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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Sce-106418
UUCD1 version UUC-SaC-00084
Ensembl Protein ID YPR178W
UniProt Accession P20053; D6W4H8; PRP4_YEAST
Genbank Protein ID AAA79332.1; AAA79011.1; AAB68111.1; DAA11594.1
Protein Name U4/U6 small nuclear ribonucleoprotein PRP4; Pre-mRNA-processing protein 4
Genbank Nucleotide ID M26597; M28518; U25842; BK006949
Gene Name PRP4; RNA4; YPR178W; P9705.6
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YPR178W YPR178W YPR178W
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFdbPTMBioGRID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.00e-29 98.3 347 379
UBD/Beta-Prp 2.50e-54 182.9 174 425
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlr 31
           gH+ +++ +a+ ++   +++G++Dg i vWD+r
   Q: 347  GHSKPIYTVAWsPNgYQVATGGGDGIINVWDIR 379
           8***********77688**************87 PP
   

   UBD/Beta-Prp
   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvtt.gkllrslsgheaevtavkfspdgk.ilvtgseDrtikvwdlstgkcvhtlk....ghedsvlslsfs 103
            +++i++v  s d+ ++atgs+ g ++v + +t + l ++l +h +++ a++++pd++  +++++eD++ik + +s+ +    l     ghe+++ +++++
   Q: 174  STKPISAVSLSTDDMVVATGSWAGDLQVLNSQTlQPLTQKLDSHVGKIGAIDWHPDSNnQMISCAEDGLIKNFQYSNEEGGLRLLgdlvGHERRISDVKYH 274
           57899*************************9883456999****************9999***************96654444443444************ PP
   S: 104  psgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtv 204
           psg+++ s+shd t r+wd +t q+l  +++ghd+ v ++++++dg+l+ sG+ D+  +lWd+++g+ + tl g h +++y +++++ng ++++g+ dg +
   Q: 275  PSGKFIGSASHDMTWRLWDASTHQELL-LQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDIRSGSKVMTLAG-HSKPIYTVAWSPNGYQVATGGGDGII 373
           ***************************.********************************************99.************************** PP
   S: 205  klwdlq...tgecvrtlnghtdnvksvrfs..pnderlvsgssDgsiriWdlr 252
           ++wd++   +g  +++  +h++ v++vrfs  + ++ lvs++ D+ i+++ ++
   Q: 374  NVWDIRkrdEG-QLNQILAHRNIVTQVRFSkeDGGKKLVSCGYDNLINVYSSD 425
           ******77444.499999************98999**************9655 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRP3, PRP4, PRP6, PRP8, PRP18, PRP31, PRP38, SNU13, SNU23, SNU66, SNU114, SPP381, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, LSM2, LSM3, LSM4, LSM5, LSM6, LSM7, LSM8, BRR2 and DIB1.
 Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRP3, PRP4, PRP6, PRP8, PRP18, PRP31, PRP38, SNU13, SNU23, SNU66, SNU114, SPP381, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, LSM2, LSM3, LSM4, LSM5, LSM6, LSM7, LSM8, BRR2 and DIB1.
Protein Sequence
(Fasta)
MSKYIALENL PVDLQHKGAT QNESTADILK QLPHERLQAV LEKIPEEDLE VRRLLSILKK 60
PEVVENEDVQ QRRIRLAEIL MVDEIDLENI NNMENINGEE VDEEDDEDFF TPATSELIFA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106418|E3,WD_repeat;UBD,Beta-Prp|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGAGTAAAT ATATTGCACT TGAAAATCTT CCGGTAGATT TGCAACATAA AGGAGCTACA 60
CAAAATGAAA GCACCGCTGA TATACTGAAA CAGTTGCCAC ATGAACGATT ACAAGCTGTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106418|E3,WD_repeat;UBD,Beta-Prp|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0747--Spliceosome
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR014906--PRP4-like
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00500--SFM
SM00320--WD40
Gene Ontology

GO:0005681--C:spliceosomal complex
GO:0046540--C:U4/U6 x U5 tri-snRNP complex
GO:0030621--F:U4 snRNA binding
GO:0017070--F:U6 snRNA binding
GO:0000398--P:mRNA splicing, via spliceosome
GO:0034247--P:snoRNA splicing
KEGG sce:YPR178W
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000771 Aegilops tauschii 33.33 4.00e-57 213.00
IUUC-Aml-001737 Ailuropoda melanoleuca 33.63 1.00e-68 251.00
IUUC-Atr-002828 Amborella trichopoda 35.83 3.00e-59 220.00
IUUC-Apl-003723 Anas platyrhynchos 33.99 1.00e-70 258.00
IUUC-Aca-004972 Anolis carolinensis 34.15 2.00e-69 254.00
IUUC-Aly-006531 Arabidopsis lyrata 34.08 2.00e-50 191.00
IUUC-Ath-007367 Arabidopsis thaliana 32.03 1.00e-60 225.00
IUUC-Ago-007893 Ashbya gossypii 40.04 6.00e-86 308.00
IUUC-Acl-008236 Aspergillus clavatus 29.31 2.00e-61 227.00
IUUC-Afl-008522 Aspergillus flavus 29.42 2.00e-67 247.00
IUUC-Afu-008904 Aspergillus fumigatus 30.00 9.00e-65 239.00
IUUC-Ani-009198 Aspergillus nidulans 32.16 7.00e-69 252.00
IUUC-Ang-009662 Aspergillus niger 35.07 6.00e-69 252.00
IUUC-Aor-009881 Aspergillus oryzae 32.25 2.00e-66 244.00
IUUC-Ate-010333 Aspergillus terreus 30.95 2.00e-61 227.00
IUUC-Ame-011697 Astyanax mexicanus 35.03 5.00e-71 259.00
IUUC-Bgr-012254 Blumeria graminis 33.68 6.00e-76 276.00
IUUC-Bta-012615 Bos taurus 33.63 9.00e-69 252.00
IUUC-Bci-013720 Botrytis cinerea 33.73 1.00e-76 278.00
IUUC-Bdi-014302 Brachypodium distachyon 33.03 2.00e-61 228.00
IUUC-Bol-015594 Brassica oleracea 34.45 1.00e-51 195.00
IUUC-Bra-017465 Brassica rapa 34.17 1.00e-51 195.00
IUUC-Cel-018632 Caenorhabditis elegans 33.33 2.00e-59 221.00
IUUC-Cja-019747 Callithrix jacchus 33.63 9.00e-69 252.00
IUUC-Cfa-020288 Canis familiaris 33.63 8.00e-69 252.00
IUUC-Cpo-021440 Cavia porcellus 33.19 3.00e-67 247.00
IUUC-Cre-022716 Chlamydomonas reinhardtii 33.24 3.00e-51 193.00
IUUC-Csa-023139 Chlorocebus sabaeus 36.20 8.00e-61 224.00
IUUC-Cho-024481 Choloepus hoffmanni 34.29 2.00e-69 254.00
IUUC-Cin-025106 Ciona intestinalis 31.87 1.00e-65 242.00
IUUC-Csv-026087 Ciona savignyi 32.09 2.00e-63 234.00
IUUC-Cgl-026538 Colletotrichum gloeosporioides 32.73 7.00e-73 266.00
IUUC-Cne-026793 Cryptococcus neoformans 30.04 8.00e-61 225.00
IUUC-Dre-028723 Danio rerio 34.37 6.00e-70 256.00
IUUC-Dno-029299 Dasypus novemcinctus 33.85 2.00e-69 254.00
IUUC-Dse-031562 Dothistroma septosporum 29.78 1.00e-64 238.00
IUUC-Dme-031783 Drosophila melanogaster 35.57 9.00e-60 222.00
IUUC-Ete-032669 Echinops telfairi 33.77 5.00e-70 256.00
IUUC-Eca-033566 Equus caballus 33.63 1.00e-68 251.00
IUUC-Eeu-034524 Erinaceus europaeus 39.33 9.00e-49 185.00
IUUC-Fca-036215 Felis catus 33.63 9.00e-69 252.00
IUUC-Fal-037018 Ficedula albicollis 34.94 9.00e-61 225.00
IUUC-Fox-037936 Fusarium oxysporum 33.40 7.00e-67 246.00
IUUC-Fso-038366 Fusarium solani 34.33 7.00e-71 259.00
IUUC-Gmo-038966 Gadus morhua 39.53 2.00e-57 214.00
IUUC-Ggr-039942 Gaeumannomyces graminis 34.87 6.00e-66 243.00
IUUC-Gga-040797 Gallus gallus 33.99 1.00e-70 258.00
IUUC-Gac-042598 Gasterosteus aculeatus 37.12 2.00e-59 221.00
IUUC-Gma-044220 Glycine max 34.17 2.00e-56 211.00
IUUC-Ggo-044682 Gorilla gorilla 33.63 1.00e-68 251.00
IUUC-Hsa-045804 Homo sapiens 33.63 9.00e-69 252.00
IUUC-Hvu-047567 Hordeum vulgare 34.73 3.00e-55 207.00
IUUC-Itr-047882 Ictidomys tridecemlineatus 33.85 2.00e-69 254.00
IUUC-Kpa-049369 Komagataella pastoris 38.19 2.00e-68 251.00
IUUC-Lch-050074 Latimeria chalumnae 31.78 5.00e-61 226.00
IUUC-Lpe-051333 Leersia perrieri 32.94 5.00e-57 213.00
IUUC-Loc-052164 Lepisosteus oculatus 35.70 2.00e-71 261.00
IUUC-Lma-053088 Leptosphaeria maculans 31.24 5.00e-63 233.00
IUUC-Laf-053460 Loxodonta africana 33.63 7.00e-69 252.00
IUUC-Mcc-055859 Macaca mulatta 33.63 9.00e-69 252.00
IUUC-Meu-056134 Macropus eugenii 34.29 2.00e-69 254.00
IUUC-Mor-057251 Magnaporthe oryzae 33.48 7.00e-69 252.00
IUUC-Mpo-057375 Magnaporthe poae 42.06 3.00e-50 189.00
IUUC-Mtr-057656 Medicago truncatula 36.19 2.00e-53 201.00
IUUC-Mla-059145 Melampsora laricipopulina 39.14 2.00e-71 260.00
IUUC-Mga-059855 Meleagris gallopavo 33.99 8.00e-71 259.00
IUUC-Mvi-060372 Microbotryum violaceum 31.74 1.00e-57 215.00
IUUC-Mmr-060826 Microcebus murinus 33.85 7.00e-69 252.00
IUUC-Mdo-062748 Monodelphis domestica 34.07 3.00e-70 257.00
IUUC-Mmu-063351 Mus musculus 34.29 9.00e-69 252.00
IUUC-Mac-064846 Musa acuminata 35.18 5.00e-48 183.00
IUUC-Mpu-066006 Mustela putorius furo 33.63 9.00e-69 252.00
IUUC-Mlu-067722 Myotis lucifugus 33.63 9.00e-69 252.00
IUUC-Nfi-068399 Neosartorya fischeri 30.02 6.00e-67 246.00
IUUC-Ncr-068711 Neurospora crassa 33.27 1.00e-71 261.00
IUUC-Nle-069982 Nomascus leucogenys 33.63 9.00e-69 252.00
IUUC-Opr-070596 Ochotona princeps 33.63 1.00e-68 251.00
IUUC-Ont-072374 Oreochromis niloticus 37.09 5.00e-67 246.00
IUUC-Oan-073166 Ornithorhynchus anatinus 34.78 5.00e-63 232.00
IUUC-Ocu-074371 Oryctolagus cuniculus 33.63 8.00e-69 252.00
IUUC-Oba-075083 Oryza barthii 31.96 1.00e-56 211.00
IUUC-Obr-076405 Oryza brachyantha 32.95 3.00e-56 210.00
IUUC-Ogl-077683 Oryza glaberrima 31.96 2.00e-56 211.00
IUUC-Ogu-078486 Oryza glumaepatula 32.42 1.00e-56 212.00
IUUC-Oin-079679 Oryza indica 32.19 3.00e-59 221.00
IUUC-Olo-080243 Oryza longistaminata 34.73 6.00e-55 206.00
IUUC-Ome-081230 Oryza meridionalis 32.19 2.00e-59 221.00
IUUC-Oni-082961 Oryza nivara 32.19 2.00e-59 221.00
IUUC-Opu-083189 Oryza punctata 32.42 3.00e-57 213.00
IUUC-Oru-084353 Oryza rufipogon 32.40 1.00e-58 218.00
IUUC-Osa-085458 Oryza sativa 32.19 2.00e-59 221.00
IUUC-Ola-086940 Oryzias latipes 37.91 6.00e-66 243.00
IUUC-Olu-087580 Ostreococcus lucimarinus 29.54 1.00e-39 155.00
IUUC-Oga-088703 Otolemur garnettii 32.31 1.00e-61 228.00
IUUC-Oar-089829 Ovis aries 33.63 2.00e-69 254.00
IUUC-Ptr-090838 Pan troglodytes 33.63 9.00e-69 252.00
IUUC-Pan-092261 Papio anubis 33.55 2.00e-67 248.00
IUUC-Psi-093020 Pelodiscus sinensis 33.85 4.00e-71 260.00
IUUC-Pno-094858 Phaeosphaeria nodorum 34.72 5.00e-63 233.00
IUUC-Ppa-095531 Physcomitrella patens 31.99 1.00e-61 228.00
IUUC-Pfo-096812 Poecilia formosa 33.15 3.00e-49 187.00
IUUC-Pab-097805 Pongo abelii 35.60 9.00e-59 219.00
IUUC-Pop-100051 Populus trichocarpa 34.17 1.00e-55 208.00
IUUC-Pca-100152 Procavia capensis 33.63 7.00e-69 252.00
IUUC-Ppe-101244 Prunus persica 33.05 1.00e-57 215.00
IUUC-Pva-102529 Pteropus vampyrus 32.09 6.00e-62 229.00
IUUC-Pgr-103550 Puccinia graminis 32.86 4.00e-64 236.00
IUUC-Ptt-103951 Puccinia triticina 33.91 1.00e-53 202.00
IUUC-Pte-104151 Pyrenophora teres 33.93 7.00e-63 232.00
IUUC-Pyt-104571 Pyrenophora triticirepentis 34.45 2.00e-65 241.00
IUUC-Rno-105747 Rattus norvegicus 34.29 4.00e-69 253.00
IUUC-Sha-107334 Sarcophilus harrisii 34.29 2.00e-69 254.00
IUUC-Sja-107794 Schizosaccharomyces japonicus 32.15 7.00e-60 222.00
IUUC-Spo-108189 Schizosaccharomyces pombe 34.89 7.00e-64 236.00
IUUC-Ssl-108550 Sclerotinia sclerotiorum 34.74 3.00e-78 283.00
IUUC-Smo-109578 Selaginella moellendorffii 30.90 2.00e-64 238.00
IUUC-Sit-110102 Setaria italica 33.41 6.00e-60 223.00
IUUC-Sly-111668 Solanum lycopersicum 35.85 1.00e-62 231.00
IUUC-Stu-111928 Solanum tuberosum 35.85 1.00e-62 231.00
IUUC-Sar-113266 Sorex araneus 37.75 1.00e-59 221.00
IUUC-Sbi-114134 Sorghum bicolor 33.18 4.00e-59 220.00
IUUC-Sre-115114 Sporisorium reilianum 33.70 1.00e-60 224.00
IUUC-Ssc-115443 Sus scrofa 33.63 7.00e-69 252.00
IUUC-Tgu-117157 Taeniopygia guttata 34.21 1.00e-71 261.00
IUUC-Tru-118587 Takifugu rubripes 36.11 7.00e-69 252.00
IUUC-Tsy-119157 Tarsius syrichta 35.60 4.00e-64 236.00
IUUC-Tni-120427 Tetraodon nigroviridis 35.66 4.00e-70 256.00
IUUC-Tca-121368 Theobroma cacao 34.73 2.00e-59 221.00
IUUC-Tre-122074 Trichoderma reesei 33.40 3.00e-69 254.00
IUUC-Tvi-122349 Trichoderma virens 32.68 8.00e-69 252.00
IUUC-Tae-125651 Triticum aestivum 33.11 9.00e-58 215.00
IUUC-Tur-125983 Triticum urartu 35.83 4.00e-53 199.00
IUUC-Tme-126951 Tuber melanosporum 31.71 8.00e-73 265.00
IUUC-Tbe-128136 Tupaia belangeri 30.89 6.00e-60 223.00
IUUC-Ttr-129169 Tursiops truncatus 30.23 9.00e-30 122.00
IUUC-Uma-129399 Ustilago maydis 34.20 8.00e-64 235.00
IUUC-Vda-129842 Verticillium dahliae 33.07 1.00e-71 261.00
IUUC-Vpa-130440 Vicugna pacos 33.63 6.00e-69 253.00
IUUC-Vvi-131075 Vitis vinifera 34.73 2.00e-60 225.00
IUUC-Xma-133002 Xiphophorus maculatus 38.36 4.00e-61 226.00
IUUC-Yli-134569 Yarrowia lipolytica 34.90 3.00e-70 256.00
IUUC-Zma-135799 Zea mays 32.39 1.00e-55 209.00
Created Date 25-Jun-2017

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