iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046161

UUCD1 version

UUC-HoS-00009

Ensembl Protein ID

ENSP00000349596.2

UniProt Accession

O00635; B2R862; TRI38_HUMAN

Genbank Protein ID

AAB82084.1; AAB53425.1; BAG36059.1; AAH26930.1

Protein Name

E3 ubiquitin-protein ligase TRIM38; RING finger protein 15; RING-type E3 ubiquitin transferase TRIM38; Tripartite motif-containing protein 38; Zinc finger protein RoRet

Genbank Nucleotide ID

U91328; U90547; AK313248; BC026930

Gene Name

TRIM38; RNF15; RORET

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000112343.10	ENST00000357085.4	ENSP00000349596.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18248090

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	3.30e-08	35.1	11	87
E3 activity/RING/RING	0.0001	24.4	16	63

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 3    peeflCpIslelMrdPvvlpsGitydrssIekwlasggk........tcPvtrqplteedlvPnltlrrliqawcee 71
            ee  C+I l lM++Pv + +G++y   +I  ++++  +         cP +r+p++ ++l Pn+ l +li+a  e+
   Q: 11   MEEATCSICLSLMTNPVSINCGHSYCHLCITDFFKNPSQkqlrqetfCCPQCRAPFHMDSLRPNKQLGSLIEALKET 87
           68899*****************************55555578899999***********************987665 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkw...pglknssskefrCPlCr 46
           C+iCl+ + + p++ +CgH +++ C+  +   p +k++ + +f CP Cr
   Q: 16   CSICLSLMTN-PVSINCGHSYCHLCITDFfknPSQKQLRQETFCCPQCR 63
           ********99.9**************888899999*************8 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase. Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling.

Protein Sequence
(Fasta)

MASTTSTKKM MEEATCSICL SLMTNPVSIN CGHSYCHLCI TDFFKNPSQK QLRQETFCCP 60
QCRAPFHMDS LRPNKQLGSL IEALKETDQE MSCEEHGEQF HLFCEDEGQL ICWRCERAPQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTAACTTCC TGACCCAGGA AGTGGCAGCA ACAGAGGGGA CTAGCAGCGA ATATGTAAGT 60
GTCTGAGCAG TGAAGGTTAC GGAAAAGGTC CAGGCTAAGG TTTTCTCAGT GGATATGTGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0391--Immunity
KW-0399--Innate immunity
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005829--C:cytosol
GO:0004871--F:signal transducer activity
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0060333--P:interferon-gamma-mediated signaling pathway
GO:0050687--P:negative regulation of defense response to virus
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0046598--P:positive regulation of viral entry into host cell
GO:0045070--P:positive regulation of viral genome replication
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0032648--P:regulation of interferon-beta production

KEGG

hsa:10475

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001649	Ailuropoda melanoleuca	72.84	0.00e+00	715.00
IUUC-Ago-007781	Ashbya gossypii	37.93	9.00e-11	61.20
IUUC-Bta-012574	Bos taurus	76.30	0.00e+00	733.00
IUUC-Cja-019759	Callithrix jacchus	88.82	0.00e+00	808.00
IUUC-Cfa-020431	Canis familiaris	71.18	0.00e+00	677.00
IUUC-Cpo-022541	Cavia porcellus	66.67	0.00e+00	649.00
IUUC-Csa-023320	Chlorocebus sabaeus	94.84	0.00e+00	924.00
IUUC-Cho-024964	Choloepus hoffmanni	70.43	4.00e-130	457.00
IUUC-Dno-029741	Dasypus novemcinctus	66.67	5.00e-179	620.00
IUUC-Dor-030298	Dipodomys ordii	60.00	6.00e-101	360.00
IUUC-Ete-032493	Echinops telfairi	65.94	2.00e-179	622.00
IUUC-Eca-033962	Equus caballus	77.20	0.00e+00	725.00
IUUC-Eeu-035228	Erinaceus europaeus	67.48	3.00e-128	452.00
IUUC-Fca-036349	Felis catus	73.43	0.00e+00	709.00
IUUC-Ggo-044493	Gorilla gorilla	98.92	0.00e+00	959.00
IUUC-Itr-048162	Ictidomys tridecemlineatus	60.82	4.00e-149	521.00
IUUC-Laf-054150	Loxodonta africana	74.19	0.00e+00	705.00
IUUC-Mcc-055076	Macaca mulatta	94.84	0.00e+00	925.00
IUUC-Mmu-063517	Mus musculus	56.32	2.00e-147	515.00
IUUC-Mpu-065752	Mustela putorius furo	71.98	0.00e+00	703.00
IUUC-Mlu-067758	Myotis lucifugus	59.71	2.00e-151	530.00
IUUC-Nle-069117	Nomascus leucogenys	96.34	0.00e+00	934.00
IUUC-Opr-071144	Ochotona princeps	68.17	0.00e+00	638.00
IUUC-Ocu-074825	Oryctolagus cuniculus	70.32	0.00e+00	688.00
IUUC-Oga-088744	Otolemur garnettii	74.58	2.00e-128	451.00
IUUC-Oar-089951	Ovis aries	75.65	0.00e+00	728.00
IUUC-Ptr-090519	Pan troglodytes	98.92	0.00e+00	960.00
IUUC-Pan-092059	Papio anubis	94.84	0.00e+00	927.00
IUUC-Pab-098747	Pongo abelii	97.63	0.00e+00	951.00
IUUC-Pca-100294	Procavia capensis	67.96	0.00e+00	661.00
IUUC-Pva-102129	Pteropus vampyrus	66.59	0.00e+00	645.00
IUUC-Sar-113760	Sorex araneus	63.64	3.00e-156	545.00
IUUC-Tsy-119422	Tarsius syrichta	77.20	0.00e+00	722.00
IUUC-Tbe-127628	Tupaia belangeri	63.54	2.00e-101	361.00
IUUC-Ttr-129039	Tursiops truncatus	77.42	0.00e+00	747.00
IUUC-Vpa-130188	Vicugna pacos	79.18	2.00e-137	481.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence