iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-074643

UUCD1 version

UUC-OrC-00992

Ensembl Protein ID

ENSOCUP00000002246.3

UniProt Accession

G1SHW4; G1SHW4_RABIT

Protein Name

Uncharacterized protein

Gene Name

OTUB2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000002601.3	ENSOCUT00000002601.3	ENSOCUP00000002246.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	3.80e-47	160.2	41	230

Active Site

Position(s)	Description	Evidence
48	N/A	{ECO:0000256\|PIRSR:PIRSR013503-1}
51	Nucleophile	{ECO:0000256\|PIRSR:PIRSR013503-1}
224		{ECO:0000256\|PIRSR:PIRSR013503-1}

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqs..........................................................llgvfdddslsd 32
           +i+ktkgDGnC++rA+++s                                                          ll+vf+d+ +sd
   Q: 41   AIRKTKGDGNCFYRALGYSylesllgkgreilrfkervlqtpndllaagfeehkfrnffnafhsvvelvekdgsvssLLKVFNDQGTSD 129
           79*************************************************************************************** PP
   S: 33   alveaLreltseylqkesdffsefieekedekefcqklvepeak.geeihifaLaqiLsrpiivvdvdsleskvggillpllfpeeklk 120
            +v++Lr+lts+++++++dff++fi++++d+k+fc+++vep+a  +++i+i+aL+q+L+++++v++vd++++    +l++++fpe++  
   Q: 130  RIVQFLRLLTSAFIRNRADFFRHFIDDEMDIKDFCTHEVEPMAMeCDHIQITALSQALNIALQVEYVDEMDT----ALNHHVFPEAA-A 213
           **********************************************************************95....***********.* PP
   S: 121  kpivLlYrsgHYdaLva 137
           ++++LlY+++HY++L+a
   Q: 214  PSVYLLYKTSHYNILYA 230
           ***************97 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MSETSFNLIS EKCDILSILR DHPENRIYQR KIQELSKRFT AIRKTKGDGN CFYRALGYSY 60
LESLLGKGRE ILRFKERVLQ TPNDLLAAGF EEHKFRNFFN AFHSVVELVE KDGSVSSLLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTCAGTG GTCGTGGGGG GAAACGCGAA GAGGGAGAGG GATGGGAACA CTGTGGGCGG 60
GGTCGCCGCC AGGGCGCATG TGCAATCGCT GGCCGGGGGT CGGGCGCCGG ACTCCGTTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003323--OTU_dom
IPR030299--OTUB2
IPR016615--Otubain
IPR019400--Peptidase_C65_otubain

PROSITE

PS50802--OTU

Pfam

PF10275--Peptidase_C65

Gene Ontology

GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination

KEGG

ocu:100357450

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002059	Ailuropoda melanoleuca	94.83	1.00e-131	461.00
IUUC-Apl-003233	Anas platyrhynchos	33.85	3.00e-07	46.20
IUUC-Aca-004648	Anolis carolinensis	46.26	2.00e-55	208.00
IUUC-Aly-005710	Arabidopsis lyrata	39.56	2.00e-35	142.00
IUUC-Ath-007112	Arabidopsis thaliana	38.94	5.00e-35	141.00
IUUC-Afl-008439	Aspergillus flavus	29.76	7.00e-04	37.40
IUUC-Ame-010740	Astyanax mexicanus	47.37	5.00e-61	227.00
IUUC-Bta-012766	Bos taurus	95.73	5.00e-133	466.00
IUUC-Bol-016100	Brassica oleracea	38.43	6.00e-35	140.00
IUUC-Bra-017705	Brassica rapa	35.77	1.00e-31	130.00
IUUC-Cel-018295	Caenorhabditis elegans	31.14	1.00e-28	119.00
IUUC-Cja-019480	Callithrix jacchus	93.16	4.00e-130	456.00
IUUC-Cfa-021106	Canis familiaris	95.26	3.00e-132	463.00
IUUC-Cpo-022187	Cavia porcellus	94.85	2.00e-131	461.00
IUUC-Cre-022997	Chlamydomonas reinhardtii	35.19	8.00e-30	124.00
IUUC-Csa-023493	Chlorocebus sabaeus	94.42	2.00e-130	457.00
IUUC-Cho-024411	Choloepus hoffmanni	76.10	4.00e-85	306.00
IUUC-Cin-025507	Ciona intestinalis	38.51	4.00e-29	120.00
IUUC-Csv-026273	Ciona savignyi	40.59	5.00e-43	167.00
IUUC-Dre-027843	Danio rerio	45.61	2.00e-60	225.00
IUUC-Dno-029346	Dasypus novemcinctus	96.57	1.00e-133	468.00
IUUC-Dor-031012	Dipodomys ordii	95.71	2.00e-133	468.00
IUUC-Dme-031922	Drosophila melanogaster	38.26	4.00e-44	171.00
IUUC-Ete-032266	Echinops telfairi	87.93	9.00e-121	425.00
IUUC-Eca-033356	Equus caballus	96.55	3.00e-132	463.00
IUUC-Eeu-034775	Erinaceus europaeus	95.26	1.00e-131	461.00
IUUC-Fca-035363	Felis catus	96.12	1.00e-132	464.00
IUUC-Gmo-038908	Gadus morhua	46.29	3.00e-57	214.00
IUUC-Ggr-040020	Gaeumannomyces graminis	27.95	2.00e-20	94.00
IUUC-Gga-040460	Gallus gallus	43.75	2.00e-52	199.00
IUUC-Gac-042417	Gasterosteus aculeatus	45.18	9.00e-58	216.00
IUUC-Gma-043712	Glycine max	36.68	2.00e-32	132.00
IUUC-Ggo-045023	Gorilla gorilla	94.02	9.00e-131	458.00
IUUC-Hsa-046984	Homo sapiens	94.44	3.00e-131	460.00
IUUC-Itr-048012	Ictidomys tridecemlineatus	94.87	8.00e-133	465.00
IUUC-Lch-050514	Latimeria chalumnae	60.89	6.00e-83	300.00
IUUC-Loc-052003	Lepisosteus oculatus	50.66	2.00e-64	238.00
IUUC-Laf-054382	Loxodonta africana	95.69	4.00e-132	463.00
IUUC-Mcc-055516	Macaca mulatta	94.42	1.00e-130	458.00
IUUC-Meu-056038	Macropus eugenii	87.30	2.00e-98	351.00
IUUC-Mtr-057712	Medicago truncatula	35.86	3.00e-29	122.00
IUUC-Mvi-060358	Microbotryum violaceum	33.33	2.00e-12	66.20
IUUC-Mmr-060918	Microcebus murinus	96.58	1.00e-134	471.00
IUUC-Mdo-062638	Monodelphis domestica	89.70	8.00e-125	439.00
IUUC-Mmu-063973	Mus musculus	95.28	2.00e-132	465.00
IUUC-Mac-065274	Musa acuminata	31.08	1.00e-23	103.00
IUUC-Mpu-066013	Mustela putorius furo	95.26	4.00e-132	463.00
IUUC-Mlu-067509	Myotis lucifugus	93.97	9.00e-129	452.00
IUUC-Nle-069673	Nomascus leucogenys	94.44	3.00e-131	460.00
IUUC-Opr-070761	Ochotona princeps	88.55	1.00e-82	298.00
IUUC-Ont-071901	Oreochromis niloticus	44.74	2.00e-56	212.00
IUUC-Oan-072922	Ornithorhynchus anatinus	82.53	5.00e-113	399.00
IUUC-Oni-082026	Oryza nivara	29.65	5.00e-17	82.40
IUUC-Oru-084761	Oryza rufipogon	29.65	5.00e-17	82.40
IUUC-Ola-086603	Oryzias latipes	45.37	1.00e-51	196.00
IUUC-Oga-088936	Otolemur garnettii	96.14	1.00e-133	468.00
IUUC-Oar-089460	Ovis aries	96.14	3.00e-132	463.00
IUUC-Ptr-090805	Pan troglodytes	94.02	6.00e-131	459.00
IUUC-Pan-091969	Papio anubis	94.44	3.00e-131	460.00
IUUC-Psi-093823	Pelodiscus sinensis	45.81	4.00e-55	207.00
IUUC-Pma-094366	Petromyzon marinus	44.00	2.00e-55	208.00
IUUC-Pfo-096734	Poecilia formosa	44.20	4.00e-50	191.00
IUUC-Pab-098476	Pongo abelii	93.99	5.00e-130	456.00
IUUC-Pop-099401	Populus trichocarpa	36.36	1.00e-31	130.00
IUUC-Pca-100252	Procavia capensis	92.08	1.00e-53	202.00
IUUC-Ppe-101977	Prunus persica	38.86	5.00e-34	138.00
IUUC-Pva-102204	Pteropus vampyrus	94.44	1.00e-132	465.00
IUUC-Pgr-103552	Puccinia graminis	75.00	2.70e-02	31.20
IUUC-Rno-105062	Rattus norvegicus	95.73	3.00e-134	470.00
IUUC-Sha-106968	Sarcophilus harrisii	89.52	8.00e-123	432.00
IUUC-Sly-111640	Solanum lycopersicum	36.60	8.00e-34	137.00
IUUC-Sar-113295	Sorex araneus	95.69	1.00e-130	458.00
IUUC-Ssc-115288	Sus scrofa	95.71	1.00e-132	465.00
IUUC-Tru-117664	Takifugu rubripes	44.98	9.00e-56	209.00
IUUC-Tni-120440	Tetraodon nigroviridis	38.96	1.00e-42	165.00
IUUC-Tca-121467	Theobroma cacao	36.36	6.00e-33	134.00
IUUC-Tbe-127717	Tupaia belangeri	94.59	3.00e-78	283.00
IUUC-Ttr-128221	Tursiops truncatus	76.39	4.00e-100	357.00
IUUC-Uma-129443	Ustilago maydis	32.37	7.00e-24	104.00
IUUC-Vvi-131389	Vitis vinifera	37.07	4.00e-32	131.00
IUUC-Xtr-131951	Xenopus tropicalis	51.97	2.00e-72	265.00
IUUC-Xma-134191	Xiphophorus maculatus	44.64	7.00e-51	193.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence