iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000018274.1	ENSSHAT00000021749.1	ENSSHAP00000021575.1
ENSSHAG00000018274.1	ENSSHAT00000021750.1	ENSSHAP00000021576.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.50e-93	313.3	743	1081

Active Site

Position(s)	Description	Evidence
1049	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvg.....EegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqd 84
            dlkkr++v++++     E+g+d gG++refl++l+k  +np+ g+f++++++    +p+ ++ + +    ++++flGr+lgk+++ 
   Q: 743  PDLKKRIRVHLLNahgldEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAQMLVGD-SFARHYYFLGRMLGKVVYV 828
           689**********99**9************************************9999999999965.999**************** PP
   S: 85   grlldlplsksfyklllgkklsl..edleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneN 169
           +  l++p s +f+ +llg ++++  ++l ++d+  ++sl +  ++   ++++  l   f++s++++g  k++eLkpgG++ipVt +N
   Q: 829  KIKLEAPRSIFFLLRLLGANVDVnfSHLLSTDRPAFNSLLFTGKSY--STDNQFLGSLFTISHNKFGHFKVVELKPGGKDIPVTSAN 913
           ******************975554499***********88877663..66666688999999************************* PP
   S: 170  keeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGe.eeidvedlkketkykggytedspaiqwFwevlee 255
           + +Y++lv++yrl+++i++++ afr+G+ +v++le+l++F+++e+++li+G    i++edlk++t+y ggy++d+p+i+ Fw+v+e+
   Q: 914  RIAYIHLVADYRLNKQIRQHCLAFRQGLANVVNLEWLRMFDQQEIQVLISGAqVPISLEDLKSFTNYSGGYSADHPVIKIFWKVVES 1000
           ****************************************************899******************************** PP
   S: 256  fsseerkafLqFvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           f++ee++++L+FvT++sr Pl Gf+el p  f+i++ +sd drlP+++TC+n+LkLPe+  ++ l++kLlyAie ++gFels
   Q: 1001 FTDEEKRKLLKFVTSCSRPPLLGFKELYPA-FCIHNGGSDlDRLPTASTCMNLLKLPEFYDENLLRSKLLYAIECAAGFELS 1081
           ****************************88.*****99999**************************************985 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

LFSFLKKTPQ TRLKAASRKE EKASLLHRTQ EERRKREEER RRLKNAIIIQ SFVRGYRDRK 60
QQYSIQRSEF DQCANLAQSG GSFSVANGPN LTLLVRQLLF FYKQNEDSKR LIWMCQNLIK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTTTTTCCT TTTTAAAAAA AATCTCTCCA GCACTTAGCT CAGTGCCTGG GATATAGCTG 60
TGTAATAGAT ACTTCTTGAT TGAGTTTTGT ATGATGCTTA TTATTTCATT TGAAGTAGTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR000048--IQ_motif_EF-hand-BS

PROSITE

PS50237--HECT
PS50096--IQ

Pfam

PF00632--HECT

SMART

SM00119--HECTc
SM00015--IQ

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0000209--P:protein polyubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001355	Ailuropoda melanoleuca	83.07	0.00e+00	1720.00
IUUC-Apl-003731	Anas platyrhynchos	87.58	0.00e+00	1819.00
IUUC-Aca-005248	Anolis carolinensis	85.73	0.00e+00	1804.00
IUUC-Ago-007748	Ashbya gossypii	39.81	2.00e-73	270.00
IUUC-Acl-008158	Aspergillus clavatus	35.81	1.00e-67	251.00
IUUC-Afl-008398	Aspergillus flavus	35.38	9.00e-69	255.00
IUUC-Afu-008937	Aspergillus fumigatus	36.71	5.00e-71	263.00
IUUC-Ani-009252	Aspergillus nidulans	35.11	4.00e-68	253.00
IUUC-Ang-009773	Aspergillus niger	31.68	5.00e-70	259.00
IUUC-Aor-009940	Aspergillus oryzae	35.38	9.00e-69	255.00
IUUC-Ate-010395	Aspergillus terreus	32.18	1.00e-70	261.00
IUUC-Ame-010769	Astyanax mexicanus	61.54	0.00e+00	992.00
IUUC-Bgr-012269	Blumeria graminis	36.60	1.00e-65	243.00
IUUC-Bta-012841	Bos taurus	80.68	0.00e+00	1683.00
IUUC-Bci-013743	Botrytis cinerea	32.82	4.00e-75	276.00
IUUC-Cel-018638	Caenorhabditis elegans	37.44	8.00e-81	295.00
IUUC-Cja-019743	Callithrix jacchus	83.07	0.00e+00	1722.00
IUUC-Cfa-021031	Canis familiaris	83.58	0.00e+00	1732.00
IUUC-Cpo-022401	Cavia porcellus	82.14	0.00e+00	1709.00
IUUC-Cre-022725	Chlamydomonas reinhardtii	41.18	5.00e-75	274.00
IUUC-Csa-024107	Chlorocebus sabaeus	84.16	0.00e+00	1754.00
IUUC-Cho-024750	Choloepus hoffmanni	72.77	0.00e+00	694.00
IUUC-Cin-025432	Ciona intestinalis	41.40	8.00e-85	306.00
IUUC-Cgl-026559	Colletotrichum gloeosporioides	33.10	3.00e-78	286.00
IUUC-Cne-026841	Cryptococcus neoformans	35.36	4.00e-86	312.00
IUUC-Cme-027265	Cyanidioschyzon merolae	43.51	9.00e-92	331.00
IUUC-Dre-028196	Danio rerio	72.68	0.00e+00	1459.00
IUUC-Dno-029024	Dasypus novemcinctus	85.54	0.00e+00	1781.00
IUUC-Dor-030483	Dipodomys ordii	85.38	0.00e+00	641.00
IUUC-Dse-031416	Dothistroma septosporum	32.42	3.00e-72	266.00
IUUC-Dme-031946	Drosophila melanogaster	35.01	8.00e-169	587.00
IUUC-Ete-032240	Echinops telfairi	77.64	2.00e-162	566.00
IUUC-Eca-033828	Equus caballus	84.96	0.00e+00	1748.00
IUUC-Eeu-034604	Erinaceus europaeus	69.38	4.00e-98	352.00
IUUC-Fca-035907	Felis catus	82.78	0.00e+00	1733.00
IUUC-Fal-037389	Ficedula albicollis	87.75	0.00e+00	1850.00
IUUC-Fox-037788	Fusarium oxysporum	36.28	2.00e-79	290.00
IUUC-Fso-038088	Fusarium solani	35.04	5.00e-78	286.00
IUUC-Gmo-039254	Gadus morhua	63.26	0.00e+00	1141.00
IUUC-Ggr-039941	Gaeumannomyces graminis	32.35	2.00e-73	271.00
IUUC-Gga-040310	Gallus gallus	86.56	0.00e+00	1825.00
IUUC-Gac-042054	Gasterosteus aculeatus	66.97	0.00e+00	1205.00
IUUC-Ggo-045031	Gorilla gorilla	84.44	0.00e+00	1760.00
IUUC-Hsa-045880	Homo sapiens	84.44	0.00e+00	1760.00
IUUC-Itr-048555	Ictidomys tridecemlineatus	78.30	5.00e-180	623.00
IUUC-Lch-050403	Latimeria chalumnae	77.75	0.00e+00	1560.00
IUUC-Loc-052218	Lepisosteus oculatus	77.39	0.00e+00	1561.00
IUUC-Lma-053096	Leptosphaeria maculans	36.11	9.00e-70	258.00
IUUC-Laf-054162	Loxodonta africana	81.01	0.00e+00	1498.00
IUUC-Mcc-055127	Macaca mulatta	84.16	0.00e+00	1755.00
IUUC-Meu-056187	Macropus eugenii	65.75	1.00e-89	324.00
IUUC-Mor-057021	Magnaporthe oryzae	32.93	7.00e-70	259.00
IUUC-Mla-059124	Melampsora laricipopulina	44.47	5.00e-87	314.00
IUUC-Mga-059581	Meleagris gallopavo	87.12	0.00e+00	1828.00
IUUC-Mvi-060445	Microbotryum violaceum	35.88	5.00e-92	332.00
IUUC-Mmr-061360	Microcebus murinus	81.13	0.00e+00	1630.00
IUUC-Mdo-062194	Monodelphis domestica	91.66	0.00e+00	1884.00
IUUC-Mmu-064189	Mus musculus	82.69	0.00e+00	1733.00
IUUC-Mpu-066439	Mustela putorius furo	82.84	0.00e+00	1710.00
IUUC-Mlu-068228	Myotis lucifugus	81.31	0.00e+00	1688.00
IUUC-Nfi-068280	Neosartorya fischeri	36.71	6.00e-71	262.00
IUUC-Ncr-068869	Neurospora crassa	34.15	2.00e-74	274.00
IUUC-Nle-069687	Nomascus leucogenys	84.68	0.00e+00	1731.00
IUUC-Opr-070592	Ochotona princeps	69.48	1.00e-105	377.00
IUUC-Ont-071836	Oreochromis niloticus	73.76	0.00e+00	1507.00
IUUC-Oan-072800	Ornithorhynchus anatinus	87.85	0.00e+00	1847.00
IUUC-Ocu-074587	Oryctolagus cuniculus	84.62	0.00e+00	1764.00
IUUC-Ola-087209	Oryzias latipes	79.32	0.00e+00	1125.00
IUUC-Oga-088776	Otolemur garnettii	79.83	0.00e+00	1595.00
IUUC-Oar-089441	Ovis aries	80.13	0.00e+00	1674.00
IUUC-Ptr-091273	Pan troglodytes	84.35	0.00e+00	1758.00
IUUC-Pan-091981	Papio anubis	84.16	0.00e+00	1756.00
IUUC-Psi-093203	Pelodiscus sinensis	85.94	0.00e+00	1573.00
IUUC-Pma-094738	Petromyzon marinus	59.05	0.00e+00	1191.00
IUUC-Pfo-097511	Poecilia formosa	73.16	0.00e+00	1517.00
IUUC-Pab-098634	Pongo abelii	81.69	0.00e+00	1684.00
IUUC-Pca-100987	Procavia capensis	76.22	0.00e+00	758.00
IUUC-Pva-103034	Pteropus vampyrus	80.64	0.00e+00	1640.00
IUUC-Pgr-103513	Puccinia graminis	36.43	1.00e-90	327.00
IUUC-Ptt-103967	Puccinia triticina	38.23	4.00e-79	289.00
IUUC-Pyt-104449	Pyrenophora triticirepentis	35.68	2.00e-68	254.00
IUUC-Rno-105380	Rattus norvegicus	80.21	0.00e+00	1472.00
IUUC-Sce-106446	Saccharomyces cerevisiae	39.09	4.00e-62	233.00
IUUC-Sja-107889	Schizosaccharomyces japonicus	40.85	2.00e-86	314.00
IUUC-Spo-108097	Schizosaccharomyces pombe	42.05	6.00e-85	308.00
IUUC-Ssl-108520	Sclerotinia sclerotiorum	31.44	3.00e-73	270.00
IUUC-Sar-113687	Sorex araneus	72.68	0.00e+00	803.00
IUUC-Sre-115038	Sporisorium reilianum	40.79	2.00e-84	308.00
IUUC-Ssc-116168	Sus scrofa	74.69	0.00e+00	660.00
IUUC-Tgu-116729	Taeniopygia guttata	87.21	0.00e+00	1832.00
IUUC-Tru-118068	Takifugu rubripes	71.42	0.00e+00	1459.00
IUUC-Tsy-118942	Tarsius syrichta	86.23	0.00e+00	663.00
IUUC-Tni-120732	Tetraodon nigroviridis	70.89	0.00e+00	1424.00
IUUC-Tvi-122354	Trichoderma virens	34.46	6.00e-79	289.00
IUUC-Tme-127102	Tuber melanosporum	35.59	5.00e-85	309.00
IUUC-Tbe-127351	Tupaia belangeri	73.10	0.00e+00	1344.00
IUUC-Ttr-129061	Tursiops truncatus	79.93	0.00e+00	1637.00
IUUC-Uma-129343	Ustilago maydis	40.44	2.00e-84	307.00
IUUC-Vda-129748	Verticillium dahliae	36.18	2.00e-71	264.00
IUUC-Xtr-132094	Xenopus tropicalis	81.62	0.00e+00	1699.00
IUUC-Xma-133923	Xiphophorus maculatus	73.35	0.00e+00	1521.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence