iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089887

Ensembl Protein ID

ENSOARP00000015585.1

UniProt Accession

W5PYQ0; W5PYQ0_SHEEP

Genbank Protein ID

ENSOARP00000015585

Protein Name

Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-specific-processing protease 16

Genbank Nucleotide ID

AMGL01005940

Gene Name

USP16

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000014528.1	ENSOART00000015815.1	ENSOARP00000015585.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.60e-90	303.2	196	825

Active Site

Position(s)	Description	Evidence
205	Nucleophile	ECO:0000256\|HAMAP-Rule:MF_03062}
761	Proton acceptor	ECO:0000256\|HAMAP-Rule:MF_03062}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle..........kkkeklneenp............kepkgellkslqklfeelwkskkka 67
           +Gl+NlgNtC++N+v+Q Ls++p lrell+e          +         p             ep g+l+ ++ ++++e++++kk++
   Q: 196  KGLSNLGNTCFFNAVMQNLSQTPVLRELLKEvkmsgtivkiE---------PpdlaltepleinLEPPGPLTLAMSQFLNEMQETKKGV 275
           5******************************86555555540.........24555555555658899********************* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlk 151
           v+prel+++++k+a++f+gy+qqD+qE+l++lld+++ e +++ +k + +++++++++ ++e     +e++kkk+ +s+++++F+g+l+
   Q: 276  VTPRELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRAEEHQRVSKGILKAFGNSTEKVDEElknkvKEYEKKKSVPSFVDRIFGGELT 364
           *******************************************************999999999999999******************* PP
   S: 152  sqikclecdnvssreepfldlslpvpgkeetkke....................................................... 185
           s+i+c ec++vs  +e+fldlslpv ++++ kk+                                                       
   Q: 365  STIMCDECRTVSLVHESFLDLSLPVLDDQSGKKSindknlkktmededkdseeekdddsylkerndipsgtskhlqkkakkqakkqakn 453
           *****************************99999******************************************************* PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 454  qrrqqkiqgkvlhlndvyaidhpednecevemslqgeadiksnhisqeevapkeycvnqkdlnghekmiesitdnqkstekaamknvsv 542
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 543  dndlevlassatecprnlngaylkegsngevdissgfenlnlnaalqpdeinieildddptpgtkvyevvnedpetafctlanreafnt 631
           ***************************************************************************************** PP
   S: 186  ...slqdcLesftkeeelegenkyycekckkkqe.................aekklklkklPevLilhLkRfsfseeqksrekinkkve 254
              s+q+cL +ft++e+l+++nk+ ce c+++q                  a+k++ ++  P+vL+lh+kRf  ++++ + +k+nk+++
   Q: 632  decSVQHCLYQFTRNEKLRDANKLLCEVCTRRQYsgpkanmkgerkhvytnAKKQMLISLAPPVLTLHFKRF--QQAGFNLRKVNKHIK 718
           ******************************777788888888888888888*********************..9999*********** PP
   S: 255  fpleLdlspfctspeekqke...kkkYeLiavvvHsGslssGHYvayvkn........................ekgkWllfdDskVte 316
           fp+ Ldl+pfct ++++++e   ++ Y+L++vv HsG+++sGHY+ay+k                         +kg+W++++D++V++
   Q: 719  FPEILDLAPFCTLKCKNVAEehtRVLYSLYGVVEHSGTMRSGHYTAYAKTrtanthlsnlvlhgdipqdfemesTKGQWFHISDTHVQA 807
           *************9999988777899************************9999999999999999999999888999*********** PP
   S: 317  vkeeevleetgstaYvlfYkr 337
           v+ ++vl+   s+aY+lfY+r
   Q: 808  VPTTKVLN---SQAYLLFYER 825
           ********...********98 PP

Organism

Ovis aries

Functional Description
(View)

Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.

Protein Sequence
(Fasta)

MGKKRTKGKT VPIDDSSESL EPMCRHIRKG LEQGNLKKAL VNVEWNICQD CKTDNKVKDK 60
SEEETEENPS VWLCLKCGHQ GCGRNSQEQH ALKHYMKPRS EPHCLVLSLD NWSVWCYLCD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGAAAGA AACGGACAAA GGGAAAAACT GTTCCAATTG ATGATTCTTC TGAATCTTTA 60
GGTATATTTC ACCAATTAAA TCTTTAAAGT AATGTTTGTA TCCCTAAATG GACATCTATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0010--Activator
KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR030849--UBP16
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0016578--P:histone deubiquitination
GO:0007067--P:mitotic nuclear division
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0051289--P:protein homotetramerization
GO:0051726--P:regulation of cell cycle
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

oas:101109404

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001931	Ailuropoda melanoleuca	91.66	0.00e+00	1425.00
IUUC-Atr-003015	Amborella trichopoda	31.98	3.00e-36	147.00
IUUC-Apl-004145	Anas platyrhynchos	62.39	0.00e+00	905.00
IUUC-Aca-004314	Anolis carolinensis	59.98	0.00e+00	897.00
IUUC-Aly-006422	Arabidopsis lyrata	29.94	3.00e-30	127.00
IUUC-Ath-006732	Arabidopsis thaliana	34.72	2.00e-34	141.00
IUUC-Aor-009965	Aspergillus oryzae	28.98	5.00e-13	69.70
IUUC-Ame-011659	Astyanax mexicanus	48.98	3.00e-109	389.00
IUUC-Bta-013362	Bos taurus	98.43	0.00e+00	1536.00
IUUC-Bol-015941	Brassica oleracea	30.00	1.00e-32	135.00
IUUC-Bra-016751	Brassica rapa	30.07	5.00e-31	130.00
IUUC-Cja-019177	Callithrix jacchus	91.41	0.00e+00	1455.00
IUUC-Cfa-020051	Canis familiaris	91.90	0.00e+00	1441.00
IUUC-Cpo-021886	Cavia porcellus	81.33	0.00e+00	1308.00
IUUC-Csa-024103	Chlorocebus sabaeus	92.02	0.00e+00	1468.00
IUUC-Cho-024315	Choloepus hoffmanni	77.62	1.00e-129	457.00
IUUC-Cin-025775	Ciona intestinalis	50.35	6.00e-40	155.00
IUUC-Csv-026075	Ciona savignyi	51.43	2.00e-58	220.00
IUUC-Cme-027348	Cyanidioschyzon merolae	38.51	2.00e-19	90.90
IUUC-Dre-028388	Danio rerio	48.05	0.00e+00	649.00
IUUC-Dno-029409	Dasypus novemcinctus	88.75	0.00e+00	1411.00
IUUC-Dor-030443	Dipodomys ordii	77.96	0.00e+00	649.00
IUUC-Ete-032807	Echinops telfairi	84.93	0.00e+00	698.00
IUUC-Eca-033479	Equus caballus	92.26	0.00e+00	1465.00
IUUC-Eeu-034835	Erinaceus europaeus	83.87	0.00e+00	671.00
IUUC-Fca-036320	Felis catus	92.62	0.00e+00	1488.00
IUUC-Fal-037029	Ficedula albicollis	60.68	0.00e+00	850.00
IUUC-Gmo-039480	Gadus morhua	52.59	2.00e-114	406.00
IUUC-Gga-040527	Gallus gallus	63.17	0.00e+00	910.00
IUUC-Gac-042343	Gasterosteus aculeatus	51.26	5.00e-114	405.00
IUUC-Gma-044402	Glycine max	29.08	7.00e-34	139.00
IUUC-Ggo-045598	Gorilla gorilla	91.41	0.00e+00	1452.00
IUUC-Hsa-046598	Homo sapiens	91.29	0.00e+00	1444.00
IUUC-Itr-047951	Ictidomys tridecemlineatus	91.17	0.00e+00	1449.00
IUUC-Lch-050536	Latimeria chalumnae	56.31	5.00e-128	452.00
IUUC-Loc-051814	Lepisosteus oculatus	57.74	6.00e-130	458.00
IUUC-Laf-053732	Loxodonta africana	86.75	0.00e+00	1418.00
IUUC-Mcc-054661	Macaca mulatta	92.26	0.00e+00	1469.00
IUUC-Meu-055967	Macropus eugenii	74.03	8.00e-160	557.00
IUUC-Mga-059551	Meleagris gallopavo	63.02	0.00e+00	931.00
IUUC-Mmr-061747	Microcebus murinus	92.81	0.00e+00	1436.00
IUUC-Mdo-062220	Monodelphis domestica	69.17	0.00e+00	1052.00
IUUC-Mmu-063582	Mus musculus	81.66	0.00e+00	1252.00
IUUC-Mac-064941	Musa acuminata	33.14	9.00e-38	152.00
IUUC-Mpu-066339	Mustela putorius furo	91.05	0.00e+00	1461.00
IUUC-Mlu-067511	Myotis lucifugus	86.82	0.00e+00	1364.00
IUUC-Nle-069252	Nomascus leucogenys	92.02	0.00e+00	1466.00
IUUC-Opr-070969	Ochotona princeps	84.97	0.00e+00	1310.00
IUUC-Ont-071786	Oreochromis niloticus	51.29	4.00e-117	416.00
IUUC-Opu-083452	Oryza punctata	29.63	7.00e-30	126.00
IUUC-Oga-088713	Otolemur garnettii	90.21	0.00e+00	1434.00
IUUC-Ptr-091670	Pan troglodytes	91.54	0.00e+00	1456.00
IUUC-Pan-092293	Papio anubis	92.26	0.00e+00	1469.00
IUUC-Psi-093101	Pelodiscus sinensis	66.59	0.00e+00	936.00
IUUC-Ppa-095825	Physcomitrella patens	30.83	9.00e-34	139.00
IUUC-Pfo-097202	Poecilia formosa	46.53	0.00e+00	645.00
IUUC-Pab-098773	Pongo abelii	90.85	0.00e+00	1124.00
IUUC-Pop-099136	Populus trichocarpa	29.97	1.00e-38	155.00
IUUC-Pca-101069	Procavia capensis	69.41	0.00e+00	1153.00
IUUC-Ppe-101794	Prunus persica	31.40	6.00e-36	146.00
IUUC-Pva-103092	Pteropus vampyrus	86.40	0.00e+00	683.00
IUUC-Rno-105237	Rattus norvegicus	82.39	0.00e+00	1269.00
IUUC-Sha-106889	Sarcophilus harrisii	72.67	0.00e+00	1114.00
IUUC-Stu-112820	Solanum tuberosum	29.23	5.00e-37	150.00
IUUC-Sar-113530	Sorex araneus	82.97	0.00e+00	1316.00
IUUC-Ssc-116091	Sus scrofa	92.66	0.00e+00	1431.00
IUUC-Tgu-117478	Taeniopygia guttata	60.07	0.00e+00	870.00
IUUC-Tru-118640	Takifugu rubripes	53.51	2.00e-119	422.00
IUUC-Tsy-119042	Tarsius syrichta	77.52	0.00e+00	913.00
IUUC-Tni-120015	Tetraodon nigroviridis	46.37	6.00e-180	624.00
IUUC-Tca-121701	Theobroma cacao	28.93	1.00e-37	152.00
IUUC-Tbe-127309	Tupaia belangeri	77.42	0.00e+00	1120.00
IUUC-Ttr-128271	Tursiops truncatus	93.47	0.00e+00	1489.00
IUUC-Vpa-130674	Vicugna pacos	92.66	0.00e+00	1359.00
IUUC-Xtr-131869	Xenopus tropicalis	52.85	0.00e+00	788.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence