iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Ath-006636

UUCD1 version

UUC-ArT-01443

Ensembl Protein ID

AT4G38600.3

UniProt Accession

Q6WWW4; Q0WN20; Q9SZN9; Q9SZP0; UPL3_ARATH

Genbank Protein ID

AAP91821.1; CAB37516.1; CAB37517.1; CAB80524.1; CAB80525.1; AEE86954.1; ANM67531.1; BAF01480.1; CAE30362.1

Protein Name

E3 ubiquitin-protein ligase UPL3; HECT ubiquitin-protein ligase 3; HECT-type E3 ubiquitin transferase UPL3; Protein KAKTUS

Genbank Nucleotide ID

AY265959; AL035540; AL035540; AL161593; AL161593; CP002687; CP002687; AK229635; BN000268

Gene Name

UPL3; KAK; At4g38600/At4g38610; F20M13.160/F20M13.170

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT4G38600	AT4G38600.3	AT4G38600.3
AT4G38600	AT4G38600.2	AT4G38600.2

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
Protein-protein Interaction
PINA	HINT
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/HECT	HECT	14530964; 12969426

Classification

Family	E-value	Score	Start	End
E3 activity/HECT	7.00e-109	365.1	1491	1887

Active Site

Position(s)	Description	Evidence
1855	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp................................ 65
           +s++k++leve+ gE g++l G+t+ef++lls++lq+++lg+++ s++dk ++q+ +d++ + +                                
   Q: 1491 YSSQKAVLEVEYFGEVGTGL-GPTLEFYTLLSHDLQKASLGMWRSSSGDKVSMQIGRDEIEDGKpsaanrdivlaplglfprpwpstadiseggqf 1585
           578999**************.**************************************988779******************************* PP
   S: 66   .ehlklFeflGrllgkalqdgrlldlplsksfyklllgkklsledleevdpelykslkeikena...........esdieelgldltfsvseei.. 147
            +++++F++lGr+++kalqdgrlld+pls++fykl+lg++l+l+d+  +d+el k+l+e++  +           +++++ ++l+l+ ++ e++  
   Q: 1586 hKVIEYFRLLGRVMAKALQDGRLLDVPLSTAFYKLILGQELDLHDIVLFDAELGKTLQELRVVVarkhylegvggDNSSTISDLCLRGCRIEDLsl 1681
           *************************************************************9988888888877777999999******9999899 PP
   S: 148  ...lgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGe.eeidvedlkketkykggy 239
              l+ + e+ L +g+e +++t  N+eeY++lvv++++k+g+++q+eafr+Gfn+v+++++l++Ft++el++l+cG+ e ++ve+l++++k+++gy
   Q: 1682 eftLPGYPEYILRSGDEIVDIT--NLEEYISLVVDATVKRGVTRQIEAFRSGFNQVFDITSLQIFTPSELDYLLCGRrELWEVETLAEHIKFDHGY 1775
           9999******999999999999..*****************************************************999**************** PP
   S: 240  tedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk...............dasddrlPssnTCfnyLkLPeYsskeilk 320
           +++spai++++e++ e+++++++af+qFvTg +rlP+gG+a l+p+l+++rk               +++dd+lPs++TC+nyLkLP+Ys+kei++
   Q: 1776 NAKSPAIINLLEIMGELTADQQRAFCQFVTGAPRLPPGGLAVLNPKLTIVRKhsstssaaangagasETADDDLPSVMTCANYLKLPPYSTKEIMY 1871
           *****************************************************************999999************************* PP
   S: 321  ekLlyAieet.kgFel 335
           +kLlyAi+e+  +F+l
   Q: 1872 KKLLYAINEGqGSFDL 1887
           **********889987 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Probable E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the repression of endoreduplication process and the cell morphogenesis in the trichomes.

Protein Sequence
(Fasta)

METRSRKRAE ATSAAPSSSS SSPPPPPSAS GPTTRSKRAR LSSSSSSSLA PTPPSSSTTT 60
RSRSSRSAAA AAPMDTSTDS SGFRRGGRGN RGNNNDNSDK GKEKEHDVRI RERERERDRA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCTCTCTCT CTCTTTTCTT TTTTTATATA ATATTTATAT GTCTTCTTCT ATTTTATTCA 60
TCAGTCGACG GACTCTCTCG ATTTAGGGTT TTCTTCTTCT AATCTCTCTT TTCATCGTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR000225--Armadillo
IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00185--ARM
SM00119--HECTc

Gene Ontology

GO:0005886--C:plasma membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0042023--P:DNA endoreduplication
GO:0010091--P:trichome branching

KEGG

ath:AT4G38600

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000750	Aegilops tauschii	63.16	0.00e+00	2014.00
IUUC-Aml-001502	Ailuropoda melanoleuca	38.71	7.00e-121	429.00
IUUC-Atr-002821	Amborella trichopoda	67.33	0.00e+00	2007.00
IUUC-Apl-003531	Anas platyrhynchos	37.29	7.00e-110	392.00
IUUC-Aly-005962	Arabidopsis lyrata	97.49	0.00e+00	2890.00
IUUC-Ago-007875	Ashbya gossypii	35.99	2.00e-83	303.00
IUUC-Acl-008242	Aspergillus clavatus	38.27	7.00e-117	415.00
IUUC-Afl-008736	Aspergillus flavus	41.70	6.00e-113	402.00
IUUC-Afu-008812	Aspergillus fumigatus	41.65	4.00e-114	406.00
IUUC-Ani-009407	Aspergillus nidulans	38.09	4.00e-112	399.00
IUUC-Ang-009763	Aspergillus niger	40.62	1.00e-107	384.00
IUUC-Aor-009941	Aspergillus oryzae	41.70	9.00e-113	401.00
IUUC-Ate-010459	Aspergillus terreus	40.35	3.00e-95	343.00
IUUC-Ame-011761	Astyanax mexicanus	38.45	1.00e-121	431.00
IUUC-Bgr-012265	Blumeria graminis	40.14	5.00e-105	376.00
IUUC-Bta-013070	Bos taurus	38.71	2.00e-120	427.00
IUUC-Bci-013890	Botrytis cinerea	41.03	2.00e-106	380.00
IUUC-Bdi-014961	Brachypodium distachyon	61.41	0.00e+00	1845.00
IUUC-Bol-015942	Brassica oleracea	88.46	0.00e+00	2707.00
IUUC-Bra-016849	Brassica rapa	88.68	0.00e+00	2734.00
IUUC-Cel-018153	Caenorhabditis elegans	36.05	4.00e-88	320.00
IUUC-Cja-019046	Callithrix jacchus	38.71	2.00e-120	427.00
IUUC-Cfa-020521	Canis familiaris	38.57	4.00e-120	426.00
IUUC-Cpo-021639	Cavia porcellus	38.71	2.00e-119	424.00
IUUC-Cre-022767	Chlamydomonas reinhardtii	52.22	5.00e-138	483.00
IUUC-Csa-023231	Chlorocebus sabaeus	38.71	2.00e-120	427.00
IUUC-Cho-024380	Choloepus hoffmanni	45.07	5.00e-92	333.00
IUUC-Cin-025482	Ciona intestinalis	38.62	5.00e-103	367.00
IUUC-Csv-026121	Ciona savignyi	34.13	5.00e-104	372.00
IUUC-Cgl-026716	Colletotrichum gloeosporioides	36.02	2.00e-112	400.00
IUUC-Cne-026857	Cryptococcus neoformans	37.10	1.00e-90	328.00
IUUC-Cme-027226	Cyanidioschyzon merolae	36.66	5.00e-78	286.00
IUUC-Dre-028174	Danio rerio	38.45	4.00e-122	433.00
IUUC-Dor-030939	Dipodomys ordii	35.00	1.00e-96	348.00
IUUC-Dse-031444	Dothistroma septosporum	38.42	2.00e-110	394.00
IUUC-Dme-031739	Drosophila melanogaster	32.29	1.00e-87	318.00
IUUC-Ete-032345	Echinops telfairi	32.95	5.00e-87	316.00
IUUC-Eca-033229	Equus caballus	38.66	2.00e-119	424.00
IUUC-Eeu-035205	Erinaceus europaeus	38.71	2.00e-117	417.00
IUUC-Fca-036444	Felis catus	38.54	5.00e-118	419.00
IUUC-Fal-037131	Ficedula albicollis	38.77	2.00e-121	430.00
IUUC-Fox-038035	Fusarium oxysporum	39.79	3.00e-111	395.00
IUUC-Fso-038320	Fusarium solani	40.66	3.00e-114	406.00
IUUC-Gmo-039497	Gadus morhua	39.02	8.00e-125	442.00
IUUC-Ggr-040057	Gaeumannomyces graminis	38.08	2.00e-113	404.00
IUUC-Gga-041021	Gallus gallus	38.63	6.00e-121	429.00
IUUC-Gac-042474	Gasterosteus aculeatus	38.86	6.00e-123	435.00
IUUC-Gma-043715	Glycine max	72.24	0.00e+00	2261.00
IUUC-Ggo-044855	Gorilla gorilla	38.71	1.00e-120	427.00
IUUC-Hsa-046147	Homo sapiens	38.71	2.00e-120	427.00
IUUC-Hvu-047775	Hordeum vulgare	65.23	0.00e+00	2034.00
IUUC-Itr-048131	Ictidomys tridecemlineatus	38.71	5.00e-120	426.00
IUUC-Kpa-049098	Komagataella pastoris	39.30	7.00e-90	325.00
IUUC-Lch-049818	Latimeria chalumnae	37.71	9.00e-113	402.00
IUUC-Lpe-051017	Leersia perrieri	64.89	0.00e+00	1862.00
IUUC-Loc-051777	Lepisosteus oculatus	39.02	3.00e-124	439.00
IUUC-Lma-052990	Leptosphaeria maculans	40.55	1.00e-111	397.00
IUUC-Laf-053727	Loxodonta africana	38.71	2.00e-120	427.00
IUUC-Mcc-055799	Macaca mulatta	38.71	3.00e-120	426.00
IUUC-Meu-056065	Macropus eugenii	36.32	8.00e-97	348.00
IUUC-Mor-057054	Magnaporthe oryzae	39.79	7.00e-109	389.00
IUUC-Mpo-057417	Magnaporthe poae	38.24	2.00e-112	400.00
IUUC-Mtr-057849	Medicago truncatula	71.26	0.00e+00	2202.00
IUUC-Mla-058870	Melampsora laricipopulina	41.33	2.00e-96	347.00
IUUC-Mga-059580	Meleagris gallopavo	32.55	8.00e-67	249.00
IUUC-Mvi-060507	Microbotryum violaceum	39.23	1.00e-110	395.00
IUUC-Mmr-060816	Microcebus murinus	38.57	3.00e-119	423.00
IUUC-Mdo-062866	Monodelphis domestica	36.57	7.00e-98	352.00
IUUC-Mmu-063906	Mus musculus	38.43	6.00e-118	419.00
IUUC-Mac-065153	Musa acuminata	65.56	0.00e+00	1004.00
IUUC-Mpu-066199	Mustela putorius furo	38.71	1.00e-120	427.00
IUUC-Mlu-067110	Myotis lucifugus	38.71	3.00e-119	423.00
IUUC-Nfi-068482	Neosartorya fischeri	41.65	6.00e-115	409.00
IUUC-Ncr-068906	Neurospora crassa	40.24	3.00e-111	396.00
IUUC-Nle-069410	Nomascus leucogenys	38.71	1.00e-120	427.00
IUUC-Opr-070401	Ochotona princeps	40.75	5.00e-49	190.00
IUUC-Ont-072100	Oreochromis niloticus	39.02	1.00e-123	437.00
IUUC-Oan-073121	Ornithorhynchus anatinus	38.29	4.00e-118	419.00
IUUC-Ocu-074623	Oryctolagus cuniculus	38.71	4.00e-120	426.00
IUUC-Oba-074990	Oryza barthii	63.72	0.00e+00	1785.00
IUUC-Obr-076915	Oryza brachyantha	64.84	0.00e+00	1912.00
IUUC-Ogl-077055	Oryza glaberrima	62.34	0.00e+00	1793.00
IUUC-Ogu-078685	Oryza glumaepatula	63.74	0.00e+00	1787.00
IUUC-Oin-079256	Oryza indica	64.75	0.00e+00	1862.00
IUUC-Olo-080343	Oryza longistaminata	64.98	0.00e+00	1857.00
IUUC-Ome-081422	Oryza meridionalis	64.72	0.00e+00	1890.00
IUUC-Oni-082469	Oryza nivara	64.05	0.00e+00	1848.00
IUUC-Opu-083792	Oryza punctata	63.40	0.00e+00	1822.00
IUUC-Oru-084607	Oryza rufipogon	63.57	0.00e+00	1785.00
IUUC-Osa-085972	Oryza sativa	70.54	0.00e+00	961.00
IUUC-Ola-087173	Oryzias latipes	38.88	2.00e-123	437.00
IUUC-Olu-087871	Ostreococcus lucimarinus	46.31	3.00e-128	451.00
IUUC-Oga-087908	Otolemur garnettii	38.57	1.00e-119	424.00
IUUC-Oar-090277	Ovis aries	38.71	2.00e-120	427.00
IUUC-Ptr-091543	Pan troglodytes	38.71	2.00e-120	427.00
IUUC-Pan-092243	Papio anubis	38.71	4.00e-120	426.00
IUUC-Psi-093150	Pelodiscus sinensis	38.86	7.00e-120	425.00
IUUC-Pno-094891	Phaeosphaeria nodorum	40.38	3.00e-113	403.00
IUUC-Ppa-095181	Physcomitrella patens	58.46	0.00e+00	718.00
IUUC-Pfo-096267	Poecilia formosa	37.88	6.00e-120	426.00
IUUC-Pab-098072	Pongo abelii	38.71	1.00e-120	427.00
IUUC-Pop-099190	Populus trichocarpa	75.31	0.00e+00	2235.00
IUUC-Pca-100311	Procavia capensis	38.96	7.00e-121	428.00
IUUC-Ppe-101284	Prunus persica	75.85	0.00e+00	2367.00
IUUC-Pva-102215	Pteropus vampyrus	36.69	3.00e-100	360.00
IUUC-Pgr-103694	Puccinia graminis	41.13	2.00e-97	350.00
IUUC-Ptt-103916	Puccinia triticina	39.77	9.00e-91	328.00
IUUC-Pte-104346	Pyrenophora teres	39.73	1.00e-113	404.00
IUUC-Pyt-104508	Pyrenophora triticirepentis	39.73	2.00e-113	404.00
IUUC-Rno-105315	Rattus norvegicus	38.71	2.00e-119	424.00
IUUC-Sha-106835	Sarcophilus harrisii	38.57	3.00e-118	420.00
IUUC-Sja-107943	Schizosaccharomyces japonicus	39.22	1.00e-94	341.00
IUUC-Spo-108081	Schizosaccharomyces pombe	37.84	1.00e-88	321.00
IUUC-Ssl-108560	Sclerotinia sclerotiorum	41.71	2.00e-109	390.00
IUUC-Smo-108776	Selaginella moellendorffii	60.78	0.00e+00	781.00
IUUC-Sit-109757	Setaria italica	62.56	0.00e+00	2000.00
IUUC-Sly-111469	Solanum lycopersicum	72.73	0.00e+00	2283.00
IUUC-Stu-112009	Solanum tuberosum	67.98	0.00e+00	1166.00
IUUC-Sar-113224	Sorex araneus	45.57	2.00e-85	311.00
IUUC-Sbi-114313	Sorghum bicolor	64.89	0.00e+00	2058.00
IUUC-Sre-114993	Sporisorium reilianum	35.83	1.00e-98	355.00
IUUC-Ssc-115535	Sus scrofa	36.31	3.00e-101	363.00
IUUC-Tgu-117493	Taeniopygia guttata	32.55	8.00e-67	249.00
IUUC-Tru-118669	Takifugu rubripes	38.31	2.00e-121	431.00
IUUC-Tsy-119373	Tarsius syrichta	33.65	6.00e-82	299.00
IUUC-Tni-120049	Tetraodon nigroviridis	38.38	2.00e-91	329.00
IUUC-Tca-121779	Theobroma cacao	76.78	0.00e+00	2338.00
IUUC-Tre-122195	Trichoderma reesei	37.48	4.00e-112	399.00
IUUC-Tvi-122650	Trichoderma virens	36.48	4.00e-111	396.00
IUUC-Tae-123120	Triticum aestivum	63.49	0.00e+00	1915.00
IUUC-Tur-126295	Triticum urartu	63.49	0.00e+00	1982.00
IUUC-Tme-126964	Tuber melanosporum	42.18	7.00e-111	395.00
IUUC-Tbe-128149	Tupaia belangeri	42.22	1.00e-71	265.00
IUUC-Ttr-128165	Tursiops truncatus	38.71	2.00e-120	427.00
IUUC-Uma-129365	Ustilago maydis	37.65	4.00e-87	317.00
IUUC-Vda-129725	Verticillium dahliae	41.73	7.00e-112	398.00
IUUC-Vpa-130678	Vicugna pacos	38.71	4.00e-120	426.00
IUUC-Vvi-131147	Vitis vinifera	74.78	0.00e+00	2301.00
IUUC-Xtr-132636	Xenopus tropicalis	37.88	5.00e-115	409.00
IUUC-Xma-133458	Xiphophorus maculatus	38.59	5.00e-123	436.00
IUUC-Yli-134481	Yarrowia lipolytica	39.43	3.00e-98	353.00
IUUC-Zma-135782	Zea mays	64.18	0.00e+00	2033.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence