iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
iRefIndex	PINA	HINT	Mentha
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	17220175; 18287201

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/SCF/F-box	0.35	11.8	42	86

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/F-box

   S: 98   pdaglldrlpeeilveilklldkeellraarvcrrwqelasqkal 142
            d  ++++lp  +l +++ +l+++   r ++vc+r++ l  ++++
   Q: 42   MDGRIWSKLPPPLLDRVIAFLPPPAFFRTRCVCKRFYSLLFSNTF 86
           4677899******************************65543554 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Considered as a meristem identity factor required for normal growth of the young floral meristem. Acts together with LEAFY to positively regulate the B class floral homeotic genes APETALA3 and PISTILLATA. In this way, operates as a region-specific regulator for petal and stamen development. Alternatively, may play a role as a negative regulator of the C class floral homeotic genes. Interacts together with the SKP1-like protein ASK1 to form a ubiquitin E3 ligase complex and could indirectly promote the ubiquitination and degradation of specific proteins controlling the floral primordia development like repressors of B class floral homeotic genes.

Protein Sequence
(Fasta)

MDSTVFINNP SLTLPFSYTF TSSSNSSTTT STTTDSSSGQ WMDGRIWSKL PPPLLDRVIA 60
FLPPPAFFRT RCVCKRFYSL LFSNTFLETY LQLLPLRHNC FLFFKHKTLK SYIYKRGGTN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CACAGAGAAA GACCAAACAC TTTTGTCTCT TTCTTCAAAA CTTTTACATA TGATCTTTGC 60
CTCTTTTCCT ACAATGGGTT TTGCATAACT TTCACCAAAA CCCTCCTCAA AAGCCCTTCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0010--Activator
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0287--Flowering
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway

Interpro

IPR001810--F-box_dom
IPR015916--Gal_Oxidase_b-propeller

PROSITE

PS50181--FBOX

Pfam

PF00646--F-box

SMART

SM00256--FBOX

Gene Ontology

GO:0005634--C:nucleus
GO:0008134--F:transcription factor binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030154--P:cell differentiation
GO:0009908--P:flower development
GO:0006355--P:regulation of transcription, DNA-templated
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0006351--P:transcription, DNA-templated

KEGG

ath:AT1G30950

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000610	Aegilops tauschii	38.74	7.00e-32	129.00
IUUC-Atr-002850	Amborella trichopoda	49.21	2.00e-94	338.00
IUUC-Aly-006302	Arabidopsis lyrata	96.38	0.00e+00	759.00
IUUC-Bdi-014051	Brachypodium distachyon	40.20	1.00e-41	163.00
IUUC-Bol-015604	Brassica oleracea	91.48	0.00e+00	708.00
IUUC-Bra-017678	Brassica rapa	91.24	0.00e+00	716.00
IUUC-Csv-026144	Ciona savignyi	31.58	6.00e-03	32.70
IUUC-Dse-031274	Dothistroma septosporum	26.67	8.00e-04	34.70
IUUC-Fal-037227	Ficedula albicollis	28.89	3.00e-03	33.90
IUUC-Gma-043918	Glycine max	68.56	2.00e-144	504.00
IUUC-Lch-049855	Latimeria chalumnae	25.52	1.30e-02	33.50
IUUC-Lpe-050979	Leersia perrieri	41.13	1.00e-68	252.00
IUUC-Mtr-058083	Medicago truncatula	68.25	2.00e-149	521.00
IUUC-Mac-065290	Musa acuminata	55.15	2.00e-75	275.00
IUUC-Ncr-068766	Neurospora crassa	30.16	2.50e-01	30.00
IUUC-Oba-075643	Oryza barthii	37.50	5.00e-33	134.00
IUUC-Obr-076079	Oryza brachyantha	43.24	1.00e-48	185.00
IUUC-Ogl-077787	Oryza glaberrima	42.20	2.00e-55	208.00
IUUC-Ogu-078033	Oryza glumaepatula	37.45	9.00e-43	166.00
IUUC-Oin-079846	Oryza indica	46.26	2.00e-59	222.00
IUUC-Ome-081692	Oryza meridionalis	43.42	1.00e-58	219.00
IUUC-Oni-082165	Oryza nivara	41.13	2.00e-44	172.00
IUUC-Opu-083728	Oryza punctata	43.66	2.00e-59	222.00
IUUC-Oru-084676	Oryza rufipogon	43.42	1.00e-58	219.00
IUUC-Osa-085876	Oryza sativa	43.42	2.00e-58	219.00
IUUC-Pan-091992	Papio anubis	28.12	1.50e-02	32.00
IUUC-Ppa-095856	Physcomitrella patens	21.52	1.00e-10	60.50
IUUC-Pop-099723	Populus trichocarpa	68.64	3.00e-159	553.00
IUUC-Ppe-101645	Prunus persica	67.00	4.00e-147	513.00
IUUC-Smo-109217	Selaginella moellendorffii	45.27	1.00e-89	322.00
IUUC-Sly-111026	Solanum lycopersicum	61.95	4.00e-137	480.00
IUUC-Stu-111937	Solanum tuberosum	61.69	2.00e-140	491.00
IUUC-Sbi-114342	Sorghum bicolor	43.84	1.00e-57	216.00
IUUC-Tca-121846	Theobroma cacao	70.90	3.00e-160	557.00
IUUC-Tre-122147	Trichoderma reesei	26.09	1.70e-01	31.20
IUUC-Tae-125944	Triticum aestivum	45.02	6.00e-57	214.00
IUUC-Tur-126494	Triticum urartu	23.12	1.00e-17	84.00
IUUC-Vpa-130065	Vicugna pacos	44.44	2.20e-02	32.70
IUUC-Vvi-130852	Vitis vinifera	70.10	2.00e-150	524.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence