iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066738

Ensembl Protein ID

ENSMPUP00000007832.1

UniProt Accession

M3Y925; M3Y925_MUSPF

Genbank Protein ID

ENSMPUP00000007832

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01039105

Gene Name

USP8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000007890.1	ENSMPUT00000007957.1	ENSMPUP00000007832.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.40e-109	365.1	775	1105

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl+NlgNtCYmNS+LQcL n p l++++++  ++ ++n++n  ++kge+++++  ++++lw+++ +++sp++++ +++k++ +f g
   Q: 775  TGLRNLGNTCYMNSILQCLCNAPHLADYFNRnCYQDDINRSNLLGHKGEVAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQFAG 861
           7*****************************9899***************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeee...dkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfl 170
           y+qqD+qE+l fl+d+l+e+l+k +n ++++ee++   d+ ++ ++a++k+k+ n+s+i+ lFqgq+ks+++cl+c+++s ++e f+
   Q: 862  YSQQDSQELLLFLMDGLHEDLNKADNRKRHKEENNdhlDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFM 948
           *********************9855555555444411145566667***************************************** PP
   S: 171  dlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpl 257
           +lslp+ + +++   +lqdcL+ f+kee+l+++n++yc++c+ ++++ kk++++klP+vL +hLkRfs++ + ++ +k++++v+fpl
   Q: 949  YLSLPLASTSKC---TLQDCLRLFSKEEKLTDNNRFYCSHCRTRRDSLKKIEIWKLPPVLLVHLKRFSYDGR-WK-QKLQTSVDFPL 1030
           ***********9...******************************************************996.55.6********** PP
   S: 258  e.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYk 336
           e Ldls++++ p+++    kkY+L++v +H+G+l++GHY+ay+kn  ++ W++fdD++V+ ++ ++v++   s aY+lfY+
   Q: 1031 EnLDLSQYVIGPKNN---LKKYNLFSVSNHYGGLDGGHYTAYCKNAARQrWFKFDDHEVSDISVSSVKS---SAAYILFYT 1105
           ***********9988...69*************************88888*******************...********8 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MPAVASVPKE LYLSSSLKDL NKKTEVKPEK ISTRNYVQSA LKIFKTAEEC RLDRDEEKAY 60
VLYMKYVTVY NLIKKRPDFK QQQDYFHSIL GLANIKKAIE EAERLSESLK LRYEEAEVRK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAAGAACTGC TTTTAATGAA GTACACCATC CATTGTGAAA GTGGAAAAGT AAAAGTAAAG 60
ATTATTCATC ATGCCTGCTG TGGCTTCAGT TCCTAAAGAA CTCTACCTCA GTTCTTCACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR001763--Rhodanese-like_dom
IPR015063--USP8_dimer
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50206--RHODANESE_3
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00581--Rhodanese
PF00443--UCH
PF08969--USP8_dimer

SMART

SM00450--RHOD

Gene Ontology

GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0019897--C:extrinsic component of plasma membrane
GO:0030496--C:midbody
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007032--P:endosome organization
GO:0000281--P:mitotic cytokinesis
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001661	Ailuropoda melanoleuca	96.70	0.00e+00	1989.00
IUUC-Apl-003226	Anas platyrhynchos	69.14	0.00e+00	1429.00
IUUC-Aca-004936	Anolis carolinensis	65.74	0.00e+00	1298.00
IUUC-Ago-007959	Ashbya gossypii	35.62	1.00e-54	208.00
IUUC-Acl-008102	Aspergillus clavatus	31.32	1.00e-50	195.00
IUUC-Afl-008604	Aspergillus flavus	32.05	2.00e-49	191.00
IUUC-Afu-009001	Aspergillus fumigatus	31.11	9.00e-50	192.00
IUUC-Ani-009291	Aspergillus nidulans	31.16	1.00e-49	191.00
IUUC-Ang-009844	Aspergillus niger	32.43	1.00e-48	188.00
IUUC-Aor-010098	Aspergillus oryzae	32.05	7.00e-49	189.00
IUUC-Ate-010585	Aspergillus terreus	31.64	7.00e-49	189.00
IUUC-Ame-011029	Astyanax mexicanus	62.37	6.00e-75	273.00
IUUC-Bta-013008	Bos taurus	89.16	0.00e+00	1837.00
IUUC-Bol-015281	Brassica oleracea	38.21	8.00e-47	181.00
IUUC-Bra-017228	Brassica rapa	39.10	1.00e-48	187.00
IUUC-Cel-018482	Caenorhabditis elegans	33.82	8.00e-52	198.00
IUUC-Cja-019173	Callithrix jacchus	90.16	0.00e+00	1882.00
IUUC-Cfa-021243	Canis familiaris	96.24	0.00e+00	1987.00
IUUC-Cpo-021522	Cavia porcellus	85.23	0.00e+00	1734.00
IUUC-Cre-022582	Chlamydomonas reinhardtii	44.35	8.00e-82	296.00
IUUC-Csa-023616	Chlorocebus sabaeus	91.69	0.00e+00	1608.00
IUUC-Cho-024381	Choloepus hoffmanni	77.28	0.00e+00	1539.00
IUUC-Cin-025287	Ciona intestinalis	50.13	3.00e-99	357.00
IUUC-Csv-026253	Ciona savignyi	47.92	3.00e-88	320.00
IUUC-Cne-026821	Cryptococcus neoformans	40.17	5.00e-75	276.00
IUUC-Dre-028440	Danio rerio	69.00	0.00e+00	734.00
IUUC-Dno-029039	Dasypus novemcinctus	89.71	0.00e+00	1908.00
IUUC-Dor-031043	Dipodomys ordii	96.12	3.00e-133	469.00
IUUC-Dse-031463	Dothistroma septosporum	28.07	5.00e-41	163.00
IUUC-Dme-032089	Drosophila melanogaster	44.50	2.00e-85	310.00
IUUC-Ete-033040	Echinops telfairi	79.72	0.00e+00	1524.00
IUUC-Eca-033449	Equus caballus	93.64	0.00e+00	1935.00
IUUC-Eeu-034693	Erinaceus europaeus	96.12	9.00e-132	464.00
IUUC-Fca-035794	Felis catus	99.58	0.00e+00	939.00
IUUC-Fal-037322	Ficedula albicollis	69.24	0.00e+00	1442.00
IUUC-Gmo-038584	Gadus morhua	66.67	0.00e+00	659.00
IUUC-Gga-041188	Gallus gallus	83.54	0.00e+00	934.00
IUUC-Gac-041850	Gasterosteus aculeatus	72.27	0.00e+00	736.00
IUUC-Ggo-045565	Gorilla gorilla	91.23	0.00e+00	1921.00
IUUC-Hsa-046438	Homo sapiens	91.14	0.00e+00	1917.00
IUUC-Itr-048883	Ictidomys tridecemlineatus	88.99	0.00e+00	1825.00
IUUC-Kpa-049321	Komagataella pastoris	33.24	4.00e-49	189.00
IUUC-Lch-050485	Latimeria chalumnae	80.76	0.00e+00	866.00
IUUC-Loc-052769	Lepisosteus oculatus	74.04	0.00e+00	778.00
IUUC-Lma-053021	Leptosphaeria maculans	33.04	2.00e-53	204.00
IUUC-Laf-053432	Loxodonta africana	78.30	0.00e+00	1706.00
IUUC-Mcc-055823	Macaca mulatta	91.06	0.00e+00	1922.00
IUUC-Meu-056099	Macropus eugenii	97.77	2.00e-165	577.00
IUUC-Mla-059089	Melampsora laricipopulina	40.18	4.00e-72	266.00
IUUC-Mga-059739	Meleagris gallopavo	83.36	0.00e+00	931.00
IUUC-Mvi-060559	Microbotryum violaceum	41.14	1.00e-77	285.00
IUUC-Mmr-061158	Microcebus murinus	90.24	0.00e+00	1844.00
IUUC-Mdo-061801	Monodelphis domestica	80.25	0.00e+00	1608.00
IUUC-Mmu-063665	Mus musculus	80.75	0.00e+00	1664.00
IUUC-Mlu-067307	Myotis lucifugus	90.09	0.00e+00	1855.00
IUUC-Nfi-068410	Neosartorya fischeri	31.39	5.00e-50	193.00
IUUC-Nle-069314	Nomascus leucogenys	90.79	0.00e+00	1909.00
IUUC-Opr-070378	Ochotona princeps	79.35	0.00e+00	1211.00
IUUC-Ont-071545	Oreochromis niloticus	76.63	0.00e+00	762.00
IUUC-Oan-073537	Ornithorhynchus anatinus	76.04	0.00e+00	1533.00
IUUC-Ocu-074193	Oryctolagus cuniculus	88.36	0.00e+00	1829.00
IUUC-Ola-086622	Oryzias latipes	57.70	0.00e+00	1085.00
IUUC-Oga-088271	Otolemur garnettii	87.59	0.00e+00	1803.00
IUUC-Oar-090431	Ovis aries	89.19	0.00e+00	1843.00
IUUC-Ptr-091339	Pan troglodytes	91.59	0.00e+00	1968.00
IUUC-Pan-091783	Papio anubis	84.50	0.00e+00	988.00
IUUC-Psi-093187	Pelodiscus sinensis	63.06	0.00e+00	1001.00
IUUC-Pma-094626	Petromyzon marinus	58.43	1.00e-141	495.00
IUUC-Pfo-096463	Poecilia formosa	75.61	0.00e+00	753.00
IUUC-Pab-097645	Pongo abelii	90.79	0.00e+00	1915.00
IUUC-Pva-103222	Pteropus vampyrus	85.71	0.00e+00	954.00
IUUC-Pgr-103408	Puccinia graminis	35.92	3.00e-54	207.00
IUUC-Ptt-103699	Puccinia triticina	45.45	2.00e-67	251.00
IUUC-Pte-104348	Pyrenophora teres	28.83	2.00e-39	157.00
IUUC-Pyt-104711	Pyrenophora triticirepentis	31.11	7.00e-51	196.00
IUUC-Rno-105510	Rattus norvegicus	80.39	0.00e+00	1678.00
IUUC-Sce-106166	Saccharomyces cerevisiae	35.26	2.00e-51	197.00
IUUC-Sha-106879	Sarcophilus harrisii	89.42	0.00e+00	1003.00
IUUC-Sja-107836	Schizosaccharomyces japonicus	36.29	4.00e-48	186.00
IUUC-Sar-113019	Sorex araneus	84.97	0.00e+00	1776.00
IUUC-Sre-115031	Sporisorium reilianum	37.05	9.00e-69	255.00
IUUC-Ssc-116334	Sus scrofa	89.72	0.00e+00	1875.00
IUUC-Tgu-117062	Taeniopygia guttata	80.76	0.00e+00	914.00
IUUC-Tru-117908	Takifugu rubripes	57.98	0.00e+00	1170.00
IUUC-Tsy-118867	Tarsius syrichta	86.38	0.00e+00	1081.00
IUUC-Tni-120206	Tetraodon nigroviridis	53.89	0.00e+00	1047.00
IUUC-Tme-127144	Tuber melanosporum	40.00	1.00e-78	288.00
IUUC-Tbe-127877	Tupaia belangeri	87.24	7.00e-102	365.00
IUUC-Ttr-128580	Tursiops truncatus	87.56	0.00e+00	1779.00
IUUC-Uma-129340	Ustilago maydis	35.75	5.00e-71	263.00
IUUC-Vpa-130541	Vicugna pacos	91.94	0.00e+00	1902.00
IUUC-Xtr-132161	Xenopus tropicalis	58.65	0.00e+00	1195.00
IUUC-Xma-134271	Xiphophorus maculatus	75.61	0.00e+00	751.00
IUUC-Yli-134561	Yarrowia lipolytica	35.92	6.00e-60	226.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence