iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-045583

UUCD1 version

UUC-GoG-00393

Ensembl Protein ID

ENSGGOP00000025803.1

UniProt Accession

G3SCH5; G3SCH5_GORGO

Protein Name

Uncharacterized protein

Gene Name

UBR2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000004079.2	ENSGGOT00000024429.1	ENSGGOP00000025803.1
ENSGGOG00000004079.2	ENSGGOT00000004114.2	ENSGGOP00000004017.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/N-recognin/N-domain	1.60e-39	134.3	227	302
E3 activity/RING/RING	4.70e-09	37.1	1114	1222
E3 activity/N-recognin/UBR-box	1.10e-31	109.5	97	167

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/N-recognin/N-domain

   S: 1    YylvLfNDEkHsyeqviyslqkAleleqkeakkfatiidkeGRravkaGdyavceeakkeilknseklaqipLkVev 77
           Yy++LfNDE+H+yeqviy+lqkA++++qkea++fat++d++GRr+v++Gd+++ce+ak++i++n++++++ pLkV+v
   Q: 227  YYCMLFNDEVHTYEQVIYTLQKAVNCTQKEAIGFATTVDRDGRRSVRYGDFQYCEQAKSVIVRNTSRQTK-PLKVQV 302
           9*********************************************************************.****98 PP

E3 activity/RING/RING

   S: 1    CaiCledf...............................................kdgplvlpCgHvfhadClqkw........... 29
           C++C+e+                                                ++g+++ +CgH++ha+C+q++           
   Q: 1114 CILCQEEQevkvesramvlaafvqrstvlsknrskfiqdpelpslykplfmhpdlSCGTHTSSCGHIMHAHCWQRYfdsvqakeqrr 1200
           7778554433333333333333322222222222222222222222223333333558999************************** PP
   S: 30   ......pglknssskefrCPlC 45
                 + +++++++ef+CPlC
   Q: 1201 qqrlrlHTSYDVENGEFLCPLC 1222
           ********************** PP

E3 activity/N-recognin/UBR-box

   S: 1    slCgrvfkvgetiyeCrtCsvdetlvlCteCfakvvHkdHeyklkksggggfCdCGdteAwedgskCkkll 71
           +lCgrvfkvge +y+Cr+C+vd+t+vlC+eCf  ++H+dH+y++++sggggfCdCGdteAw++g++C+k++
   Q: 97   HLCGRVFKVGEPTYSCRDCAVDPTCVLCMECFLGSIHRDHRYRMTTSGGGGFCDCGDTEAWKEGPYCQKHE 167
           68******************************************************************996 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

MASELEPEVQ AIDRSLLECS AEEIAGKWLQ ATDLTREVYQ HLAHYVPKIY CRGPNPFPQK 60
EDMLAQHVLL GPMEWYLCGE DPAFGFPKLE QANKPSHLCG RVFKVGEPTY SCRDCAVDPT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGTCGG AGCTAGAGCC AGAGGTGCAG GCCATCGACC GGAGTTTGCT GGAATGTTCG 60
GCCGAGGAGA TTGCGGGGGT GAGTGCCGGG ACCCGGGCGG GTGCGTCTGC CCCTCGCAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003769--ClpS_core
IPR014719--Ribosomal_L7/12_C/ClpS-like
IPR011991--WHTH_DNA-bd_dom
IPR013083--Znf_RING/FYVE/PHD
IPR003126--Znf_UBR

PROSITE

PS51157--ZF_UBR

Pfam

PF02617--ClpS
PF02207--zf-UBR

SMART

SM00396--ZnF_UBR1

Gene Ontology

GO:0000785--C:chromatin
GO:0000151--C:ubiquitin ligase complex
GO:0070728--F:leucine binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0071233--P:cellular response to leucine
GO:0006342--P:chromatin silencing
GO:0033522--P:histone H2A ubiquitination
GO:0007141--P:male meiosis I
GO:0032007--P:negative regulation of TOR signaling
GO:0007283--P:spermatogenesis
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000949	Aegilops tauschii	27.45	5.00e-22	100.00
IUUC-Aml-001876	Ailuropoda melanoleuca	82.85	0.00e+00	2690.00
IUUC-Atr-002501	Amborella trichopoda	29.33	1.00e-30	129.00
IUUC-Apl-003828	Anas platyrhynchos	85.37	0.00e+00	3017.00
IUUC-Aca-005189	Anolis carolinensis	84.14	0.00e+00	2986.00
IUUC-Aly-005901	Arabidopsis lyrata	32.39	5.00e-26	114.00
IUUC-Ath-007148	Arabidopsis thaliana	30.99	9.00e-25	110.00
IUUC-Ago-007946	Ashbya gossypii	23.10	9.00e-21	97.10
IUUC-Afl-008479	Aspergillus flavus	22.86	5.00e-47	184.00
IUUC-Afu-008929	Aspergillus fumigatus	23.95	1.00e-54	209.00
IUUC-Ang-009550	Aspergillus niger	23.36	1.00e-46	182.00
IUUC-Aor-010124	Aspergillus oryzae	23.10	2.00e-47	186.00
IUUC-Ate-010550	Aspergillus terreus	22.85	1.00e-47	186.00
IUUC-Ame-011917	Astyanax mexicanus	72.15	0.00e+00	2459.00
IUUC-Bgr-011999	Blumeria graminis	21.72	2.00e-43	172.00
IUUC-Bta-012768	Bos taurus	90.83	0.00e+00	3211.00
IUUC-Bci-013834	Botrytis cinerea	23.39	7.00e-32	134.00
IUUC-Bdi-014635	Brachypodium distachyon	25.61	1.00e-31	132.00
IUUC-Bol-015669	Brassica oleracea	30.39	2.00e-29	125.00
IUUC-Bra-017776	Brassica rapa	30.39	5.00e-30	127.00
IUUC-Cel-018476	Caenorhabditis elegans	31.85	2.00e-84	308.00
IUUC-Cja-019797	Callithrix jacchus	95.88	0.00e+00	2650.00
IUUC-Cfa-020950	Canis familiaris	94.33	0.00e+00	3316.00
IUUC-Cpo-022385	Cavia porcellus	91.16	0.00e+00	3243.00
IUUC-Csa-024082	Chlorocebus sabaeus	97.39	0.00e+00	3410.00
IUUC-Cho-025029	Choloepus hoffmanni	84.79	0.00e+00	2156.00
IUUC-Cin-025148	Ciona intestinalis	35.13	2.00e-135	476.00
IUUC-Csv-026296	Ciona savignyi	31.48	2.00e-21	96.70
IUUC-Cgl-026605	Colletotrichum gloeosporioides	23.79	1.00e-46	182.00
IUUC-Cne-026823	Cryptococcus neoformans	22.01	1.00e-37	153.00
IUUC-Dre-028343	Danio rerio	71.04	0.00e+00	2456.00
IUUC-Dno-030002	Dasypus novemcinctus	92.15	0.00e+00	1956.00
IUUC-Dor-030207	Dipodomys ordii	77.46	0.00e+00	1568.00
IUUC-Dse-031531	Dothistroma septosporum	23.74	2.00e-53	205.00
IUUC-Dme-031910	Drosophila melanogaster	34.44	0.00e+00	676.00
IUUC-Ete-033162	Echinops telfairi	81.78	0.00e+00	1358.00
IUUC-Eca-033454	Equus caballus	92.75	0.00e+00	3252.00
IUUC-Eeu-034783	Erinaceus europaeus	79.46	0.00e+00	1460.00
IUUC-Fca-036588	Felis catus	94.33	0.00e+00	3305.00
IUUC-Fal-036919	Ficedula albicollis	85.49	0.00e+00	2958.00
IUUC-Fox-037984	Fusarium oxysporum	26.15	1.00e-38	156.00
IUUC-Fso-038463	Fusarium solani	24.52	4.00e-44	174.00
IUUC-Gmo-039698	Gadus morhua	68.68	0.00e+00	1592.00
IUUC-Ggr-040070	Gaeumannomyces graminis	22.82	6.00e-43	171.00
IUUC-Gga-041123	Gallus gallus	86.86	0.00e+00	3078.00
IUUC-Gac-042622	Gasterosteus aculeatus	64.94	0.00e+00	2157.00
IUUC-Gma-043803	Glycine max	30.04	6.00e-29	124.00
IUUC-Hsa-046343	Homo sapiens	96.88	0.00e+00	3388.00
IUUC-Hvu-047707	Hordeum vulgare	27.53	1.00e-23	105.00
IUUC-Kpa-049088	Komagataella pastoris	22.58	2.00e-47	185.00
IUUC-Lch-049649	Latimeria chalumnae	73.61	0.00e+00	2565.00
IUUC-Lpe-051516	Leersia perrieri	25.59	4.00e-33	138.00
IUUC-Loc-052818	Lepisosteus oculatus	73.82	0.00e+00	2608.00
IUUC-Laf-054142	Loxodonta africana	91.57	0.00e+00	3243.00
IUUC-Mcc-055677	Macaca mulatta	97.00	0.00e+00	3386.00
IUUC-Meu-056204	Macropus eugenii	78.72	0.00e+00	643.00
IUUC-Mor-057051	Magnaporthe oryzae	23.35	8.00e-50	193.00
IUUC-Mpo-057372	Magnaporthe poae	24.56	8.00e-45	176.00
IUUC-Mtr-058538	Medicago truncatula	29.33	2.00e-29	125.00
IUUC-Mla-058963	Melampsora laricipopulina	25.53	4.00e-57	218.00
IUUC-Mga-059698	Meleagris gallopavo	87.07	0.00e+00	3054.00
IUUC-Mvi-060535	Microbotryum violaceum	24.69	8.00e-51	196.00
IUUC-Mmr-060901	Microcebus murinus	91.27	0.00e+00	3199.00
IUUC-Mdo-062014	Monodelphis domestica	89.86	0.00e+00	3190.00
IUUC-Mmu-063699	Mus musculus	88.10	0.00e+00	3112.00
IUUC-Mac-064773	Musa acuminata	30.39	5.00e-28	120.00
IUUC-Mpu-066153	Mustela putorius furo	94.39	0.00e+00	3316.00
IUUC-Mlu-068151	Myotis lucifugus	91.50	0.00e+00	3210.00
IUUC-Nfi-068403	Neosartorya fischeri	24.17	5.00e-55	211.00
IUUC-Ncr-068864	Neurospora crassa	22.50	8.00e-43	170.00
IUUC-Nle-069529	Nomascus leucogenys	97.62	0.00e+00	3417.00
IUUC-Opr-071107	Ochotona princeps	87.45	0.00e+00	1342.00
IUUC-Ont-072189	Oreochromis niloticus	65.11	0.00e+00	2140.00
IUUC-Oan-072893	Ornithorhynchus anatinus	87.20	0.00e+00	3084.00
IUUC-Ocu-074082	Oryctolagus cuniculus	90.83	0.00e+00	3210.00
IUUC-Oba-075295	Oryza barthii	21.11	2.00e-13	72.40
IUUC-Obr-076117	Oryza brachyantha	25.77	3.00e-28	122.00
IUUC-Ogl-077571	Oryza glaberrima	28.45	6.00e-21	97.40
IUUC-Ogu-078497	Oryza glumaepatula	21.43	3.00e-15	78.60
IUUC-Olo-081056	Oryza longistaminata	23.79	1.00e-17	86.30
IUUC-Ome-081738	Oryza meridionalis	22.60	3.00e-16	82.00
IUUC-Oni-083099	Oryza nivara	21.11	2.00e-13	72.80
IUUC-Opu-083202	Oryza punctata	27.09	5.00e-28	120.00
IUUC-Oru-084471	Oryza rufipogon	21.11	2.00e-13	72.80
IUUC-Osa-085336	Oryza sativa	28.74	3.00e-21	97.40
IUUC-Ola-087460	Oryzias latipes	63.65	0.00e+00	2116.00
IUUC-Oga-088432	Otolemur garnettii	92.29	0.00e+00	3287.00
IUUC-Oar-090206	Ovis aries	91.36	0.00e+00	3227.00
IUUC-Ptr-091180	Pan troglodytes	96.71	0.00e+00	3392.00
IUUC-Pan-092375	Papio anubis	97.17	0.00e+00	3405.00
IUUC-Psi-093049	Pelodiscus sinensis	86.13	0.00e+00	3024.00
IUUC-Pma-094152	Petromyzon marinus	47.59	0.00e+00	647.00
IUUC-Pno-094877	Phaeosphaeria nodorum	23.69	3.00e-31	131.00
IUUC-Ppa-095715	Physcomitrella patens	34.24	5.00e-23	104.00
IUUC-Pfo-096524	Poecilia formosa	62.70	0.00e+00	2019.00
IUUC-Pab-097989	Pongo abelii	95.81	0.00e+00	3331.00
IUUC-Pca-100207	Procavia capensis	80.14	0.00e+00	1251.00
IUUC-Ppe-101802	Prunus persica	28.90	3.00e-26	115.00
IUUC-Pva-102538	Pteropus vampyrus	93.08	0.00e+00	1215.00
IUUC-Pgr-103372	Puccinia graminis	23.89	4.00e-52	201.00
IUUC-Ptt-103878	Puccinia triticina	23.94	5.00e-49	190.00
IUUC-Rno-105567	Rattus norvegicus	88.05	0.00e+00	3059.00
IUUC-Sce-106272	Saccharomyces cerevisiae	21.02	7.00e-25	110.00
IUUC-Sha-106980	Sarcophilus harrisii	89.25	0.00e+00	3040.00
IUUC-Sja-107980	Schizosaccharomyces japonicus	23.31	8.00e-49	190.00
IUUC-Spo-108183	Schizosaccharomyces pombe	25.10	3.00e-49	191.00
IUUC-Smo-108719	Selaginella moellendorffii	30.22	4.00e-28	121.00
IUUC-Sit-110716	Setaria italica	26.34	2.00e-33	139.00
IUUC-Sly-111701	Solanum lycopersicum	30.47	3.00e-28	122.00
IUUC-Sar-113332	Sorex araneus	84.93	0.00e+00	2155.00
IUUC-Sbi-114577	Sorghum bicolor	28.61	4.00e-32	134.00
IUUC-Sre-115045	Sporisorium reilianum	26.37	4.00e-46	181.00
IUUC-Ssc-115525	Sus scrofa	93.45	0.00e+00	2529.00
IUUC-Tgu-116943	Taeniopygia guttata	86.70	0.00e+00	3066.00
IUUC-Tru-117673	Takifugu rubripes	64.50	0.00e+00	2162.00
IUUC-Tsy-119032	Tarsius syrichta	91.04	0.00e+00	1821.00
IUUC-Tni-119987	Tetraodon nigroviridis	64.16	0.00e+00	2112.00
IUUC-Tca-121077	Theobroma cacao	29.68	2.00e-26	116.00
IUUC-Tre-122137	Trichoderma reesei	24.69	4.00e-48	187.00
IUUC-Tvi-122272	Trichoderma virens	22.97	2.00e-54	208.00
IUUC-Tae-125358	Triticum aestivum	28.01	3.00e-22	102.00
IUUC-Tur-126562	Triticum urartu	28.50	2.00e-28	122.00
IUUC-Tme-127156	Tuber melanosporum	23.53	2.00e-51	199.00
IUUC-Tbe-128103	Tupaia belangeri	84.97	0.00e+00	1208.00
IUUC-Ttr-128253	Tursiops truncatus	87.37	0.00e+00	3033.00
IUUC-Uma-129344	Ustilago maydis	25.91	1.00e-50	196.00
IUUC-Vda-129778	Verticillium dahliae	23.42	8.00e-47	183.00
IUUC-Vpa-130540	Vicugna pacos	88.71	0.00e+00	2915.00
IUUC-Vvi-131290	Vitis vinifera	33.02	3.00e-28	121.00
IUUC-Xtr-132690	Xenopus tropicalis	79.00	0.00e+00	2794.00
IUUC-Xma-133748	Xiphophorus maculatus	63.63	0.00e+00	1985.00
IUUC-Yli-134662	Yarrowia lipolytica	23.67	1.00e-30	129.00
IUUC-Zma-135553	Zea mays	22.65	1.00e-16	83.20

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence