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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Sce-106384
UUCD1 version UUC-SaC-00061
Ensembl Protein ID YDL074C
UniProt Accession Q07457; D6VRS5; BRE1_YEAST
Genbank Protein ID CAA98640.1; DAA11785.1
Protein Name E3 ubiquitin-protein ligase BRE1; Brefeldin A-sensitivity protein 1; RING-type E3 ubiquitin transferase BRE1
Genbank Nucleotide ID Z74122; BK006938
Gene Name BRE1; YDL074C
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YDL074C YDL074C YDL074C
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFBioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 19662160; 19635810
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.014 14.4 648 687
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C++C    k+   +  CgHvf+++C  +++      + +  +CP+C+
   Q: 648  CSLCSKNWKN-MAIKTCGHVFCENCCkERL------AARMRKCPTCN 687
           9999999999.88899*********97777......9999******7 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1 in association with the E2 enzyme RAD6/UBC2. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. It thereby plays a central role in histone code and gene regulation. Also modulates the formation of double-strand breaks during meiosis.
 E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1 in association with the E2 enzyme RAD6/UBC2. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. It thereby plays a central role in histone code and gene regulation. Also modulates the formation of double-strand breaks during meiosis.
Protein Sequence
(Fasta)
MTAEPATKKI KLELSDPSEP LTQSDVIAFQ KEALFRCINR RRVDFEALRK QYELSRRECI 60
DVSRKLANIM ALIVTLARFI ETFCTDANEK QLCREIAQGD ETLIVQRSDS FMKLLTKYGK 120
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Protein Fasta Sequence


>IUUC-Sce-106384|E3,RING|Saccharomyces cerevisiae
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Nucleotide Sequence
(Fasta)
ATGACGGCCG AGCCTGCTAC TAAGAAGATC AAGCTAGAAT TAAGCGATCC TAGTGAACCG 60
CTTACTCAAT CTGATGTGAT AGCGTTTCAA AAAGAAGCTT TGTTTAGATG TATAAATCGT 120
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Nucleotide Fasta Sequence


>IUUC-Sce-106384|E3,RING|Saccharomyces cerevisiae
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Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR013956--E3_ubiquit_lig_BRE1
IPR013087--Znf_C2H2_type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF08647--BRE1
SMART

SM00184--RING
Gene Ontology

GO:0000781--C:chromosome, telomeric region
GO:0005634--C:nucleus
GO:0003688--F:DNA replication origin binding
GO:0042802--F:identical protein binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006348--P:chromatin silencing at telomere
GO:0000724--P:double-strand break repair via homologous recombination
GO:0010390--P:histone monoubiquitination
GO:0016574--P:histone ubiquitination
GO:0031573--P:intra-S DNA damage checkpoint
GO:0042138--P:meiotic DNA double-strand break formation
GO:0031571--P:mitotic G1 DNA damage checkpoint
GO:0070534--P:protein K63-linked ubiquitination
GO:0030174--P:regulation of DNA-dependent DNA replication initiation
GO:0000722--P:telomere maintenance via recombination
GO:0006366--P:transcription from RNA polymerase II promoter
KEGG sce:YDL074C
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000620 Aegilops tauschii 33.96 3.00e-07 47.00
IUUC-Aml-002295 Ailuropoda melanoleuca 24.63 1.00e-16 80.10
IUUC-Apl-003407 Anas platyrhynchos 23.22 3.00e-16 78.60
IUUC-Aca-005267 Anolis carolinensis 38.03 4.00e-14 69.70
IUUC-Aly-006469 Arabidopsis lyrata 37.88 2.00e-11 62.80
IUUC-Ath-007462 Arabidopsis thaliana 34.25 1.00e-11 63.50
IUUC-Ago-007988 Ashbya gossypii 47.57 3.00e-119 420.00
IUUC-Acl-008319 Aspergillus clavatus 28.88 7.00e-35 140.00
IUUC-Afl-008679 Aspergillus flavus 28.45 8.00e-15 73.60
IUUC-Afu-008884 Aspergillus fumigatus 27.88 4.00e-18 84.70
IUUC-Ani-009487 Aspergillus nidulans 26.72 3.00e-13 68.60
IUUC-Ang-009601 Aspergillus niger 31.10 2.00e-40 158.00
IUUC-Aor-010142 Aspergillus oryzae 28.90 8.00e-38 150.00
IUUC-Ate-010547 Aspergillus terreus 29.10 3.00e-38 151.00
IUUC-Ame-011745 Astyanax mexicanus 38.57 6.00e-13 67.80
IUUC-Bgr-012245 Blumeria graminis 32.49 2.00e-43 168.00
IUUC-Bta-013173 Bos taurus 24.63 1.00e-16 80.10
IUUC-Bci-013926 Botrytis cinerea 30.63 5.00e-41 160.00
IUUC-Bdi-014799 Brachypodium distachyon 25.00 7.00e-15 73.90
IUUC-Bol-015858 Brassica oleracea 26.76 4.00e-13 68.20
IUUC-Bra-016804 Brassica rapa 26.76 5.00e-13 68.20
IUUC-Cel-018208 Caenorhabditis elegans 32.73 3.00e-05 41.60
IUUC-Cja-019042 Callithrix jacchus 23.51 7.00e-14 70.90
IUUC-Cfa-020318 Canis familiaris 24.63 1.00e-16 80.10
IUUC-Cpo-021539 Cavia porcellus 24.25 2.00e-16 79.70
IUUC-Cre-022940 Chlamydomonas reinhardtii 35.58 1.00e-07 49.30
IUUC-Csa-024051 Chlorocebus sabaeus 24.25 2.00e-16 79.30
IUUC-Cho-024616 Choloepus hoffmanni 24.34 1.00e-13 70.10
IUUC-Cin-025174 Ciona intestinalis 25.94 8.00e-22 97.40
IUUC-Csv-025830 Ciona savignyi 24.38 2.00e-17 82.40
IUUC-Cgl-026569 Colletotrichum gloeosporioides 44.59 3.00e-18 85.10
IUUC-Cne-026878 Cryptococcus neoformans 26.88 2.00e-22 99.00
IUUC-Cme-027134 Cyanidioschyzon merolae 33.90 4.00e-10 57.80
IUUC-Dre-028171 Danio rerio 25.00 4.00e-16 78.20
IUUC-Dno-028892 Dasypus novemcinctus 24.63 1.00e-16 80.50
IUUC-Dor-030268 Dipodomys ordii 24.63 7.00e-17 80.90
IUUC-Dse-031300 Dothistroma septosporum 27.34 4.00e-33 134.00
IUUC-Dme-032034 Drosophila melanogaster 22.99 7.00e-15 74.30
IUUC-Ete-033164 Echinops telfairi 24.72 3.00e-14 72.40
IUUC-Eca-033436 Equus caballus 24.63 1.00e-16 79.70
IUUC-Eeu-034801 Erinaceus europaeus 37.84 5.00e-14 70.90
IUUC-Fca-035720 Felis catus 24.63 1.00e-16 80.10
IUUC-Fal-037622 Ficedula albicollis 39.13 3.00e-14 72.40
IUUC-Fox-038017 Fusarium oxysporum 30.32 9.00e-37 146.00
IUUC-Fso-038414 Fusarium solani 30.28 9.00e-38 149.00
IUUC-Gmo-039446 Gadus morhua 36.62 5.00e-13 68.20
IUUC-Ggr-040117 Gaeumannomyces graminis 30.85 9.00e-37 146.00
IUUC-Gga-040412 Gallus gallus 23.22 8.00e-16 77.40
IUUC-Gac-042205 Gasterosteus aculeatus 22.43 8.00e-14 70.90
IUUC-Gma-042797 Glycine max 24.21 2.00e-15 75.50
IUUC-Ggo-045426 Gorilla gorilla 24.25 2.00e-16 79.70
IUUC-Hsa-045732 Homo sapiens 24.25 2.00e-16 79.70
IUUC-Hvu-047689 Hordeum vulgare 24.07 6.00e-15 74.30
IUUC-Itr-048724 Ictidomys tridecemlineatus 24.63 1.00e-16 80.50
IUUC-Kpa-049345 Komagataella pastoris 27.91 1.00e-44 172.00
IUUC-Lch-049429 Latimeria chalumnae 25.37 1.00e-17 83.60
IUUC-Lpe-051253 Leersia perrieri 25.00 7.00e-14 70.90
IUUC-Loc-052847 Lepisosteus oculatus 38.57 1.00e-12 65.10
IUUC-Lma-053312 Leptosphaeria maculans 29.40 2.00e-31 128.00
IUUC-Laf-054267 Loxodonta africana 24.63 1.00e-16 80.10
IUUC-Mcc-055240 Macaca mulatta 24.25 2.00e-16 79.30
IUUC-Meu-056559 Macropus eugenii 24.72 3.00e-14 72.40
IUUC-Mor-057068 Magnaporthe oryzae 30.17 4.00e-29 121.00
IUUC-Mpo-057568 Magnaporthe poae 29.95 2.00e-35 141.00
IUUC-Mtr-057632 Medicago truncatula 23.64 1.00e-14 73.60
IUUC-Mla-059072 Melampsora laricipopulina 25.00 2.00e-17 82.80
IUUC-Mga-059731 Meleagris gallopavo 23.22 2.00e-15 76.30
IUUC-Mvi-060341 Microbotryum violaceum 25.76 7.00e-21 94.00
IUUC-Mmr-061177 Microcebus murinus 24.25 2.00e-16 79.70
IUUC-Mdo-062415 Monodelphis domestica 23.71 2.00e-16 79.70
IUUC-Mmu-063981 Mus musculus 24.63 1.00e-16 80.50
IUUC-Mac-065103 Musa acuminata 22.74 4.00e-17 81.30
IUUC-Mpu-066498 Mustela putorius furo 24.63 1.00e-16 80.10
IUUC-Mlu-067242 Myotis lucifugus 24.63 1.00e-16 79.70
IUUC-Nfi-068269 Neosartorya fischeri 27.44 7.00e-18 83.60
IUUC-Ncr-068695 Neurospora crassa 32.00 1.00e-40 159.00
IUUC-Nle-069058 Nomascus leucogenys 24.34 1.00e-13 70.50
IUUC-Opr-071149 Ochotona princeps 37.84 3.00e-14 72.00
IUUC-Ont-072543 Oreochromis niloticus 23.13 2.00e-13 69.30
IUUC-Oan-072996 Ornithorhynchus anatinus 24.34 2.00e-16 79.30
IUUC-Ocu-073799 Oryctolagus cuniculus 24.63 1.00e-16 79.70
IUUC-Oba-075000 Oryza barthii 25.00 5.00e-15 74.70
IUUC-Obr-076532 Oryza brachyantha 24.21 6.00e-15 74.30
IUUC-Ogl-077200 Oryza glaberrima 25.00 5.00e-15 74.70
IUUC-Ogu-078279 Oryza glumaepatula 25.00 4.00e-15 74.70
IUUC-Oin-079097 Oryza indica 25.00 5.00e-15 74.70
IUUC-Olo-080612 Oryza longistaminata 32.79 2.00e-08 53.10
IUUC-Ome-081304 Oryza meridionalis 26.56 6.00e-16 77.40
IUUC-Oni-082162 Oryza nivara 25.00 5.00e-15 74.70
IUUC-Opu-083683 Oryza punctata 31.82 3.00e-09 55.10
IUUC-Oru-084382 Oryza rufipogon 25.00 5.00e-15 74.70
IUUC-Osa-085839 Oryza sativa 31.82 3.00e-09 55.10
IUUC-Ola-087287 Oryzias latipes 36.62 4.00e-13 68.60
IUUC-Olu-087683 Ostreococcus lucimarinus 31.25 5.00e-10 54.70
IUUC-Oga-089016 Otolemur garnettii 24.25 2.00e-16 79.30
IUUC-Oar-089589 Ovis aries 24.63 1.00e-16 79.70
IUUC-Ptr-091602 Pan troglodytes 24.34 1.00e-13 70.50
IUUC-Pan-092502 Papio anubis 24.25 2.00e-16 79.30
IUUC-Psi-093554 Pelodiscus sinensis 39.13 3.00e-14 72.40
IUUC-Pno-095079 Phaeosphaeria nodorum 30.60 4.00e-30 124.00
IUUC-Ppa-095651 Physcomitrella patens 24.15 6.00e-17 80.90
IUUC-Pfo-097527 Poecilia formosa 38.57 1.00e-13 70.10
IUUC-Pab-098619 Pongo abelii 24.25 2.00e-16 79.30
IUUC-Pop-099583 Populus trichocarpa 23.95 8.00e-14 68.90
IUUC-Pca-100544 Procavia capensis 24.63 1.00e-16 80.50
IUUC-Ppe-102065 Prunus persica 23.57 1.00e-13 69.70
IUUC-Pva-102479 Pteropus vampyrus 24.63 1.00e-16 80.10
IUUC-Pgr-103536 Puccinia graminis 26.12 1.00e-18 86.30
IUUC-Pte-104415 Pyrenophora teres 28.29 1.00e-28 119.00
IUUC-Pyt-104762 Pyrenophora triticirepentis 27.45 2.00e-28 119.00
IUUC-Rno-105165 Rattus norvegicus 24.63 9.00e-17 80.50
IUUC-Sha-107602 Sarcophilus harrisii 23.71 1.00e-16 80.10
IUUC-Sja-107993 Schizosaccharomyces japonicus 23.66 1.00e-24 106.00
IUUC-Spo-108304 Schizosaccharomyces pombe 32.57 7.00e-29 120.00
IUUC-Ssl-108546 Sclerotinia sclerotiorum 30.56 1.00e-39 155.00
IUUC-Smo-109550 Selaginella moellendorffii 42.65 4.00e-14 71.60
IUUC-Sit-109889 Setaria italica 21.93 2.00e-17 82.40
IUUC-Sly-111490 Solanum lycopersicum 21.53 1.00e-12 66.20
IUUC-Sar-113349 Sorex araneus 27.60 3.00e-14 72.40
IUUC-Sbi-114734 Sorghum bicolor 23.05 4.00e-14 69.30
IUUC-Sre-115087 Sporisorium reilianum 25.93 4.00e-18 84.70
IUUC-Ssc-115723 Sus scrofa 24.34 9.00e-14 70.50
IUUC-Tgu-116549 Taeniopygia guttata 39.13 3.00e-14 72.00
IUUC-Tru-118776 Takifugu rubripes 36.62 2.00e-13 69.30
IUUC-Tsy-118808 Tarsius syrichta 24.34 1.00e-13 69.70
IUUC-Tni-120790 Tetraodon nigroviridis 37.14 3.00e-13 68.90
IUUC-Tca-121060 Theobroma cacao 26.22 9.00e-15 73.60
IUUC-Tre-122150 Trichoderma reesei 26.18 4.00e-37 147.00
IUUC-Tvi-122431 Trichoderma virens 26.84 3.00e-39 154.00
IUUC-Tae-122767 Triticum aestivum 23.87 4.00e-16 78.20
IUUC-Tur-126160 Triticum urartu 31.88 7.00e-10 57.40
IUUC-Tme-127177 Tuber melanosporum 25.53 1.00e-39 156.00
IUUC-Tbe-127597 Tupaia belangeri 24.48 2.00e-16 79.70
IUUC-Ttr-128266 Tursiops truncatus 24.34 8.00e-14 70.90
IUUC-Uma-129488 Ustilago maydis 23.64 1.00e-15 76.30
IUUC-Vda-129815 Verticillium dahliae 26.03 2.00e-27 115.00
IUUC-Vpa-130237 Vicugna pacos 24.34 1.00e-13 70.50
IUUC-Vvi-131316 Vitis vinifera 22.51 3.00e-13 68.60
IUUC-Xtr-132906 Xenopus tropicalis 36.11 2.00e-13 69.30
IUUC-Xma-133365 Xiphophorus maculatus 38.57 1.00e-13 70.10
IUUC-Yli-134445 Yarrowia lipolytica 28.17 8.00e-44 169.00
IUUC-Zma-135805 Zea mays 22.18 1.00e-14 73.20
Created Date 25-Jun-2017

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