• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-045833
UUCD1 version UUC-HoS-00935
Ensembl Protein ID ENSP00000325377.3
UniProt Accession Q9C0J8; Q05DP8; Q53FG9; Q587J1; Q69YF7; Q6NUQ0; Q9NUL1; WDR33_HUMAN
Genbank Protein ID BAB32435.1; BAA92113.1; BAD97039.1; AAX82033.1; EAW95342.1; EAW95343.1; AAH05401.1; AAH13990.1; AAH68484.1; CAH10688.1
Protein Name pre-mRNA 3' end processing protein WDR33; WD repeat-containing protein 33; WD repeat-containing protein WDC146
Genbank Nucleotide ID AB044749; AK002156; AK223319; AC006011; CH471103; CH471103; BC005401; BC013990; BC068484; AL834365
Gene Name WDR33; WDC146
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000136709.11 ENST00000322313.8 ENSP00000325377.3
ENSG00000136709.11 ENST00000393006.5 ENSP00000376730.1
ENSG00000136709.11 ENST00000409658.7 ENSP00000387186.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
GWASdbGWAS Central
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.20e-29 101.9 201 231
UBD/Beta-Prp 2.60e-64 218.9 197 403
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf..sdtllvsGsdDgtikvWDl 30
           H++ ++  +f  +d+ ++++sdDgt+++WD+
   Q: 201  HKEAIREASFspTDNKFATCSDDGTVRIWDF 231
           999999999**555****************6 PP
   

   UBD/Beta-Prp
   S: 5    lkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseD..rtikvwdlstgkcvhtlkghe 94
           ++++hk+ i+   fsp ++ +at s+dgt+++wd+ +    r l gh a v++v+++p++ + v+gs+D  + ik wd++tg+ + tl++h+
   Q: 197  MFQAHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEERILRGHGADVKCVDWHPTKGLVVSGSKDsqQPIKFWDPKTGQSLATLHAHK 288
           6789999******************************9*9*****************************9999******************* PP
   S: 95   dsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkllrtltgghtdsvys 185
           ++v+ ++++ +g++l+++s+d   +++d+++ ++  ++++gh++  + v++hp    l++sG+ D+ + +W +  +k +  ++ +h++++ s
   Q: 289  NTVMEVKLNLNGNWLLTASRDHLCKLFDIRNLKEELQVFRGHKKEATAVAWHPVHeGLFASGGSDGSLLFWHVGVEKEVGGMEMAHEGMIWS 380
           *********************************9999******************************************************* PP
   S: 186  lsfdsngkelvsgsldgtvklwd 208
           l++++ g  l sgs+d t k+w 
   Q: 381  LAWHPLGHILCSGSNDHTSKFWT 403
           **********************6 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Essential for both cleavage and polyadenylation of pre-mRNA 3' ends.
 Essential for both cleavage and polyadenylation of pre-mRNA 3' ends.
Protein Sequence
(Fasta)
MATEIGSPPR FFHMPRFQHQ APRQLFYKRP DFAQQQAMQQ LTFDGKRMRK AVNRKTIDYN 60
PSVIKYLENR IWQRDQRDMR AIQPDAGYYN DLVPPIGMLN NPMNAVTTKF VRTSTNKVKC 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045833|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGTGCGTGAT GACCCCAGAG CGTGCGTTCG GTGGCCCATA GGGGAAGATG GCGGCTGCTC 60
CTTTGGAGGA GCGGGATTGA GAGGATCGGG GTGGGGAGAC CAAACAAGAG AGACATTTCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045833|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0176--Collagen
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0488--Methylation
KW-0507--mRNA processing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
KW-0853--WD repeat
Interpro

IPR016133--Insect_antifreeze_prot
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0005581--C:collagen trimer
GO:0001650--C:fibrillar center
GO:0005847--C:mRNA cleavage and polyadenylation specificity factor complex
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003723--F:RNA binding
GO:0031124--P:mRNA 3'-end processing
GO:0006379--P:mRNA cleavage
GO:0006406--P:mRNA export from nucleus
GO:0000398--P:mRNA splicing, via spliceosome
GO:0006301--P:postreplication repair
GO:0007283--P:spermatogenesis
GO:0006369--P:termination of RNA polymerase II transcription
KEGG hsa:55339
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001064 Aegilops tauschii 49.64 2.00e-121 429.00
IUUC-Aml-001363 Ailuropoda melanoleuca 99.84 0.00e+00 1169.00
IUUC-Atr-003030 Amborella trichopoda 56.27 5.00e-135 474.00
IUUC-Apl-003409 Anas platyrhynchos 97.15 0.00e+00 1143.00
IUUC-Aca-004694 Anolis carolinensis 98.07 0.00e+00 1103.00
IUUC-Aly-006063 Arabidopsis lyrata 54.63 2.00e-134 473.00
IUUC-Ath-006583 Arabidopsis thaliana 50.69 8.00e-129 454.00
IUUC-Ago-007805 Ashbya gossypii 41.42 8.00e-80 291.00
IUUC-Acl-008075 Aspergillus clavatus 41.00 9.00e-92 331.00
IUUC-Afl-008582 Aspergillus flavus 41.82 6.00e-90 325.00
IUUC-Afu-008817 Aspergillus fumigatus 41.01 2.00e-79 289.00
IUUC-Ani-009391 Aspergillus nidulans 39.90 7.00e-84 305.00
IUUC-Ang-009750 Aspergillus niger 42.90 2.00e-75 276.00
IUUC-Aor-010085 Aspergillus oryzae 40.50 3.00e-91 329.00
IUUC-Ate-010397 Aspergillus terreus 40.75 7.00e-91 328.00
IUUC-Ame-010741 Astyanax mexicanus 85.76 6.00e-172 598.00
IUUC-Bgr-012169 Blumeria graminis 48.90 7.00e-98 351.00
IUUC-Bta-013265 Bos taurus 99.51 0.00e+00 1175.00
IUUC-Bci-013762 Botrytis cinerea 45.71 4.00e-102 365.00
IUUC-Bdi-014849 Brachypodium distachyon 55.73 1.00e-132 466.00
IUUC-Bol-015325 Brassica oleracea 54.39 7.00e-139 487.00
IUUC-Bra-017187 Brassica rapa 54.28 1.00e-138 487.00
IUUC-Cel-018378 Caenorhabditis elegans 50.72 9.00e-144 504.00
IUUC-Cja-019547 Callithrix jacchus 99.84 0.00e+00 1179.00
IUUC-Cfa-020031 Canis familiaris 99.84 0.00e+00 1164.00
IUUC-Cpo-021554 Cavia porcellus 94.60 0.00e+00 1068.00
IUUC-Cre-022830 Chlamydomonas reinhardtii 42.20 2.00e-70 259.00
IUUC-Csa-023146 Chlorocebus sabaeus 99.67 0.00e+00 1162.00
IUUC-Cho-024679 Choloepus hoffmanni 89.76 0.00e+00 1029.00
IUUC-Cin-025415 Ciona intestinalis 59.41 4.00e-170 591.00
IUUC-Csv-026003 Ciona savignyi 60.26 1.00e-173 602.00
IUUC-Cgl-026391 Colletotrichum gloeosporioides 46.85 4.00e-99 355.00
IUUC-Cne-026983 Cryptococcus neoformans 42.89 6.00e-96 345.00
IUUC-Cme-027147 Cyanidioschyzon merolae 51.38 1.00e-117 416.00
IUUC-Dre-028545 Danio rerio 90.64 0.00e+00 1088.00
IUUC-Dno-029677 Dasypus novemcinctus 99.51 0.00e+00 1163.00
IUUC-Dse-031371 Dothistroma septosporum 42.20 1.00e-86 314.00
IUUC-Dme-031663 Drosophila melanogaster 67.44 0.00e+00 685.00
IUUC-Ete-032511 Echinops telfairi 91.71 0.00e+00 1104.00
IUUC-Eca-034152 Equus caballus 99.84 0.00e+00 1166.00
IUUC-Eeu-034560 Erinaceus europaeus 86.31 7.00e-121 428.00
IUUC-Fca-035820 Felis catus 99.67 0.00e+00 1165.00
IUUC-Fox-037958 Fusarium oxysporum 45.90 5.00e-97 348.00
IUUC-Fso-038162 Fusarium solani 45.63 1.00e-95 344.00
IUUC-Gmo-039708 Gadus morhua 89.05 0.00e+00 1050.00
IUUC-Ggr-040031 Gaeumannomyces graminis 39.80 1.00e-83 304.00
IUUC-Gga-040963 Gallus gallus 97.31 0.00e+00 1144.00
IUUC-Gac-041541 Gasterosteus aculeatus 87.35 0.00e+00 1048.00
IUUC-Gma-044352 Glycine max 56.12 2.00e-133 469.00
IUUC-Ggo-045564 Gorilla gorilla 99.67 0.00e+00 1160.00
IUUC-Hvu-047848 Hordeum vulgare 52.48 2.00e-92 332.00
IUUC-Itr-048083 Ictidomys tridecemlineatus 99.84 0.00e+00 1164.00
IUUC-Kpa-049308 Komagataella pastoris 40.31 3.00e-82 299.00
IUUC-Lch-050525 Latimeria chalumnae 94.14 0.00e+00 1044.00
IUUC-Lpe-051364 Leersia perrieri 51.06 2.00e-116 413.00
IUUC-Loc-052696 Lepisosteus oculatus 89.30 0.00e+00 1075.00
IUUC-Lma-052951 Leptosphaeria maculans 47.70 6.00e-103 368.00
IUUC-Laf-053653 Loxodonta africana 99.84 0.00e+00 1161.00
IUUC-Mcc-055797 Macaca mulatta 100.00 0.00e+00 1166.00
IUUC-Meu-056331 Macropus eugenii 93.65 0.00e+00 712.00
IUUC-Mor-057168 Magnaporthe oryzae 41.22 8.00e-92 331.00
IUUC-Mpo-057510 Magnaporthe poae 42.25 3.00e-61 228.00
IUUC-Mtr-058032 Medicago truncatula 55.87 2.00e-132 466.00
IUUC-Mla-058852 Melampsora laricipopulina 47.45 2.00e-112 399.00
IUUC-Mga-059311 Meleagris gallopavo 96.98 0.00e+00 1138.00
IUUC-Mvi-060544 Microbotryum violaceum 51.31 4.00e-114 405.00
IUUC-Mmr-061143 Microcebus murinus 99.84 0.00e+00 1164.00
IUUC-Mdo-061977 Monodelphis domestica 99.48 0.00e+00 1144.00
IUUC-Mmu-063922 Mus musculus 99.18 0.00e+00 1173.00
IUUC-Mac-064961 Musa acuminata 57.40 5.00e-138 484.00
IUUC-Mpu-066079 Mustela putorius furo 99.80 0.00e+00 963.00
IUUC-Mlu-067247 Myotis lucifugus 99.51 0.00e+00 1179.00
IUUC-Nfi-068255 Neosartorya fischeri 41.94 3.00e-86 312.00
IUUC-Ncr-068909 Neurospora crassa 44.05 1.00e-98 354.00
IUUC-Nle-068994 Nomascus leucogenys 100.00 0.00e+00 1166.00
IUUC-Opr-071079 Ochotona princeps 97.72 0.00e+00 1177.00
IUUC-Ont-071971 Oreochromis niloticus 89.84 0.00e+00 1085.00
IUUC-Oan-073135 Ornithorhynchus anatinus 99.39 0.00e+00 980.00
IUUC-Ocu-073982 Oryctolagus cuniculus 99.50 0.00e+00 1164.00
IUUC-Oba-075297 Oryza barthii 51.73 4.00e-119 422.00
IUUC-Obr-076641 Oryza brachyantha 55.95 1.00e-130 460.00
IUUC-Ogl-077539 Oryza glaberrima 58.78 1.00e-94 340.00
IUUC-Ogu-078807 Oryza glumaepatula 51.73 3.00e-119 422.00
IUUC-Oin-079229 Oryza indica 56.00 2.00e-132 466.00
IUUC-Olo-080371 Oryza longistaminata 51.62 3.00e-117 415.00
IUUC-Ome-081149 Oryza meridionalis 50.78 7.00e-119 421.00
IUUC-Oni-082970 Oryza nivara 51.73 4.00e-119 422.00
IUUC-Opu-083415 Oryza punctata 51.20 8.00e-117 414.00
IUUC-Oru-085236 Oryza rufipogon 51.73 2.00e-119 423.00
IUUC-Ola-087421 Oryzias latipes 91.20 0.00e+00 1082.00
IUUC-Olu-087821 Ostreococcus lucimarinus 49.45 9.00e-104 370.00
IUUC-Oga-088132 Otolemur garnettii 99.84 0.00e+00 1164.00
IUUC-Oar-089513 Ovis aries 99.51 0.00e+00 1175.00
IUUC-Ptr-090717 Pan troglodytes 100.00 0.00e+00 1167.00
IUUC-Pan-092108 Papio anubis 100.00 0.00e+00 1166.00
IUUC-Psi-093892 Pelodiscus sinensis 99.29 0.00e+00 1124.00
IUUC-Pma-094561 Petromyzon marinus 75.43 0.00e+00 940.00
IUUC-Pno-094943 Phaeosphaeria nodorum 45.04 2.00e-103 369.00
IUUC-Ppa-095359 Physcomitrella patens 61.23 4.00e-144 505.00
IUUC-Pfo-096516 Poecilia formosa 90.88 0.00e+00 1047.00
IUUC-Pab-097759 Pongo abelii 100.00 0.00e+00 1166.00
IUUC-Pop-098892 Populus trichocarpa 56.91 3.00e-137 482.00
IUUC-Pca-100405 Procavia capensis 89.15 8.00e-109 389.00
IUUC-Ppe-101957 Prunus persica 55.21 7.00e-135 474.00
IUUC-Pva-102918 Pteropus vampyrus 99.51 0.00e+00 1162.00
IUUC-Pgr-103594 Puccinia graminis 50.81 1.00e-115 410.00
IUUC-Ptt-103879 Puccinia triticina 54.52 5.00e-101 362.00
IUUC-Pte-104419 Pyrenophora teres 45.69 3.00e-104 372.00
IUUC-Pyt-104718 Pyrenophora triticirepentis 47.80 2.00e-102 366.00
IUUC-Rno-105838 Rattus norvegicus 98.82 0.00e+00 1205.00
IUUC-Sce-106331 Saccharomyces cerevisiae 39.14 1.00e-76 280.00
IUUC-Sha-107435 Sarcophilus harrisii 98.95 0.00e+00 1137.00
IUUC-Sja-107796 Schizosaccharomyces japonicus 44.78 3.00e-100 358.00
IUUC-Spo-108163 Schizosaccharomyces pombe 44.53 2.00e-103 369.00
IUUC-Smo-109602 Selaginella moellendorffii 57.33 7.00e-135 473.00
IUUC-Sit-109729 Setaria italica 57.33 4.00e-134 472.00
IUUC-Sly-111679 Solanum lycopersicum 57.82 4.00e-138 485.00
IUUC-Sar-113157 Sorex araneus 98.85 0.00e+00 1173.00
IUUC-Sbi-114853 Sorghum bicolor 53.68 4.00e-133 468.00
IUUC-Sre-115085 Sporisorium reilianum 41.13 3.00e-101 362.00
IUUC-Ssc-116286 Sus scrofa 99.34 0.00e+00 1163.00
IUUC-Tgu-117219 Taeniopygia guttata 97.31 0.00e+00 1145.00
IUUC-Tru-117550 Takifugu rubripes 90.24 0.00e+00 1057.00
IUUC-Tsy-119294 Tarsius syrichta 99.84 0.00e+00 1166.00
IUUC-Tni-120561 Tetraodon nigroviridis 89.16 0.00e+00 1068.00
IUUC-Tca-121347 Theobroma cacao 56.12 5.00e-135 475.00
IUUC-Tre-122018 Trichoderma reesei 43.91 2.00e-97 349.00
IUUC-Tvi-122413 Trichoderma virens 43.91 2.00e-96 346.00
IUUC-Tae-123904 Triticum aestivum 51.92 2.00e-131 462.00
IUUC-Tme-127077 Tuber melanosporum 50.54 4.00e-105 375.00
IUUC-Tbe-127744 Tupaia belangeri 74.12 9.00e-160 558.00
IUUC-Ttr-128777 Tursiops truncatus 90.77 0.00e+00 1025.00
IUUC-Uma-129568 Ustilago maydis 43.54 1.00e-97 350.00
IUUC-Vda-129834 Verticillium dahliae 43.97 3.00e-95 342.00
IUUC-Vpa-130563 Vicugna pacos 84.57 5.00e-76 279.00
IUUC-Vvi-131360 Vitis vinifera 57.03 2.00e-136 480.00
IUUC-Xtr-132630 Xenopus tropicalis 88.58 0.00e+00 1062.00
IUUC-Xma-133665 Xiphophorus maculatus 91.40 0.00e+00 1058.00
IUUC-Yli-134556 Yarrowia lipolytica 37.19 6.00e-85 308.00
IUUC-Zma-135787 Zea mays 55.38 5.00e-135 475.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved