iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-011761

Ensembl Protein ID

ENSAMXP00000022252.1

UniProt Accession

W5LQF5; W5LQF5_ASTMX

Genbank Protein ID

ENSAMXP00000022252

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

APWO01093768

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000021606.1	ENSAMXT00000022252.1	ENSAMXP00000022252.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.10e-96	324.4	1710	2089

Active Site

Position(s)	Description	Evidence
2056	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 6    kkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.......................ehlk 69
           ++ le+++++E g++l G+t+ef+al+s+elq++dlgl++ +e   ++ + ++ +g+  +                       +   
   Q: 1710 RAMLEIQYENEVGTGL-GPTLEFYALVSQELQRADLGLWRGEEVTLANPKGSQ-EGT--KymfssrglfavpfgrstkpahiaKIKM 1792
           56899***********.**********************54444333322222.111..123455667777799********99999 PP
   S: 70   lFeflGrllgkalqdgrlldlplsksfyklllgkklsl..edleevdpelykslkeikenaes...............dieelgldl 139
            F+flG+l++ka++d rlldlpl  +fyk +l+++ s+   dl ++dp ++ks++ +++   +               ++  ++l++
   Q: 1793 KFRFLGKLMAKAIMDFRLLDLPLGLPFYKWMLRHESSIssFDLVNIDPGVAKSIQHLEDIIRQkrrleqdqshtretlQLALESLNM 1879
           9*********************************6554439*****************99833445555565666666334444444 PP
   S: 140  tfsvseei.....lgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGe 221
           + +  e++     l+   + eLk gG+++pVt+ N+eeY +lvv ++l+eg+ +q+e+freGf++v+pl++l++F +eel++l+cG+
   Q: 1880 NGCSVEDLgldftLPGFPNIELKKGGKDVPVTIHNLEEYLRLVVYWTLNEGVSRQFESFREGFESVFPLHHLQYFYPEELDQLLCGS 1966
           44433333666668999*********************************************************************9 PP
   S: 222  ..eeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk.....dasddrlPss 301
             e++dv++l + ++ ++gyt+ds+a+++++evl++f++e+++ fLqFvTgs+rlP+gGf++l+p l+++rk     ++ dd lPs+
   Q: 1967 ksETWDVKTLMECCRPDHGYTHDSRAVRFLFEVLSSFDAEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKtfestENPDDFLPSV 2053
           8889***********************************************************************988888****** PP
   S: 302  nTCfnyLkLPeYsskeilkekLlyAieet.kgFels 336
           +TC+nyLkLP+Yss ei++ekLl+A +e+ ++F+ls
   Q: 2054 MTCVNYLKLPDYSSIEIMREKLLIAAREGqQSFHLS 2089
           *********************************985 PP

Organism

Astyanax mexicanus

Protein Sequence
(Fasta)

MSNRPNSNPG GSLRRSQRNT AAAQPHDHTL AGRLQSEHAK QKANSPPESR RSYSKASKAP 60
PTSAAGSARG HTSRRNSLSH SVSDPDSEAA GSSGQQEQRE GGSSSVSNVS SSRSLKRNSA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCTACAATT GTAACATATA AAATATTAGC GCATGTCAGC GCATGCGCAG TGTTGGTAAG 60
TGGCACATAT CGATGGGTAT CAGAACTCGA CGGAACACCA ACAGTCAAAA GAGACTCATA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR000569--HECT_dom
IPR004170--WWE-dom
IPR018123--WWE-dom_subgr

PROSITE

PS50237--HECT
PS50918--WWE

Pfam

PF00632--HECT
PF02825--WWE

SMART

SM00119--HECTc
SM00678--WWE

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000750	Aegilops tauschii	38.52	7.00e-128	452.00
IUUC-Aml-001502	Ailuropoda melanoleuca	80.85	0.00e+00	3016.00
IUUC-Atr-002821	Amborella trichopoda	37.59	5.00e-119	423.00
IUUC-Apl-003531	Anas platyrhynchos	85.88	0.00e+00	2897.00
IUUC-Aly-005962	Arabidopsis lyrata	38.74	2.00e-115	411.00
IUUC-Ath-006636	Arabidopsis thaliana	44.55	4.00e-116	413.00
IUUC-Ago-007875	Ashbya gossypii	36.77	2.00e-82	301.00
IUUC-Acl-008242	Aspergillus clavatus	36.27	1.00e-118	422.00
IUUC-Afl-008736	Aspergillus flavus	41.02	1.00e-117	418.00
IUUC-Afu-008812	Aspergillus fumigatus	36.87	4.00e-121	430.00
IUUC-Ani-009407	Aspergillus nidulans	38.04	1.00e-116	415.00
IUUC-Ang-009763	Aspergillus niger	40.84	2.00e-111	398.00
IUUC-Aor-009941	Aspergillus oryzae	31.97	4.00e-120	426.00
IUUC-Ate-010459	Aspergillus terreus	39.00	9.00e-92	332.00
IUUC-Bgr-012265	Blumeria graminis	35.76	2.00e-107	384.00
IUUC-Bta-013070	Bos taurus	79.31	0.00e+00	2982.00
IUUC-Bci-013890	Botrytis cinerea	40.48	2.00e-106	382.00
IUUC-Bdi-014046	Brachypodium distachyon	37.75	8.00e-123	436.00
IUUC-Bol-015942	Brassica oleracea	43.65	1.00e-114	408.00
IUUC-Bra-016849	Brassica rapa	43.65	3.00e-114	407.00
IUUC-Cja-019046	Callithrix jacchus	85.71	0.00e+00	2948.00
IUUC-Cfa-020521	Canis familiaris	87.50	0.00e+00	2862.00
IUUC-Cpo-021639	Cavia porcellus	77.50	0.00e+00	2923.00
IUUC-Cre-022767	Chlamydomonas reinhardtii	40.27	1.00e-92	333.00
IUUC-Csa-023231	Chlorocebus sabaeus	88.29	0.00e+00	3023.00
IUUC-Cho-024380	Choloepus hoffmanni	80.96	0.00e+00	1907.00
IUUC-Cin-025482	Ciona intestinalis	51.02	4.00e-160	557.00
IUUC-Csv-026121	Ciona savignyi	48.66	0.00e+00	1547.00
IUUC-Cgl-026716	Colletotrichum gloeosporioides	36.08	6.00e-113	402.00
IUUC-Cne-026857	Cryptococcus neoformans	39.54	5.00e-94	340.00
IUUC-Cme-027226	Cyanidioschyzon merolae	35.91	5.00e-75	276.00
IUUC-Dre-028174	Danio rerio	95.19	0.00e+00	3237.00
IUUC-Dor-030939	Dipodomys ordii	76.88	0.00e+00	1273.00
IUUC-Dse-031444	Dothistroma septosporum	34.56	4.00e-109	390.00
IUUC-Dme-032162	Drosophila melanogaster	67.12	4.00e-170	593.00
IUUC-Ete-032345	Echinops telfairi	79.64	0.00e+00	2044.00
IUUC-Eca-033229	Equus caballus	80.40	0.00e+00	2979.00
IUUC-Eeu-035205	Erinaceus europaeus	75.64	0.00e+00	2482.00
IUUC-Fca-036444	Felis catus	86.43	0.00e+00	2921.00
IUUC-Fal-037131	Ficedula albicollis	88.93	0.00e+00	3020.00
IUUC-Fox-038035	Fusarium oxysporum	37.37	2.00e-111	396.00
IUUC-Fso-038320	Fusarium solani	36.91	9.00e-112	399.00
IUUC-Gmo-039497	Gadus morhua	91.80	0.00e+00	3115.00
IUUC-Ggr-040057	Gaeumannomyces graminis	35.31	7.00e-109	389.00
IUUC-Gga-041021	Gallus gallus	89.26	0.00e+00	3045.00
IUUC-Gac-042474	Gasterosteus aculeatus	83.12	0.00e+00	3100.00
IUUC-Gma-043060	Glycine max	38.97	2.00e-121	431.00
IUUC-Ggo-044855	Gorilla gorilla	85.77	0.00e+00	2950.00
IUUC-Hsa-046147	Homo sapiens	86.36	0.00e+00	2955.00
IUUC-Hvu-047775	Hordeum vulgare	38.52	9.00e-126	445.00
IUUC-Itr-048131	Ictidomys tridecemlineatus	87.92	0.00e+00	3006.00
IUUC-Kpa-049098	Komagataella pastoris	37.70	6.00e-84	306.00
IUUC-Lch-049818	Latimeria chalumnae	87.68	0.00e+00	2932.00
IUUC-Lpe-051017	Leersia perrieri	38.31	7.00e-120	426.00
IUUC-Loc-051777	Lepisosteus oculatus	86.62	0.00e+00	3309.00
IUUC-Lma-052990	Leptosphaeria maculans	40.30	3.00e-115	410.00
IUUC-Laf-053727	Loxodonta africana	80.42	0.00e+00	3000.00
IUUC-Mcc-055799	Macaca mulatta	88.94	0.00e+00	2967.00
IUUC-Meu-056065	Macropus eugenii	83.11	0.00e+00	1897.00
IUUC-Mor-057054	Magnaporthe oryzae	39.13	3.00e-107	384.00
IUUC-Mpo-057417	Magnaporthe poae	39.70	3.00e-109	390.00
IUUC-Mtr-057849	Medicago truncatula	36.95	1.00e-112	401.00
IUUC-Mla-058870	Melampsora laricipopulina	43.80	1.00e-110	395.00
IUUC-Mga-059580	Meleagris gallopavo	87.37	0.00e+00	2528.00
IUUC-Mvi-060507	Microbotryum violaceum	40.73	9.00e-118	419.00
IUUC-Mmr-060816	Microcebus murinus	87.91	0.00e+00	3008.00
IUUC-Mdo-062866	Monodelphis domestica	88.79	0.00e+00	2866.00
IUUC-Mmu-063906	Mus musculus	87.96	0.00e+00	3010.00
IUUC-Mac-064675	Musa acuminata	38.34	7.00e-113	401.00
IUUC-Mpu-066199	Mustela putorius furo	88.71	0.00e+00	2917.00
IUUC-Mlu-067110	Myotis lucifugus	80.51	0.00e+00	2999.00
IUUC-Nfi-068482	Neosartorya fischeri	36.87	7.00e-121	429.00
IUUC-Ncr-068906	Neurospora crassa	38.75	1.00e-107	385.00
IUUC-Nle-069410	Nomascus leucogenys	86.64	0.00e+00	2942.00
IUUC-Opr-070401	Ochotona princeps	76.16	0.00e+00	1731.00
IUUC-Ont-072100	Oreochromis niloticus	94.18	0.00e+00	3185.00
IUUC-Oan-073121	Ornithorhynchus anatinus	82.24	0.00e+00	3151.00
IUUC-Ocu-074623	Oryctolagus cuniculus	88.82	0.00e+00	2967.00
IUUC-Oba-075380	Oryza barthii	31.45	3.00e-117	417.00
IUUC-Obr-076915	Oryza brachyantha	37.61	8.00e-121	429.00
IUUC-Ogl-077055	Oryza glaberrima	38.32	8.00e-120	426.00
IUUC-Ogu-078892	Oryza glumaepatula	39.68	1.00e-112	401.00
IUUC-Oin-079256	Oryza indica	38.14	2.00e-118	421.00
IUUC-Olo-080343	Oryza longistaminata	38.14	1.00e-118	421.00
IUUC-Ome-081422	Oryza meridionalis	38.14	2.00e-118	421.00
IUUC-Oni-083047	Oryza nivara	40.77	7.00e-114	405.00
IUUC-Opu-083641	Oryza punctata	40.22	5.00e-110	393.00
IUUC-Oru-084439	Oryza rufipogon	40.59	9.00e-113	402.00
IUUC-Osa-085972	Oryza sativa	38.32	6.00e-118	418.00
IUUC-Olu-087871	Ostreococcus lucimarinus	37.28	1.00e-88	320.00
IUUC-Oga-087908	Otolemur garnettii	85.39	0.00e+00	2938.00
IUUC-Oar-090277	Ovis aries	80.42	0.00e+00	3053.00
IUUC-Ptr-091543	Pan troglodytes	86.42	0.00e+00	2958.00
IUUC-Pan-092243	Papio anubis	88.88	0.00e+00	2966.00
IUUC-Psi-093150	Pelodiscus sinensis	81.25	0.00e+00	3096.00
IUUC-Pno-094891	Phaeosphaeria nodorum	41.28	5.00e-117	416.00
IUUC-Ppa-095181	Physcomitrella patens	42.33	1.00e-107	384.00
IUUC-Pfo-096267	Poecilia formosa	93.52	0.00e+00	3183.00
IUUC-Pab-098072	Pongo abelii	86.91	0.00e+00	2951.00
IUUC-Pop-099190	Populus trichocarpa	37.14	8.00e-118	419.00
IUUC-Pca-100311	Procavia capensis	79.68	0.00e+00	2708.00
IUUC-Ppe-101284	Prunus persica	37.28	2.00e-115	411.00
IUUC-Pva-102215	Pteropus vampyrus	81.18	0.00e+00	1029.00
IUUC-Pgr-103694	Puccinia graminis	36.46	3.00e-109	390.00
IUUC-Ptt-103916	Puccinia triticina	40.00	3.00e-102	367.00
IUUC-Pte-104346	Pyrenophora teres	40.93	7.00e-116	412.00
IUUC-Pyt-104508	Pyrenophora triticirepentis	40.93	3.00e-115	410.00
IUUC-Rno-105315	Rattus norvegicus	88.65	0.00e+00	2940.00
IUUC-Sce-106273	Saccharomyces cerevisiae	34.26	4.00e-71	264.00
IUUC-Sha-106835	Sarcophilus harrisii	88.41	0.00e+00	3063.00
IUUC-Sja-107943	Schizosaccharomyces japonicus	39.52	3.00e-97	350.00
IUUC-Spo-108081	Schizosaccharomyces pombe	39.96	3.00e-97	350.00
IUUC-Ssl-108560	Sclerotinia sclerotiorum	40.48	2.00e-110	394.00
IUUC-Smo-109590	Selaginella moellendorffii	43.10	5.00e-112	400.00
IUUC-Sit-109757	Setaria italica	37.77	2.00e-122	434.00
IUUC-Sly-111469	Solanum lycopersicum	38.59	1.00e-121	432.00
IUUC-Stu-112896	Solanum tuberosum	37.41	1.00e-105	377.00
IUUC-Sar-113224	Sorex araneus	77.75	0.00e+00	1426.00
IUUC-Sbi-113884	Sorghum bicolor	38.81	7.00e-125	442.00
IUUC-Sre-114993	Sporisorium reilianum	33.81	7.00e-102	366.00
IUUC-Ssc-115535	Sus scrofa	83.93	0.00e+00	2883.00
IUUC-Tgu-117493	Taeniopygia guttata	87.64	0.00e+00	2256.00
IUUC-Tru-118669	Takifugu rubripes	90.82	0.00e+00	3046.00
IUUC-Tsy-119373	Tarsius syrichta	81.77	0.00e+00	1640.00
IUUC-Tni-120049	Tetraodon nigroviridis	82.75	0.00e+00	904.00
IUUC-Tca-121779	Theobroma cacao	37.77	3.00e-114	407.00
IUUC-Tre-122195	Trichoderma reesei	36.06	2.00e-107	385.00
IUUC-Tvi-122650	Trichoderma virens	35.89	4.00e-109	390.00
IUUC-Tae-123580	Triticum aestivum	38.58	3.00e-126	446.00
IUUC-Tur-126295	Triticum urartu	38.69	1.00e-127	452.00
IUUC-Tme-126964	Tuber melanosporum	41.27	1.00e-108	389.00
IUUC-Tbe-128149	Tupaia belangeri	74.83	0.00e+00	1126.00
IUUC-Ttr-128165	Tursiops truncatus	84.75	0.00e+00	2763.00
IUUC-Uma-129365	Ustilago maydis	35.71	3.00e-89	324.00
IUUC-Vda-129725	Verticillium dahliae	40.78	9.00e-110	392.00
IUUC-Vpa-130678	Vicugna pacos	85.55	0.00e+00	2406.00
IUUC-Vvi-131147	Vitis vinifera	38.83	4.00e-121	430.00
IUUC-Xtr-132636	Xenopus tropicalis	78.53	0.00e+00	2918.00
IUUC-Xma-133458	Xiphophorus maculatus	93.57	0.00e+00	3212.00
IUUC-Yli-134481	Yarrowia lipolytica	39.56	5.00e-99	356.00
IUUC-Zma-135657	Zea mays	38.33	5.00e-122	433.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence