iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-045737

UUCD1 version

UUC-HoS-00314

Ensembl Protein ID

ENSP00000321239.5

UniProt Accession

Q96PM5; B3KRG3; C7E541; C7E542; C7E543; D3YRV2; E7EMC8; E7ETW5; J3KPI0; Q2KN33; Q59GN7; Q86X26; Q96PR5; ZN363_HUMAN

Genbank Protein ID

ACT35531.1; ACT35532.1; ACT35533.1; AAL76101.1; AAK96896.1; AAL09356.1; BAD92309.1; AAX78233.1; ADD21555.1; BAG52375.1; EAX05725.1; AAH47393.1

Protein Name

RING finger and CHY zinc finger domain-containing protein 1; Androgen receptor N-terminal-interacting protein; CH-rich-interacting match with PLAG1; E3 ubiquitin-protein ligase Pirh2; RING finger protein 199; RING-type E3 ubiquitin transferase RCHY1; Zinc finger protein 363; p53-induced RING-H2 protein

Genbank Nucleotide ID

GQ250944; GQ250945; GQ250946; AF247041; AF255666; AF305424; AB209072; AY888047; GU937000; AK091501; AC096759; BC047393

Gene Name

RCHY1; ARNIP; CHIMP; PIRH2; RNF199; ZNF363

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000163743.13	ENST00000513257.5	ENSP00000421084.1
ENSG00000163743.13	ENST00000324439.9	ENSP00000321239.5
ENSG00000163743.13	ENST00000380840.6	ENSP00000370220.2
ENSG00000163743.13	ENST00000505105.5	ENSP00000424631.1
ENSG00000163743.13	ENST00000512706.5	ENSP00000423976.1
ENSG00000163743.13	ENST00000507014.1	ENSP00000424472.1
ENSG00000163743.13	ENST00000513909.5	ENSP00000427205.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
DNA Methylation
MethyCancer	TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	20210701; 20598683; 18344599; 20357911

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	9.70e-07	30.9	145	186

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdg...plvlpCgHvfhadClqkwpglknssskefrCPlC 45
           C+iCled+ +     +vlpCgH+ h++C + +       +   rCPlC
   Q: 145  CPICLEDIHTSrvvAHVLPCGHLLHRTCYEEM------LKEGYRCPLC 186
           ********553334668***********8888......9********* PP

Organism

Homo sapiens

Functional Description
(View)

Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity.

Protein Sequence
(Fasta)

MAATAREDGA SGQERGQRGC EHYDRGCLLK APCCDKLYTC RLCHDNNEDH QLDRFKVKEV 60
QCINCEKIQH AQQTCEECST LFGEYYCDIC HLFDKDKKQY HCENCGICRI GPKEDFFHCL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAGCAGCGC GCGGGACCCG CTGAGCCCAG GGCCCGGGCC GAGCTCCGCC CCTTTCTCCA 60
GGCTCCCCGC CACCGGAGGG AGAGAGGGAG GACCCGTCAC AGGTAACGAT GCGCCCAGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR004039--Rubredoxin-type_fold
IPR008913--Znf_CHY
IPR017921--Znf_CTCHY
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51266--ZF_CHY
PS51270--ZF_CTCHY
PS50089--ZF_RING_2

Pfam

PF05495--zf-CHY
PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0016607--C:nuclear speck
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0002039--F:p53 binding
GO:0042803--F:protein homodimerization activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0070987--P:error-free translesion synthesis
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0031398--P:positive regulation of protein ubiquitination
GO:0051865--P:protein autoubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

hsa:25898

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000576	Aegilops tauschii	45.00	3.00e-54	207.00
IUUC-Aml-002312	Ailuropoda melanoleuca	96.17	2.00e-149	521.00
IUUC-Atr-003010	Amborella trichopoda	46.06	7.00e-59	221.00
IUUC-Apl-003676	Anas platyrhynchos	85.62	2.00e-67	247.00
IUUC-Aly-005993	Arabidopsis lyrata	48.64	3.00e-65	241.00
IUUC-Ath-007665	Arabidopsis thaliana	47.06	2.00e-57	215.00
IUUC-Ago-007995	Ashbya gossypii	44.44	1.00e-53	203.00
IUUC-Acl-008144	Aspergillus clavatus	44.73	8.00e-58	218.00
IUUC-Afl-008618	Aspergillus flavus	44.49	7.00e-57	215.00
IUUC-Afu-008863	Aspergillus fumigatus	44.92	1.00e-58	221.00
IUUC-Ani-009131	Aspergillus nidulans	43.64	2.00e-49	190.00
IUUC-Ang-009555	Aspergillus niger	44.07	1.00e-57	218.00
IUUC-Aor-010177	Aspergillus oryzae	42.92	1.00e-51	196.00
IUUC-Ate-010343	Aspergillus terreus	41.49	1.00e-50	194.00
IUUC-Bgr-012193	Blumeria graminis	45.57	5.00e-57	216.00
IUUC-Bta-013191	Bos taurus	91.19	2.00e-137	481.00
IUUC-Bci-013852	Botrytis cinerea	45.76	8.00e-57	215.00
IUUC-Bdi-014852	Brachypodium distachyon	44.98	2.00e-59	222.00
IUUC-Bol-015118	Brassica oleracea	46.69	1.00e-63	236.00
IUUC-Bra-017289	Brassica rapa	45.78	6.00e-62	230.00
IUUC-Cja-019581	Callithrix jacchus	99.62	5.00e-154	536.00
IUUC-Cfa-021051	Canis familiaris	95.95	3.00e-139	487.00
IUUC-Cpo-022137	Cavia porcellus	96.73	6.00e-87	312.00
IUUC-Cre-022565	Chlamydomonas reinhardtii	42.34	1.00e-53	202.00
IUUC-Csa-024259	Chlorocebus sabaeus	100.00	8.00e-155	539.00
IUUC-Cho-024855	Choloepus hoffmanni	89.27	1.00e-133	469.00
IUUC-Cin-025667	Ciona intestinalis	50.83	2.00e-69	255.00
IUUC-Csv-025807	Ciona savignyi	49.60	8.00e-70	256.00
IUUC-Cgl-026589	Colletotrichum gloeosporioides	44.44	4.00e-55	209.00
IUUC-Cme-027329	Cyanidioschyzon merolae	43.15	2.00e-54	208.00
IUUC-Dre-028584	Danio rerio	72.46	3.00e-105	374.00
IUUC-Dor-030930	Dipodomys ordii	83.11	5.00e-104	369.00
IUUC-Dse-031251	Dothistroma septosporum	37.23	2.00e-51	197.00
IUUC-Dme-031649	Drosophila melanogaster	48.41	5.00e-62	231.00
IUUC-Ete-032847	Echinops telfairi	68.68	9.00e-104	369.00
IUUC-Eca-033470	Equus caballus	97.40	8.00e-133	465.00
IUUC-Eeu-034769	Erinaceus europaeus	71.71	4.00e-58	218.00
IUUC-Fca-035728	Felis catus	95.79	2.00e-147	514.00
IUUC-Fal-036768	Ficedula albicollis	81.28	4.00e-107	380.00
IUUC-Fox-037872	Fusarium oxysporum	45.39	4.00e-35	142.00
IUUC-Fso-038415	Fusarium solani	43.67	1.00e-58	221.00
IUUC-Gmo-038620	Gadus morhua	65.35	2.00e-95	342.00
IUUC-Ggr-040055	Gaeumannomyces graminis	43.16	4.00e-54	206.00
IUUC-Gga-040156	Gallus gallus	79.83	4.00e-114	403.00
IUUC-Gac-041535	Gasterosteus aculeatus	69.92	3.00e-92	331.00
IUUC-Gma-043631	Glycine max	45.85	2.00e-61	229.00
IUUC-Ggo-044951	Gorilla gorilla	100.00	7.00e-155	539.00
IUUC-Hvu-047085	Hordeum vulgare	46.44	2.00e-58	219.00
IUUC-Itr-048684	Ictidomys tridecemlineatus	97.70	7.00e-152	529.00
IUUC-Kpa-049272	Komagataella pastoris	42.26	5.00e-53	202.00
IUUC-Lch-050661	Latimeria chalumnae	70.69	8.00e-100	356.00
IUUC-Lpe-051107	Leersia perrieri	46.44	1.00e-58	219.00
IUUC-Loc-051936	Lepisosteus oculatus	71.31	5.00e-105	374.00
IUUC-Lma-053154	Leptosphaeria maculans	42.53	2.00e-20	92.80
IUUC-Laf-054226	Loxodonta africana	95.79	4.00e-146	510.00
IUUC-Mcc-055281	Macaca mulatta	100.00	8.00e-155	539.00
IUUC-Meu-056901	Macropus eugenii	83.12	7.00e-104	369.00
IUUC-Mor-057100	Magnaporthe oryzae	43.87	1.00e-60	228.00
IUUC-Mpo-057579	Magnaporthe poae	42.86	7.00e-56	212.00
IUUC-Mtr-058223	Medicago truncatula	44.31	2.00e-60	226.00
IUUC-Mla-059118	Melampsora laricipopulina	33.33	5.00e-04	41.60
IUUC-Mga-059512	Meleagris gallopavo	86.78	1.00e-60	224.00
IUUC-Mmr-060992	Microcebus murinus	95.75	7.00e-140	489.00
IUUC-Mdo-062157	Monodelphis domestica	88.09	1.00e-115	409.00
IUUC-Mmu-063959	Mus musculus	90.42	4.00e-135	473.00
IUUC-Mac-065603	Musa acuminata	43.87	3.00e-60	225.00
IUUC-Mpu-065859	Mustela putorius furo	95.37	4.00e-58	216.00
IUUC-Mlu-067798	Myotis lucifugus	87.79	3.00e-131	461.00
IUUC-Nfi-068506	Neosartorya fischeri	44.49	1.00e-57	218.00
IUUC-Ncr-068859	Neurospora crassa	41.98	4.00e-54	206.00
IUUC-Nle-069585	Nomascus leucogenys	100.00	8.00e-155	539.00
IUUC-Opr-070267	Ochotona princeps	93.49	1.00e-142	498.00
IUUC-Ont-071374	Oreochromis niloticus	70.34	3.00e-97	348.00
IUUC-Oan-073381	Ornithorhynchus anatinus	83.19	9.00e-114	402.00
IUUC-Ocu-074867	Oryctolagus cuniculus	96.93	5.00e-151	526.00
IUUC-Oba-075296	Oryza barthii	46.44	1.00e-58	219.00
IUUC-Obr-076751	Oryza brachyantha	45.60	1.00e-58	219.00
IUUC-Ogl-077845	Oryza glaberrima	46.44	1.00e-58	219.00
IUUC-Ogu-078233	Oryza glumaepatula	43.90	2.00e-55	209.00
IUUC-Oin-079830	Oryza indica	44.84	2.00e-59	222.00
IUUC-Olo-080782	Oryza longistaminata	45.19	8.00e-57	214.00
IUUC-Ome-081602	Oryza meridionalis	46.44	1.00e-58	219.00
IUUC-Oni-082797	Oryza nivara	46.44	1.00e-58	219.00
IUUC-Opu-083572	Oryza punctata	46.44	1.00e-58	219.00
IUUC-Oru-085188	Oryza rufipogon	46.44	1.00e-58	221.00
IUUC-Osa-085573	Oryza sativa	46.44	2.00e-58	219.00
IUUC-Ola-087568	Oryzias latipes	69.07	2.00e-93	335.00
IUUC-Olu-087838	Ostreococcus lucimarinus	40.91	8.00e-52	197.00
IUUC-Oga-089082	Otolemur garnettii	91.57	3.00e-140	490.00
IUUC-Oar-089298	Ovis aries	89.66	4.00e-136	477.00
IUUC-Ptr-091569	Pan troglodytes	99.62	3.00e-154	537.00
IUUC-Pan-092256	Papio anubis	97.70	3.00e-150	524.00
IUUC-Psi-093159	Pelodiscus sinensis	83.81	9.00e-106	375.00
IUUC-Pma-094483	Petromyzon marinus	57.46	4.00e-78	284.00
IUUC-Pno-094998	Phaeosphaeria nodorum	41.53	4.00e-53	202.00
IUUC-Ppa-095916	Physcomitrella patens	45.70	4.00e-63	234.00
IUUC-Pfo-096583	Poecilia formosa	68.64	3.00e-100	357.00
IUUC-Pab-098741	Pongo abelii	100.00	8.00e-155	539.00
IUUC-Pop-099476	Populus trichocarpa	45.12	2.00e-63	235.00
IUUC-Pca-100669	Procavia capensis	92.59	2.00e-71	262.00
IUUC-Ppe-101325	Prunus persica	44.92	1.00e-60	226.00
IUUC-Pva-102213	Pteropus vampyrus	94.64	2.00e-145	508.00
IUUC-Ptt-103991	Puccinia triticina	44.12	4.00e-03	37.00
IUUC-Pte-104080	Pyrenophora teres	40.60	7.00e-51	196.00
IUUC-Pyt-104774	Pyrenophora triticirepentis	40.60	3.00e-51	196.00
IUUC-Rno-105229	Rattus norvegicus	90.04	1.00e-141	495.00
IUUC-Sha-106745	Sarcophilus harrisii	86.58	7.00e-112	396.00
IUUC-Sja-107843	Schizosaccharomyces japonicus	42.74	1.00e-53	203.00
IUUC-Spo-108194	Schizosaccharomyces pombe	41.67	3.00e-53	202.00
IUUC-Ssl-108426	Sclerotinia sclerotiorum	37.50	9.00e-42	165.00
IUUC-Smo-108873	Selaginella moellendorffii	46.56	2.00e-59	222.00
IUUC-Sit-110031	Setaria italica	45.64	3.00e-59	222.00
IUUC-Sly-110906	Solanum lycopersicum	46.12	2.00e-60	225.00
IUUC-Stu-112734	Solanum tuberosum	44.80	2.00e-59	223.00
IUUC-Sar-113709	Sorex araneus	91.19	3.00e-140	490.00
IUUC-Sbi-114253	Sorghum bicolor	46.90	5.00e-63	234.00
IUUC-Ssc-116428	Sus scrofa	87.50	4.00e-117	413.00
IUUC-Tgu-116992	Taeniopygia guttata	80.66	1.00e-110	392.00
IUUC-Tru-118486	Takifugu rubripes	68.58	1.00e-83	302.00
IUUC-Tsy-118833	Tarsius syrichta	81.39	3.00e-106	377.00
IUUC-Tni-120395	Tetraodon nigroviridis	69.49	5.00e-91	327.00
IUUC-Tca-121091	Theobroma cacao	45.34	4.00e-56	211.00
IUUC-Tre-121938	Trichoderma reesei	43.39	4.00e-58	219.00
IUUC-Tvi-122465	Trichoderma virens	43.39	9.00e-59	221.00
IUUC-Tae-122877	Triticum aestivum	46.06	2.00e-58	219.00
IUUC-Tur-126465	Triticum urartu	42.48	2.00e-56	212.00
IUUC-Tme-127113	Tuber melanosporum	44.76	2.00e-60	227.00
IUUC-Tbe-127598	Tupaia belangeri	76.19	1.00e-90	325.00
IUUC-Ttr-128736	Tursiops truncatus	88.89	5.00e-67	247.00
IUUC-Vda-129684	Verticillium dahliae	45.38	2.00e-52	200.00
IUUC-Vpa-130311	Vicugna pacos	91.77	1.00e-124	438.00
IUUC-Vvi-131084	Vitis vinifera	44.88	5.00e-54	204.00
IUUC-Xtr-132909	Xenopus tropicalis	76.17	1.00e-107	382.00
IUUC-Xma-133441	Xiphophorus maculatus	69.07	1.00e-100	359.00
IUUC-Yli-134456	Yarrowia lipolytica	45.57	3.00e-58	219.00
IUUC-Zma-134792	Zea mays	46.06	2.00e-60	226.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence