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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046896
UUCD1 version UUC-HoS-00311
Ensembl Protein ID ENSP00000298288.6
UniProt Accession Q96L50; A5D6X3; B4DDE0; Q52M24; Q86SZ1; Q8N6H9; LLR1_HUMAN
Genbank Protein ID AAL11430.1; CAD62625.1; BAG56701.1; EAW65761.1; AAH30142.1; AAH93697.1; AAI12242.1; AAI39922.1
Protein Name Leucine-rich repeat protein 1; 4-1BB-mediated-signaling molecule; 4-1BBlrr; LRR-repeat protein 1; Peptidylprolyl isomerase-like 5
Genbank Nucleotide ID AY052405; BX248298; AK293156; CH471078; BC030142; BC093697; BC112241; BC139921
Gene Name LRR1; PPIL5
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000165501.16 ENST00000298288.10 ENSP00000298288.6
ENSG00000165501.16 ENST00000318317.8 ENSP00000315628.4
ENSG00000165501.16 ENST00000554869.5 ENSP00000452355.1
ENSG00000165501.16 ENST00000540712.1 ENSP00000439452.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
THPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box SOCS 21074711; 23555289
Organism Homo sapiens
Functional Description
(View)

Functional Description


     May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1. Probable substrate recognition subunit of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
 May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1. Probable substrate recognition subunit of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Protein Sequence
(Fasta)
MKLHCEVEVI SRHLPALGLR NRGKGVRAVL SLCQQTSRSQ PPVRAFLLIS TLKDKRGTRY 60
ELRENIEQFF TKFVDEGKAT VRLKEPPVDI CLSKAISSSL KGFLSAMRLA HRGCNVDTPV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046896|E3,SOCS|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AACCACCGCT GCCAGCTGCG CGCTCGGGGG AAAAGACGTT GCGCCCCCGC CGACTGCCGG 60
TTTCCCGGGC GCGAGCCCGG ATCCAGGTGG TCAGTCCCGG TACGCAACCA CGGCGAGAAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046896|E3,SOCS|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0433--Leucine-rich repeat
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR032675--L_dom-like
IPR001611--Leu-rich_rpt
IPR025875--Leu-rich_rpt_4
IPR003591--Leu-rich_rpt_typical-subtyp
PROSITE

PS51450--LRR
Pfam

PF12799--LRR_4
PF13516--LRR_6
SMART

SM00369--LRR_TYP
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005886--C:plasma membrane
GO:0016567--P:protein ubiquitination
GO:0007165--P:signal transduction
KEGG hsa:122769
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001780 Ailuropoda melanoleuca 85.61 0.00e+00 744.00
IUUC-Atr-002772 Amborella trichopoda 38.05 6.00e-10 58.20
IUUC-Apl-003947 Anas platyrhynchos 72.54 3.00e-97 347.00
IUUC-Aca-004845 Anolis carolinensis 66.83 3.00e-142 498.00
IUUC-Ame-011571 Astyanax mexicanus 63.73 7.00e-138 483.00
IUUC-Bta-013510 Bos taurus 87.74 0.00e+00 742.00
IUUC-Cel-018313 Caenorhabditis elegans 26.90 1.00e-13 71.20
IUUC-Cja-019616 Callithrix jacchus 92.75 0.00e+00 785.00
IUUC-Cfa-020085 Canis familiaris 85.07 0.00e+00 732.00
IUUC-Cpo-022006 Cavia porcellus 82.06 0.00e+00 651.00
IUUC-Csa-023376 Chlorocebus sabaeus 95.89 0.00e+00 816.00
IUUC-Cho-024851 Choloepus hoffmanni 87.92 0.00e+00 696.00
IUUC-Csv-025951 Ciona savignyi 39.57 2.00e-78 286.00
IUUC-Dre-028231 Danio rerio 52.42 4.00e-48 184.00
IUUC-Dno-029840 Dasypus novemcinctus 86.35 0.00e+00 733.00
IUUC-Dor-030722 Dipodomys ordii 84.54 0.00e+00 721.00
IUUC-Dme-031624 Drosophila melanogaster 29.92 3.00e-30 126.00
IUUC-Ete-032265 Echinops telfairi 85.27 0.00e+00 731.00
IUUC-Eca-034050 Equus caballus 90.40 0.00e+00 657.00
IUUC-Eeu-034807 Erinaceus europaeus 75.84 3.00e-173 601.00
IUUC-Fca-035883 Felis catus 86.35 0.00e+00 736.00
IUUC-Fal-037470 Ficedula albicollis 66.57 4.00e-122 431.00
IUUC-Gmo-039145 Gadus morhua 58.82 1.00e-138 486.00
IUUC-Gga-040580 Gallus gallus 68.87 7.00e-150 523.00
IUUC-Gac-041408 Gasterosteus aculeatus 59.07 2.00e-137 482.00
IUUC-Ggo-044999 Gorilla gorilla 99.52 0.00e+00 838.00
IUUC-Itr-048389 Ictidomys tridecemlineatus 85.18 0.00e+00 733.00
IUUC-Lch-049921 Latimeria chalumnae 69.61 1.00e-156 546.00
IUUC-Loc-052946 Lepisosteus oculatus 62.75 3.00e-135 474.00
IUUC-Laf-053665 Loxodonta africana 88.44 0.00e+00 747.00
IUUC-Mcc-055451 Macaca mulatta 96.14 0.00e+00 817.00
IUUC-Meu-056760 Macropus eugenii 74.26 5.00e-94 337.00
IUUC-Mga-059693 Meleagris gallopavo 71.11 6.00e-117 413.00
IUUC-Mmr-061640 Microcebus murinus 87.44 0.00e+00 729.00
IUUC-Mdo-062013 Monodelphis domestica 74.94 9.00e-161 559.00
IUUC-Mmu-064208 Mus musculus 77.43 3.00e-175 607.00
IUUC-Mpu-066695 Mustela putorius furo 83.77 2.00e-169 588.00
IUUC-Mlu-067598 Myotis lucifugus 84.47 0.00e+00 715.00
IUUC-Nle-069282 Nomascus leucogenys 98.07 0.00e+00 804.00
IUUC-Opr-070622 Ochotona princeps 82.21 0.00e+00 656.00
IUUC-Ont-072349 Oreochromis niloticus 59.31 3.00e-136 478.00
IUUC-Oan-073270 Ornithorhynchus anatinus 77.59 1.00e-136 479.00
IUUC-Ocu-074328 Oryctolagus cuniculus 89.02 0.00e+00 745.00
IUUC-Ome-081910 Oryza meridionalis 32.03 1.00e-10 61.60
IUUC-Ola-087391 Oryzias latipes 58.80 6.00e-141 493.00
IUUC-Oga-088088 Otolemur garnettii 85.40 0.00e+00 714.00
IUUC-Oar-089741 Ovis aries 86.32 0.00e+00 687.00
IUUC-Ptr-091019 Pan troglodytes 99.52 0.00e+00 839.00
IUUC-Pan-092495 Papio anubis 96.38 0.00e+00 818.00
IUUC-Psi-092946 Pelodiscus sinensis 77.41 1.00e-104 372.00
IUUC-Pma-094443 Petromyzon marinus 44.98 9.00e-81 294.00
IUUC-Pfo-096494 Poecilia formosa 58.09 3.00e-135 475.00
IUUC-Pab-097847 Pongo abelii 97.34 0.00e+00 823.00
IUUC-Pva-103223 Pteropus vampyrus 90.10 0.00e+00 736.00
IUUC-Rno-105407 Rattus norvegicus 77.73 3.00e-172 597.00
IUUC-Sha-106939 Sarcophilus harrisii 77.01 1.00e-145 509.00
IUUC-Sly-111052 Solanum lycopersicum 31.65 1.00e-16 80.50
IUUC-Sar-113321 Sorex araneus 78.50 2.00e-179 622.00
IUUC-Ssc-116378 Sus scrofa 90.97 1.00e-138 485.00
IUUC-Tgu-117441 Taeniopygia guttata 66.77 6.00e-112 397.00
IUUC-Tru-118303 Takifugu rubripes 59.56 1.00e-130 459.00
IUUC-Tsy-119397 Tarsius syrichta 87.00 6.00e-112 397.00
IUUC-Tni-120292 Tetraodon nigroviridis 58.35 1.00e-136 479.00
IUUC-Tbe-128087 Tupaia belangeri 86.53 7.00e-166 576.00
IUUC-Ttr-128489 Tursiops truncatus 87.65 0.00e+00 737.00
IUUC-Vpa-130640 Vicugna pacos 77.54 0.00e+00 630.00
IUUC-Xtr-132352 Xenopus tropicalis 63.48 1.00e-142 499.00
Created Date 25-Jun-2017

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