iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ont-071638

Ensembl Protein ID

ENSONIP00000019314.1

UniProt Accession

I3KDW9; I3KDW9_ORENI

Genbank Protein ID

ENSONIP00000019314

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AERX01005334

Gene Name

usp3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000015351.1	ENSONIT00000019331.1	ENSONIP00000019314.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.10e-101	340.8	115	467

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle...........kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalk 78
           tGl+NlgNtC+mN++LQ+Lsni+++ ++++e             ++  + +++ +++ +l+++++k + +lw+++++a+sp +l+ a++
   Q: 115  TGLRNLGNTCFMNAILQSLSNIEQFSCYFKElpavalrsgktAGRRMYHTRSQGDNSVSLVEEFRKTLCSLWQGNQTAFSPDSLFYAIW 203
           7******************************888888777664444444455588889******************************* PP
   S: 79   keaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssree 167
           k+ ++f+gy+qqDa+Ef+++lld+l++el+ ++n   + ++ +d  +ls+   +  ++ + s+++ +F+g l++++ cl c+++s +++
   Q: 204  KIMPSFRGYQQQDAHEFMRYLLDHLHRELQYSRNGASHPLSPQDGVRLSSTDGKCCTNGTASVVTSIFGGILQNEVNCLICGTESRKFD 292
           *****************************9999999999************************************************** PP
   S: 168  pfldlslpvpgkeetkke.........slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksre 247
           pfldlsl++p++  +k +         +l+dcL+sft  eel++ + yyc kckk+q+++kk++++klP+vL+lhLkRf++  +   r+
   Q: 293  PFLDLSLDIPSQFRQKRNkdqepvptcTLRDCLHSFTDLEELDDTELYYCHKCKKRQKSTKKFWIQKLPKVLCLHLKRFHW--TAFLRN 379
           **********766555556788999******************************************************77..558*** PP
   S: 248  kinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlf 334
           k++++vefpl+ Ld++ ++ +pe++   ++ Y+L+avvvH+G +++sGHY+ay  + +g+W++f+Ds+Vt ++e++v +   ++aY+lf
   Q: 380  KVDTYVEFPLKgLDMRGYLLEPEKSLPGSCLYDLVAVVVHHGsGVGSGHYTAYGSH-EGRWYHFNDSTVTLTNEDTVRK---AKAYILF 464
           ********************************************************.9*********************...******* PP
   S: 335  Ykr 337
           Y +
   Q: 465  YVE 467
           *76 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

MVHCGRYVNG HAKKHFEENQ VLGVSQRKGE KHEKEKIHHS VCMDCSSYSV FCYRCDEFVV 60
NDTKLGQVQK LREHLQSLEN SALMGERQRK RKLQDSPAGD GKLLKDSDGV ALGATGLRNL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTCCCTAAC GGTACTCCGT CCTCCTGGTG TTGCAACGGT AAGAGGAGTG TTTTTCTGTC 60
TTTTATTTTA CTTCAGTAAA ATTCATTTCG TTGTACTTAA GCGTAGCTCG GTGCGCAACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001537	Ailuropoda melanoleuca	77.05	0.00e+00	701.00
IUUC-Apl-003358	Anas platyrhynchos	77.26	0.00e+00	684.00
IUUC-Aca-004454	Anolis carolinensis	77.07	0.00e+00	651.00
IUUC-Aor-010035	Aspergillus oryzae	37.26	7.00e-37	147.00
IUUC-Ame-011544	Astyanax mexicanus	78.45	0.00e+00	696.00
IUUC-Bta-012738	Bos taurus	77.26	0.00e+00	665.00
IUUC-Cel-018186	Caenorhabditis elegans	36.57	7.00e-61	228.00
IUUC-Cja-018893	Callithrix jacchus	76.63	0.00e+00	657.00
IUUC-Cfa-020607	Canis familiaris	77.26	0.00e+00	663.00
IUUC-Cpo-021828	Cavia porcellus	76.21	0.00e+00	656.00
IUUC-Csa-023884	Chlorocebus sabaeus	79.01	2.00e-177	614.00
IUUC-Cho-024863	Choloepus hoffmanni	71.90	1.00e-163	569.00
IUUC-Dre-028452	Danio rerio	77.71	0.00e+00	716.00
IUUC-Dno-029531	Dasypus novemcinctus	76.63	0.00e+00	660.00
IUUC-Dor-030913	Dipodomys ordii	69.25	3.00e-129	455.00
IUUC-Ete-032611	Echinops telfairi	71.79	2.00e-178	619.00
IUUC-Eca-033622	Equus caballus	77.05	0.00e+00	661.00
IUUC-Eeu-035268	Erinaceus europaeus	73.68	6.00e-176	610.00
IUUC-Fca-035801	Felis catus	77.26	0.00e+00	679.00
IUUC-Fal-036749	Ficedula albicollis	78.13	0.00e+00	669.00
IUUC-Gmo-039598	Gadus morhua	84.37	0.00e+00	783.00
IUUC-Gga-040883	Gallus gallus	77.26	0.00e+00	665.00
IUUC-Gac-042235	Gasterosteus aculeatus	85.95	0.00e+00	810.00
IUUC-Ggo-044767	Gorilla gorilla	72.06	7.00e-177	613.00
IUUC-Hsa-046581	Homo sapiens	76.84	0.00e+00	678.00
IUUC-Itr-047898	Ictidomys tridecemlineatus	76.42	0.00e+00	658.00
IUUC-Lch-049732	Latimeria chalumnae	78.69	0.00e+00	733.00
IUUC-Loc-052371	Lepisosteus oculatus	79.83	0.00e+00	743.00
IUUC-Laf-054565	Loxodonta africana	76.42	0.00e+00	657.00
IUUC-Mcc-055522	Macaca mulatta	77.26	0.00e+00	681.00
IUUC-Meu-056754	Macropus eugenii	67.29	1.00e-114	406.00
IUUC-Mga-060095	Meleagris gallopavo	73.15	4.00e-136	477.00
IUUC-Mmr-060839	Microcebus murinus	77.05	0.00e+00	666.00
IUUC-Mdo-062339	Monodelphis domestica	78.80	4.00e-177	614.00
IUUC-Mmu-063638	Mus musculus	75.79	0.00e+00	636.00
IUUC-Mpu-066647	Mustela putorius furo	79.03	9.00e-178	616.00
IUUC-Mlu-067921	Myotis lucifugus	76.00	0.00e+00	680.00
IUUC-Nle-069752	Nomascus leucogenys	77.47	0.00e+00	682.00
IUUC-Opr-070636	Ochotona princeps	69.47	7.00e-162	563.00
IUUC-Oan-073417	Ornithorhynchus anatinus	73.26	0.00e+00	630.00
IUUC-Ocu-074620	Oryctolagus cuniculus	77.05	0.00e+00	660.00
IUUC-Ola-087281	Oryzias latipes	92.11	0.00e+00	791.00
IUUC-Olu-087697	Ostreococcus lucimarinus	39.67	3.00e-55	208.00
IUUC-Oga-088448	Otolemur garnettii	77.26	0.00e+00	686.00
IUUC-Oar-090132	Ovis aries	77.05	0.00e+00	662.00
IUUC-Ptr-090696	Pan troglodytes	77.05	0.00e+00	679.00
IUUC-Pan-092124	Papio anubis	77.05	0.00e+00	677.00
IUUC-Psi-093801	Pelodiscus sinensis	78.57	6.00e-176	610.00
IUUC-Pma-094300	Petromyzon marinus	70.83	4.00e-101	360.00
IUUC-Pfo-096330	Poecilia formosa	82.32	0.00e+00	934.00
IUUC-Pab-098191	Pongo abelii	77.26	0.00e+00	681.00
IUUC-Pca-100341	Procavia capensis	73.76	1.00e-137	483.00
IUUC-Pva-103177	Pteropus vampyrus	76.79	0.00e+00	658.00
IUUC-Rno-105048	Rattus norvegicus	75.37	0.00e+00	633.00
IUUC-Sha-107429	Sarcophilus harrisii	77.05	0.00e+00	663.00
IUUC-Sar-113024	Sorex araneus	76.81	0.00e+00	646.00
IUUC-Ssc-115749	Sus scrofa	73.10	5.00e-119	420.00
IUUC-Tgu-117277	Taeniopygia guttata	78.13	0.00e+00	686.00
IUUC-Tru-117844	Takifugu rubripes	89.68	0.00e+00	858.00
IUUC-Tsy-119456	Tarsius syrichta	74.11	0.00e+00	653.00
IUUC-Tni-120251	Tetraodon nigroviridis	85.95	0.00e+00	860.00
IUUC-Tbe-127423	Tupaia belangeri	72.21	2.00e-172	599.00
IUUC-Ttr-128401	Tursiops truncatus	70.74	2.00e-169	588.00
IUUC-Vda-129829	Verticillium dahliae	31.76	2.00e-33	136.00
IUUC-Vpa-130549	Vicugna pacos	66.77	1.00e-119	422.00
IUUC-Xtr-131892	Xenopus tropicalis	71.01	9.00e-176	610.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence