iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mcc-054701

Ensembl Protein ID

ENSMMUP00000012778.2

UniProt Accession

F6ZID0; F6ZID0_MACMU

Genbank Protein ID

AFE80990.1; AFH34753.1; AFI38860.1

Protein Name

E3 ubiquitin-protein ligase RNF14 isoform 1

Genbank Nucleotide ID

JSUE03037101; JU477949; JV048789

Gene Name

RNF14

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000009768.3	ENSMMUT00000013638.3	ENSMMUP00000012778.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RBR	4.40e-56	190.5	220	433

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RBR

   S: 1    CkvCllelsveeltvlleCehtfCkeClkqylelkikegqvteiscpaaecpekleeseikellveeelykryekllleevveadaalkw 90
           C++C++e+  +e++++leC+h++Ck+Clk+y+e++i++gqv++++cp+++cp+ +++ ++ke lve+el++ry++lll+++++ +a++ +
   Q: 220  CNICFCEKLGSECMYFLECRHVYCKACLKDYFEIQIRDGQVQCLNCPEPKCPSVATPGQVKE-LVEAELFARYDRLLLQSTLDLMADVVY 308
           **************************************************************.7************************** PP
   S: 91   cpapdCslvvllekeaekleve.cekcgkefCveCkeewHeglsCkelkeklakteeek........................eeaeske 155
           cp+p+C+l+v++e+     ++  c++c+++fC+ C+ ++H  + Ck ++ekl++ ++e+                        ee+eske
   Q: 309  CPRPCCQLPVMQEPG---CTMGiCSSCNFAFCTLCRLTYHGVSPCKVTAEKLMDLRNEYlqadeankrlldqrygkrviqkalEEMESKE 395
           *************95...33337**********************************99******************************* PP
   S: 156  lleanskkCpkCkvyieknegCnhmtCakCkaefCwlC 193
           +le+nsk+Cp+C ++iek +gCn+mtC+ Ck++fCw+C
   Q: 396  WLEKNSKSCPCCGTPIEKLDGCNKMTCTGCKQYFCWIC 433
           ************************************** PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MSSEDREAQE DELLALASIY DGDEFRKAES VQGGETRIYL DLPQNFKIFV SGNSNECLQN 60
SGFEYTICFL PPLVLNFELP PDYPSSSPPS FTLSGKWLSP TQLSALCKHL DNLWEEHRGS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACTACCCCAC CAGCGGGATC CGCTTGGCTC AGCTGACAGC TCCCGAGAAC GGAAGAGGCG 60
GTGCGCCGGT TGAGCAGGGA ATTGCTAGGC CTGGTCGGCT GGCGGCGGTG AGTGGGCCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR006575--RWD-domain
IPR016135--UBQ-conjugating_enzyme/RWD
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50908--RWD
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF01485--IBR
PF05773--RWD

SMART

SM00647--IBR
SM00591--RWD

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0016874--F:ligase activity
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0060765--P:regulation of androgen receptor signaling pathway
GO:0007165--P:signal transduction

KEGG

mcc:705363

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001130	Aegilops tauschii	29.85	7.00e-51	195.00
IUUC-Aml-001458	Ailuropoda melanoleuca	96.64	0.00e+00	919.00
IUUC-Atr-002560	Amborella trichopoda	30.22	4.00e-45	176.00
IUUC-Apl-003680	Anas platyrhynchos	82.07	0.00e+00	776.00
IUUC-Aca-005000	Anolis carolinensis	72.28	0.00e+00	674.00
IUUC-Aly-006288	Arabidopsis lyrata	31.03	7.00e-54	205.00
IUUC-Ath-006719	Arabidopsis thaliana	30.94	4.00e-53	202.00
IUUC-Acl-008213	Aspergillus clavatus	25.27	1.00e-30	128.00
IUUC-Afl-008433	Aspergillus flavus	25.00	6.00e-31	129.00
IUUC-Afu-008772	Aspergillus fumigatus	25.49	1.00e-32	134.00
IUUC-Ani-009249	Aspergillus nidulans	25.89	9.00e-34	138.00
IUUC-Ang-009757	Aspergillus niger	28.23	3.00e-37	149.00
IUUC-Aor-009963	Aspergillus oryzae	25.00	1.00e-30	128.00
IUUC-Ate-010460	Aspergillus terreus	25.11	2.00e-31	130.00
IUUC-Ame-011312	Astyanax mexicanus	58.82	1.00e-145	509.00
IUUC-Bgr-012052	Blumeria graminis	23.74	2.00e-29	124.00
IUUC-Bta-013529	Bos taurus	96.20	0.00e+00	922.00
IUUC-Bci-013729	Botrytis cinerea	25.16	5.00e-27	115.00
IUUC-Bdi-014940	Brachypodium distachyon	31.96	3.00e-48	186.00
IUUC-Bra-016998	Brassica rapa	30.04	2.00e-50	193.00
IUUC-Cel-018547	Caenorhabditis elegans	31.37	2.00e-50	193.00
IUUC-Cja-019791	Callithrix jacchus	97.26	0.00e+00	931.00
IUUC-Cfa-020403	Canis familiaris	96.20	0.00e+00	923.00
IUUC-Cpo-022229	Cavia porcellus	90.76	0.00e+00	858.00
IUUC-Cre-022601	Chlamydomonas reinhardtii	35.35	2.00e-29	121.00
IUUC-Csa-024115	Chlorocebus sabaeus	99.79	0.00e+00	949.00
IUUC-Cho-024911	Choloepus hoffmanni	96.41	0.00e+00	923.00
IUUC-Cin-025578	Ciona intestinalis	41.86	4.00e-98	351.00
IUUC-Csv-026355	Ciona savignyi	40.10	2.00e-82	299.00
IUUC-Cne-026782	Cryptococcus neoformans	25.96	9.00e-31	128.00
IUUC-Dre-027380	Danio rerio	56.47	9.00e-153	533.00
IUUC-Dno-029640	Dasypus novemcinctus	95.79	0.00e+00	913.00
IUUC-Dor-030681	Dipodomys ordii	94.94	0.00e+00	907.00
IUUC-Dse-031208	Dothistroma septosporum	24.44	4.00e-31	129.00
IUUC-Ete-033122	Echinops telfairi	61.17	3.00e-135	474.00
IUUC-Eca-033755	Equus caballus	94.65	0.00e+00	891.00
IUUC-Eeu-035034	Erinaceus europaeus	98.63	2.00e-73	269.00
IUUC-Fca-036461	Felis catus	96.41	0.00e+00	924.00
IUUC-Fal-037516	Ficedula albicollis	81.05	0.00e+00	772.00
IUUC-Fso-038307	Fusarium solani	25.16	2.00e-25	110.00
IUUC-Gmo-039563	Gadus morhua	57.27	2.00e-148	518.00
IUUC-Ggr-039920	Gaeumannomyces graminis	25.24	3.00e-23	103.00
IUUC-Gga-040331	Gallus gallus	80.89	0.00e+00	756.00
IUUC-Gac-042164	Gasterosteus aculeatus	59.45	5.00e-160	557.00
IUUC-Gma-044080	Glycine max	32.08	6.00e-58	218.00
IUUC-Ggo-045257	Gorilla gorilla	98.95	0.00e+00	942.00
IUUC-Hsa-046887	Homo sapiens	99.13	0.00e+00	915.00
IUUC-Hvu-047317	Hordeum vulgare	29.49	3.00e-49	189.00
IUUC-Itr-048199	Ictidomys tridecemlineatus	95.57	0.00e+00	917.00
IUUC-Lch-050155	Latimeria chalumnae	64.16	5.00e-165	573.00
IUUC-Lpe-051669	Leersia perrieri	30.87	2.00e-39	157.00
IUUC-Loc-051779	Lepisosteus oculatus	60.27	3.00e-155	541.00
IUUC-Lma-052969	Leptosphaeria maculans	23.90	1.00e-30	127.00
IUUC-Laf-053488	Loxodonta africana	93.25	0.00e+00	889.00
IUUC-Meu-056577	Macropus eugenii	83.27	3.00e-127	448.00
IUUC-Mor-057157	Magnaporthe oryzae	25.77	1.00e-27	118.00
IUUC-Mpo-057518	Magnaporthe poae	23.27	1.00e-26	115.00
IUUC-Mtr-058125	Medicago truncatula	29.30	1.00e-45	177.00
IUUC-Mga-059906	Meleagris gallopavo	80.68	0.00e+00	752.00
IUUC-Mvi-060374	Microbotryum violaceum	31.43	5.00e-33	135.00
IUUC-Mmr-061786	Microcebus murinus	97.05	0.00e+00	926.00
IUUC-Mdo-062453	Monodelphis domestica	90.35	0.00e+00	833.00
IUUC-Mmu-063521	Mus musculus	90.49	0.00e+00	812.00
IUUC-Mac-065119	Musa acuminata	30.37	1.00e-40	160.00
IUUC-Mpu-066274	Mustela putorius furo	95.99	0.00e+00	920.00
IUUC-Mlu-067202	Myotis lucifugus	92.61	0.00e+00	845.00
IUUC-Nfi-068564	Neosartorya fischeri	24.84	4.00e-31	129.00
IUUC-Ncr-068823	Neurospora crassa	25.11	3.00e-30	127.00
IUUC-Nle-068987	Nomascus leucogenys	99.35	0.00e+00	919.00
IUUC-Opr-070453	Ochotona princeps	92.19	0.00e+00	878.00
IUUC-Ont-072611	Oreochromis niloticus	57.98	2.00e-159	555.00
IUUC-Oan-073738	Ornithorhynchus anatinus	81.96	0.00e+00	746.00
IUUC-Ocu-074396	Oryctolagus cuniculus	94.30	0.00e+00	902.00
IUUC-Oba-075472	Oryza barthii	32.09	2.00e-43	170.00
IUUC-Obr-076277	Oryza brachyantha	31.87	3.00e-45	176.00
IUUC-Ogl-077046	Oryza glaberrima	31.78	5.00e-42	166.00
IUUC-Ogu-078634	Oryza glumaepatula	32.09	1.00e-43	171.00
IUUC-Oin-080080	Oryza indica	29.58	6.00e-45	175.00
IUUC-Olo-080828	Oryza longistaminata	29.00	2.00e-42	167.00
IUUC-Ome-081387	Oryza meridionalis	29.57	2.00e-47	183.00
IUUC-Oni-082934	Oryza nivara	32.09	1.00e-43	171.00
IUUC-Opu-083719	Oryza punctata	28.81	2.00e-41	163.00
IUUC-Oru-084518	Oryza rufipogon	32.09	1.00e-43	171.00
IUUC-Ola-087312	Oryzias latipes	59.09	2.00e-156	545.00
IUUC-Olu-087661	Ostreococcus lucimarinus	28.42	6.00e-46	178.00
IUUC-Oga-089129	Otolemur garnettii	96.83	0.00e+00	922.00
IUUC-Oar-089839	Ovis aries	95.99	0.00e+00	921.00
IUUC-Ptr-091626	Pan troglodytes	99.35	0.00e+00	917.00
IUUC-Pan-092798	Papio anubis	100.00	0.00e+00	922.00
IUUC-Psi-093253	Pelodiscus sinensis	82.03	0.00e+00	789.00
IUUC-Pma-094512	Petromyzon marinus	54.96	5.00e-144	504.00
IUUC-Pno-094937	Phaeosphaeria nodorum	23.68	5.00e-30	125.00
IUUC-Ppa-095211	Physcomitrella patens	30.52	3.00e-53	203.00
IUUC-Pfo-097049	Poecilia formosa	53.39	5.00e-139	487.00
IUUC-Pab-097911	Pongo abelii	99.13	0.00e+00	915.00
IUUC-Pop-099841	Populus trichocarpa	30.84	1.00e-49	191.00
IUUC-Pca-100814	Procavia capensis	74.47	0.00e+00	659.00
IUUC-Ppe-101972	Prunus persica	29.96	9.00e-50	191.00
IUUC-Pva-103038	Pteropus vampyrus	95.78	0.00e+00	914.00
IUUC-Pgr-103277	Puccinia graminis	32.82	7.00e-39	155.00
IUUC-Ptt-103855	Puccinia triticina	30.48	6.00e-35	142.00
IUUC-Pte-104113	Pyrenophora teres	23.25	5.00e-26	112.00
IUUC-Pyt-104619	Pyrenophora triticirepentis	25.27	4.00e-27	115.00
IUUC-Rno-106003	Rattus norvegicus	90.91	0.00e+00	831.00
IUUC-Sce-106287	Saccharomyces cerevisiae	27.45	3.00e-23	103.00
IUUC-Sha-106652	Sarcophilus harrisii	90.02	0.00e+00	841.00
IUUC-Spo-108167	Schizosaccharomyces pombe	31.22	1.00e-51	197.00
IUUC-Ssl-108396	Sclerotinia sclerotiorum	25.45	5.00e-09	56.60
IUUC-Smo-109393	Selaginella moellendorffii	31.04	2.00e-48	186.00
IUUC-Sit-110529	Setaria italica	34.03	2.00e-42	167.00
IUUC-Sly-111829	Solanum lycopersicum	29.93	6.00e-53	202.00
IUUC-Stu-112811	Solanum tuberosum	30.16	2.00e-53	204.00
IUUC-Sar-113259	Sorex araneus	90.29	1.00e-138	486.00
IUUC-Sbi-114591	Sorghum bicolor	32.60	3.00e-35	143.00
IUUC-Sre-115227	Sporisorium reilianum	28.34	2.00e-36	147.00
IUUC-Ssc-115293	Sus scrofa	94.30	0.00e+00	904.00
IUUC-Tgu-117335	Taeniopygia guttata	81.68	0.00e+00	771.00
IUUC-Tru-118458	Takifugu rubripes	56.99	1.00e-154	539.00
IUUC-Tsy-119475	Tarsius syrichta	88.40	0.00e+00	817.00
IUUC-Tni-119827	Tetraodon nigroviridis	56.69	2.00e-153	535.00
IUUC-Tca-121023	Theobroma cacao	32.02	6.00e-51	195.00
IUUC-Tre-121965	Trichoderma reesei	23.91	7.00e-30	125.00
IUUC-Tvi-122564	Trichoderma virens	21.54	7.00e-27	115.00
IUUC-Tae-124793	Triticum aestivum	33.26	2.00e-39	157.00
IUUC-Tur-126258	Triticum urartu	30.67	4.00e-45	176.00
IUUC-Tbe-127227	Tupaia belangeri	72.96	1.00e-77	283.00
IUUC-Ttr-128984	Tursiops truncatus	73.42	0.00e+00	632.00
IUUC-Uma-129565	Ustilago maydis	27.36	2.00e-34	140.00
IUUC-Vpa-130301	Vicugna pacos	97.05	0.00e+00	927.00
IUUC-Vvi-131244	Vitis vinifera	31.21	5.00e-53	202.00
IUUC-Xtr-132880	Xenopus tropicalis	59.96	6.00e-166	577.00
IUUC-Xma-134055	Xiphophorus maculatus	58.61	3.00e-159	554.00
IUUC-Yli-134342	Yarrowia lipolytica	29.74	2.00e-43	169.00
IUUC-Zma-135021	Zea mays	32.87	1.00e-37	151.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence