iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
iRefIndex	Mentha
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.30e-101	339.0	715	1078

Active Site

Position(s)	Description	Evidence
1046	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvg.....EegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpls 93
           ++lk +++v+f +     E+g+d++Gv++efl++ +k++++p+l+lf+++++  + l+p+p s++++ +hl+lFef+Gr+lgka+++g ++d+p++
   Q: 715  QALKGVIRVRFINqqglhEAGIDQDGVFKEFLEETIKKVFDPSLNLFKTTSD--QRLYPSPISYVQD-NHLELFEFVGRMLGKAVYEGIVVDVPFA 807
           67999********999*9*****************************88775..567799****976.**************************** PP
   S: 94   ksfyklllgk.....klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlke 184
           ++f+++llg+        +++l+++d+ely+sl++ik++ ++d+++  l+ltfsv+++++g++ +  L pgG+   V+  Nk  Y++ ++ +++++
   Q: 808  SFFLSQLLGQtqqalYSCMDELPSLDNELYRSLTFIKHY-KQDVSD--LNLTFSVDQDVMGKIVTLALHPGGKARVVNDHNKLVYIHYMAFFHMNT 900
           **********777655677********************.567777..7999******************************************** PP
   S: 185  gikeqveafreGfneviplellslFteeelellicGe.eeidvedlkketkykggytedspaiqwFwevl.eefsseerkafLqFvTgssrlPlgG 278
           +i+eq+ af +Gf++++++e+lslF++ el+ li+G+ + +d++dl+k+t y gg++++++++ w+w++l ++f++eerk fL+FvT++s+ Pl G
   Q: 901  QIREQTIAFNRGFRSIVNPEWLSLFSPPELQRLISGDtSPLDLKDLQKHTHYYGGFHDTHQVVCWLWDILaKDFTEEERKLFLKFVTSCSKPPLLG 996
           *************************************99*******************************99************************ PP
   S: 279  faelk........................prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           fa l+                        + +f irk+   +rlP+s+TCfn+LkLP+Y++k++l++kL+yA+++++gFels
   Q: 997  FAHLEppfsircvevsddedtgdtigsviRGFFAIRKKDPLNRLPTSSTCFNLLKLPNYQKKSTLRDKLRYAVSSNTGFELS 1078
           ****************************999******7777**************************************985 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MFAQNQKASF LEQTKAAREE RALEKRREQA AILLQSTLKG YAARRKYQKR IILDFDAMFT 60
ENHDDKDAEL ELVASNVYPV LRRYLTQIRL DKSDVRARER LERICRYIIK AMESENTKLS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCTGTGGTTA TTTGACAGTA AGCGGAGACG GTGACACTGT ACCACCAATT GGAACAAAAT 60
AAGGATATTT TCTTTTTGCA TTTTGCTCGA TATGCAATGC AGAAAATATC CAGCGAGGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR000048--IQ_motif_EF-hand-BS

PROSITE

PS50237--HECT
PS50096--IQ

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0016567--P:protein ubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000128	Aegilops tauschii	39.96	5.00e-102	365.00
IUUC-Aml-002107	Ailuropoda melanoleuca	48.15	0.00e+00	979.00
IUUC-Atr-003017	Amborella trichopoda	38.15	6.00e-110	391.00
IUUC-Apl-003328	Anas platyrhynchos	50.96	0.00e+00	942.00
IUUC-Aly-005768	Arabidopsis lyrata	34.78	2.00e-104	373.00
IUUC-Ath-007269	Arabidopsis thaliana	38.45	7.00e-107	381.00
IUUC-Bta-013547	Bos taurus	47.69	0.00e+00	990.00
IUUC-Bdi-014502	Brachypodium distachyon	39.61	5.00e-106	378.00
IUUC-Bol-015093	Brassica oleracea	38.98	1.00e-107	384.00
IUUC-Bra-016722	Brassica rapa	38.80	3.00e-108	385.00
IUUC-Cel-018447	Caenorhabditis elegans	37.32	0.00e+00	637.00
IUUC-Cja-019855	Callithrix jacchus	47.83	0.00e+00	980.00
IUUC-Cfa-020066	Canis familiaris	48.18	0.00e+00	959.00
IUUC-Cpo-021504	Cavia porcellus	48.52	0.00e+00	1003.00
IUUC-Cre-022673	Chlamydomonas reinhardtii	36.83	6.00e-75	275.00
IUUC-Csa-023579	Chlorocebus sabaeus	47.83	0.00e+00	978.00
IUUC-Cho-024430	Choloepus hoffmanni	38.87	2.00e-171	595.00
IUUC-Cin-025750	Ciona intestinalis	40.26	0.00e+00	739.00
IUUC-Csv-026016	Ciona savignyi	39.78	0.00e+00	783.00
IUUC-Dre-028271	Danio rerio	48.07	0.00e+00	934.00
IUUC-Dno-029054	Dasypus novemcinctus	48.15	0.00e+00	985.00
IUUC-Dor-030938	Dipodomys ordii	57.01	0.00e+00	716.00
IUUC-Ete-033041	Echinops telfairi	48.34	2.00e-142	499.00
IUUC-Eca-034411	Equus caballus	48.15	0.00e+00	969.00
IUUC-Eeu-035201	Erinaceus europaeus	53.76	3.00e-147	515.00
IUUC-Fca-036594	Felis catus	48.24	0.00e+00	970.00
IUUC-Fal-037317	Ficedula albicollis	46.94	0.00e+00	929.00
IUUC-Gmo-039412	Gadus morhua	46.90	0.00e+00	959.00
IUUC-Gga-040149	Gallus gallus	48.85	0.00e+00	946.00
IUUC-Gac-042088	Gasterosteus aculeatus	47.84	0.00e+00	1001.00
IUUC-Gma-042728	Glycine max	39.18	4.00e-108	385.00
IUUC-Ggo-045279	Gorilla gorilla	48.01	0.00e+00	980.00
IUUC-Hsa-045660	Homo sapiens	48.11	0.00e+00	981.00
IUUC-Hvu-047770	Hordeum vulgare	36.18	5.00e-103	368.00
IUUC-Itr-048372	Ictidomys tridecemlineatus	68.51	4.00e-174	603.00
IUUC-Lch-050664	Latimeria chalumnae	48.53	0.00e+00	979.00
IUUC-Lpe-050755	Leersia perrieri	38.24	2.00e-96	346.00
IUUC-Loc-052791	Lepisosteus oculatus	48.53	0.00e+00	951.00
IUUC-Laf-053902	Loxodonta africana	48.52	0.00e+00	987.00
IUUC-Mcc-054730	Macaca mulatta	47.92	0.00e+00	979.00
IUUC-Meu-056527	Macropus eugenii	43.55	0.00e+00	796.00
IUUC-Mtr-057671	Medicago truncatula	38.45	2.00e-108	386.00
IUUC-Mga-059260	Meleagris gallopavo	48.39	0.00e+00	943.00
IUUC-Mmr-060804	Microcebus murinus	47.92	0.00e+00	957.00
IUUC-Mdo-062575	Monodelphis domestica	46.49	0.00e+00	894.00
IUUC-Mmu-063636	Mus musculus	47.79	0.00e+00	956.00
IUUC-Mac-064989	Musa acuminata	38.38	2.00e-109	389.00
IUUC-Mpu-066677	Mustela putorius furo	46.18	0.00e+00	873.00
IUUC-Mlu-067952	Myotis lucifugus	49.55	0.00e+00	939.00
IUUC-Nle-069153	Nomascus leucogenys	48.01	0.00e+00	978.00
IUUC-Opr-070554	Ochotona princeps	49.80	0.00e+00	920.00
IUUC-Ont-071372	Oreochromis niloticus	48.71	0.00e+00	989.00
IUUC-Ocu-074183	Oryctolagus cuniculus	47.47	0.00e+00	964.00
IUUC-Oba-075006	Oryza barthii	35.40	3.00e-104	372.00
IUUC-Obr-076320	Oryza brachyantha	40.43	8.00e-106	377.00
IUUC-Ogl-077093	Oryza glaberrima	40.07	6.00e-105	375.00
IUUC-Ogu-078947	Oryza glumaepatula	35.39	6.00e-103	368.00
IUUC-Oin-080058	Oryza indica	40.07	1.00e-104	374.00
IUUC-Olo-080742	Oryza longistaminata	39.89	4.00e-105	375.00
IUUC-Ome-081741	Oryza meridionalis	39.28	2.00e-97	349.00
IUUC-Oni-082385	Oryza nivara	35.39	5.00e-103	368.00
IUUC-Opu-083529	Oryza punctata	38.76	5.00e-105	375.00
IUUC-Oru-085128	Oryza rufipogon	37.99	8.00e-91	328.00
IUUC-Osa-085557	Oryza sativa	40.07	3.00e-104	372.00
IUUC-Ola-087337	Oryzias latipes	47.84	0.00e+00	944.00
IUUC-Oga-088342	Otolemur garnettii	49.21	0.00e+00	940.00
IUUC-Oar-090234	Ovis aries	47.25	0.00e+00	968.00
IUUC-Ptr-091661	Pan troglodytes	48.01	0.00e+00	980.00
IUUC-Pan-092728	Papio anubis	47.88	0.00e+00	976.00
IUUC-Psi-093251	Pelodiscus sinensis	46.35	0.00e+00	838.00
IUUC-Pma-094195	Petromyzon marinus	44.90	0.00e+00	858.00
IUUC-Ppa-095867	Physcomitrella patens	39.78	3.00e-116	412.00
IUUC-Pfo-097472	Poecilia formosa	48.30	0.00e+00	983.00
IUUC-Pab-098570	Pongo abelii	48.11	0.00e+00	980.00
IUUC-Pop-098928	Populus trichocarpa	34.85	6.00e-94	338.00
IUUC-Pca-100110	Procavia capensis	43.20	0.00e+00	815.00
IUUC-Ppe-101281	Prunus persica	39.22	9.00e-109	387.00
IUUC-Pva-102887	Pteropus vampyrus	46.08	0.00e+00	909.00
IUUC-Rno-106028	Rattus norvegicus	46.00	0.00e+00	870.00
IUUC-Sha-107331	Sarcophilus harrisii	47.33	0.00e+00	908.00
IUUC-Smo-109488	Selaginella moellendorffii	39.55	3.00e-109	389.00
IUUC-Sit-109811	Setaria italica	39.68	2.00e-105	376.00
IUUC-Sly-111362	Solanum lycopersicum	35.31	6.00e-98	351.00
IUUC-Sar-113287	Sorex araneus	54.04	8.00e-96	344.00
IUUC-Sbi-114433	Sorghum bicolor	40.18	1.00e-107	384.00
IUUC-Ssc-116103	Sus scrofa	48.38	0.00e+00	965.00
IUUC-Tgu-117275	Taeniopygia guttata	48.39	0.00e+00	936.00
IUUC-Tru-118681	Takifugu rubripes	47.69	0.00e+00	988.00
IUUC-Tsy-118985	Tarsius syrichta	34.75	2.00e-86	313.00
IUUC-Tni-120850	Tetraodon nigroviridis	70.18	3.00e-172	596.00
IUUC-Tca-121770	Theobroma cacao	38.27	5.00e-110	391.00
IUUC-Tae-125466	Triticum aestivum	36.02	7.00e-103	368.00
IUUC-Tur-126086	Triticum urartu	39.30	7.00e-102	365.00
IUUC-Tbe-127461	Tupaia belangeri	44.96	0.00e+00	835.00
IUUC-Ttr-129269	Tursiops truncatus	47.97	0.00e+00	964.00
IUUC-Vpa-130523	Vicugna pacos	65.77	2.00e-58	220.00
IUUC-Vvi-131524	Vitis vinifera	36.42	1.00e-111	397.00
IUUC-Xtr-132146	Xenopus tropicalis	47.61	0.00e+00	947.00
IUUC-Xma-133526	Xiphophorus maculatus	48.30	0.00e+00	980.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence