iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Loc-051777

Ensembl Protein ID

ENSLOCP00000009968.1

UniProt Accession

W5MNK9; W5MNK9_LEPOC

Genbank Protein ID

ENSLOCP00000009968

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AHAT01015290

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000008188.1	ENSLOCT00000009980.1	ENSLOCP00000009968.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.40e-97	326.5	1682	2061

Active Site

Position(s)	Description	Evidence
2028	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 6    kkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.......................ehlk 69
           ++ le+++++E g++l G+t+ef+al+s+elq++dlgl++ +e   ++ + n++     +                       ++  
   Q: 1682 RAMLEIQYENEVGTGL-GPTLEFYALVSQELQRADLGLWRGEEVTLSNPKGNQEGT---KyifssrglfavpfgrttkpahiaKVKM 1764
           56899***********.**********************55555333333332221...12445567788889*********9999* PP
   S: 70   lFeflGrllgkalqdgrlldlplsksfyklllgk..klsledleevdpelykslkeikenaes........................ 130
            F+flG+l++ka++d rlldlpl  +fyk +l++  +++ +dl ++dp ++ks+  +++   +                        
   Q: 1765 KFRFLGKLMAKAIMDFRLLDLPLGLPFYKWMLRHesSITSHDLVNIDPGVAKSIHHLEDIIRQkkkleqdrshtretlqqalesltm 1851
           **********************************444666*************9999998833445555666667777555555555 PP
   S: 131  ...dieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeel 214
              ++e+lgld+t       l+   ++eLk gG++ipV++ N+eeY +lvv ++l+eg+ +q+e+freGf++v+pl++l++F +eel
   Q: 1852 ngcSVEDLGLDFT-------LPGFPNVELKKGGKDIPVNIHNLEEYLRLVVYWTLNEGVSRQFESFREGFESVFPLHHLQYFYPEEL 1931
           5445555444444.......78999999*********************************************************** PP
   S: 215  ellicGe..eeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk.....das 294
           ++l+cG+  e++dv++l + ++ ++gyt+ds+a+++++evl++f++e+++ fLqFvTgs+rlP+gGf++l+p l+++rk     ++ 
   Q: 1932 DQLLCGSksETWDVKTLMECCRPDHGYTHDSRAVKFLFEVLSSFDAEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKtfestENP 2018
           ******98889***********************************************************************98888 PP
   S: 295  ddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFels 336
           dd lPs++TC+nyLkLP+Yss ei++ekLl+A +e+ ++F+ls
   Q: 2019 DDFLPSVMTCVNYLKLPDYSSIEIMREKLLIAAREGqQSFHLS 2061
           8***************************************985 PP

Organism

Lepisosteus oculatus

Protein Sequence
(Fasta)

MSNRPNNNPG GSLRRSQRNT AAAQPQDEAV GGRLQSEQVN HKANTPPENR RPISKASKVQ 60
SNTVSGKSRG HSSRRSGISS SAPLVQQEDP DTASTSERDK TGQTSKRDGS RGFKRSSGPE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCAGATTAA AAGGAATAAT AGATCTGTTA TCTTTAATTA AAGAGGCCAA AGATGGACTC 60
TCATACTTAC ATTTTTAATG TTAAACGCCC TTAAACGTTG AATAAAAGTT GCCTTTCTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR000569--HECT_dom
IPR004170--WWE-dom
IPR018123--WWE-dom_subgr

PROSITE

PS50237--HECT
PS50918--WWE

Pfam

PF00632--HECT
PF02825--WWE

SMART

SM00119--HECTc
SM00678--WWE

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000750	Aegilops tauschii	38.81	6.00e-128	452.00
IUUC-Aml-001502	Ailuropoda melanoleuca	87.15	0.00e+00	3262.00
IUUC-Atr-002821	Amborella trichopoda	37.87	1.00e-120	428.00
IUUC-Apl-003531	Anas platyrhynchos	85.33	0.00e+00	3165.00
IUUC-Aly-005962	Arabidopsis lyrata	39.26	1.00e-118	422.00
IUUC-Ath-006636	Arabidopsis thaliana	38.97	2.00e-118	421.00
IUUC-Ago-007875	Ashbya gossypii	36.84	9.00e-83	302.00
IUUC-Acl-008242	Aspergillus clavatus	37.18	9.00e-120	425.00
IUUC-Afl-008736	Aspergillus flavus	40.80	9.00e-118	419.00
IUUC-Afu-008812	Aspergillus fumigatus	37.48	7.00e-122	432.00
IUUC-Ani-009407	Aspergillus nidulans	37.99	1.00e-115	411.00
IUUC-Ang-009763	Aspergillus niger	41.25	1.00e-111	399.00
IUUC-Aor-009941	Aspergillus oryzae	32.25	8.00e-123	435.00
IUUC-Ate-010459	Aspergillus terreus	38.92	1.00e-92	335.00
IUUC-Ame-011761	Astyanax mexicanus	93.52	0.00e+00	3157.00
IUUC-Bgr-012265	Blumeria graminis	35.41	5.00e-106	380.00
IUUC-Bta-013070	Bos taurus	84.15	0.00e+00	3179.00
IUUC-Bci-013890	Botrytis cinerea	40.08	9.00e-105	375.00
IUUC-Bdi-014046	Brachypodium distachyon	38.07	6.00e-124	439.00
IUUC-Bol-015942	Brassica oleracea	44.04	1.00e-116	415.00
IUUC-Bra-016849	Brassica rapa	44.04	2.00e-116	414.00
IUUC-Cja-019046	Callithrix jacchus	89.19	0.00e+00	3068.00
IUUC-Cfa-020521	Canis familiaris	85.46	0.00e+00	3149.00
IUUC-Cpo-021639	Cavia porcellus	83.41	0.00e+00	3153.00
IUUC-Cre-022767	Chlamydomonas reinhardtii	40.27	5.00e-93	334.00
IUUC-Csa-023231	Chlorocebus sabaeus	91.77	0.00e+00	3141.00
IUUC-Cho-024380	Choloepus hoffmanni	83.95	0.00e+00	1965.00
IUUC-Cin-025482	Ciona intestinalis	51.40	1.00e-162	566.00
IUUC-Csv-026121	Ciona savignyi	48.27	0.00e+00	1543.00
IUUC-Cgl-026716	Colletotrichum gloeosporioides	35.34	2.00e-112	401.00
IUUC-Cne-026857	Cryptococcus neoformans	40.19	3.00e-95	344.00
IUUC-Cme-027226	Cyanidioschyzon merolae	34.92	6.00e-75	276.00
IUUC-Dre-028174	Danio rerio	93.20	0.00e+00	3207.00
IUUC-Dor-030939	Dipodomys ordii	80.24	0.00e+00	1318.00
IUUC-Dse-031444	Dothistroma septosporum	39.92	1.00e-109	392.00
IUUC-Dme-032162	Drosophila melanogaster	59.34	0.00e+00	720.00
IUUC-Ete-032345	Echinops telfairi	82.59	0.00e+00	2108.00
IUUC-Eca-033229	Equus caballus	86.57	0.00e+00	3197.00
IUUC-Eeu-035205	Erinaceus europaeus	76.69	0.00e+00	2757.00
IUUC-Fca-036444	Felis catus	86.63	0.00e+00	3237.00
IUUC-Fal-037131	Ficedula albicollis	88.08	0.00e+00	3321.00
IUUC-Fox-038035	Fusarium oxysporum	36.32	5.00e-112	398.00
IUUC-Fso-038320	Fusarium solani	36.02	3.00e-111	397.00
IUUC-Gmo-039497	Gadus morhua	85.63	0.00e+00	3219.00
IUUC-Ggr-040057	Gaeumannomyces graminis	34.70	8.00e-108	385.00
IUUC-Gga-041021	Gallus gallus	88.52	0.00e+00	3327.00
IUUC-Gac-042474	Gasterosteus aculeatus	85.94	0.00e+00	3210.00
IUUC-Gma-043060	Glycine max	38.92	4.00e-123	436.00
IUUC-Ggo-044855	Gorilla gorilla	89.24	0.00e+00	3070.00
IUUC-Hsa-046147	Homo sapiens	89.84	0.00e+00	3072.00
IUUC-Hvu-047775	Hordeum vulgare	38.83	1.00e-125	444.00
IUUC-Itr-048131	Ictidomys tridecemlineatus	91.40	0.00e+00	3124.00
IUUC-Kpa-049098	Komagataella pastoris	37.30	2.00e-84	308.00
IUUC-Lch-049818	Latimeria chalumnae	85.81	0.00e+00	3124.00
IUUC-Lpe-051017	Leersia perrieri	38.32	2.00e-120	427.00
IUUC-Lma-052990	Leptosphaeria maculans	35.87	8.00e-116	412.00
IUUC-Laf-053727	Loxodonta africana	86.62	0.00e+00	3238.00
IUUC-Mcc-055799	Macaca mulatta	85.60	0.00e+00	3236.00
IUUC-Meu-056065	Macropus eugenii	85.93	0.00e+00	1949.00
IUUC-Mor-057054	Magnaporthe oryzae	38.82	3.00e-107	384.00
IUUC-Mpo-057417	Magnaporthe poae	39.13	2.00e-108	388.00
IUUC-Mtr-057849	Medicago truncatula	37.45	8.00e-116	412.00
IUUC-Mla-058870	Melampsora laricipopulina	42.25	1.00e-108	388.00
IUUC-Mga-059580	Meleagris gallopavo	87.02	0.00e+00	2821.00
IUUC-Mvi-060507	Microbotryum violaceum	40.18	1.00e-116	415.00
IUUC-Mmr-060816	Microcebus murinus	87.69	0.00e+00	3320.00
IUUC-Mdo-062866	Monodelphis domestica	85.59	0.00e+00	3141.00
IUUC-Mmu-063906	Mus musculus	86.33	0.00e+00	3264.00
IUUC-Mac-064675	Musa acuminata	38.97	8.00e-113	401.00
IUUC-Mpu-066199	Mustela putorius furo	86.47	0.00e+00	3211.00
IUUC-Mlu-067110	Myotis lucifugus	86.47	0.00e+00	3235.00
IUUC-Nfi-068482	Neosartorya fischeri	37.33	4.00e-121	430.00
IUUC-Ncr-068906	Neurospora crassa	38.48	3.00e-108	387.00
IUUC-Nle-069410	Nomascus leucogenys	90.12	0.00e+00	3063.00
IUUC-Opr-070401	Ochotona princeps	78.83	0.00e+00	1788.00
IUUC-Ont-072100	Oreochromis niloticus	88.57	0.00e+00	3363.00
IUUC-Oan-073121	Ornithorhynchus anatinus	87.89	0.00e+00	3373.00
IUUC-Ocu-074623	Oryctolagus cuniculus	87.05	0.00e+00	3254.00
IUUC-Oba-075380	Oryza barthii	36.81	8.00e-115	408.00
IUUC-Obr-076915	Oryza brachyantha	37.36	4.00e-120	427.00
IUUC-Ogl-077055	Oryza glaberrima	38.58	8.00e-120	425.00
IUUC-Ogu-078892	Oryza glumaepatula	36.51	1.00e-113	405.00
IUUC-Oin-079256	Oryza indica	38.40	9.00e-119	422.00
IUUC-Olo-080343	Oryza longistaminata	38.40	1.00e-118	421.00
IUUC-Ome-081422	Oryza meridionalis	38.40	1.00e-118	422.00
IUUC-Oni-083047	Oryza nivara	36.81	2.00e-115	410.00
IUUC-Opu-083641	Oryza punctata	36.36	7.00e-112	399.00
IUUC-Oru-084439	Oryza rufipogon	36.66	3.00e-114	406.00
IUUC-Osa-085972	Oryza sativa	38.58	3.00e-118	419.00
IUUC-Ola-087173	Oryzias latipes	86.18	0.00e+00	3257.00
IUUC-Olu-087871	Ostreococcus lucimarinus	37.48	2.00e-91	330.00
IUUC-Oga-087908	Otolemur garnettii	85.09	0.00e+00	3247.00
IUUC-Oar-090277	Ovis aries	85.22	0.00e+00	3246.00
IUUC-Ptr-091543	Pan troglodytes	89.90	0.00e+00	3076.00
IUUC-Pan-092243	Papio anubis	85.55	0.00e+00	3237.00
IUUC-Psi-093150	Pelodiscus sinensis	87.22	0.00e+00	3333.00
IUUC-Pno-094891	Phaeosphaeria nodorum	41.09	4.00e-116	413.00
IUUC-Ppa-095181	Physcomitrella patens	42.14	7.00e-108	384.00
IUUC-Pfo-096267	Poecilia formosa	88.14	0.00e+00	3279.00
IUUC-Pab-098072	Pongo abelii	90.45	0.00e+00	3071.00
IUUC-Pop-099190	Populus trichocarpa	37.00	2.00e-117	418.00
IUUC-Pca-100311	Procavia capensis	81.05	0.00e+00	2925.00
IUUC-Ppe-101284	Prunus persica	37.28	6.00e-118	419.00
IUUC-Pva-102215	Pteropus vampyrus	82.37	0.00e+00	1134.00
IUUC-Pgr-103694	Puccinia graminis	40.68	2.00e-107	384.00
IUUC-Ptt-103916	Puccinia triticina	39.88	3.00e-102	367.00
IUUC-Pte-104346	Pyrenophora teres	40.75	6.00e-116	412.00
IUUC-Pyt-104508	Pyrenophora triticirepentis	40.75	3.00e-115	410.00
IUUC-Rno-105315	Rattus norvegicus	89.78	0.00e+00	3028.00
IUUC-Sce-106273	Saccharomyces cerevisiae	34.44	3.00e-72	267.00
IUUC-Sha-106835	Sarcophilus harrisii	88.36	0.00e+00	3380.00
IUUC-Sja-107943	Schizosaccharomyces japonicus	38.66	4.00e-97	350.00
IUUC-Spo-108081	Schizosaccharomyces pombe	39.15	2.00e-97	351.00
IUUC-Ssl-108560	Sclerotinia sclerotiorum	40.12	8.00e-109	389.00
IUUC-Smo-109590	Selaginella moellendorffii	43.28	2.00e-113	404.00
IUUC-Sit-109757	Setaria italica	38.02	1.00e-122	435.00
IUUC-Sly-111469	Solanum lycopersicum	38.94	3.00e-122	434.00
IUUC-Stu-112896	Solanum tuberosum	37.57	3.00e-105	376.00
IUUC-Sar-113224	Sorex araneus	76.27	0.00e+00	1652.00
IUUC-Sbi-114313	Sorghum bicolor	38.71	1.00e-126	448.00
IUUC-Sre-114993	Sporisorium reilianum	33.95	7.00e-103	370.00
IUUC-Ssc-115535	Sus scrofa	82.76	0.00e+00	3121.00
IUUC-Tgu-117493	Taeniopygia guttata	86.74	0.00e+00	2571.00
IUUC-Tru-118669	Takifugu rubripes	86.03	0.00e+00	3212.00
IUUC-Tsy-119373	Tarsius syrichta	84.65	0.00e+00	1689.00
IUUC-Tni-120049	Tetraodon nigroviridis	82.20	0.00e+00	910.00
IUUC-Tca-121779	Theobroma cacao	37.96	4.00e-116	413.00
IUUC-Tre-122195	Trichoderma reesei	36.10	1.00e-107	385.00
IUUC-Tvi-122650	Trichoderma virens	35.63	4.00e-108	387.00
IUUC-Tae-123580	Triticum aestivum	38.87	4.00e-126	445.00
IUUC-Tur-126295	Triticum urartu	38.83	3.00e-127	450.00
IUUC-Tme-126964	Tuber melanosporum	40.87	3.00e-109	390.00
IUUC-Tbe-128149	Tupaia belangeri	77.13	0.00e+00	1162.00
IUUC-Ttr-128165	Tursiops truncatus	87.43	0.00e+00	2832.00
IUUC-Uma-129365	Ustilago maydis	35.77	4.00e-89	324.00
IUUC-Vda-129725	Verticillium dahliae	40.52	4.00e-109	390.00
IUUC-Vpa-130678	Vicugna pacos	88.55	0.00e+00	2477.00
IUUC-Vvi-131147	Vitis vinifera	39.26	4.00e-124	440.00
IUUC-Xtr-132636	Xenopus tropicalis	82.86	0.00e+00	3082.00
IUUC-Xma-133458	Xiphophorus maculatus	88.04	0.00e+00	3325.00
IUUC-Yli-134481	Yarrowia lipolytica	38.91	3.00e-101	363.00
IUUC-Zma-135782	Zea mays	37.55	7.00e-120	426.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence