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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046854
UUCD1 version UUC-HoS-00294
Ensembl Protein ID ENSP00000328327.7
UniProt Accession Q9H672; A8K1E5; Q6GSJ6; Q7Z4S3; ASB7_HUMAN
Genbank Protein ID AAP97683.1; BAB15392.1; BAF82549.1; EAX02274.1; EAX02276.1; AAH63581.1
Protein Name Ankyrin repeat and SOCS box protein 7
Genbank Nucleotide ID AF451994; AK026204; AK289860; CH471101; CH471101; BC063581
Gene Name ASB7
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000183475.12 ENST00000332783.11 ENSP00000328327.7
ENSG00000183475.12 ENST00000558747.5 ENSP00000453626.1
ENSG00000183475.12 ENST00000343276.4 ENSP00000339819.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusBioGRID
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box SOCS 16325183
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box 6.90e-19 69.1 267 315
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box
   S: 3    klwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyed 51
            l++++++pr+Lq+LCR++Ir+c+g q+lk++d+LP+ k++kdYL+++ 
   Q: 267  FLQEVTRQPRNLQDLCRIKIRQCIGLQNLKLLDELPIAKVMKDYLKHKF 315
           68899******************************************95 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
 Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Protein Sequence
(Fasta)
MLHHHCRRNP ELQEELQIQA AVAAGDVHTV RKMLEQGYSP NGRDANGWTL LHFSAARGKE 60
RCVRVFLEHG ADPTVKDLIG GFTALHYAAM HGRARIARLM LESEYRSDII NAKSNDGWTP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046854|E3,SOCS|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGGCTCAGGC TCCACTGCGG GCGCTGATTG GTTGTTGAAG GCTTGGTCCC ATCCCAGTGA 60
CCCCAAAGTG CTGAAGGGAG GGGGCGGGGG TGGCCCAGTG CAAAGTGCAT CCCGAAAGCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046854|E3,SOCS|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR001496--SOCS_box
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50225--SOCS
Pfam

PF12796--Ank_2
PF07525--SOCS_box
PRINTS

PR01415--ANKYRIN
SMART

SM00248--ANK
SM00253--SOCS
SM00969--SOCS_box
Gene Ontology

GO:0005622--C:intracellular
GO:0035556--P:intracellular signal transduction
GO:0016567--P:protein ubiquitination
KEGG hsa:140460
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000539 Aegilops tauschii 29.41 2.00e-17 83.60
IUUC-Aml-001863 Ailuropoda melanoleuca 98.76 0.00e+00 655.00
IUUC-Apl-003527 Anas platyrhynchos 99.37 0.00e+00 655.00
IUUC-Aca-004849 Anolis carolinensis 98.74 0.00e+00 656.00
IUUC-Ath-006849 Arabidopsis thaliana 28.57 5.00e-16 79.00
IUUC-Ame-011273 Astyanax mexicanus 92.77 8.00e-180 622.00
IUUC-Bta-012762 Bos taurus 100.00 0.00e+00 662.00
IUUC-Bdi-014839 Brachypodium distachyon 29.46 1.00e-16 81.30
IUUC-Bol-016185 Brassica oleracea 28.57 2.00e-16 80.50
IUUC-Cja-019889 Callithrix jacchus 99.65 7.00e-171 592.00
IUUC-Cfa-021240 Canis familiaris 100.00 0.00e+00 662.00
IUUC-Cpo-021783 Cavia porcellus 100.00 0.00e+00 662.00
IUUC-Csa-023934 Chlorocebus sabaeus 100.00 0.00e+00 662.00
IUUC-Cho-024313 Choloepus hoffmanni 99.37 0.00e+00 657.00
IUUC-Dre-027494 Danio rerio 92.45 1.00e-179 622.00
IUUC-Dor-030507 Dipodomys ordii 100.00 0.00e+00 662.00
IUUC-Ete-032364 Echinops telfairi 99.06 0.00e+00 650.00
IUUC-Eca-033549 Equus caballus 99.69 0.00e+00 659.00
IUUC-Fca-035963 Felis catus 100.00 0.00e+00 662.00
IUUC-Fal-037425 Ficedula albicollis 99.37 0.00e+00 658.00
IUUC-Gmo-039083 Gadus morhua 88.99 3.00e-172 597.00
IUUC-Gga-040499 Gallus gallus 99.69 0.00e+00 660.00
IUUC-Gac-042002 Gasterosteus aculeatus 89.94 4.00e-174 603.00
IUUC-Ggo-045128 Gorilla gorilla 100.00 0.00e+00 662.00
IUUC-Hvu-047098 Hordeum vulgare 28.81 2.00e-16 80.50
IUUC-Itr-048086 Ictidomys tridecemlineatus 100.00 2.00e-171 594.00
IUUC-Lch-050335 Latimeria chalumnae 96.86 0.00e+00 642.00
IUUC-Loc-051896 Lepisosteus oculatus 96.86 0.00e+00 647.00
IUUC-Laf-053453 Loxodonta africana 100.00 0.00e+00 662.00
IUUC-Mcc-054654 Macaca mulatta 100.00 0.00e+00 662.00
IUUC-Mtr-058135 Medicago truncatula 28.21 3.00e-18 86.70
IUUC-Mga-059478 Meleagris gallopavo 99.69 0.00e+00 660.00
IUUC-Mmr-060770 Microcebus murinus 100.00 0.00e+00 662.00
IUUC-Mdo-061889 Monodelphis domestica 99.69 0.00e+00 659.00
IUUC-Mmu-063541 Mus musculus 99.37 0.00e+00 658.00
IUUC-Mpu-066042 Mustela putorius furo 100.00 0.00e+00 662.00
IUUC-Mlu-067745 Myotis lucifugus 97.80 0.00e+00 648.00
IUUC-Nle-069597 Nomascus leucogenys 100.00 0.00e+00 662.00
IUUC-Opr-071125 Ochotona princeps 99.37 0.00e+00 658.00
IUUC-Oan-072883 Ornithorhynchus anatinus 99.69 0.00e+00 658.00
IUUC-Ocu-074304 Oryctolagus cuniculus 99.37 0.00e+00 659.00
IUUC-Ola-087334 Oryzias latipes 87.97 3.00e-166 577.00
IUUC-Oga-088131 Otolemur garnettii 100.00 0.00e+00 662.00
IUUC-Oar-090403 Ovis aries 100.00 0.00e+00 662.00
IUUC-Ptr-091191 Pan troglodytes 100.00 0.00e+00 662.00
IUUC-Pan-092357 Papio anubis 100.00 0.00e+00 662.00
IUUC-Pma-094205 Petromyzon marinus 40.43 6.00e-49 187.00
IUUC-Ppa-095298 Physcomitrella patens 27.39 2.00e-13 70.90
IUUC-Pfo-097228 Poecilia formosa 90.25 9.00e-175 605.00
IUUC-Pab-098397 Pongo abelii 100.00 0.00e+00 662.00
IUUC-Pca-100512 Procavia capensis 77.73 2.00e-106 378.00
IUUC-Pva-102669 Pteropus vampyrus 98.74 0.00e+00 654.00
IUUC-Rno-105591 Rattus norvegicus 98.74 0.00e+00 654.00
IUUC-Sha-106755 Sarcophilus harrisii 99.69 0.00e+00 659.00
IUUC-Sit-110762 Setaria italica 28.99 3.00e-17 83.20
IUUC-Sbi-114785 Sorghum bicolor 28.99 2.00e-17 84.00
IUUC-Ssc-115855 Sus scrofa 100.00 0.00e+00 662.00
IUUC-Tgu-116574 Taeniopygia guttata 99.37 0.00e+00 658.00
IUUC-Tru-118561 Takifugu rubripes 89.94 1.00e-173 602.00
IUUC-Tsy-119067 Tarsius syrichta 87.11 1.00e-161 562.00
IUUC-Tni-120352 Tetraodon nigroviridis 90.25 7.00e-175 605.00
IUUC-Tae-123967 Triticum aestivum 28.57 2.00e-16 80.50
IUUC-Tme-127091 Tuber melanosporum 34.38 5.00e-05 40.80
IUUC-Ttr-129317 Tursiops truncatus 96.23 2.00e-175 607.00
IUUC-Vpa-130472 Vicugna pacos 100.00 0.00e+00 662.00
IUUC-Xtr-132653 Xenopus tropicalis 96.23 0.00e+00 640.00
IUUC-Xma-134170 Xiphophorus maculatus 89.94 2.00e-174 605.00
Created Date 25-Jun-2017

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