iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ssc-115903

Ensembl Protein ID

ENSSSCP00000027429.1

UniProt Accession

I3LTI2; I3LTI2_PIG

Genbank Protein ID

ENSSSCP00000027429

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

FP565655

Gene Name

NLE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSSCG00000025796.1	ENSSSCT00000026878.1	ENSSSCP00000027429.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.00e-67	219.8	197	240
UBD/Beta-Prp	2.30e-79	267.0	106	302

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf......sd.tllvsGsdDgtikvWDlrtgvllk 37
           gH+ ++t+l++      ++ ++++s+s Dg+++vWD++ g++++
   Q: 197  GHSKWITALSWeplhanPEcRYVASSSKDGSVRVWDTTAGRCER 240
           8***************9889**********************86 PP

UBD/Beta-Prp

   S: 44   llrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleet 132
           + +sl+gh+++v +v fsp+gk+l++gs D t++ wdlst ++  t +gh + vls+s+sp+g+kl+sG +   i +wd +tg+ +   
   Q: 106  CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCQGHRHWVLSISWSPDGKKLASGCKNGQILLWDPSTGKQVGRA 194
           6799************************************************************************************* PP
   S: 133  lsghdgvvncvvv.....hpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvr 216
           l+gh+++++ +++     +p++++++s+s+D+ vr+Wd   g++ r ltg ht+sv++l +  +g  l s+s+d+t+k+w  + g   r
   Q: 195  LAGHSKWITALSWeplhaNPECRYVASSSKDGSVRVWDTTAGRCERILTG-HTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCR 281
           **********9873332257889**************************9.************98.*********************** PP
   S: 217  tlnghtdnvksvrfspnderlv 238
           tl+gh  +v+ +++s  d  l 
   Q: 282  TLQGHGHWVNTMALS-TDYALR 302
           **************9.444444 PP

Organism

Sus scrofa

Protein Sequence
(Fasta)

MAAAVADEAA PRDVQRLLVQ FQDEGGQLLG SPFDVPVDIT PDKLQLVCNA LLAQEDPLPL 60
AFYVHDAEII SSLGKTLESQ AVETEKVLDI IYQPQAVFRV RAVTRCTSSL EGHSEAVISV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGACACTTCC CCTCCGCAAC AGCAGAGGGC GATGTCGCAG ACTGCGGCGC CGCAGGACCA 60
CGGGGGCGGC GCTCTGTCCG ACCGGCGTTT TCCCCTCCAC GTGGGGACGC GGGATGGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR020472--G-protein_beta_WD-40_rep
IPR001632--Gprotein_B
IPR012972--NLE
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF08154--NLE
PF00400--WD40

PRINTS

PR00319--GPROTEINB
PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005730--C:nucleolus
GO:0005840--C:ribosome
GO:0061484--P:hematopoietic stem cell homeostasis
GO:0001826--P:inner cell mass cell differentiation
GO:0001822--P:kidney development
GO:2001268--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0045930--P:negative regulation of mitotic cell cycle
GO:0007219--P:Notch signaling pathway
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0000027--P:ribosomal large subunit assembly
GO:0048705--P:skeletal system morphogenesis
GO:0001756--P:somitogenesis

KEGG

ssc:100626208

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000437	Aegilops tauschii	58.58	3.00e-169	587.00
IUUC-Aml-001793	Ailuropoda melanoleuca	97.46	0.00e+00	946.00
IUUC-Atr-002507	Amborella trichopoda	58.21	8.00e-167	579.00
IUUC-Apl-003964	Anas platyrhynchos	84.36	0.00e+00	809.00
IUUC-Aly-006396	Arabidopsis lyrata	54.47	1.00e-159	555.00
IUUC-Ath-007278	Arabidopsis thaliana	54.68	1.00e-159	556.00
IUUC-Ago-007951	Ashbya gossypii	48.17	4.00e-130	457.00
IUUC-Acl-008298	Aspergillus clavatus	46.93	2.00e-121	428.00
IUUC-Afl-008581	Aspergillus flavus	52.22	1.00e-109	389.00
IUUC-Afu-008906	Aspergillus fumigatus	45.93	4.00e-121	427.00
IUUC-Ani-009189	Aspergillus nidulans	44.44	2.00e-117	416.00
IUUC-Ang-009630	Aspergillus niger	46.56	7.00e-124	437.00
IUUC-Aor-010038	Aspergillus oryzae	47.05	2.00e-128	452.00
IUUC-Ate-010278	Aspergillus terreus	46.81	2.00e-123	436.00
IUUC-Ame-011890	Astyanax mexicanus	80.97	0.00e+00	823.00
IUUC-Bgr-012011	Blumeria graminis	47.66	4.00e-131	461.00
IUUC-Bta-012964	Bos taurus	97.47	0.00e+00	950.00
IUUC-Bci-013592	Botrytis cinerea	45.16	2.00e-121	429.00
IUUC-Bdi-015035	Brachypodium distachyon	58.67	2.00e-170	591.00
IUUC-Bol-015501	Brassica oleracea	55.56	9.00e-160	556.00
IUUC-Bra-017642	Brassica rapa	55.34	3.00e-159	554.00
IUUC-Cel-018430	Caenorhabditis elegans	58.24	3.00e-167	580.00
IUUC-Cja-019125	Callithrix jacchus	95.99	0.00e+00	936.00
IUUC-Cfa-021013	Canis familiaris	96.30	0.00e+00	858.00
IUUC-Cpo-021743	Cavia porcellus	94.50	0.00e+00	931.00
IUUC-Cre-022973	Chlamydomonas reinhardtii	47.13	2.00e-118	419.00
IUUC-Csa-024270	Chlorocebus sabaeus	96.84	0.00e+00	944.00
IUUC-Cin-025795	Ciona intestinalis	66.52	0.00e+00	685.00
IUUC-Csv-025953	Ciona savignyi	67.80	0.00e+00	688.00
IUUC-Cgl-026517	Colletotrichum gloeosporioides	51.99	4.00e-109	387.00
IUUC-Cne-026901	Cryptococcus neoformans	49.50	9.00e-139	486.00
IUUC-Cme-027281	Cyanidioschyzon merolae	47.47	7.00e-114	404.00
IUUC-Dre-028515	Danio rerio	78.22	0.00e+00	802.00
IUUC-Dno-029596	Dasypus novemcinctus	97.67	0.00e+00	946.00
IUUC-Dor-030494	Dipodomys ordii	95.97	0.00e+00	930.00
IUUC-Dse-031538	Dothistroma septosporum	48.27	7.00e-131	460.00
IUUC-Dme-031974	Drosophila melanogaster	58.77	1.00e-169	589.00
IUUC-Ete-032948	Echinops telfairi	96.65	3.00e-117	414.00
IUUC-Eca-033399	Equus caballus	97.66	0.00e+00	946.00
IUUC-Eeu-035013	Erinaceus europaeus	96.52	5.00e-115	407.00
IUUC-Fca-035860	Felis catus	97.26	0.00e+00	946.00
IUUC-Fal-037069	Ficedula albicollis	87.60	1.00e-130	458.00
IUUC-Fox-038059	Fusarium oxysporum	47.18	5.00e-126	444.00
IUUC-Fso-038445	Fusarium solani	47.39	2.00e-126	445.00
IUUC-Gmo-039319	Gadus morhua	75.96	0.00e+00	732.00
IUUC-Ggr-040095	Gaeumannomyces graminis	47.30	3.00e-123	434.00
IUUC-Gga-040303	Gallus gallus	85.20	2.00e-128	451.00
IUUC-Gac-042267	Gasterosteus aculeatus	78.69	0.00e+00	762.00
IUUC-Gma-043974	Glycine max	56.81	1.00e-168	585.00
IUUC-Ggo-044637	Gorilla gorilla	96.18	0.00e+00	932.00
IUUC-Hsa-046128	Homo sapiens	96.62	0.00e+00	945.00
IUUC-Hvu-047373	Hordeum vulgare	58.03	2.00e-168	585.00
IUUC-Itr-048070	Ictidomys tridecemlineatus	95.82	0.00e+00	939.00
IUUC-Kpa-049274	Komagataella pastoris	45.01	8.00e-129	453.00
IUUC-Lch-049907	Latimeria chalumnae	82.81	0.00e+00	823.00
IUUC-Lpe-050778	Leersia perrieri	53.65	1.00e-151	529.00
IUUC-Loc-051889	Lepisosteus oculatus	80.97	0.00e+00	825.00
IUUC-Lma-053041	Leptosphaeria maculans	49.65	5.00e-117	414.00
IUUC-Laf-053598	Loxodonta africana	97.68	0.00e+00	950.00
IUUC-Mcc-055660	Macaca mulatta	96.84	0.00e+00	944.00
IUUC-Meu-056197	Macropus eugenii	81.02	0.00e+00	776.00
IUUC-Mor-056949	Magnaporthe oryzae	45.96	2.00e-119	422.00
IUUC-Mpo-057571	Magnaporthe poae	53.70	1.00e-63	236.00
IUUC-Mtr-058530	Medicago truncatula	58.30	5.00e-166	577.00
IUUC-Mla-059133	Melampsora laricipopulina	45.89	2.00e-125	442.00
IUUC-Mga-059252	Meleagris gallopavo	83.84	0.00e+00	654.00
IUUC-Mvi-060522	Microbotryum violaceum	50.61	6.00e-136	477.00
IUUC-Mmr-061117	Microcebus murinus	96.21	0.00e+00	935.00
IUUC-Mdo-062892	Monodelphis domestica	90.27	0.00e+00	893.00
IUUC-Mmu-064108	Mus musculus	95.77	0.00e+00	909.00
IUUC-Mac-064430	Musa acuminata	59.31	5.00e-172	597.00
IUUC-Mpu-065882	Mustela putorius furo	96.62	0.00e+00	935.00
IUUC-Mlu-068123	Myotis lucifugus	95.99	0.00e+00	943.00
IUUC-Nfi-068484	Neosartorya fischeri	46.61	2.00e-121	428.00
IUUC-Ncr-068649	Neurospora crassa	44.28	2.00e-116	412.00
IUUC-Nle-069140	Nomascus leucogenys	96.39	0.00e+00	934.00
IUUC-Opr-070220	Ochotona princeps	88.11	0.00e+00	813.00
IUUC-Ont-072643	Oreochromis niloticus	79.79	0.00e+00	813.00
IUUC-Ocu-074007	Oryctolagus cuniculus	95.77	0.00e+00	908.00
IUUC-Oba-075904	Oryza barthii	59.10	1.00e-171	595.00
IUUC-Obr-076280	Oryza brachyantha	58.67	6.00e-171	593.00
IUUC-Ogl-077425	Oryza glaberrima	59.10	8.00e-172	596.00
IUUC-Ogu-078586	Oryza glumaepatula	59.10	1.00e-171	595.00
IUUC-Oin-079489	Oryza indica	56.96	1.00e-162	565.00
IUUC-Olo-080766	Oryza longistaminata	58.97	2.00e-171	595.00
IUUC-Ome-081905	Oryza meridionalis	59.10	9.00e-172	596.00
IUUC-Oni-083022	Oryza nivara	59.10	5.00e-172	597.00
IUUC-Opu-083615	Oryza punctata	59.10	6.00e-172	596.00
IUUC-Oru-085076	Oryza rufipogon	59.10	5.00e-172	597.00
IUUC-Osa-085516	Oryza sativa	59.10	5.00e-172	597.00
IUUC-Ola-087290	Oryzias latipes	77.89	0.00e+00	798.00
IUUC-Olu-087898	Ostreococcus lucimarinus	53.14	4.00e-143	501.00
IUUC-Oga-088980	Otolemur garnettii	95.97	0.00e+00	932.00
IUUC-Oar-089580	Ovis aries	98.29	0.00e+00	831.00
IUUC-Ptr-090845	Pan troglodytes	95.97	0.00e+00	929.00
IUUC-Pan-092836	Papio anubis	96.62	0.00e+00	943.00
IUUC-Psi-093965	Pelodiscus sinensis	84.21	7.00e-57	211.00
IUUC-Pno-095052	Phaeosphaeria nodorum	47.02	2.00e-122	432.00
IUUC-Ppa-095432	Physcomitrella patens	58.85	2.00e-171	594.00
IUUC-Pfo-096963	Poecilia formosa	71.37	0.00e+00	696.00
IUUC-Pab-097716	Pongo abelii	92.99	0.00e+00	889.00
IUUC-Pop-099224	Populus trichocarpa	57.87	6.00e-170	590.00
IUUC-Pca-100682	Procavia capensis	92.39	0.00e+00	672.00
IUUC-Ppe-101819	Prunus persica	58.21	4.00e-168	583.00
IUUC-Pva-102338	Pteropus vampyrus	97.21	0.00e+00	722.00
IUUC-Pgr-103583	Puccinia graminis	54.50	3.00e-131	461.00
IUUC-Ptt-103737	Puccinia triticina	44.80	2.00e-99	355.00
IUUC-Pte-104150	Pyrenophora teres	50.00	4.00e-122	431.00
IUUC-Pyt-104606	Pyrenophora triticirepentis	49.77	8.00e-122	430.00
IUUC-Rno-105987	Rattus norvegicus	95.34	0.00e+00	930.00
IUUC-Sce-106315	Saccharomyces cerevisiae	47.57	4.00e-131	461.00
IUUC-Sha-107273	Sarcophilus harrisii	91.33	0.00e+00	902.00
IUUC-Sja-107677	Schizosaccharomyces japonicus	45.77	2.00e-118	419.00
IUUC-Spo-108092	Schizosaccharomyces pombe	48.97	3.00e-123	434.00
IUUC-Ssl-108442	Sclerotinia sclerotiorum	44.72	3.00e-117	415.00
IUUC-Smo-108855	Selaginella moellendorffii	56.26	2.00e-164	571.00
IUUC-Sit-110329	Setaria italica	59.31	9.00e-172	596.00
IUUC-Sly-111830	Solanum lycopersicum	59.74	2.00e-173	602.00
IUUC-Stu-112603	Solanum tuberosum	59.74	2.00e-173	601.00
IUUC-Sar-113504	Sorex araneus	92.25	1.00e-74	273.00
IUUC-Sbi-114560	Sorghum bicolor	58.24	2.00e-168	585.00
IUUC-Sre-115133	Sporisorium reilianum	41.79	2.00e-123	436.00
IUUC-Tgu-116798	Taeniopygia guttata	84.99	0.00e+00	852.00
IUUC-Tru-118361	Takifugu rubripes	78.74	0.00e+00	803.00
IUUC-Tsy-118849	Tarsius syrichta	96.81	0.00e+00	937.00
IUUC-Tni-120094	Tetraodon nigroviridis	78.69	0.00e+00	798.00
IUUC-Tca-121634	Theobroma cacao	57.87	4.00e-167	580.00
IUUC-Tre-122051	Trichoderma reesei	46.25	2.00e-119	422.00
IUUC-Tvi-122322	Trichoderma virens	48.33	2.00e-124	439.00
IUUC-Tae-125822	Triticum aestivum	58.46	2.00e-169	588.00
IUUC-Tur-126766	Triticum urartu	52.19	7.00e-161	560.00
IUUC-Tme-127175	Tuber melanosporum	50.92	2.00e-132	465.00
IUUC-Tbe-127779	Tupaia belangeri	94.85	0.00e+00	826.00
IUUC-Ttr-128224	Tursiops truncatus	93.46	0.00e+00	818.00
IUUC-Uma-129537	Ustilago maydis	41.99	1.00e-124	439.00
IUUC-Vda-129927	Verticillium dahliae	45.61	1.00e-111	396.00
IUUC-Vpa-130658	Vicugna pacos	84.71	0.00e+00	796.00
IUUC-Vvi-131659	Vitis vinifera	58.00	1.00e-169	588.00
IUUC-Xtr-132918	Xenopus tropicalis	77.05	0.00e+00	783.00
IUUC-Xma-133700	Xiphophorus maculatus	79.79	0.00e+00	810.00
IUUC-Yli-134478	Yarrowia lipolytica	50.20	4.00e-140	491.00
IUUC-Zma-135835	Zea mays	55.78	2.00e-165	575.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence