iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mtr-058278

Ensembl Protein ID

AES99632

UniProt Accession

E4NKF8; A0A0C3XRJ4; G7K272; PUB1_MEDTR

Genbank Protein ID

DAA33939.1; AES99632.2

Protein Name

U-box domain-containing protein 1; Plant U-box protein 1; RING-type E3 ubiquitin transferase PUB1

Genbank Nucleotide ID

BK007068; CM001221

Gene Name

PUB1; MTR_5g083030

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
MTR_5g083030	AES99632	AES99632

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/U-box	U-box	20971894

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	2.20e-32	112.3	293	365

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqawceenss 74
           +p+ef+CpIsl+lMrdPv+++sG+tydr sI++w++sg++tcP+ +q+l ++ l+Pn++l++l+++wc en++
   Q: 293  IPDEFRCPISLDLMRDPVIVSSGHTYDRISIAEWINSGHHTCPKSGQRLIHTALIPNYALKSLVHQWCYENNV 365
           8********************************************************************9976 PP

Organism

Medicago truncatula

Functional Description
(View)

Exhibits U-box-dependent E3 ubiquitin ligase activity in vitro (PubMed:20971894, PubMed:26839127). Negatively modulates successive stages of infection and development of rhizobial (e.g. Sinorhizobium meliloti) and arbuscular mycorrhizal fungi (AM, e.g. Rhizophagus irregularis) symbioses, in an ubiquitin ligase activity-dependent manner (PubMed:26839127). Negative regulator of the LYK3 signaling pathway leading to nitrogen-fixing symbiosis (eg. infection and nodulation) by rhizobia. May be involved in the discrimination of rhizobium strains producing variant Nod factors (PubMed:20971894).

Protein Sequence
(Fasta)

MNDPRSKMMI SPGLLPTESL LDSLILISNE VSSMQKFPLV QIKNVSSMIR RIKLLSSLFE 60
EIQESDSPLP PSSILCFIEI FSVITRVKVL IQECTDGSSL WSLIQLDFIS NQFFVLVKEM 120

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Nucleotide Sequence
(Fasta)

AAAATGAATG ATCCTAGATC AAAGATGATG ATATCTCCAG GTTTATTACC AACAGAATCA 60
TTACTAGATT CATTGATTCT AATATCCAAT GAAGTTAGTT CAATGCAGAA ATTTCCATTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0472--Membrane
KW-0536--Nodulation
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR000225--Armadillo
IPR003613--Ubox_domain
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50176--ARM_REPEAT
PS51698--U_BOX

Pfam

PF00514--Arm
PF04564--U-box

SMART

SM00185--ARM
SM00504--Ubox

Gene Ontology

GO:0005886--C:plasma membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0036377--P:arbuscular mycorrhizal association
GO:0009877--P:nodulation
GO:0002237--P:response to molecule of bacterial origin
GO:0009609--P:response to symbiotic bacterium
GO:0009610--P:response to symbiotic fungus

KEGG

mtr:MTR_5g083030

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-002723	Amborella trichopoda	48.96	6.00e-155	540.00
IUUC-Gma-042912	Glycine max	69.61	0.00e+00	763.00
IUUC-Ppa-095610	Physcomitrella patens	43.13	2.00e-142	499.00
IUUC-Pop-099478	Populus trichocarpa	68.39	0.00e+00	802.00
IUUC-Ppe-101201	Prunus persica	68.88	0.00e+00	868.00
IUUC-Smo-109110	Selaginella moellendorffii	42.88	6.00e-139	487.00
IUUC-Sly-111580	Solanum lycopersicum	64.06	0.00e+00	664.00
IUUC-Stu-112508	Solanum tuberosum	65.03	0.00e+00	800.00
IUUC-Tca-121845	Theobroma cacao	69.41	0.00e+00	920.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence