iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-091233

UUCD1 version

UUC-PaT-00883

Ensembl Protein ID

ENSPTRP00000049387.2

UniProt Accession

H2R6R0; H2R6R0_PANTR

Genbank Protein ID

JAA07174.1; JAA21026.1; JAA25471.1; JAA41180.1

Protein Name

Topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase

Genbank Nucleotide ID

AACZ03066949; GABF01001119; GABD01007629; GABE01003559

Gene Name

TOPORS

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000029303.4	ENSPTRT00000056627.2	ENSPTRP00000049387.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	3.00e-09	37.3	103	142

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCl++f++  ++ +C H f++ C+q w      s++++ CPlC+
   Q: 103  CPICLDRFDNVSYLDRCLHKFCFRCVQEW------SKNKAECPLCK 142
           **********999999*************......**********7 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MGSQPPLGSP LSREEGEAPP PAPASEGRRR SRRVRLRGSC RHRPSFLGCR ELAASAPARP 60
APASSEIMAS AAKEFKMDNF SPKAGTSKLQ QTVPADASPD SKCPICLDRF DNVSYLDRCL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCCAGGAAG AGGCGGAGTC GAGGTGAGGG AGTGAAATGC TTAATTCAGG AATGGATTTT 60
GGAGTTTCTG GGTGCTGAAG AAATAGGGCC TTTCCGCCTG CGGGCCCAGT GAGTCGACAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0413--Isomerase
KW-0436--Ligase
KW-1185--Reference proteome

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005814--C:centriole
GO:0036064--C:ciliary basal body
GO:0000930--C:gamma-tubulin complex
GO:0016607--C:nuclear speck
GO:0032391--C:photoreceptor connecting cilium
GO:0016605--C:PML body
GO:0000922--C:spindle pole
GO:0000151--C:ubiquitin ligase complex
GO:0003823--F:antigen binding
GO:0003677--F:DNA binding
GO:0016853--F:isomerase activity
GO:0016874--F:ligase activity
GO:0019789--F:SUMO transferase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0042771--P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0051457--P:maintenance of protein location in nucleus
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0006513--P:protein monoubiquitination
GO:0042127--P:regulation of cell proliferation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000940	Aegilops tauschii	36.76	2.00e-09	55.80
IUUC-Aml-002240	Ailuropoda melanoleuca	89.80	0.00e+00	902.00
IUUC-Atr-002964	Amborella trichopoda	33.33	4.00e-11	61.60
IUUC-Apl-003666	Anas platyrhynchos	57.72	1.00e-143	503.00
IUUC-Aca-005305	Anolis carolinensis	63.21	4.00e-148	519.00
IUUC-Aly-005926	Arabidopsis lyrata	36.56	2.00e-12	65.90
IUUC-Ath-007299	Arabidopsis thaliana	36.17	7.00e-12	64.30
IUUC-Ame-011109	Astyanax mexicanus	53.76	1.00e-114	407.00
IUUC-Bta-012637	Bos taurus	90.85	0.00e+00	916.00
IUUC-Bdi-014270	Brachypodium distachyon	40.00	2.00e-11	62.80
IUUC-Bol-015307	Brassica oleracea	34.41	2.00e-10	59.70
IUUC-Bra-017451	Brassica rapa	31.25	2.00e-08	52.40
IUUC-Cja-019105	Callithrix jacchus	96.26	0.00e+00	1010.00
IUUC-Cfa-021203	Canis familiaris	91.17	0.00e+00	912.00
IUUC-Cpo-022335	Cavia porcellus	85.52	0.00e+00	867.00
IUUC-Csa-023870	Chlorocebus sabaeus	98.64	0.00e+00	1020.00
IUUC-Cho-024870	Choloepus hoffmanni	91.96	0.00e+00	889.00
IUUC-Cne-026788	Cryptococcus neoformans	33.85	4.00e-07	50.10
IUUC-Dre-027535	Danio rerio	50.22	1.00e-120	427.00
IUUC-Dno-028963	Dasypus novemcinctus	92.36	0.00e+00	900.00
IUUC-Dor-030239	Dipodomys ordii	90.16	0.00e+00	801.00
IUUC-Dme-031941	Drosophila melanogaster	54.69	5.00e-19	90.10
IUUC-Ete-032300	Echinops telfairi	84.63	0.00e+00	1119.00
IUUC-Eca-033690	Equus caballus	93.71	0.00e+00	912.00
IUUC-Eeu-035257	Erinaceus europaeus	87.84	0.00e+00	866.00
IUUC-Fca-036383	Felis catus	90.23	0.00e+00	906.00
IUUC-Fal-037209	Ficedula albicollis	62.64	1.00e-163	570.00
IUUC-Gmo-039416	Gadus morhua	53.86	4.00e-118	417.00
IUUC-Gga-041267	Gallus gallus	71.68	2.00e-172	600.00
IUUC-Gac-042227	Gasterosteus aculeatus	51.73	4.00e-114	404.00
IUUC-Gma-042777	Glycine max	36.47	1.00e-08	53.50
IUUC-Ggo-044445	Gorilla gorilla	99.32	0.00e+00	1051.00
IUUC-Hsa-045844	Homo sapiens	99.49	0.00e+00	1053.00
IUUC-Hvu-047531	Hordeum vulgare	46.00	1.00e-10	57.00
IUUC-Itr-048818	Ictidomys tridecemlineatus	92.02	0.00e+00	936.00
IUUC-Lch-050031	Latimeria chalumnae	65.69	1.00e-167	583.00
IUUC-Lpe-051274	Leersia perrieri	37.74	1.00e-08	53.50
IUUC-Loc-052944	Lepisosteus oculatus	58.20	2.00e-141	496.00
IUUC-Laf-053820	Loxodonta africana	93.66	0.00e+00	869.00
IUUC-Mcc-054800	Macaca mulatta	98.64	0.00e+00	1016.00
IUUC-Meu-056806	Macropus eugenii	72.03	0.00e+00	637.00
IUUC-Mtr-058378	Medicago truncatula	36.04	4.00e-12	65.10
IUUC-Mla-059017	Melampsora laricipopulina	36.07	4.00e-09	55.50
IUUC-Mvi-060417	Microbotryum violaceum	25.36	5.00e-17	83.20
IUUC-Mmr-061481	Microcebus murinus	94.48	0.00e+00	935.00
IUUC-Mdo-062219	Monodelphis domestica	81.45	4.00e-107	382.00
IUUC-Mmu-064138	Mus musculus	89.87	0.00e+00	839.00
IUUC-Mac-064635	Musa acuminata	38.57	7.00e-11	59.70
IUUC-Mlu-067088	Myotis lucifugus	91.53	0.00e+00	932.00
IUUC-Nle-069862	Nomascus leucogenys	98.86	0.00e+00	1065.00
IUUC-Opr-071076	Ochotona princeps	89.75	0.00e+00	801.00
IUUC-Ont-072225	Oreochromis niloticus	51.70	1.00e-109	390.00
IUUC-Oan-073069	Ornithorhynchus anatinus	66.97	9.00e-157	546.00
IUUC-Ocu-074826	Oryctolagus cuniculus	93.04	0.00e+00	939.00
IUUC-Oba-075429	Oryza barthii	37.68	1.00e-10	59.70
IUUC-Obr-076084	Oryza brachyantha	36.23	4.00e-10	58.20
IUUC-Ogl-077444	Oryza glaberrima	37.68	2.00e-10	59.70
IUUC-Ogu-078603	Oryza glumaepatula	37.68	1.00e-10	59.70
IUUC-Oin-079777	Oryza indica	37.68	2.00e-10	59.30
IUUC-Oni-082396	Oryza nivara	37.68	1.00e-10	59.70
IUUC-Opu-083698	Oryza punctata	36.62	8.00e-10	57.40
IUUC-Oru-084305	Oryza rufipogon	37.68	2.00e-10	59.70
IUUC-Ola-087377	Oryzias latipes	54.15	2.00e-106	379.00
IUUC-Oga-088059	Otolemur garnettii	90.65	0.00e+00	919.00
IUUC-Oar-089592	Ovis aries	91.22	0.00e+00	886.00
IUUC-Pan-092743	Papio anubis	98.64	0.00e+00	1019.00
IUUC-Psi-093669	Pelodiscus sinensis	60.46	0.00e+00	848.00
IUUC-Ppa-095668	Physcomitrella patens	25.71	3.00e-20	92.80
IUUC-Pfo-096706	Poecilia formosa	54.26	5.00e-105	375.00
IUUC-Pop-098813	Populus trichocarpa	24.49	5.00e-13	68.20
IUUC-Pca-100967	Procavia capensis	90.94	0.00e+00	821.00
IUUC-Ppe-101922	Prunus persica	35.06	9.00e-09	53.50
IUUC-Pva-102982	Pteropus vampyrus	93.90	0.00e+00	924.00
IUUC-Pgr-103551	Puccinia graminis	38.46	8.00e-09	53.90
IUUC-Ptt-103977	Puccinia triticina	33.33	6.00e-08	50.80
IUUC-Rno-105730	Rattus norvegicus	88.93	0.00e+00	791.00
IUUC-Sha-106588	Sarcophilus harrisii	68.45	7.00e-179	620.00
IUUC-Sja-107735	Schizosaccharomyces japonicus	35.38	2.00e-07	49.30
IUUC-Smo-109039	Selaginella moellendorffii	24.46	5.00e-17	82.00
IUUC-Stu-111938	Solanum tuberosum	31.91	6.00e-07	47.80
IUUC-Sar-113622	Sorex araneus	88.95	7.00e-162	564.00
IUUC-Sre-115041	Sporisorium reilianum	37.84	1.00e-09	57.00
IUUC-Ssc-115244	Sus scrofa	94.40	0.00e+00	882.00
IUUC-Tgu-117180	Taeniopygia guttata	64.85	3.00e-173	602.00
IUUC-Tru-118393	Takifugu rubripes	53.23	3.00e-120	425.00
IUUC-Tsy-119408	Tarsius syrichta	93.74	0.00e+00	938.00
IUUC-Tni-120664	Tetraodon nigroviridis	49.15	1.00e-120	426.00
IUUC-Tca-121712	Theobroma cacao	26.90	9.00e-16	77.40
IUUC-Tae-122787	Triticum aestivum	38.57	1.00e-10	60.50
IUUC-Tbe-127301	Tupaia belangeri	85.08	0.00e+00	839.00
IUUC-Ttr-128204	Tursiops truncatus	92.32	0.00e+00	951.00
IUUC-Uma-129420	Ustilago maydis	43.06	1.00e-09	57.40
IUUC-Vpa-130297	Vicugna pacos	93.78	0.00e+00	909.00
IUUC-Vvi-131157	Vitis vinifera	25.50	1.00e-16	80.50
IUUC-Xtr-132845	Xenopus tropicalis	67.36	2.00e-169	589.00
IUUC-Xma-133439	Xiphophorus maculatus	53.04	3.00e-107	382.00
IUUC-Yli-134652	Yarrowia lipolytica	38.78	4.00e-06	46.20

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence