iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000005968.1	ENSONIT00000007522.1	ENSONIP00000007517.1
ENSONIG00000005968.1	ENSONIT00000007523.1	ENSONIP00000007518.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.80e-105	352.4	746	1083

Active Site

Position(s)	Description	Evidence
1051	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvg.....EegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqd 84
            dlkkr++v++++     E+g+d gG++refl++l+k  +np+ g+f++++++    +p+ ++ + +   +++++flGr+lgkal++
   Q: 746  PDLKKRIRVHLLNahgldEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPSPAAEMLVGD-SFTRHYYFLGRILGKALYE 831
           689**********99**9*******************************************999965.9****************** PP
   S: 85   grlldlplsksfyklllgk..klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneN 169
           + l++lp++++f+++llg+  ++++++l+++dpe+y++l ++k++ e d+eelgl++t+   ++ lge++++eLkpgG++ipVt +N
   Q: 832  NMLVELPFASFFLSKLLGTsaDVDIHHLASLDPEMYRNLLFLKSY-EGDVEELGLNFTVV--NNDLGEAQVVELKPGGKDIPVTTAN 915
           ******************9666889******************99.78999987777765..888********************** PP
   S: 170  keeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGe.eeidvedlkketkykggytedspaiqwFwevlee 255
           + +Y++lv++yrl+++i+ ++ afr+G+ +v++le+l++F+++e+++li+G    i ++dlk++t+y ggy++++p+iq Fwev+e+
   Q: 916  RIAYIHLVADYRLNKQIRPHCLAFRQGLAKVVNLEWLRMFDQQEIQVLISGAhVPICLDDLKNFTNYSGGYSATHPVIQIFWEVVEG 1002
           ****************************************************999******************************** PP
   S: 256  fsseerkafLqFvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           f++ee++++L+FvT++sr Pl Gf+el p  f+i++ ++d drlP+++TC+n+LkLPe+  +  +++kLlyAie+++gFels
   Q: 1003 FTDEEKRKLLKFVTSCSRPPLLGFKELYPA-FCIHNGGTDlDRLPTASTCMNLLKLPEFCDQHLMRNKLLYAIESSSGFELS 1083
           ****************************88.*****99999**************************************985 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

MFSFEGDFKT RPKVSLGGAS KKEEKASLLH RTQEERRKRE DERRRLKNAI IIQSYVRGYQ 60
DLKKQYAIQR AKFDERVSQT QSGGAQHALD GVGLCLLSRQ LIFFYRQSVD AHRLIWLCQN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTTTATTGT TTATTTTAAT TACCTAAAAT GGTTAGCTTT AGTTAACTTT AACAACCTTG 60
GTTCATGTTT CCCTTACGTT AGAGGACCTT ACCCAAACCG TAATCTAAAC GTCTATCCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001355	Ailuropoda melanoleuca	76.51	0.00e+00	1612.00
IUUC-Apl-003731	Anas platyrhynchos	80.37	0.00e+00	1726.00
IUUC-Aca-005248	Anolis carolinensis	80.06	0.00e+00	1740.00
IUUC-Aly-005768	Arabidopsis lyrata	46.51	2.00e-107	384.00
IUUC-Ago-007748	Ashbya gossypii	43.10	2.00e-80	294.00
IUUC-Acl-008158	Aspergillus clavatus	38.46	6.00e-76	279.00
IUUC-Afl-008398	Aspergillus flavus	38.81	7.00e-78	286.00
IUUC-Afu-008937	Aspergillus fumigatus	39.07	1.00e-78	288.00
IUUC-Ani-009252	Aspergillus nidulans	38.51	2.00e-80	294.00
IUUC-Ang-009773	Aspergillus niger	37.95	3.00e-76	281.00
IUUC-Aor-009940	Aspergillus oryzae	38.81	7.00e-78	286.00
IUUC-Ate-010395	Aspergillus terreus	37.53	2.00e-78	288.00
IUUC-Ame-010769	Astyanax mexicanus	67.43	0.00e+00	1119.00
IUUC-Bgr-012269	Blumeria graminis	38.04	2.00e-74	273.00
IUUC-Bta-012841	Bos taurus	77.33	0.00e+00	1657.00
IUUC-Bci-013743	Botrytis cinerea	37.90	3.00e-83	303.00
IUUC-Bol-015390	Brassica oleracea	46.51	3.00e-102	366.00
IUUC-Bra-016853	Brassica rapa	35.69	6.00e-108	385.00
IUUC-Cel-018638	Caenorhabditis elegans	38.65	2.00e-88	320.00
IUUC-Cja-019743	Callithrix jacchus	75.93	0.00e+00	1618.00
IUUC-Cfa-021031	Canis familiaris	77.76	0.00e+00	1673.00
IUUC-Cpo-022401	Cavia porcellus	78.39	0.00e+00	1677.00
IUUC-Cre-022725	Chlamydomonas reinhardtii	44.25	6.00e-85	307.00
IUUC-Csa-024107	Chlorocebus sabaeus	77.84	0.00e+00	1681.00
IUUC-Cho-024750	Choloepus hoffmanni	75.42	0.00e+00	732.00
IUUC-Cin-025432	Ciona intestinalis	45.15	9.00e-97	347.00
IUUC-Cgl-026559	Colletotrichum gloeosporioides	33.98	3.00e-85	310.00
IUUC-Cne-026841	Cryptococcus neoformans	35.71	4.00e-93	336.00
IUUC-Cme-027265	Cyanidioschyzon merolae	47.58	1.00e-104	374.00
IUUC-Dre-028196	Danio rerio	84.86	0.00e+00	1739.00
IUUC-Dno-029024	Dasypus novemcinctus	78.14	0.00e+00	1686.00
IUUC-Dor-030483	Dipodomys ordii	81.46	2.00e-175	609.00
IUUC-Dse-031416	Dothistroma septosporum	34.02	6.00e-77	283.00
IUUC-Dme-031946	Drosophila melanogaster	36.46	0.00e+00	672.00
IUUC-Ete-032240	Echinops telfairi	70.60	7.00e-149	521.00
IUUC-Eca-033828	Equus caballus	77.12	0.00e+00	1634.00
IUUC-Eeu-034604	Erinaceus europaeus	81.92	8.00e-122	431.00
IUUC-Fca-035907	Felis catus	77.21	0.00e+00	1670.00
IUUC-Fal-037389	Ficedula albicollis	80.26	0.00e+00	1743.00
IUUC-Fox-037788	Fusarium oxysporum	37.25	5.00e-90	326.00
IUUC-Fso-038088	Fusarium solani	35.95	2.00e-86	314.00
IUUC-Gmo-039254	Gadus morhua	76.85	0.00e+00	1441.00
IUUC-Ggr-039941	Gaeumannomyces graminis	34.09	1.00e-82	301.00
IUUC-Gga-040310	Gallus gallus	79.98	0.00e+00	1732.00
IUUC-Gac-042054	Gasterosteus aculeatus	85.54	0.00e+00	1562.00
IUUC-Ggo-045031	Gorilla gorilla	78.12	0.00e+00	1686.00
IUUC-Hsa-045880	Homo sapiens	78.02	0.00e+00	1685.00
IUUC-Itr-048555	Ictidomys tridecemlineatus	63.27	1.00e-147	516.00
IUUC-Kpa-049307	Komagataella pastoris	33.79	3.00e-67	250.00
IUUC-Lch-050403	Latimeria chalumnae	78.84	0.00e+00	1619.00
IUUC-Loc-052218	Lepisosteus oculatus	86.64	0.00e+00	1815.00
IUUC-Lma-053096	Leptosphaeria maculans	38.44	2.00e-80	295.00
IUUC-Laf-054162	Loxodonta africana	74.97	0.00e+00	1417.00
IUUC-Mcc-055127	Macaca mulatta	77.75	0.00e+00	1679.00
IUUC-Meu-056187	Macropus eugenii	80.43	8.00e-103	368.00
IUUC-Mor-057021	Magnaporthe oryzae	33.56	9.00e-77	282.00
IUUC-Mpo-057570	Magnaporthe poae	36.54	2.00e-76	281.00
IUUC-Mtr-058154	Medicago truncatula	34.84	8.00e-103	369.00
IUUC-Mla-059124	Melampsora laricipopulina	47.54	6.00e-101	361.00
IUUC-Mga-059581	Meleagris gallopavo	79.96	0.00e+00	1717.00
IUUC-Mvi-060445	Microbotryum violaceum	37.70	2.00e-102	367.00
IUUC-Mmr-061360	Microcebus murinus	74.74	0.00e+00	1540.00
IUUC-Mdo-062194	Monodelphis domestica	76.60	0.00e+00	1711.00
IUUC-Mmu-064189	Mus musculus	78.60	0.00e+00	1679.00
IUUC-Mpu-066439	Mustela putorius furo	76.50	0.00e+00	1613.00
IUUC-Mlu-068228	Myotis lucifugus	75.12	0.00e+00	1623.00
IUUC-Nfi-068280	Neosartorya fischeri	39.28	3.00e-79	290.00
IUUC-Ncr-068869	Neurospora crassa	35.96	2.00e-84	308.00
IUUC-Nle-069687	Nomascus leucogenys	77.47	0.00e+00	1632.00
IUUC-Opr-070592	Ochotona princeps	92.00	8.00e-109	388.00
IUUC-Oan-072800	Ornithorhynchus anatinus	79.98	0.00e+00	1744.00
IUUC-Ocu-074587	Oryctolagus cuniculus	78.58	0.00e+00	1695.00
IUUC-Ola-087209	Oryzias latipes	91.04	0.00e+00	1866.00
IUUC-Olu-087699	Ostreococcus lucimarinus	43.94	2.00e-88	318.00
IUUC-Oga-088776	Otolemur garnettii	75.25	0.00e+00	1551.00
IUUC-Oar-089441	Ovis aries	77.07	0.00e+00	1645.00
IUUC-Ptr-091273	Pan troglodytes	78.02	0.00e+00	1685.00
IUUC-Pan-091981	Papio anubis	77.93	0.00e+00	1683.00
IUUC-Psi-093203	Pelodiscus sinensis	79.38	0.00e+00	1498.00
IUUC-Pma-094738	Petromyzon marinus	64.60	0.00e+00	1301.00
IUUC-Pno-095132	Phaeosphaeria nodorum	29.73	3.00e-62	233.00
IUUC-Pfo-097511	Poecilia formosa	93.54	0.00e+00	1984.00
IUUC-Pab-098634	Pongo abelii	75.18	0.00e+00	1604.00
IUUC-Pop-098928	Populus trichocarpa	47.28	2.00e-98	354.00
IUUC-Pca-100987	Procavia capensis	77.96	0.00e+00	789.00
IUUC-Pva-103034	Pteropus vampyrus	73.45	0.00e+00	1542.00
IUUC-Pgr-103513	Puccinia graminis	39.21	8.00e-107	382.00
IUUC-Ptt-103967	Puccinia triticina	40.80	7.00e-94	338.00
IUUC-Pte-104105	Pyrenophora teres	31.70	1.00e-80	295.00
IUUC-Pyt-104449	Pyrenophora triticirepentis	31.55	1.00e-78	288.00
IUUC-Rno-105380	Rattus norvegicus	77.67	0.00e+00	1458.00
IUUC-Sce-106446	Saccharomyces cerevisiae	41.73	5.00e-69	256.00
IUUC-Sha-107108	Sarcophilus harrisii	73.76	0.00e+00	1566.00
IUUC-Sja-107889	Schizosaccharomyces japonicus	43.90	3.00e-98	353.00
IUUC-Spo-108097	Schizosaccharomyces pombe	44.85	1.00e-95	344.00
IUUC-Ssl-108520	Sclerotinia sclerotiorum	30.31	4.00e-85	310.00
IUUC-Sly-111362	Solanum lycopersicum	35.68	4.00e-100	359.00
IUUC-Sar-113687	Sorex araneus	74.23	0.00e+00	826.00
IUUC-Sre-115038	Sporisorium reilianum	44.09	6.00e-97	349.00
IUUC-Ssc-115378	Sus scrofa	88.86	0.00e+00	704.00
IUUC-Tgu-116729	Taeniopygia guttata	79.82	0.00e+00	1731.00
IUUC-Tru-118068	Takifugu rubripes	90.12	0.00e+00	1884.00
IUUC-Tsy-118942	Tarsius syrichta	77.48	6.00e-175	608.00
IUUC-Tni-120732	Tetraodon nigroviridis	89.79	0.00e+00	1843.00
IUUC-Tre-121892	Trichoderma reesei	35.51	5.00e-86	313.00
IUUC-Tvi-122354	Trichoderma virens	35.15	2.00e-86	314.00
IUUC-Tme-127102	Tuber melanosporum	36.06	4.00e-93	336.00
IUUC-Tbe-127351	Tupaia belangeri	68.35	0.00e+00	1299.00
IUUC-Ttr-129061	Tursiops truncatus	74.63	0.00e+00	1588.00
IUUC-Uma-129343	Ustilago maydis	44.83	5.00e-100	359.00
IUUC-Vda-129748	Verticillium dahliae	37.86	5.00e-78	286.00
IUUC-Vvi-131234	Vitis vinifera	35.56	3.00e-101	363.00
IUUC-Xtr-132094	Xenopus tropicalis	79.28	0.00e+00	1665.00
IUUC-Xma-133923	Xiphophorus maculatus	93.72	0.00e+00	1986.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence