• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Rno-104855
Ensembl Protein ID ENSRNOP00000059795.2
UniProt Accession D4A1R8; D3ZSJ8; H1UBM6; CPNE1_RAT
Genbank Protein ID CAO00504.1; EDL85869.1; EDL85870.1; EDL85872.1; EDL85873.1
Protein Name Copine-1; Copine I
Genbank Nucleotide ID AM747279; AABR07054396; CH474050; CH474050; CH474050
Gene Name Cpne1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000046990.2 ENSRNOT00000067490.3 ENSRNOP00000059795.2
Annotation
mRNA Expression
GEO
Post-translational Modifications (PTMs)
CPLMdbPAF
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 30.12 2.00e-26 112.00 IUUC-Ots-000026
E3 activity/RING/RING 33.94 8.00e-27 112.00 IUUC-Ots-000013
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner. Exhibits calcium-dependent phospholipid binding properties. Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner. May recruit target proteins to the cell membrane in a calcium-dependent manner. May function in membrane trafficking. Involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit. Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL.
 Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner. Exhibits calcium-dependent phospholipid binding properties. Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner. May recruit target proteins to the cell membrane in a calcium-dependent manner. May function in membrane trafficking. Involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit. Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL.
Protein Sequence
(Fasta)
MAHCVTLVQL SVSCDHLIDK DIGSKSDPLC VLLQDVGGAW AELCRTERVR NCSSPAFSKT 60
LQIEYYFETV QKLRFGIYDI DNKTPELGDD DFLGGAECSL GQIVSSQTLT LPLMLKPGKP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-104855|E3,RING|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATTGCTAAGG TTAAGGCCAC TTTCAGAGTA AGAACTGATT TGGAGCCAGA GTTTGGTGTC 60
ACAACTGTGT CCTGTGCTAG TGAGCTTACT TGGAGTTCAG GGGTGTGAAG TGTGTGGCTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-104855|E3,RING|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0221--Differentiation
KW-0472--Membrane
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR000008--C2_dom
IPR010734--Copine
IPR002035--VWF_A
PROSITE

PS50004--C2
Pfam

PF00168--C2
PF07002--Copine
SMART

SM00239--C2
SM00327--VWA
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0030154--P:cell differentiation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG rno:100910990; rno:362249
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000336 Aegilops tauschii 34.96 2.00e-23 103.00
IUUC-Aml-002030 Ailuropoda melanoleuca 91.89 0.00e+00 979.00
IUUC-Atr-003148 Amborella trichopoda 32.09 7.00e-23 101.00
IUUC-Apl-003690 Anas platyrhynchos 69.64 0.00e+00 744.00
IUUC-Aca-005177 Anolis carolinensis 74.07 0.00e+00 813.00
IUUC-Aly-006212 Arabidopsis lyrata 30.77 5.00e-26 112.00
IUUC-Ath-007080 Arabidopsis thaliana 29.80 5.00e-27 115.00
IUUC-Ang-009660 Aspergillus niger 27.71 7.10e-01 29.60
IUUC-Ame-011404 Astyanax mexicanus 47.64 6.00e-112 397.00
IUUC-Bta-012757 Bos taurus 50.95 3.00e-143 501.00
IUUC-Bdi-014521 Brachypodium distachyon 32.60 3.00e-25 109.00
IUUC-Bol-016568 Brassica oleracea 31.50 3.00e-27 116.00
IUUC-Bra-017730 Brassica rapa 31.87 5.00e-28 118.00
IUUC-Cel-018357 Caenorhabditis elegans 29.24 1.00e-20 98.60
IUUC-Cja-019806 Callithrix jacchus 91.79 0.00e+00 1001.00
IUUC-Cfa-020719 Canis familiaris 92.28 0.00e+00 973.00
IUUC-Cpo-022547 Cavia porcellus 89.74 0.00e+00 983.00
IUUC-Cre-022882 Chlamydomonas reinhardtii 32.57 2.00e-18 86.30
IUUC-Csa-023455 Chlorocebus sabaeus 92.16 0.00e+00 1004.00
IUUC-Cho-024698 Choloepus hoffmanni 58.72 4.00e-176 610.00
IUUC-Cin-025331 Ciona intestinalis 29.20 7.00e-18 84.00
IUUC-Csv-026082 Ciona savignyi 32.03 5.00e-20 90.90
IUUC-Dre-027464 Danio rerio 48.88 2.00e-142 499.00
IUUC-Dno-029223 Dasypus novemcinctus 87.15 0.00e+00 868.00
IUUC-Dor-030419 Dipodomys ordii 49.63 4.00e-111 395.00
IUUC-Ete-032325 Echinops telfairi 39.73 2.00e-91 330.00
IUUC-Eca-034145 Equus caballus 51.14 4.00e-144 504.00
IUUC-Eeu-034962 Erinaceus europaeus 67.05 0.00e+00 706.00
IUUC-Fca-035987 Felis catus 92.28 0.00e+00 973.00
IUUC-Fal-036712 Ficedula albicollis 70.21 0.00e+00 764.00
IUUC-Gmo-038771 Gadus morhua 55.02 4.00e-81 295.00
IUUC-Gga-040253 Gallus gallus 73.92 0.00e+00 823.00
IUUC-Gac-042313 Gasterosteus aculeatus 48.98 5.00e-139 488.00
IUUC-Gma-043577 Glycine max 31.27 1.00e-28 120.00
IUUC-Ggo-045589 Gorilla gorilla 91.98 0.00e+00 997.00
IUUC-Hsa-046724 Homo sapiens 89.89 0.00e+00 989.00
IUUC-Hvu-047606 Hordeum vulgare 31.87 3.00e-24 106.00
IUUC-Itr-048186 Ictidomys tridecemlineatus 46.86 3.00e-134 472.00
IUUC-Lch-049873 Latimeria chalumnae 48.93 3.00e-107 382.00
IUUC-Lpe-051660 Leersia perrieri 31.50 2.00e-23 103.00
IUUC-Loc-052575 Lepisosteus oculatus 50.95 3.00e-143 501.00
IUUC-Laf-054417 Loxodonta africana 92.08 0.00e+00 969.00
IUUC-Mcc-055340 Macaca mulatta 91.98 0.00e+00 1002.00
IUUC-Meu-056765 Macropus eugenii 48.73 1.00e-88 320.00
IUUC-Mtr-058065 Medicago truncatula 31.58 2.00e-26 113.00
IUUC-Mga-059862 Meleagris gallopavo 73.80 0.00e+00 760.00
IUUC-Mmr-061707 Microcebus murinus 91.89 0.00e+00 964.00
IUUC-Mdo-061966 Monodelphis domestica 78.65 0.00e+00 846.00
IUUC-Mmu-064072 Mus musculus 96.82 0.00e+00 1045.00
IUUC-Mac-065151 Musa acuminata 32.85 9.00e-25 108.00
IUUC-Mpu-065680 Mustela putorius furo 92.47 0.00e+00 981.00
IUUC-Mlu-067845 Myotis lucifugus 53.55 8.00e-79 286.00
IUUC-Nle-069867 Nomascus leucogenys 92.35 0.00e+00 1001.00
IUUC-Opr-070639 Ochotona princeps 52.28 2.00e-65 243.00
IUUC-Ont-071744 Oreochromis niloticus 47.00 1.00e-139 489.00
IUUC-Oan-073203 Ornithorhynchus anatinus 52.31 1.00e-114 406.00
IUUC-Ocu-074096 Oryctolagus cuniculus 91.51 0.00e+00 966.00
IUUC-Oba-075646 Oryza barthii 32.01 1.00e-23 103.00
IUUC-Obr-076544 Oryza brachyantha 32.60 1.00e-25 110.00
IUUC-Ogl-077518 Oryza glaberrima 32.23 6.00e-24 105.00
IUUC-Ogu-078761 Oryza glumaepatula 32.01 1.00e-23 103.00
IUUC-Oin-079486 Oryza indica 32.37 8.00e-24 104.00
IUUC-Olo-080405 Oryza longistaminata 32.60 6.00e-24 105.00
IUUC-Ome-081961 Oryza meridionalis 31.65 8.00e-24 104.00
IUUC-Oni-082579 Oryza nivara 32.23 5.00e-24 105.00
IUUC-Opu-083235 Oryza punctata 31.33 7.00e-25 108.00
IUUC-Oru-084447 Oryza rufipogon 32.23 5.00e-24 105.00
IUUC-Osa-085996 Oryza sativa 32.37 7.00e-24 104.00
IUUC-Ola-087558 Oryzias latipes 51.94 3.00e-110 391.00
IUUC-Oga-088715 Otolemur garnettii 91.12 0.00e+00 966.00
IUUC-Oar-089570 Ovis aries 67.74 0.00e+00 723.00
IUUC-Ptr-090898 Pan troglodytes 91.57 0.00e+00 627.00
IUUC-Pan-092519 Papio anubis 92.16 0.00e+00 1013.00
IUUC-Psi-093065 Pelodiscus sinensis 73.62 0.00e+00 798.00
IUUC-Pma-094267 Petromyzon marinus 54.99 5.00e-167 580.00
IUUC-Ppa-095320 Physcomitrella patens 32.79 1.00e-23 104.00
IUUC-Pfo-097293 Poecilia formosa 67.11 0.00e+00 677.00
IUUC-Pab-098607 Pongo abelii 44.47 2.00e-108 386.00
IUUC-Pop-099752 Populus trichocarpa 34.55 8.00e-27 114.00
IUUC-Pca-100224 Procavia capensis 63.41 0.00e+00 679.00
IUUC-Ppe-101655 Prunus persica 32.12 2.00e-24 107.00
IUUC-Pva-102684 Pteropus vampyrus 46.69 6.00e-126 444.00
IUUC-Sha-106541 Sarcophilus harrisii 46.69 7.00e-135 474.00
IUUC-Smo-108807 Selaginella moellendorffii 33.20 2.00e-22 99.80
IUUC-Sit-110666 Setaria italica 32.96 7.00e-25 108.00
IUUC-Sly-111136 Solanum lycopersicum 32.07 4.00e-27 115.00
IUUC-Stu-112115 Solanum tuberosum 32.97 1.00e-26 114.00
IUUC-Sar-113010 Sorex araneus 63.95 0.00e+00 665.00
IUUC-Sbi-114268 Sorghum bicolor 33.33 2.00e-26 113.00
IUUC-Ssc-115580 Sus scrofa 93.82 0.00e+00 978.00
IUUC-Tgu-117459 Taeniopygia guttata 49.34 2.00e-140 492.00
IUUC-Tru-118245 Takifugu rubripes 66.92 0.00e+00 682.00
IUUC-Tsy-119089 Tarsius syrichta 67.55 0.00e+00 721.00
IUUC-Tni-119926 Tetraodon nigroviridis 49.62 2.00e-139 488.00
IUUC-Tca-121637 Theobroma cacao 32.69 6.00e-29 122.00
IUUC-Tae-123953 Triticum aestivum 34.96 1.00e-23 103.00
IUUC-Tur-126574 Triticum urartu 34.96 3.00e-23 102.00
IUUC-Tbe-127814 Tupaia belangeri 47.87 2.00e-92 333.00
IUUC-Ttr-128567 Tursiops truncatus 48.46 9.00e-135 473.00
IUUC-Vpa-130269 Vicugna pacos 48.10 6.00e-131 461.00
IUUC-Vvi-131538 Vitis vinifera 31.08 1.00e-26 114.00
IUUC-Xtr-132921 Xenopus tropicalis 58.97 2.00e-177 615.00
IUUC-Xma-133656 Xiphophorus maculatus 65.84 0.00e+00 706.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved