iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/SCF/F-box	89.67	0.00e+00	1944.00	IUUC-Hsa-046650
E3 adaptor/Cullin RING/SCF/F-box	28.88	5.00e-42	167.00	IUUC-Spo-108147

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MRRFKRKHLT VVDCQQLARS HLAATQPFSQ RWTNRDPNHG LYPRARTKGR NRGRGCQRYI 60
SEFFLASHQH CTNDMAKSNS VGQDSCQDSE NDMIFPAESS CSLPQVENGE VRLGSPGSAQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGTCCGTCGT CTCCGGTTGG AGGTTGAGTC TTGGCAGTGA AGAGGCGGAG CTCGCGGAGG 60
AAGTCTGCAG TCGTCTCTGC TCGCTGCCTG GGCCGAAGGA GGGGCTTGCT GGTCGGGGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR014017--DNA_helicase_UvrD-like_C
IPR000212--DNA_helicase_UvrD/REP
IPR001810--F-box_dom
IPR027417--P-loop_NTPase

PROSITE

PS50181--FBOX

Pfam

PF12937--F-box-like
PF13361--UvrD_C

Gene Ontology

GO:0000785--C:chromatin
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0043138--F:3'-5' DNA helicase activity
GO:0005524--F:ATP binding
GO:0004003--F:ATP-dependent DNA helicase activity
GO:0015616--F:DNA translocase activity
GO:0003690--F:double-stranded DNA binding
GO:0003697--F:single-stranded DNA binding
GO:0008219--P:cell death
GO:0006974--P:cellular response to DNA damage stimulus
GO:0000737--P:DNA catabolic process, endonucleolytic
GO:0035562--P:negative regulation of chromatin binding
GO:2000042--P:negative regulation of double-strand break repair via homologous recombination
GO:1902231--P:positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:0001934--P:positive regulation of protein phosphorylation
GO:0016567--P:protein ubiquitination
GO:0031297--P:replication fork processing
GO:0048478--P:replication fork protection
GO:0072429--P:response to intra-S DNA damage checkpoint signaling

KEGG

rno:291293

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000424	Aegilops tauschii	43.48	2.00e-03	38.90
IUUC-Aml-001396	Ailuropoda melanoleuca	88.15	0.00e+00	1872.00
IUUC-Atr-002826	Amborella trichopoda	41.54	1.00e-04	42.70
IUUC-Apl-003317	Anas platyrhynchos	48.07	0.00e+00	929.00
IUUC-Aca-004498	Anolis carolinensis	53.90	0.00e+00	942.00
IUUC-Aly-006174	Arabidopsis lyrata	30.77	4.00e-05	40.00
IUUC-Ath-007293	Arabidopsis thaliana	37.88	3.00e-03	38.10
IUUC-Ani-009226	Aspergillus nidulans	33.33	3.00e-06	47.80
IUUC-Ate-010526	Aspergillus terreus	41.18	2.00e-04	42.00
IUUC-Ame-011808	Astyanax mexicanus	58.15	1.00e-132	466.00
IUUC-Bta-013250	Bos taurus	87.19	0.00e+00	1845.00
IUUC-Bol-015348	Brassica oleracea	35.94	3.00e-03	37.70
IUUC-Cja-019638	Callithrix jacchus	89.87	0.00e+00	1937.00
IUUC-Cfa-020195	Canis familiaris	90.23	0.00e+00	1807.00
IUUC-Cpo-022269	Cavia porcellus	84.89	0.00e+00	1766.00
IUUC-Cre-022611	Chlamydomonas reinhardtii	40.28	4.00e-08	54.30
IUUC-Csa-024060	Chlorocebus sabaeus	90.95	0.00e+00	1741.00
IUUC-Cho-025003	Choloepus hoffmanni	89.90	0.00e+00	714.00
IUUC-Cin-025694	Ciona intestinalis	27.43	1.00e-28	120.00
IUUC-Dre-028083	Danio rerio	50.11	0.00e+00	848.00
IUUC-Dno-029203	Dasypus novemcinctus	84.72	0.00e+00	1727.00
IUUC-Dor-030477	Dipodomys ordii	96.68	0.00e+00	792.00
IUUC-Ete-032861	Echinops telfairi	85.66	0.00e+00	1808.00
IUUC-Eca-033205	Equus caballus	89.01	0.00e+00	1926.00
IUUC-Eeu-034784	Erinaceus europaeus	85.23	0.00e+00	1186.00
IUUC-Fca-035797	Felis catus	88.36	0.00e+00	1886.00
IUUC-Gmo-038855	Gadus morhua	46.55	1.00e-120	427.00
IUUC-Gga-040326	Gallus gallus	50.63	0.00e+00	974.00
IUUC-Gac-042240	Gasterosteus aculeatus	42.11	0.00e+00	723.00
IUUC-Ggo-045050	Gorilla gorilla	85.75	0.00e+00	1783.00
IUUC-Hsa-046650	Homo sapiens	88.65	0.00e+00	1877.00
IUUC-Itr-047965	Ictidomys tridecemlineatus	94.57	0.00e+00	766.00
IUUC-Lch-050231	Latimeria chalumnae	49.67	5.00e-158	551.00
IUUC-Loc-051884	Lepisosteus oculatus	49.44	0.00e+00	977.00
IUUC-Lma-053267	Leptosphaeria maculans	34.25	3.00e-03	37.70
IUUC-Laf-053843	Loxodonta africana	87.86	0.00e+00	1871.00
IUUC-Mcc-055570	Macaca mulatta	89.77	0.00e+00	1902.00
IUUC-Meu-056798	Macropus eugenii	66.67	3.00e-149	523.00
IUUC-Mtr-057915	Medicago truncatula	37.50	6.00e-04	40.40
IUUC-Mga-059648	Meleagris gallopavo	51.08	0.00e+00	929.00
IUUC-Mmr-060757	Microcebus murinus	87.40	0.00e+00	1818.00
IUUC-Mdo-061913	Monodelphis domestica	68.83	0.00e+00	1349.00
IUUC-Mmu-064337	Mus musculus	96.64	0.00e+00	2086.00
IUUC-Mpu-066483	Mustela putorius furo	88.15	0.00e+00	1899.00
IUUC-Mlu-068204	Myotis lucifugus	82.46	0.00e+00	1754.00
IUUC-Ncr-068735	Neurospora crassa	39.06	1.00e-03	39.70
IUUC-Nle-070053	Nomascus leucogenys	89.67	0.00e+00	1845.00
IUUC-Opr-070588	Ochotona princeps	83.46	0.00e+00	1754.00
IUUC-Ont-072655	Oreochromis niloticus	46.72	0.00e+00	739.00
IUUC-Oan-073351	Ornithorhynchus anatinus	61.90	0.00e+00	1281.00
IUUC-Ocu-074465	Oryctolagus cuniculus	87.88	0.00e+00	1795.00
IUUC-Obr-076710	Oryza brachyantha	35.94	3.00e-03	38.10
IUUC-Oin-079176	Oryza indica	24.55	9.00e-06	45.10
IUUC-Olu-087831	Ostreococcus lucimarinus	31.84	2.00e-63	238.00
IUUC-Oga-089088	Otolemur garnettii	86.90	0.00e+00	1788.00
IUUC-Oar-089870	Ovis aries	86.81	0.00e+00	1820.00
IUUC-Ptr-090957	Pan troglodytes	89.28	0.00e+00	1850.00
IUUC-Pan-092632	Papio anubis	89.67	0.00e+00	1848.00
IUUC-Psi-093035	Pelodiscus sinensis	55.38	0.00e+00	1128.00
IUUC-Pno-094870	Phaeosphaeria nodorum	24.91	2.00e-03	38.50
IUUC-Ppa-095660	Physcomitrella patens	39.73	1.00e-04	43.10
IUUC-Pfo-096902	Poecilia formosa	44.41	0.00e+00	669.00
IUUC-Pab-098206	Pongo abelii	89.39	0.00e+00	1739.00
IUUC-Pop-098801	Populus trichocarpa	34.72	8.00e-04	39.70
IUUC-Pca-100238	Procavia capensis	82.31	0.00e+00	1736.00
IUUC-Ppe-101748	Prunus persica	35.94	5.00e-03	37.40
IUUC-Pva-103182	Pteropus vampyrus	87.38	0.00e+00	1817.00
IUUC-Pte-104033	Pyrenophora teres	32.86	1.00e-02	35.80
IUUC-Pyt-104599	Pyrenophora triticirepentis	25.00	4.00e-03	37.40
IUUC-Sce-106341	Saccharomyces cerevisiae	25.76	3.00e-03	37.40
IUUC-Sha-106827	Sarcophilus harrisii	66.44	0.00e+00	1400.00
IUUC-Sja-107882	Schizosaccharomyces japonicus	29.22	3.00e-41	163.00
IUUC-Spo-108147	Schizosaccharomyces pombe	28.88	5.00e-42	166.00
IUUC-Ssl-108584	Sclerotinia sclerotiorum	25.00	2.00e-03	38.10
IUUC-Sly-111170	Solanum lycopersicum	40.32	7.00e-02	32.30
IUUC-Sre-115025	Sporisorium reilianum	33.33	3.00e-39	157.00
IUUC-Ssc-116188	Sus scrofa	93.53	0.00e+00	1253.00
IUUC-Tgu-116612	Taeniopygia guttata	56.85	1.00e-155	542.00
IUUC-Tsy-119560	Tarsius syrichta	82.26	1.00e-115	411.00
IUUC-Tni-120734	Tetraodon nigroviridis	45.24	0.00e+00	704.00
IUUC-Tca-121338	Theobroma cacao	33.01	8.00e-03	36.60
IUUC-Tre-122089	Trichoderma reesei	40.74	3.00e-04	40.80
IUUC-Tme-127009	Tuber melanosporum	32.05	5.00e-04	40.40
IUUC-Tbe-127431	Tupaia belangeri	88.02	0.00e+00	1593.00
IUUC-Ttr-128744	Tursiops truncatus	86.06	0.00e+00	1795.00
IUUC-Uma-129536	Ustilago maydis	33.05	9.00e-42	166.00
IUUC-Vpa-130123	Vicugna pacos	73.12	7.00e-98	351.00
IUUC-Vvi-131025	Vitis vinifera	37.50	2.00e-03	38.50
IUUC-Xtr-132902	Xenopus tropicalis	58.14	0.00e+00	1002.00
IUUC-Xma-133978	Xiphophorus maculatus	45.07	1.00e-146	514.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence