iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	PINA	HINT	Mentha
Post-translational Modifications (PTMs)
UniProt
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	17220175

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	6.80e-08	33.8	52	131

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf.................kdgplv............................lpCgHvfhadClqkwpglknssskefrCPlC 45
           CaiC++++                 +    +                            + C+H+fh++C+ +w       ++++ CPl+
   Q: 52   CAICRNHImdlciecqanqasatseE----CtvaweddqnncnkyfcildcsmkddhleGVCNHAFHFHCISRW------LKTRQVCPLD 131
           ****9988333333333333333330....0233333333333333334444444444477*************......********97 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The SCF complex plays a crucial role in regulating response to auxin and is essential for growth and development. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL1.

Protein Sequence
(Fasta)

MATLDSDVTM IPAGEASSSV AASSSNKKAK RFEIKKWSAV ALWAWDIVVD NCAICRNHIM 60
DLCIECQANQ ASATSEECTV AWEDDQNNCN KYFCILDCSM KDDHLEGVCN HAFHFHCISR 120

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Nucleotide Sequence
(Fasta)

TCTCTCTACA ACAAAATCAG CGACAGCTCA AACGTTGATA TTTTTCTCCG GCTTTTCTAG 60
GGTTTAAATT TTCTTTCCGA TCAGAGATTA ATGGCGACTC TAGACTCCGA CGTTACCATG 120

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Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR024766--Znf_RING_H2

PROSITE

PS50089--ZF_RING_2

Pfam

PF12678--zf-rbx1

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0008270--F:zinc ion binding
GO:0016567--P:protein ubiquitination

KEGG

ath:AT5G20570

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-002900	Amborella trichopoda	71.43	7.00e-49	184.00
IUUC-Aly-005923	Arabidopsis lyrata	81.69	4.00e-50	188.00
IUUC-Bol-015701	Brassica oleracea	79.58	4.00e-52	195.00
IUUC-Bra-017850	Brassica rapa	79.58	6.00e-50	188.00
IUUC-Gma-042692	Glycine max	75.35	4.00e-47	178.00
IUUC-Mtr-058375	Medicago truncatula	73.24	1.00e-53	200.00
IUUC-Oin-079918	Oryza indica	68.46	4.00e-45	172.00
IUUC-Olo-080968	Oryza longistaminata	96.15	2.00e-25	105.00
IUUC-Ppa-095730	Physcomitrella patens	69.93	3.00e-47	179.00
IUUC-Pop-099697	Populus trichocarpa	72.66	2.00e-50	189.00
IUUC-Ppe-101429	Prunus persica	75.35	7.00e-53	197.00
IUUC-Sly-110933	Solanum lycopersicum	71.83	2.00e-52	196.00
IUUC-Tca-121820	Theobroma cacao	78.17	3.00e-52	196.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence