iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	RAID2
Protein-protein Interaction
HINT
Post-translational Modifications (PTMs)
CPLM	dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.10e-108	363.9	740	1070

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl+NlgNtCYmNS+LQcL n p l++++++  ++ ++n++n  ++kge+++++  ++++lw+++ +++sp++++ +++k++ +f g
   Q: 740  TGLRNLGNTCYMNSILQCLCNAPHLADYFNRnCYQDDINRSNLLGHKGEVAEEFGIIMKALWTGQYRYISPKDFKVTIGKINDQFAG 826
           7*****************************9899***************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeee...dkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfl 170
           ++qqD+qE+l fl+d+l+e+l+k +n ++++ee++   d+ ++ ++a++k+k+ n+s+i+ lFqgq+ks+++cl+c+++s ++e f+
   Q: 827  SSQQDSQELLLFLMDGLHEDLNKADNRKRHKEENNdhlDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFM 913
           *********************9855555555444411145566667***************************************** PP
   S: 171  dlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpl 257
           +lslp+ + +++   +lqdcL+ f+kee+l+++n++yc++c++++++ kk++++klP+vL +hLkRfs++ + ++ +k++++v+fpl
   Q: 914  YLSLPLASTSKC---TLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGR-WK-QKLQTSVDFPL 995
           ***********9...******************************************************996.55.6********** PP
   S: 258  e.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYk 336
           e Ldls++++ p+++    kkY+L++v +H+G+l++GHY+ay+kn  ++ W++fdD++V+ ++ ++v +   s aY+lfY+
   Q: 996  EnLDLSQYVIGPKSS---LKKYNLFSVSNHYGGLDGGHYTAYCKNAARQrWFKFDDHEVSDISVSSVRS---SAAYILFYT 1070
           ***********9988...69*************************88888*******************...********8 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MPAVASVPKE LYLSSSLKDL NKKTEVKPEK TSTKNYIHSA QKIFKAAEEC RLDRDEERAY 60
VLYMKYVAVY NLIKKRPDFK QQQDYYLSIL GPANIKKAIE EAERLSESLK LRYEEAEVRK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGTCGCACG CAATGCGAAT CGGGAAGAGG GGATGATCTG CGCTGCTTTG CGTCTGAGAA 60
CGGAGGCTCG TTCTCCTTCT GGTGGTGGGC GATGGGCGTC AGGCGAGAAG GCCGGCGTTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR001763--Rhodanese-like_dom
IPR015063--USP8_dimer
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50206--RHODANESE_3
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00581--Rhodanese
PF00443--UCH
PF08969--USP8_dimer

SMART

SM00450--RHOD

Gene Ontology

GO:0005829--C:cytosol
GO:0043197--C:dendritic spine
GO:0005769--C:early endosome
GO:0031313--C:extrinsic component of endosome membrane
GO:0019897--C:extrinsic component of plasma membrane
GO:0030496--C:midbody
GO:0014069--C:postsynaptic density
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007032--P:endosome organization
GO:0000281--P:mitotic cytokinesis
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

rno:296121

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001661	Ailuropoda melanoleuca	80.98	0.00e+00	1650.00
IUUC-Apl-003226	Anas platyrhynchos	69.08	0.00e+00	1422.00
IUUC-Aca-004936	Anolis carolinensis	65.26	0.00e+00	1266.00
IUUC-Ago-007959	Ashbya gossypii	35.34	4.00e-54	206.00
IUUC-Acl-008102	Aspergillus clavatus	31.32	3.00e-51	197.00
IUUC-Afl-008604	Aspergillus flavus	30.77	2.00e-50	194.00
IUUC-Afu-009001	Aspergillus fumigatus	31.94	7.00e-51	196.00
IUUC-Ani-009291	Aspergillus nidulans	31.45	3.00e-50	194.00
IUUC-Ang-009844	Aspergillus niger	32.13	1.00e-48	188.00
IUUC-Aor-010098	Aspergillus oryzae	30.77	9.00e-50	192.00
IUUC-Ate-010585	Aspergillus terreus	31.64	1.00e-49	192.00
IUUC-Ame-011029	Astyanax mexicanus	59.79	1.00e-69	256.00
IUUC-Bta-013008	Bos taurus	83.01	0.00e+00	1652.00
IUUC-Bol-015281	Brassica oleracea	38.21	5.00e-47	182.00
IUUC-Bra-017228	Brassica rapa	39.40	5.00e-49	188.00
IUUC-Cel-018482	Caenorhabditis elegans	33.82	1.00e-51	198.00
IUUC-Cja-019173	Callithrix jacchus	81.66	0.00e+00	1689.00
IUUC-Cfa-021243	Canis familiaris	81.02	0.00e+00	1653.00
IUUC-Cpo-021522	Cavia porcellus	80.62	0.00e+00	1639.00
IUUC-Cre-022582	Chlamydomonas reinhardtii	44.35	3.00e-80	291.00
IUUC-Csa-023616	Chlorocebus sabaeus	81.47	0.00e+00	1407.00
IUUC-Cho-024381	Choloepus hoffmanni	70.02	0.00e+00	1382.00
IUUC-Cin-025287	Ciona intestinalis	49.62	9.00e-97	348.00
IUUC-Csv-026253	Ciona savignyi	48.16	2.00e-86	314.00
IUUC-Cne-026821	Cryptococcus neoformans	40.44	1.00e-75	278.00
IUUC-Dre-028440	Danio rerio	67.50	0.00e+00	728.00
IUUC-Dno-029039	Dasypus novemcinctus	80.05	0.00e+00	1687.00
IUUC-Dor-031043	Dipodomys ordii	96.12	9.00e-132	464.00
IUUC-Dse-031463	Dothistroma septosporum	28.35	2.00e-42	168.00
IUUC-Dme-032089	Drosophila melanogaster	45.60	4.00e-85	309.00
IUUC-Ete-033040	Echinops telfairi	74.60	0.00e+00	1362.00
IUUC-Eca-033449	Equus caballus	81.47	0.00e+00	1663.00
IUUC-Eeu-034693	Erinaceus europaeus	94.83	2.00e-130	460.00
IUUC-Fca-035794	Felis catus	96.21	0.00e+00	915.00
IUUC-Fal-037322	Ficedula albicollis	87.32	0.00e+00	863.00
IUUC-Gmo-038584	Gadus morhua	62.20	0.00e+00	661.00
IUUC-Gga-041188	Gallus gallus	89.37	0.00e+00	883.00
IUUC-Gac-041850	Gasterosteus aculeatus	74.00	0.00e+00	740.00
IUUC-Ggo-045565	Gorilla gorilla	81.66	0.00e+00	1703.00
IUUC-Hsa-046438	Homo sapiens	81.48	0.00e+00	1698.00
IUUC-Itr-048883	Ictidomys tridecemlineatus	84.48	0.00e+00	1685.00
IUUC-Kpa-049321	Komagataella pastoris	32.97	5.00e-49	189.00
IUUC-Lch-050485	Latimeria chalumnae	80.97	0.00e+00	851.00
IUUC-Loc-052769	Lepisosteus oculatus	75.57	0.00e+00	756.00
IUUC-Lma-053021	Leptosphaeria maculans	31.99	1.00e-53	205.00
IUUC-Laf-053432	Loxodonta africana	78.58	0.00e+00	1612.00
IUUC-Mcc-055823	Macaca mulatta	81.84	0.00e+00	1701.00
IUUC-Meu-056099	Macropus eugenii	95.91	4.00e-162	565.00
IUUC-Mla-059089	Melampsora laricipopulina	40.49	3.00e-72	267.00
IUUC-Mga-059739	Meleagris gallopavo	89.16	0.00e+00	878.00
IUUC-Mvi-060559	Microbotryum violaceum	40.11	8.00e-78	285.00
IUUC-Mmr-061158	Microcebus murinus	80.81	0.00e+00	1632.00
IUUC-Mdo-061801	Monodelphis domestica	87.18	0.00e+00	937.00
IUUC-Mmu-063665	Mus musculus	94.17	0.00e+00	1886.00
IUUC-Mpu-066738	Mustela putorius furo	80.57	0.00e+00	1615.00
IUUC-Mlu-067307	Myotis lucifugus	77.95	0.00e+00	1627.00
IUUC-Nfi-068410	Neosartorya fischeri	31.94	6.00e-51	196.00
IUUC-Nle-069314	Nomascus leucogenys	81.57	0.00e+00	1696.00
IUUC-Opr-070378	Ochotona princeps	72.23	0.00e+00	1083.00
IUUC-Ont-071545	Oreochromis niloticus	76.06	0.00e+00	759.00
IUUC-Oan-073537	Ornithorhynchus anatinus	71.69	0.00e+00	1424.00
IUUC-Ocu-074193	Oryctolagus cuniculus	83.47	0.00e+00	1707.00
IUUC-Ola-086622	Oryzias latipes	57.60	0.00e+00	1066.00
IUUC-Oga-088271	Otolemur garnettii	79.91	0.00e+00	1623.00
IUUC-Oar-090431	Ovis aries	82.60	0.00e+00	1648.00
IUUC-Ptr-091339	Pan troglodytes	81.22	0.00e+00	1729.00
IUUC-Pan-091783	Papio anubis	70.39	0.00e+00	781.00
IUUC-Psi-093187	Pelodiscus sinensis	62.96	8.00e-152	531.00
IUUC-Pma-094626	Petromyzon marinus	58.19	5.00e-141	494.00
IUUC-Pfo-096463	Poecilia formosa	74.44	0.00e+00	744.00
IUUC-Pab-097645	Pongo abelii	81.31	0.00e+00	1695.00
IUUC-Pva-103222	Pteropus vampyrus	93.03	0.00e+00	744.00
IUUC-Pgr-103408	Puccinia graminis	35.66	1.00e-53	205.00
IUUC-Ptt-103699	Puccinia triticina	46.15	2.00e-68	254.00
IUUC-Pte-104348	Pyrenophora teres	28.53	1.00e-39	158.00
IUUC-Pyt-104711	Pyrenophora triticirepentis	30.83	4.00e-51	196.00
IUUC-Sce-106166	Saccharomyces cerevisiae	34.99	4.00e-51	196.00
IUUC-Sha-106879	Sarcophilus harrisii	93.29	0.00e+00	922.00
IUUC-Sja-107836	Schizosaccharomyces japonicus	36.86	3.00e-49	189.00
IUUC-Sar-113019	Sorex araneus	74.40	0.00e+00	1569.00
IUUC-Sre-115031	Sporisorium reilianum	36.77	5.00e-68	253.00
IUUC-Ssc-116334	Sus scrofa	82.77	0.00e+00	1677.00
IUUC-Tgu-117062	Taeniopygia guttata	82.19	0.00e+00	869.00
IUUC-Tru-117908	Takifugu rubripes	58.22	0.00e+00	1149.00
IUUC-Tsy-118867	Tarsius syrichta	76.83	0.00e+00	938.00
IUUC-Tni-120206	Tetraodon nigroviridis	74.25	0.00e+00	726.00
IUUC-Tme-127144	Tuber melanosporum	40.28	2.00e-79	290.00
IUUC-Tbe-127877	Tupaia belangeri	95.42	6.00e-82	299.00
IUUC-Ttr-128580	Tursiops truncatus	78.25	0.00e+00	1570.00
IUUC-Uma-129340	Ustilago maydis	37.63	5.00e-70	259.00
IUUC-Vpa-130541	Vicugna pacos	80.66	0.00e+00	1641.00
IUUC-Xtr-132161	Xenopus tropicalis	75.90	0.00e+00	783.00
IUUC-Xma-134271	Xiphophorus maculatus	74.65	0.00e+00	747.00
IUUC-Yli-134561	Yarrowia lipolytica	36.19	2.00e-60	227.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence