iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ani-009173

Ensembl Protein ID

CADANIAP00006811

UniProt Accession

Q00664; C8V209; Q5AZT3; LIS1_EMENI

Genbank Protein ID

AAA91301.1; EAA57983.1; CBF69989.1

Protein Name

Nuclear distribution protein nudF; Lissencephaly-1 homolog; Nuclear migration protein nudF

Genbank Nucleotide ID

U22009; AACD01000105; BN001301

Gene Name

nudF; lis1; pac1; AN6197

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CADANIAG00006811	CADANIAT00006811	CADANIAP00006811

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.70e-52	172.1	199	238
UBD/Beta-Prp	2.20e-62	210.0	111	404

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf...sdtllvsGsdDgtikvWDlrtgvllk 37
           gH  sv++++f   +d++l+s+s+Dgt+++WD++tg ++k
   Q: 199  GHDHSVSSVRFltsNDNHLISASRDGTLRIWDVSTGFCVK 238
           8************666********************9986 PP

UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk..ilvtgseDrtikvwdls.tgkcvhtlkgheds 96
           ++h + +tcv+f+p  + la+gs+d tik+wd++ g   r+l+gh  +v+ +++  ++   +l+++s+D tik+wd+s ++  ++tl+gh++s
   Q: 111  TSHRDAVTCVAFHPVFTSLASGSEDCTIKIWDWELGEIERTLKGHIRGVSGLDYGGQKGntLLASCSSDLTIKLWDPSkDYANIRTLSGHDHS 203
           456678888*********************************************8887678**************9886899*********** PP
   S: 97   vlslsfsp.sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsf 188
           v s++f   ++++l+s+s+d t+r+wd++tg c++ ++s ++++++ v+ + dg+ lvsG+ D+++ +W +++++    l g h++ +++  f
   Q: 204  VSSVRFLTsNDNHLISASRDGTLRIWDVSTGFCVKVIKSATESWIRDVSPSFDGKWLVSGGRDQAITVWEVSSAEPKAALLG-HENFIECCVF 295
           ********666**********************************************************************9.*********8 PP
   S: 189  dsng.....................kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdl.rsgdllkt 259
            +                       +++++g++d+t+klw+  +g+ ++tl+gh+++v+ + f+p +++l s+s+D++ir+Wdl + g l+kt
   Q: 296  APPAsyehlatlaglkkpppatsscEFVATGARDKTIKLWEA-RGRLIKTLHGHDNWVRGLVFHPGGKYLFSVSDDKTIRCWDLsQEGRLVKT 387
           8877888899999999999999999****************9.7889***********************************9736799**** PP
   S: 260  lqlhnssvisvavlsfg 276
           +++ +++++s+  + ++
   Q: 388  ISGAHEHFVSCIRWAPS 404
           *****887777664444 PP

Organism

Aspergillus nidulans

Functional Description
(View)

Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.

Protein Sequence
(Fasta)

MSQILTAPQA EALHKAMLAY LSVINAPQTA ETLREELHFD ESYNEATCKK FEGVLEKKWT 60
GIARLQRRIN DLEAEVRSLQ AELEASPSAA RAKNQDPTNW LPKPSSTHTL TSHRDAVTCV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGCCAAA TATTGACAGC TCCGCAAGCG GAGGCACTGT AAGCATAGCA CTCGAAATTC 60
TGTTCCAGGG GTCTTACTGA CGATGCGCGT CTAGACACAA AGCCATGCTC GCTTACCTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005938--C:cell cortex
GO:0000776--C:kinetochore
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0000922--C:spindle pole
GO:0005816--C:spindle pole body
GO:0008017--F:microtubule binding
GO:0051301--P:cell division
GO:0048315--P:conidium formation
GO:0000132--P:establishment of mitotic spindle orientation
GO:0031023--P:microtubule organizing center organization
GO:0007067--P:mitotic nuclear division
GO:0007097--P:nuclear migration
GO:2000574--P:regulation of microtubule motor activity
GO:0043935--P:sexual sporulation resulting in formation of a cellular spore
GO:0047496--P:vesicle transport along microtubule

KEGG

ani:AN6197.2

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001589	Ailuropoda melanoleuca	42.86	5.00e-89	319.00
IUUC-Apl-004024	Anas platyrhynchos	42.54	7.00e-91	325.00
IUUC-Aca-004564	Anolis carolinensis	42.54	5.00e-89	319.00
IUUC-Ago-007862	Ashbya gossypii	27.85	4.00e-33	134.00
IUUC-Acl-008360	Aspergillus clavatus	59.10	1.00e-151	527.00
IUUC-Afl-008502	Aspergillus flavus	56.11	1.00e-143	501.00
IUUC-Afu-008848	Aspergillus fumigatus	59.10	1.00e-160	557.00
IUUC-Ang-009873	Aspergillus niger	72.42	0.00e+00	655.00
IUUC-Aor-009973	Aspergillus oryzae	53.83	1.00e-140	491.00
IUUC-Ate-010523	Aspergillus terreus	75.34	0.00e+00	698.00
IUUC-Ame-011154	Astyanax mexicanus	43.28	8.00e-92	328.00
IUUC-Bgr-011972	Blumeria graminis	60.09	3.00e-165	573.00
IUUC-Bta-013106	Bos taurus	42.54	4.00e-91	326.00
IUUC-Bci-013615	Botrytis cinerea	64.15	1.00e-176	610.00
IUUC-Cel-018459	Caenorhabditis elegans	41.96	1.00e-84	305.00
IUUC-Cja-018755	Callithrix jacchus	42.18	4.00e-89	320.00
IUUC-Cfa-020749	Canis familiaris	42.54	4.00e-91	326.00
IUUC-Cpo-022371	Cavia porcellus	42.54	4.00e-91	326.00
IUUC-Csa-023524	Chlorocebus sabaeus	44.61	6.00e-79	285.00
IUUC-Cho-024764	Choloepus hoffmanni	40.45	1.00e-75	274.00
IUUC-Cin-025753	Ciona intestinalis	39.90	1.00e-81	294.00
IUUC-Csv-025817	Ciona savignyi	39.65	7.00e-84	302.00
IUUC-Cgl-026529	Colletotrichum gloeosporioides	60.52	3.00e-158	549.00
IUUC-Cne-027087	Cryptococcus neoformans	48.99	6.00e-99	352.00
IUUC-Dre-028314	Danio rerio	43.28	3.00e-91	326.00
IUUC-Dno-029050	Dasypus novemcinctus	42.54	4.00e-91	326.00
IUUC-Dor-030222	Dipodomys ordii	39.39	6.00e-82	295.00
IUUC-Dse-031164	Dothistroma septosporum	56.83	9.00e-151	524.00
IUUC-Dme-031745	Drosophila melanogaster	42.64	1.00e-82	298.00
IUUC-Ete-032508	Echinops telfairi	45.49	4.00e-62	229.00
IUUC-Eca-034288	Equus caballus	43.11	7.00e-89	318.00
IUUC-Eeu-034984	Erinaceus europaeus	39.14	8.00e-81	292.00
IUUC-Fca-036498	Felis catus	42.54	4.00e-91	326.00
IUUC-Fal-036920	Ficedula albicollis	42.54	7.00e-91	325.00
IUUC-Fox-037996	Fusarium oxysporum	59.40	6.00e-161	558.00
IUUC-Fso-038160	Fusarium solani	57.05	3.00e-151	526.00
IUUC-Gmo-038983	Gadus morhua	43.18	3.00e-91	327.00
IUUC-Ggr-040051	Gaeumannomyces graminis	56.49	2.00e-151	527.00
IUUC-Gga-040623	Gallus gallus	42.54	7.00e-91	325.00
IUUC-Gac-041613	Gasterosteus aculeatus	43.07	2.00e-90	324.00
IUUC-Ggo-045410	Gorilla gorilla	42.24	4.00e-76	276.00
IUUC-Hsa-046358	Homo sapiens	42.54	5.00e-91	326.00
IUUC-Itr-047890	Ictidomys tridecemlineatus	42.54	4.00e-91	326.00
IUUC-Kpa-049351	Komagataella pastoris	27.45	4.00e-43	167.00
IUUC-Lch-049936	Latimeria chalumnae	42.79	3.00e-90	323.00
IUUC-Loc-052476	Lepisosteus oculatus	43.88	7.00e-90	322.00
IUUC-Lma-053170	Leptosphaeria maculans	62.17	7.00e-164	568.00
IUUC-Laf-053713	Loxodonta africana	43.04	2.00e-90	323.00
IUUC-Mcc-054628	Macaca mulatta	42.54	6.00e-91	325.00
IUUC-Meu-055927	Macropus eugenii	38.26	7.00e-44	168.00
IUUC-Mor-056962	Magnaporthe oryzae	57.70	2.00e-154	537.00
IUUC-Mpo-057583	Magnaporthe poae	57.79	2.00e-147	513.00
IUUC-Mla-058819	Melampsora laricipopulina	44.20	4.00e-102	363.00
IUUC-Mga-059945	Meleagris gallopavo	42.54	1.00e-90	325.00
IUUC-Mvi-060403	Microbotryum violaceum	47.59	2.00e-110	390.00
IUUC-Mmr-061289	Microcebus murinus	42.86	5.00e-89	319.00
IUUC-Mdo-061912	Monodelphis domestica	42.29	3.00e-90	323.00
IUUC-Mmu-063253	Mus musculus	42.54	4.00e-91	326.00
IUUC-Mpu-066638	Mustela putorius furo	42.54	4.00e-91	326.00
IUUC-Mlu-067267	Myotis lucifugus	42.86	6.00e-89	319.00
IUUC-Nfi-068571	Neosartorya fischeri	56.53	1.00e-149	520.00
IUUC-Ncr-068895	Neurospora crassa	61.32	3.00e-158	549.00
IUUC-Nle-069087	Nomascus leucogenys	40.52	4.00e-72	263.00
IUUC-Opr-070579	Ochotona princeps	42.54	4.00e-91	326.00
IUUC-Ont-072432	Oreochromis niloticus	42.93	7.00e-92	328.00
IUUC-Oan-073072	Ornithorhynchus anatinus	42.54	4.00e-91	326.00
IUUC-Ocu-074180	Oryctolagus cuniculus	42.54	4.00e-91	326.00
IUUC-Ola-086815	Oryzias latipes	43.00	4.00e-91	326.00
IUUC-Oga-088219	Otolemur garnettii	41.94	1.00e-89	321.00
IUUC-Oar-090394	Ovis aries	42.54	4.00e-91	326.00
IUUC-Ptr-091517	Pan troglodytes	42.54	4.00e-91	326.00
IUUC-Pan-092421	Papio anubis	42.54	6.00e-91	325.00
IUUC-Psi-093370	Pelodiscus sinensis	42.54	7.00e-91	325.00
IUUC-Pma-094319	Petromyzon marinus	42.34	9.00e-77	278.00
IUUC-Pno-094815	Phaeosphaeria nodorum	61.47	1.00e-169	587.00
IUUC-Pfo-097089	Poecilia formosa	42.93	2.00e-91	327.00
IUUC-Pab-098421	Pongo abelii	42.54	4.00e-91	326.00
IUUC-Pca-100120	Procavia capensis	33.82	2.00e-48	184.00
IUUC-Pva-102960	Pteropus vampyrus	42.29	1.00e-89	321.00
IUUC-Pgr-103538	Puccinia graminis	46.29	1.00e-107	381.00
IUUC-Ptt-103990	Puccinia triticina	42.91	6.00e-40	157.00
IUUC-Pte-104261	Pyrenophora teres	60.52	4.00e-169	585.00
IUUC-Pyt-104780	Pyrenophora triticirepentis	60.30	5.00e-169	585.00
IUUC-Rno-105123	Rattus norvegicus	42.54	4.00e-91	326.00
IUUC-Sce-106208	Saccharomyces cerevisiae	26.13	4.00e-33	134.00
IUUC-Sha-107010	Sarcophilus harrisii	42.29	2.00e-90	323.00
IUUC-Sja-107899	Schizosaccharomyces japonicus	35.23	7.00e-70	256.00
IUUC-Ssl-108571	Sclerotinia sclerotiorum	65.41	4.00e-169	585.00
IUUC-Sar-113309	Sorex araneus	42.60	5.00e-87	312.00
IUUC-Sre-115003	Sporisorium reilianum	46.88	1.00e-110	391.00
IUUC-Ssc-116148	Sus scrofa	42.54	4.00e-91	326.00
IUUC-Tgu-117299	Taeniopygia guttata	42.33	4.00e-90	323.00
IUUC-Tru-117721	Takifugu rubripes	42.43	1.00e-90	324.00
IUUC-Tsy-119493	Tarsius syrichta	42.79	3.00e-90	323.00
IUUC-Tni-120355	Tetraodon nigroviridis	42.46	1.00e-89	321.00
IUUC-Tre-121977	Trichoderma reesei	55.56	2.00e-141	493.00
IUUC-Tvi-122661	Trichoderma virens	57.39	1.00e-142	498.00
IUUC-Tme-127031	Tuber melanosporum	60.45	6.00e-156	541.00
IUUC-Tbe-127492	Tupaia belangeri	40.00	2.00e-41	161.00
IUUC-Ttr-128929	Tursiops truncatus	42.54	9.00e-91	325.00
IUUC-Uma-129347	Ustilago maydis	48.79	5.00e-115	405.00
IUUC-Vda-129837	Verticillium dahliae	57.33	3.00e-144	503.00
IUUC-Vpa-130532	Vicugna pacos	36.36	2.00e-70	257.00
IUUC-Xtr-131985	Xenopus tropicalis	42.79	4.00e-91	326.00
IUUC-Xma-133314	Xiphophorus maculatus	43.28	2.00e-91	327.00
IUUC-Yli-134403	Yarrowia lipolytica	38.97	3.00e-87	313.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence