iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-028196

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin protein ligase E3C

Genbank Nucleotide ID

BX247878

Gene Name

ube3c

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000035978.8	ENSDART00000134547.3	ENSDARP00000116921.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.70e-104	350.8	744	1081

Active Site

Position(s)	Description	Evidence
1049	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvg.....EegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqd 84
            dlkkr++v++++     E+g+d gG++refl++l+k  +np+ g+f++++++    +p  ++ +  +  +++++flGr+lgkal++
   Q: 744  PDLKKRIRVHLLNahgldEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPSPTAEMLVG-ESFTRHYYFLGRILGKALYE 829
           689**********99**9*******************************************99985.5******************* PP
   S: 85   grlldlplsksfyklllgk..klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneN 169
           + l++lp++++f+++llg+  ++++++l+++dpe+y++l ++k++ e d+e+lgl++t+   ++ lge++++eLkpgG++ipVt +N
   Q: 830  NMLVELPFASFFLSKLLGTsaDVDIHHLASLDPEMYRNLLFLKSY-EGDVEDLGLNFTVV--NNDLGEAQVVELKPGGKDIPVTTAN 913
           ******************9666889******************99.78999987777765..888********************** PP
   S: 170  keeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGe.eeidvedlkketkykggytedspaiqwFwevlee 255
           + +Y++lv++yrl+++i+ ++ afr+G+ +v++le+l++F+++e+++l++G    i +edlk++t+y ggy++++p+i+ Fw+v+e+
   Q: 914  RIAYIHLVADYRLNKQIRAHCLAFRQGLANVVNLEWLRMFDQQEIQVLVSGAhVPICLEDLKRFTNYSGGYSATHPVIKIFWDVVES 1000
           ****************************************************999******************************** PP
   S: 256  fsseerkafLqFvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           fs+ee++++L+FvT++sr Pl Gf+el p  f+i++ ++d +rlP+++TC+n+LkLPe+   + +++kLlyAie+++gFels
   Q: 1001 FSDEEKRKLLKFVTSCSRPPLLGFKELYPA-FCIHNGGTDlERLPTASTCMNLLKLPEFCDPQLMRNKLLYAIESSAGFELS 1081
           ****************************88.*****99999**************************************985 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MFSFEGDFRR TPKVSLGGAS RKEEKASLLH RTQEERRKRE DERKRLKNAI IIQSYIRGYQ 60
DRKQQYAIQR GSFDHCVCQC QSGSGPQLTD SAILSQLVRQ LLFFYRLSED RPRMIWMCQC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTTGTTTGG TAGAGCAAGA GCTACGATTT CGGTTTTGTT TTCTTTGATT TCCAGTCGCT 60
GAACTATACC GTTCGGCTGA TCATTCTGTA AAGTCAGGTA AACGATTTGC ATTACATTGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR000048--IQ_motif_EF-hand-BS

PROSITE

PS50237--HECT
PS50096--IQ

Pfam

PF00632--HECT
PF00612--IQ

SMART

SM00119--HECTc
SM00015--IQ

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

KEGG

dre:393445

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001355	Ailuropoda melanoleuca	75.77	0.00e+00	1589.00
IUUC-Apl-003731	Anas platyrhynchos	79.54	0.00e+00	1694.00
IUUC-Aca-005248	Anolis carolinensis	79.15	0.00e+00	1706.00
IUUC-Ath-006576	Arabidopsis thaliana	29.05	1.00e-113	404.00
IUUC-Ago-007748	Ashbya gossypii	42.14	3.00e-79	290.00
IUUC-Acl-008158	Aspergillus clavatus	39.53	5.00e-80	293.00
IUUC-Afl-008398	Aspergillus flavus	39.02	4.00e-80	293.00
IUUC-Afu-008937	Aspergillus fumigatus	39.92	3.00e-82	300.00
IUUC-Ani-009252	Aspergillus nidulans	38.98	3.00e-83	303.00
IUUC-Ang-009773	Aspergillus niger	35.34	7.00e-83	302.00
IUUC-Aor-009940	Aspergillus oryzae	39.02	5.00e-80	293.00
IUUC-Ate-010395	Aspergillus terreus	38.59	1.00e-80	295.00
IUUC-Ame-010769	Astyanax mexicanus	69.01	0.00e+00	1142.00
IUUC-Bgr-012269	Blumeria graminis	38.21	7.00e-77	281.00
IUUC-Bta-012841	Bos taurus	76.68	0.00e+00	1622.00
IUUC-Bci-013743	Botrytis cinerea	37.90	2.00e-83	304.00
IUUC-Bol-015390	Brassica oleracea	30.23	5.00e-107	382.00
IUUC-Bra-016853	Brassica rapa	30.79	9.00e-114	405.00
IUUC-Cel-018638	Caenorhabditis elegans	38.65	1.00e-89	325.00
IUUC-Cja-019743	Callithrix jacchus	75.19	0.00e+00	1587.00
IUUC-Cfa-021031	Canis familiaris	76.84	0.00e+00	1647.00
IUUC-Cpo-022401	Cavia porcellus	77.65	0.00e+00	1640.00
IUUC-Cre-022725	Chlamydomonas reinhardtii	43.73	9.00e-83	300.00
IUUC-Csa-024107	Chlorocebus sabaeus	76.92	0.00e+00	1645.00
IUUC-Cho-024750	Choloepus hoffmanni	75.42	0.00e+00	733.00
IUUC-Cin-025432	Ciona intestinalis	45.87	5.00e-100	357.00
IUUC-Cgl-026559	Colletotrichum gloeosporioides	34.38	7.00e-86	312.00
IUUC-Cne-026841	Cryptococcus neoformans	36.22	7.00e-94	338.00
IUUC-Cme-027265	Cyanidioschyzon merolae	47.34	6.00e-105	375.00
IUUC-Dno-029024	Dasypus novemcinctus	77.21	0.00e+00	1657.00
IUUC-Dor-030483	Dipodomys ordii	80.94	3.00e-172	599.00
IUUC-Dse-031416	Dothistroma septosporum	33.73	4.00e-78	286.00
IUUC-Dme-031946	Drosophila melanogaster	37.34	0.00e+00	673.00
IUUC-Ete-032240	Echinops telfairi	68.67	1.00e-142	501.00
IUUC-Eca-033828	Equus caballus	76.65	0.00e+00	1607.00
IUUC-Eeu-034604	Erinaceus europaeus	80.38	2.00e-120	427.00
IUUC-Fca-035907	Felis catus	77.12	0.00e+00	1644.00
IUUC-Fal-037389	Ficedula albicollis	79.61	0.00e+00	1704.00
IUUC-Fox-037788	Fusarium oxysporum	37.36	3.00e-89	323.00
IUUC-Fso-038088	Fusarium solani	36.01	6.00e-86	313.00
IUUC-Gmo-039254	Gadus morhua	72.69	0.00e+00	1338.00
IUUC-Ggr-039941	Gaeumannomyces graminis	34.26	1.00e-83	305.00
IUUC-Gga-040310	Gallus gallus	79.15	0.00e+00	1696.00
IUUC-Gac-042054	Gasterosteus aculeatus	76.66	0.00e+00	1388.00
IUUC-Ggo-045031	Gorilla gorilla	77.10	0.00e+00	1649.00
IUUC-Hsa-045880	Homo sapiens	77.10	0.00e+00	1650.00
IUUC-Itr-048555	Ictidomys tridecemlineatus	63.51	9.00e-146	509.00
IUUC-Kpa-049307	Komagataella pastoris	33.46	3.00e-67	250.00
IUUC-Lch-050403	Latimeria chalumnae	78.07	0.00e+00	1595.00
IUUC-Loc-052218	Lepisosteus oculatus	83.93	0.00e+00	1772.00
IUUC-Lma-053096	Leptosphaeria maculans	38.88	1.00e-81	298.00
IUUC-Laf-054162	Loxodonta africana	74.04	0.00e+00	1395.00
IUUC-Mcc-055127	Macaca mulatta	76.92	0.00e+00	1642.00
IUUC-Meu-056187	Macropus eugenii	79.57	1.00e-102	367.00
IUUC-Mor-057021	Magnaporthe oryzae	33.68	2.00e-78	288.00
IUUC-Mpo-057570	Magnaporthe poae	37.20	2.00e-78	287.00
IUUC-Mtr-058154	Medicago truncatula	35.24	1.00e-104	375.00
IUUC-Mla-059124	Melampsora laricipopulina	48.03	1.00e-102	367.00
IUUC-Mga-059581	Meleagris gallopavo	79.04	0.00e+00	1685.00
IUUC-Mvi-060445	Microbotryum violaceum	39.05	9.00e-104	372.00
IUUC-Mmr-061360	Microcebus murinus	74.65	0.00e+00	1517.00
IUUC-Mdo-062194	Monodelphis domestica	76.24	0.00e+00	1676.00
IUUC-Mmu-064189	Mus musculus	77.10	0.00e+00	1646.00
IUUC-Mac-065275	Musa acuminata	50.12	3.00e-109	390.00
IUUC-Mpu-066439	Mustela putorius furo	76.50	0.00e+00	1590.00
IUUC-Mlu-068228	Myotis lucifugus	74.42	0.00e+00	1584.00
IUUC-Nfi-068280	Neosartorya fischeri	40.13	7.00e-83	302.00
IUUC-Ncr-068869	Neurospora crassa	36.67	3.00e-85	310.00
IUUC-Nle-069687	Nomascus leucogenys	76.81	0.00e+00	1602.00
IUUC-Opr-070592	Ochotona princeps	91.00	4.00e-107	382.00
IUUC-Ont-071836	Oreochromis niloticus	84.86	0.00e+00	1769.00
IUUC-Oan-072800	Ornithorhynchus anatinus	78.32	0.00e+00	1692.00
IUUC-Ocu-074587	Oryctolagus cuniculus	77.75	0.00e+00	1664.00
IUUC-Ola-087209	Oryzias latipes	83.56	0.00e+00	1709.00
IUUC-Olu-087699	Ostreococcus lucimarinus	43.55	3.00e-88	318.00
IUUC-Oga-088776	Otolemur garnettii	75.16	0.00e+00	1526.00
IUUC-Oar-089441	Ovis aries	76.61	0.00e+00	1615.00
IUUC-Ptr-091273	Pan troglodytes	77.10	0.00e+00	1650.00
IUUC-Pan-091981	Papio anubis	77.10	0.00e+00	1647.00
IUUC-Psi-093203	Pelodiscus sinensis	78.60	0.00e+00	1465.00
IUUC-Pma-094738	Petromyzon marinus	64.08	0.00e+00	1280.00
IUUC-Pno-095132	Phaeosphaeria nodorum	29.60	3.00e-62	233.00
IUUC-Pfo-097511	Poecilia formosa	84.27	0.00e+00	1771.00
IUUC-Pab-098634	Pongo abelii	74.17	0.00e+00	1569.00
IUUC-Pop-098928	Populus trichocarpa	36.10	2.00e-99	357.00
IUUC-Pca-100987	Procavia capensis	77.87	0.00e+00	785.00
IUUC-Pva-103034	Pteropus vampyrus	72.69	0.00e+00	1510.00
IUUC-Pgr-103513	Puccinia graminis	39.97	3.00e-107	383.00
IUUC-Ptt-103967	Puccinia triticina	41.52	2.00e-95	344.00
IUUC-Pte-104105	Pyrenophora teres	35.48	4.00e-83	303.00
IUUC-Pyt-104449	Pyrenophora triticirepentis	38.79	2.00e-80	295.00
IUUC-Rno-105380	Rattus norvegicus	75.88	0.00e+00	1433.00
IUUC-Sce-106446	Saccharomyces cerevisiae	40.14	4.00e-68	253.00
IUUC-Sha-107108	Sarcophilus harrisii	72.68	0.00e+00	1536.00
IUUC-Sja-107889	Schizosaccharomyces japonicus	44.13	4.00e-98	353.00
IUUC-Spo-108097	Schizosaccharomyces pombe	45.59	2.00e-97	351.00
IUUC-Ssl-108520	Sclerotinia sclerotiorum	34.73	5.00e-84	306.00
IUUC-Sly-111362	Solanum lycopersicum	35.93	1.00e-100	361.00
IUUC-Sar-113687	Sorex araneus	74.05	0.00e+00	806.00
IUUC-Sre-115038	Sporisorium reilianum	44.83	7.00e-99	355.00
IUUC-Ssc-115378	Sus scrofa	88.59	0.00e+00	707.00
IUUC-Tgu-116729	Taeniopygia guttata	78.62	0.00e+00	1691.00
IUUC-Tru-118068	Takifugu rubripes	83.16	0.00e+00	1722.00
IUUC-Tsy-118942	Tarsius syrichta	76.03	6.00e-168	585.00
IUUC-Tni-120732	Tetraodon nigroviridis	82.58	0.00e+00	1672.00
IUUC-Tre-121892	Trichoderma reesei	36.22	5.00e-87	316.00
IUUC-Tvi-122354	Trichoderma virens	36.20	1.00e-88	322.00
IUUC-Tme-127102	Tuber melanosporum	37.11	2.00e-97	350.00
IUUC-Tbe-127351	Tupaia belangeri	68.06	0.00e+00	1276.00
IUUC-Ttr-129061	Tursiops truncatus	73.71	0.00e+00	1550.00
IUUC-Uma-129343	Ustilago maydis	44.33	3.00e-99	357.00
IUUC-Vda-129748	Verticillium dahliae	38.24	4.00e-78	286.00
IUUC-Vvi-131234	Vitis vinifera	30.18	2.00e-105	377.00
IUUC-Xtr-132094	Xenopus tropicalis	77.37	0.00e+00	1614.00
IUUC-Xma-133923	Xiphophorus maculatus	84.37	0.00e+00	1770.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence