iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mtr-058626

Ensembl Protein ID

KEH42290

UniProt Accession

A0A072VW29; A0A072VW29_MEDTR

Genbank Protein ID

KEH42290.1

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

CM001217

Gene Name

MTR_1g066940

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
MTR_1g066940	KEH42290	KEH42290
MTR_1g066940	KEH42288	KEH42288
MTR_1g066940	KEH42289	KEH42289

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.90e-104	351.1	1174	1549

Active Site

Position(s)	Description	Evidence
1516	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp..........................ehlklFeflGr 76
           + k +leve+ +E g++l G+t+ef++l+++elq++  g+++ +  +++t+++n ++    +                          e+++ F +lG+
   Q: 1174 SHKVVLEVEYDEEVGTGL-GPTLEFYTLVCQELQKSGSGMWRED-ASSYTIKTNLQAEE--TgihslyglfprpwlstqdtsggiqfsEVTNKFFLLGQ 1268
           567899************.**********************555.56777777777764..2357889******************************* PP
   S: 77   llgkalqdgrlldlplsksfyklllgkklsledleevdpelykslkeikenaes.....................dieelgldltfsvseeilgetkee 154
           +++kalqdgr+ldl++sk+fykl+lgk+l l d++++dpel + l e ++++++                     d+  ++l+l f+     l+ + + 
   Q: 1269 VVAKALQDGRVLDLHFSKAFYKLILGKELYLYDIQSLDPELGRVLHEFQALVNRkfclesvcegnseleqglsfrDSRIEDLCLDFT-----LPGYPDI 1362
           *************************************************99944555555666666666666666555555566665.....8899999 PP
   S: 155  eLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGe.eeidvedlkketkykggytedspaiqwFwev 252
            L +g+++++V++ N+e+Yv+l+v++++k+gi +qveaf++Gfn+v+p+e l++F eeele ++cGe +++ +++l++++k+++gyt++sp i +++e+
   Q: 1363 VLASGSDHTMVNMRNLEDYVSLIVDATVKSGISRQVEAFKSGFNQVFPIENLQIFYEEELERILCGEdDSWAINELADHIKFDHGYTASSPPIVNLLEI 1461
           9******************************************************************99****************************** PP
   S: 253  leefsseerkafLqFvTgssrlPlgGfaelkprlfvirk...dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFels 336
           ++ef+  +r+afLqFvTg++rlP+gG+a+l+p+l+++rk   +++d++lPs++TC+nyLkLP+Ysske +kekLlyAi+e+  +F+ls
   Q: 1462 IREFDHGQRRAFLQFVTGTPRLPPGGLASLNPKLTIVRKhcsNQADTDLPSVMTCANYLKLPPYSSKERMKEKLLYAITEGqGSFHLS 1549
           *****************************************99999***********************************9999985 PP

Organism

Medicago truncatula

Protein Sequence
(Fasta)

MGSRGQKRPE MVDELPADKR ACSSLDFRPS SSTASVQTDI SSTQSTMEPH DDMDTSSSAS 60
SHSEEEPEKD SADGSCDSDE MEHYHSTLHE YHRQRLSSDH GKFKTIISSL SGQTEPSGQL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTACACCTA AGCACCTATA TAGCCACGAT CATAACAAAA CAAGGATTAT GATGGAGGCA 60
TTGCATCAAG CTTGACACAC CTCTTAGGCA CTAAATCCTC CCCAAACAAT AAAAATCATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000935	Aegilops tauschii	44.99	0.00e+00	1128.00
IUUC-Atr-002515	Amborella trichopoda	51.68	0.00e+00	664.00
IUUC-Aca-004521	Anolis carolinensis	38.43	3.00e-44	174.00
IUUC-Aly-006493	Arabidopsis lyrata	55.25	0.00e+00	1563.00
IUUC-Ath-006679	Arabidopsis thaliana	54.57	0.00e+00	1533.00
IUUC-Bdi-014101	Brachypodium distachyon	45.75	0.00e+00	1196.00
IUUC-Bol-016355	Brassica oleracea	52.58	0.00e+00	1455.00
IUUC-Bra-016937	Brassica rapa	50.90	0.00e+00	1371.00
IUUC-Cho-024380	Choloepus hoffmanni	44.42	1.00e-89	325.00
IUUC-Dno-029954	Dasypus novemcinctus	38.08	4.00e-43	171.00
IUUC-Gma-043501	Glycine max	80.32	0.00e+00	2417.00
IUUC-Hvu-047811	Hordeum vulgare	45.79	0.00e+00	1204.00
IUUC-Lpe-051509	Leersia perrieri	45.28	0.00e+00	1181.00
IUUC-Mac-065046	Musa acuminata	60.82	0.00e+00	637.00
IUUC-Oba-075380	Oryza barthii	45.62	0.00e+00	1116.00
IUUC-Obr-076904	Oryza brachyantha	45.39	0.00e+00	1150.00
IUUC-Ogl-076926	Oryza glaberrima	46.59	0.00e+00	1201.00
IUUC-Ogu-078892	Oryza glumaepatula	46.36	0.00e+00	1157.00
IUUC-Oin-079148	Oryza indica	44.00	0.00e+00	1095.00
IUUC-Olo-081086	Oryza longistaminata	44.52	0.00e+00	1071.00
IUUC-Ome-081955	Oryza meridionalis	44.97	0.00e+00	1147.00
IUUC-Oni-083047	Oryza nivara	45.10	0.00e+00	1148.00
IUUC-Opu-083641	Oryza punctata	45.48	0.00e+00	1150.00
IUUC-Oru-084439	Oryza rufipogon	45.51	0.00e+00	1115.00
IUUC-Osa-085605	Oryza sativa	36.43	0.00e+00	785.00
IUUC-Pop-099725	Populus trichocarpa	62.48	0.00e+00	1807.00
IUUC-Ppe-101229	Prunus persica	64.31	0.00e+00	1906.00
IUUC-Sce-106273	Saccharomyces cerevisiae	35.52	2.00e-73	270.00
IUUC-Sit-110332	Setaria italica	46.40	0.00e+00	1188.00
IUUC-Sly-111552	Solanum lycopersicum	55.57	0.00e+00	1593.00
IUUC-Sar-113224	Sorex araneus	45.70	4.00e-84	306.00
IUUC-Sbi-114106	Sorghum bicolor	45.21	0.00e+00	1170.00
IUUC-Tgu-117167	Taeniopygia guttata	38.79	4.00e-44	173.00
IUUC-Tca-121574	Theobroma cacao	62.65	0.00e+00	1862.00
IUUC-Tae-125470	Triticum aestivum	46.18	0.00e+00	1216.00
IUUC-Tur-126486	Triticum urartu	46.26	0.00e+00	1149.00
IUUC-Tbe-128149	Tupaia belangeri	40.35	8.00e-69	256.00
IUUC-Vvi-130904	Vitis vinifera	60.80	0.00e+00	1762.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence