.00e+00 1088.00
IUUC-Pgr-103331 Puccinia graminis 37.69 2.00e-52 199.00
IUUC-Ptt-103853 Puccinia triticina 32.30 4.00e-61 228.00
IUUC-Pte-104392 Pyrenophora teres 37.01 5.00e-47 182.00
IUUC-Pyt-104678 Pyrenophora triticirepentis 37.37 3.00e-47 184.00
IUUC-Rno-105304 Rattus norvegicus 99.49 0.00e+00 1221.00
IUUC-Sha-107454 Sarcophilus harrisii 93.69 0.00e+00 1195.00
IUUC-Sar-113471 Sorex araneus 77.85 0.00e+00 921.00
IUUC-Sre-114916 Sporisorium reilianum 34.08 9.00e-46 179.00
IUUC-Ssc-115490 Sus scrofa 99.01 0.00e+00 1046.00
IUUC-Tgu-117445 Taeniopygia guttata 97.69 0.00e+00 1234.00
IUUC-Tsy-118983 Tarsius syrichta 94.40 0.00e+00 1157.00
IUUC-Tre-122207 Trichoderma reesei 33.63 1.00e-55 211.00
IUUC-Tvi-122344 Trichoderma virens 33.63 1.00e-55 211.00
IUUC-Tme-127141 Tuber melanosporum 34.48 2.00e-64 240.00
IUUC-Tbe-128146 Tupaia belangeri 89.09 0.00e+00 1064.00
IUUC-Ttr-128946 Tursiops truncatus 98.68 0.00e+00 1249.00
IUUC-Uma-129491 Ustilago maydis 33.42 6.00e-47 182.00
IUUC-Vda-129941 Verticillium dahliae 32.59 2.00e-57 217.00
IUUC-Vpa-130709 Vicugna pacos 96.86 0.00e+00 1217.00
IUUC-Xtr-132861 Xenopus tropicalis 92.04 0.00e+00 1161.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved