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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046009
Ensembl Protein ID ENSP00000331201.4
UniProt Accession O14964; Q9NR36; HGS_HUMAN
Genbank Protein ID AAC51929.1; BAA23366.1; AAF82361.1; AAP88756.1; AAH03565.1
Protein Name Hepatocyte growth factor-regulated tyrosine kinase substrate; Hrs; Protein pp110
Genbank Nucleotide ID U43895; D84064; AF260566; BT009754; BC003565
Gene Name HGS; HRS
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000185359.12 ENST00000329138.8 ENSP00000331201.4
ENSG00000185359.12 ENST00000572392.1 ENSP00000458987.1
ENSG00000185359.12 ENST00000571237.1 ENSP00000458775.1
ENSG00000185359.12 ENST00000575078.5 ENSP00000460130.1
ENSG00000185359.12 ENST00000573320.1 ENSP00000458789.1
ENSG00000185359.12 ENST00000570652.1 ENSP00000460165.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACmiRWalk
TargetScanmiRecordsRepTarmiRNAMap
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
OMIM
Drug and target
DrugBank
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UIM UIM 11919637; 12230472; 12750381; 15640163
UBD/Alpha-Helix/DUIM DUIM 16462748
UBD/Alpha-Helix/VHS VHS 22493438
Classification
Family E-value Score Start End
UBD/Alpha-Helix/VHS 7.70e-51 173.2 15 143
UBD/Alpha-Helix/DUIM 8.60e-05 9.1 258 276
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/VHS
   S: 1    atselvtsedwelileicdliqetkegakdalralrkrinnknphvalraLtlLdscvsnCgkkfhvevaskdlleelrellknenepkvie 92
           ats+l+ ++dwe+il+icdli++ +++ak+a+++++k++n+knphval+aL++++s+v+nCg+++h+eva+k+++eel++llk+++e++v++
   Q: 15   ATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHVALYALEVMESVVKNCGQTVHDEVANKQTMEELKDLLKRQVEVNVRN 106
           799***************************************************************************************** PP
   S: 93   KlkalivsWadelknepalslivaliktlkeeGlefp 129
           K+++li++Wa++++nep++++++++++ +k eG++fp
   Q: 107  KILYLIQAWAHAFRNEPKYKVVQDTYQIMKVEGHVFP 143
           ************************************8 PP
   

   UBD/Alpha-Helix/DUIM
   S: 1    dEdeeLqlAlalSlqEeee 19
           +E+eeLqlAlalS +E+ee
   Q: 258  QEEEELQLALALSQSEAEE 276
           69***************97 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Interacts with TRAK1. Interacts with TRAK2 (By similarity). Interacts with TRAK1. Component of the ESCRT-0 complex composed of STAM or STAM2 and HGS. Part of a complex at least composed of HSG, STAM2 (or probably STAM) and EPS15. Interacts with STAM. Interacts with STAM2. Interacts with EPS15; the interaction is direct, calcium-dependent and inhibited by SNAP25. Interacts with NF2; the interaction is direct. Interacts with ubiquitin; the interaction is direct. Interacts with VPS37C. Interacts with SMAD1, SMAD2 and SMAD3. Interacts with TSG101; the interaction mediates the association with the ESCRT-I complex. Interacts with SNAP25; the interaction is direct and decreases with addition of increasing concentrations of free calcium. Interacts with SNX1; the interaction is direct. Component of a 550 kDa membrane complex at least composed of HGS and SNX1 but excluding EGFR. Component of the CART complex, at least composed of ACTN4, HGS/HRS, MYO5B and TRIM3. Interacts (via UIM domain) with UBQLN1 (via ubiquitin-like domain) (By similarity). Interacts with ARRDC3 (PubMed:23208550). Identified in a complex containing at least ARRDC4, V2R and HGS (PubMed:23236378).
 Interacts with TRAK1. Interacts with TRAK2 (By similarity). Interacts with TRAK1. Component of the ESCRT-0 complex composed of STAM or STAM2 and HGS. Part of a complex at least composed of HSG, STAM2 (or probably STAM) and EPS15. Interacts with STAM. Interacts with STAM2. Interacts with EPS15; the interaction is direct, calcium-dependent and inhibited by SNAP25. Interacts with NF2; the interaction is direct. Interacts with ubiquitin; the interaction is direct. Interacts with VPS37C. Interacts with SMAD1, SMAD2 and SMAD3. Interacts with TSG101; the interaction mediates the association with the ESCRT-I complex. Interacts with SNAP25; the interaction is direct and decreases with addition of increasing concentrations of free calcium. Interacts with SNX1; the interaction is direct. Component of a 550 kDa membrane complex at least composed of HGS and SNX1 but excluding EGFR. Component of the CART complex, at least composed of ACTN4, HGS/HRS, MYO5B and TRIM3. Interacts (via UIM domain) with UBQLN1 (via ubiquitin-like domain) (By similarity). Interacts with ARRDC3 (PubMed:23208550). Identified in a complex containing at least ARRDC4, V2R and HGS (PubMed:23236378).
Protein Sequence
(Fasta)
MGRGSGTFER LLDKATSQLL LETDWESILQ ICDLIRQGDT QAKYAVNSIK KKVNDKNPHV 60
ALYALEVMES VVKNCGQTVH DEVANKQTME ELKDLLKRQV EVNVRNKILY LIQAWAHAFR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046009|UBD,UIM;UBD,DUIM;UBD,VHS|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCGAGGGGAG AGGAAGTGCC CGTGGAGGGC GGCAGGCCCC CTCATCCCGC GCCAATTATC 60
CTCAGCTCGG GCCGTCCCCC GCTCCCGAAG GCTGGCCTTA AGTCACGACC TGACCCGCTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046009|UBD,UIM;UBD,DUIM;UBD,VHS|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR008942--ENTH_VHS
IPR024641--HRS_helical
IPR017073--Ubi-bd_Hrs_VPS27
IPR003903--UIM_dom
IPR002014--VHS_dom
IPR000306--Znf_FYVE
IPR017455--Znf_FYVE-rel
IPR011011--Znf_FYVE_PHD
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50330--UIM
PS50179--VHS
PS50178--ZF_FYVE
Pfam

PF01363--FYVE
PF12210--Hrs_helical
PF00790--VHS
SMART

SM00064--FYVE
SM00288--VHS
Gene Ontology

GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0031901--C:early endosome membrane
GO:0005768--C:endosome
GO:0033565--C:ESCRT-0 complex
GO:0070062--C:extracellular exosome
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005764--C:lysosome
GO:0032585--C:multivesicular body membrane
GO:0046872--F:metal ion binding
GO:0019904--F:protein domain specific binding
GO:0016197--P:endosomal transport
GO:0016236--P:macroautophagy
GO:0010324--P:membrane invagination
GO:0061024--P:membrane organization
GO:0036258--P:multivesicular body assembly
GO:0008285--P:negative regulation of cell proliferation
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:1903543--P:positive regulation of exosomal secretion
GO:0010628--P:positive regulation of gene expression
GO:0016579--P:protein deubiquitination
GO:0072657--P:protein localization to membrane
GO:0006622--P:protein targeting to lysosome
GO:0043405--P:regulation of MAP kinase activity
GO:0042176--P:regulation of protein catabolic process
GO:0007165--P:signal transduction
KEGG hsa:9146
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001518 Ailuropoda melanoleuca 87.90 0.00e+00 1011.00
IUUC-Apl-003662 Anas platyrhynchos 81.79 0.00e+00 958.00
IUUC-Aca-004940 Anolis carolinensis 83.04 0.00e+00 1138.00
IUUC-Ago-007931 Ashbya gossypii 30.43 8.00e-27 115.00
IUUC-Acl-008274 Aspergillus clavatus 31.41 3.00e-40 160.00
IUUC-Afl-008521 Aspergillus flavus 33.98 6.00e-41 162.00
IUUC-Afu-008774 Aspergillus fumigatus 33.33 7.00e-41 162.00
IUUC-Ani-009445 Aspergillus nidulans 32.96 2.00e-41 164.00
IUUC-Ang-009863 Aspergillus niger 33.57 1.00e-42 168.00
IUUC-Ate-010444 Aspergillus terreus 35.53 7.00e-43 168.00
IUUC-Ame-011111 Astyanax mexicanus 77.73 0.00e+00 951.00
IUUC-Bgr-012087 Blumeria graminis 33.57 5.00e-43 169.00
IUUC-Bta-012506 Bos taurus 92.85 0.00e+00 1184.00
IUUC-Bci-013782 Botrytis cinerea 34.57 1.00e-41 164.00
IUUC-Cel-018493 Caenorhabditis elegans 52.61 3.00e-68 253.00
IUUC-Cja-019998 Callithrix jacchus 95.63 0.00e+00 1172.00
IUUC-Cfa-020615 Canis familiaris 89.66 0.00e+00 1098.00
IUUC-Cpo-022019 Cavia porcellus 93.37 0.00e+00 1250.00
IUUC-Csa-023596 Chlorocebus sabaeus 98.71 0.00e+00 1164.00
IUUC-Cin-025488 Ciona intestinalis 45.91 6.00e-127 448.00
IUUC-Csv-025802 Ciona savignyi 49.91 1.00e-112 400.00
IUUC-Cgl-026560 Colletotrichum gloeosporioides 35.42 3.00e-40 160.00
IUUC-Cne-026847 Cryptococcus neoformans 31.89 3.00e-38 153.00
IUUC-Dre-028353 Danio rerio 77.59 0.00e+00 929.00
IUUC-Dno-029005 Dasypus novemcinctus 86.62 0.00e+00 1143.00
IUUC-Dor-030280 Dipodomys ordii 92.15 0.00e+00 1181.00
IUUC-Dse-031238 Dothistroma septosporum 38.71 8.00e-43 168.00
IUUC-Dme-031952 Drosophila melanogaster 48.24 4.00e-79 289.00
IUUC-Ete-032235 Echinops telfairi 96.36 2.00e-132 466.00
IUUC-Eca-033873 Equus caballus 93.88 0.00e+00 1182.00
IUUC-Eeu-034652 Erinaceus europaeus 95.53 1.00e-104 374.00
IUUC-Fca-036563 Felis catus 91.15 0.00e+00 1141.00
IUUC-Fal-036649 Ficedula albicollis 83.05 0.00e+00 1030.00
IUUC-Fox-037962 Fusarium oxysporum 32.86 1.00e-39 158.00
IUUC-Fso-038396 Fusarium solani 33.57 3.00e-40 160.00
IUUC-Gmo-039510 Gadus morhua 74.43 0.00e+00 954.00
IUUC-Ggr-039938 Gaeumannomyces graminis 31.91 9.00e-38 152.00
IUUC-Gga-040201 Gallus gallus 82.33 0.00e+00 1095.00
IUUC-Gac-041459 Gasterosteus aculeatus 74.65 0.00e+00 956.00
IUUC-Ggo-044573 Gorilla gorilla 99.36 0.00e+00 1279.00
IUUC-Itr-049065 Ictidomys tridecemlineatus 94.72 0.00e+00 1250.00
IUUC-Kpa-049327 Komagataella pastoris 31.42 6.00e-33 135.00
IUUC-Lch-049944 Latimeria chalumnae 73.11 4.00e-157 548.00
IUUC-Loc-051850 Lepisosteus oculatus 79.59 0.00e+00 1015.00
IUUC-Lma-053252 Leptosphaeria maculans 35.65 4.00e-41 163.00
IUUC-Laf-053346 Loxodonta africana 83.97 0.00e+00 1047.00
IUUC-Mcc-055789 Macaca mulatta 98.92 0.00e+00 1233.00
IUUC-Meu-056329 Macropus eugenii 73.13 1.00e-159 557.00
IUUC-Mor-057205 Magnaporthe oryzae 33.56 9.00e-39 155.00
IUUC-Mpo-057295 Magnaporthe poae 31.56 3.00e-39 156.00
IUUC-Mla-058849 Melampsora laricipopulina 33.03 6.00e-32 132.00
IUUC-Mga-059361 Meleagris gallopavo 81.82 0.00e+00 1023.00
IUUC-Mvi-060561 Microbotryum violaceum 32.33 3.00e-40 160.00
IUUC-Mmr-061122 Microcebus murinus 95.37 0.00e+00 1047.00
IUUC-Mdo-062171 Monodelphis domestica 89.59 0.00e+00 1194.00
IUUC-Mmu-063952 Mus musculus 93.44 0.00e+00 1280.00
IUUC-Mpu-065852 Mustela putorius furo 91.17 0.00e+00 1105.00
IUUC-Mlu-066996 Myotis lucifugus 84.18 9.00e-148 516.00
IUUC-Nfi-068539 Neosartorya fischeri 33.33 4.00e-41 163.00
IUUC-Ncr-068726 Neurospora crassa 39.19 6.00e-40 159.00
IUUC-Nle-070148 Nomascus leucogenys 93.05 0.00e+00 1144.00
IUUC-Opr-070833 Ochotona princeps 72.51 0.00e+00 798.00
IUUC-Ont-071261 Oreochromis niloticus 77.33 0.00e+00 963.00
IUUC-Oan-073684 Ornithorhynchus anatinus 70.59 2.00e-154 538.00
IUUC-Ola-087570 Oryzias latipes 74.41 0.00e+00 972.00
IUUC-Oga-089087 Otolemur garnettii 88.67 0.00e+00 1099.00
IUUC-Oar-089534 Ovis aries 92.44 0.00e+00 1181.00
IUUC-Ptr-091654 Pan troglodytes 93.95 0.00e+00 1170.00
IUUC-Pan-092652 Papio anubis 98.97 0.00e+00 1238.00
IUUC-Pno-095125 Phaeosphaeria nodorum 37.39 2.00e-42 167.00
IUUC-Pfo-096757 Poecilia formosa 75.84 0.00e+00 936.00
IUUC-Pab-097788 Pongo abelii 99.79 0.00e+00 886.00
IUUC-Pca-100145 Procavia capensis 79.02 0.00e+00 915.00
IUUC-Pva-102965 Pteropus vampyrus 86.79 0.00e+00 1113.00
IUUC-Pgr-103609 Puccinia graminis 34.69 2.00e-33 137.00
IUUC-Ptt-103865 Puccinia triticina 35.71 4.00e-34 140.00
IUUC-Pte-104095 Pyrenophora teres 35.24 8.00e-42 165.00
IUUC-Pyt-104668 Pyrenophora triticirepentis 35.87 2.00e-41 164.00
IUUC-Rno-105125 Rattus norvegicus 93.79 0.00e+00 1210.00
IUUC-Sce-106192 Saccharomyces cerevisiae 28.00 7.00e-27 115.00
IUUC-Sha-107066 Sarcophilus harrisii 90.18 0.00e+00 1156.00
IUUC-Sja-107931 Schizosaccharomyces japonicus 33.42 1.00e-41 164.00
IUUC-Spo-108220 Schizosaccharomyces pombe 36.41 1.00e-36 147.00
IUUC-Stu-112464 Solanum tuberosum 45.90 4.00e-13 70.90
IUUC-Sar-113393 Sorex araneus 91.58 3.00e-106 379.00
IUUC-Sre-114986 Sporisorium reilianum 38.12 2.00e-42 168.00
IUUC-Tgu-117505 Taeniopygia guttata 81.99 0.00e+00 1045.00
IUUC-Tru-118494 Takifugu rubripes 77.32 0.00e+00 994.00
IUUC-Tsy-119626 Tarsius syrichta 100.00 3.00e-54 206.00
IUUC-Tni-120174 Tetraodon nigroviridis 73.18 0.00e+00 998.00
IUUC-Tre-122191 Trichoderma reesei 33.82 1.00e-40 161.00
IUUC-Tvi-122318 Trichoderma virens 33.33 8.00e-42 165.00
IUUC-Tme-126914 Tuber melanosporum 34.40 6.00e-44 172.00
IUUC-Ttr-129095 Tursiops truncatus 92.98 0.00e+00 1226.00
IUUC-Uma-129475 Ustilago maydis 36.61 3.00e-39 157.00
IUUC-Vda-129908 Verticillium dahliae 32.87 2.00e-35 144.00
IUUC-Xtr-131900 Xenopus tropicalis 76.14 0.00e+00 1028.00
IUUC-Xma-133124 Xiphophorus maculatus 75.81 0.00e+00 976.00
IUUC-Yli-134682 Yarrowia lipolytica 35.27 1.00e-32 134.00
Created Date 25-Jun-2017

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