iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000178184.15	ENST00000470488.2	ENSP00000468735.1
ENSG00000178184.15	ENST00000463384.1	ENSP00000466076.1
ENSG00000178184.15	ENST00000353265.7	ENSP00000343144.3

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
InWeb_IM
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
ULD/UDP/UFD/PB1	PB1	17726178

Classification

Family	E-value	Score	Start	End
ULD/UDP/UFD/PB1	1.60e-23	84.4	19	97

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UFD/PB1

   S: 2    vrvkvsykgeirsfaldlekpgkfedLlkavrtltelknsevalkYeDedGDlvtlksDedldkavsllaskksllrlliqk 83
           v+vk+++++e+r+f+ld++kpgkfed++k+v ++++++ns+v+++Y+D +GDl+++++D++++kavs   s+++llr++iqk
   Q: 19   VEVKSKFGAEFRRFSLDRHKPGKFEDFYKLVVHTHHISNSDVTIGYADVHGDLLPINNDDNFCKAVS---SANPLLRVFIQK 97
           89*****************************************************************...**********98 PP

Organism

Homo sapiens

Functional Description
(View)

Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (By similarity).

Protein Sequence
(Fasta)

MNRSFHKSQT LRFYDCSAVE VKSKFGAEFR RFSLDRHKPG KFEDFYKLVV HTHHISNSDV 60
TIGYADVHGD LLPINNDDNF CKAVSSANPL LRVFIQKREE AERGSLGAGS LCRRRRALGA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCTCCTCCC GCGCGCGGCC CCTGGAGTCC CTGAGGCGCG CGGCCAGCCC AGCTCGGGCC 60
CGCAGCACCG GGAGCAGCCC GCCGGCCAAG CGAGCGCGGG CCGGGGCCGG GGCCGGGGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-1185--Reference proteome
KW-0796--Tight junction

Interpro

IPR000270--PB1_dom
IPR001478--PDZ

PROSITE

PS51745--PB1
PS50106--PDZ

Pfam

PF00564--PB1
PF00595--PDZ

SMART

SM00666--PB1
SM00228--PDZ

Gene Ontology

GO:0005923--C:bicellular tight junction
GO:0005829--C:cytosol
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0070830--P:bicellular tight junction assembly
GO:0007049--P:cell cycle
GO:0051301--P:cell division

KEGG

hsa:84552

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001983	Ailuropoda melanoleuca	86.75	2.00e-117	415.00
IUUC-Aca-004233	Anolis carolinensis	64.84	2.00e-124	439.00
IUUC-Aor-009995	Aspergillus oryzae	50.00	2.30e-01	28.50
IUUC-Bta-013061	Bos taurus	81.91	1.00e-157	549.00
IUUC-Cja-019288	Callithrix jacchus	97.34	0.00e+00	690.00
IUUC-Cfa-020018	Canis familiaris	86.89	2.00e-116	412.00
IUUC-Cpo-021968	Cavia porcellus	79.11	6.00e-166	576.00
IUUC-Dno-030047	Dasypus novemcinctus	88.65	2.00e-113	401.00
IUUC-Dor-030583	Dipodomys ordii	79.83	3.00e-145	508.00
IUUC-Ete-032289	Echinops telfairi	75.80	1.00e-144	506.00
IUUC-Eca-033748	Equus caballus	80.17	9.00e-138	483.00
IUUC-Fal-037480	Ficedula albicollis	70.08	7.00e-128	450.00
IUUC-Gmo-039039	Gadus morhua	76.31	9.00e-111	393.00
IUUC-Gga-040274	Gallus gallus	71.35	5.00e-141	494.00
IUUC-Gac-042010	Gasterosteus aculeatus	60.31	9.00e-122	430.00
IUUC-Ggo-045470	Gorilla gorilla	99.40	0.00e+00	627.00
IUUC-Itr-047961	Ictidomys tridecemlineatus	80.94	1.00e-165	575.00
IUUC-Loc-052275	Lepisosteus oculatus	78.68	2.00e-118	418.00
IUUC-Laf-054415	Loxodonta africana	77.50	2.00e-136	478.00
IUUC-Mcc-055488	Macaca mulatta	99.20	0.00e+00	675.00
IUUC-Meu-055939	Macropus eugenii	73.86	4.00e-135	474.00
IUUC-Mga-059223	Meleagris gallopavo	68.60	3.00e-131	461.00
IUUC-Mmr-061228	Microcebus murinus	81.38	6.00e-162	563.00
IUUC-Mdo-062481	Monodelphis domestica	72.06	1.00e-150	525.00
IUUC-Mmu-063392	Mus musculus	76.82	7.00e-155	540.00
IUUC-Mlu-066944	Myotis lucifugus	71.01	2.00e-127	448.00
IUUC-Nle-070107	Nomascus leucogenys	99.15	6.00e-180	623.00
IUUC-Opr-071041	Ochotona princeps	77.52	4.00e-90	325.00
IUUC-Ont-071705	Oreochromis niloticus	64.72	4.00e-110	391.00
IUUC-Ola-086859	Oryzias latipes	56.62	1.00e-120	426.00
IUUC-Oga-088071	Otolemur garnettii	77.53	3.00e-144	504.00
IUUC-Oar-089299	Ovis aries	75.07	2.00e-126	445.00
IUUC-Ptr-090642	Pan troglodytes	99.73	0.00e+00	709.00
IUUC-Pan-092434	Papio anubis	99.20	0.00e+00	704.00
IUUC-Psi-094040	Pelodiscus sinensis	70.57	5.00e-153	533.00
IUUC-Pfo-096745	Poecilia formosa	66.88	3.00e-107	382.00
IUUC-Ppe-102100	Prunus persica	27.59	2.40e-02	32.70
IUUC-Rno-105280	Rattus norvegicus	77.86	3.00e-158	551.00
IUUC-Sha-106890	Sarcophilus harrisii	68.48	7.00e-109	386.00
IUUC-Sar-113368	Sorex araneus	72.61	1.00e-131	462.00
IUUC-Ssc-115590	Sus scrofa	80.05	2.00e-151	528.00
IUUC-Tgu-117002	Taeniopygia guttata	70.08	8.00e-128	450.00
IUUC-Tru-117877	Takifugu rubripes	55.80	5.00e-128	451.00
IUUC-Tsy-118978	Tarsius syrichta	76.99	2.00e-135	475.00
IUUC-Tni-120078	Tetraodon nigroviridis	62.29	3.00e-124	438.00
IUUC-Tbe-127843	Tupaia belangeri	82.39	2.00e-153	535.00
IUUC-Ttr-128298	Tursiops truncatus	80.59	4.00e-152	530.00
IUUC-Vpa-130773	Vicugna pacos	80.11	6.00e-136	477.00
IUUC-Xtr-132537	Xenopus tropicalis	64.94	2.00e-132	465.00
IUUC-Xma-133861	Xiphophorus maculatus	67.61	2.00e-105	375.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence