iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000011301.1	ENSSHAT00000013325.1	ENSSHAP00000013216.1
ENSSHAG00000011301.1	ENSSHAT00000013326.1	ENSSHAP00000013217.1
ENSSHAG00000011301.1	ENSSHAT00000013327.1	ENSSHAP00000013218.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.30e-67	228.6	70	503

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenp.kepkgellkslqklfeelw.......kskkkavsprellkalkkeae 82
           Gl NlgNtC+mNS+LQ Ls++p + + l e ++ + +++++ +++ + l+ +l +l+++l        ++++ + +   ll++l+++  
   Q: 70   GLLNLGNTCFMNSLLQGLSACPTFIKWLEE-FTAQYPADQReTTKPQYLSLTLLRLLKALScqevasgEEEEDVLDAGCLLEVLRMYRW 157
           9*****************************.55555554441566778999999***9996666677788888999999********** PP
   S: 83   efsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde..........aeekkkkknkslisdlFqgqlksqikclecdn 161
           ++s++e+qDa+E+++++ ++le+e    ++ ++ ++++ ++ el++e          +   +++++    ++ F+g+l+s+++c++c++
   Q: 158  QISSFEEQDAHELFHVITSSLEDER--DRHPRVAHLFDMQSLELQQEmtpqqiscriRGALHPMSSAWKSQHPFHGRLTSNMVCKHCEH 244
           ************************9..6688888999999999999989999999999999999999********************** PP
   S: 162  vs.sreepfldlslpvpgkeetkkeslqdcLesftkeeelegenkyycekck...............kkqeaekklklkklPevLilhL 234
           +s +r+++f +lsl++p  +   +++l++cL++f + e++++   + c++c+               ++++ +k+lkl klP++L++hL
   Q: 245  QSpVRYDTFDSLSLSIPAATWGRPLTLDHCLHHFISSESVRD---VVCDNCTkieaegtlngevvehQRTTFVKQLKLGKLPQCLCIHL 330
           ****************************************97...9******8888888888888777777****************** PP
   S: 235  kRfsfseeqksrekinkkvefpleLdls..pfcts.............peekqke.................................. 274
           +R s+s++ + + k +++v+f++ L ++  ++                +                                        
   Q: 331  QRLSWSSQ-GTPLKRHEHVQFNEFLIMDiyKYHLPgckphqhnpklkeN-----Avtvlevkdgmtaptyvlntpsrtkalfvngacss 413
           *****996.8889*********886666225555555555555555440.....15556666666666666666666666666666666 PP
   S: 275  .....................kkkYeLiavvvHsGslssGHYvayvkn.........ekgkWllfdDskVtevkeeevleetgstaYvl 333
                                 + ++L+avvvH+G ++sGH+v+y ++         ++ +Wl ++D++V++ + +evl+   s+aY+l
   Q: 414  ptllpttgafslpgvpdysssVYLFRLMAVVVHHGDMHSGHFVTYRRSppsaknplsTSSQWLWISDDTVRKASLQEVLS---SSAYLL 499
           6666666666677777777669999***********************9988888877888*******************...****** PP
   S: 334  fYkr 337
           fY+r
   Q: 500  FYER 503
           **98 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

RLGTGGPGAP PSSQRAAQVH ECRTAGALGC KVMKNWGVLG GVAAALAAGI YVLWGPITER 60
KKRRKGLVPG LLNLGNTCFM NSLLQGLSAC PTFIKWLEEF TAQYPADQRE TTKPQYLSLT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCTTGGGAA CGGGAGGGCC AGGAGCTCCT CCGAGCTCTC AAAGGGCTGC ACAGGTGCAC 60
GAGTGCCGCA CAGCAGGAGC TCTGGGGCAG GAAGGAGCCC TCCCGGGGTC CCACCTCTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0005741--C:mitochondrial outer membrane
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008053--P:mitochondrial fusion
GO:0000422--P:mitophagy
GO:0035871--P:protein K11-linked deubiquitination
GO:0044313--P:protein K6-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000204	Aegilops tauschii	26.02	8.00e-18	84.70
IUUC-Aml-001733	Ailuropoda melanoleuca	79.76	0.00e+00	730.00
IUUC-Atr-002510	Amborella trichopoda	24.23	6.00e-16	79.00
IUUC-Apl-003645	Anas platyrhynchos	74.91	3.00e-111	394.00
IUUC-Aca-004583	Anolis carolinensis	68.42	3.00e-24	102.00
IUUC-Aly-005754	Arabidopsis lyrata	24.69	2.00e-24	106.00
IUUC-Ath-007622	Arabidopsis thaliana	26.57	4.00e-24	105.00
IUUC-Ani-009286	Aspergillus nidulans	20.68	2.00e-10	60.50
IUUC-Ame-010896	Astyanax mexicanus	60.82	7.00e-157	546.00
IUUC-Bta-012321	Bos taurus	80.04	0.00e+00	729.00
IUUC-Bol-015637	Brassica oleracea	27.13	2.00e-23	103.00
IUUC-Bra-016801	Brassica rapa	26.20	4.00e-23	102.00
IUUC-Cel-018308	Caenorhabditis elegans	27.37	2.00e-36	146.00
IUUC-Cja-018826	Callithrix jacchus	81.91	0.00e+00	775.00
IUUC-Cfa-021206	Canis familiaris	80.85	0.00e+00	733.00
IUUC-Cpo-021343	Cavia porcellus	80.44	0.00e+00	743.00
IUUC-Csa-023419	Chlorocebus sabaeus	81.87	0.00e+00	777.00
IUUC-Cho-024475	Choloepus hoffmanni	80.59	6.00e-122	430.00
IUUC-Cgl-026621	Colletotrichum gloeosporioides	21.78	1.00e-09	58.50
IUUC-Cne-027061	Cryptococcus neoformans	25.68	7.00e-10	58.90
IUUC-Dre-027563	Danio rerio	61.32	1.00e-159	555.00
IUUC-Dno-029929	Dasypus novemcinctus	78.16	0.00e+00	749.00
IUUC-Dor-030166	Dipodomys ordii	71.06	4.00e-180	624.00
IUUC-Dme-031627	Drosophila melanogaster	35.31	1.00e-36	147.00
IUUC-Ete-032634	Echinops telfairi	72.40	3.00e-177	614.00
IUUC-Eca-033968	Equus caballus	82.56	0.00e+00	741.00
IUUC-Eeu-035279	Erinaceus europaeus	69.82	8.00e-52	197.00
IUUC-Fca-036525	Felis catus	80.44	0.00e+00	750.00
IUUC-Fal-036606	Ficedula albicollis	72.58	7.00e-157	546.00
IUUC-Gmo-038726	Gadus morhua	55.28	1.00e-143	502.00
IUUC-Gga-040718	Gallus gallus	74.50	2.00e-161	561.00
IUUC-Gac-042645	Gasterosteus aculeatus	60.12	3.00e-153	534.00
IUUC-Gma-042890	Glycine max	24.81	3.00e-23	103.00
IUUC-Ggo-045021	Gorilla gorilla	82.07	0.00e+00	775.00
IUUC-Hsa-045832	Homo sapiens	82.07	0.00e+00	775.00
IUUC-Itr-048392	Ictidomys tridecemlineatus	82.35	0.00e+00	746.00
IUUC-Lch-050662	Latimeria chalumnae	71.04	6.00e-175	606.00
IUUC-Lpe-051078	Leersia perrieri	25.70	2.00e-28	120.00
IUUC-Loc-052611	Lepisosteus oculatus	65.69	4.00e-175	607.00
IUUC-Lma-053048	Leptosphaeria maculans	19.53	4.00e-11	63.50
IUUC-Laf-053752	Loxodonta africana	81.74	0.00e+00	729.00
IUUC-Mcc-054892	Macaca mulatta	82.27	0.00e+00	780.00
IUUC-Meu-056673	Macropus eugenii	84.44	0.00e+00	656.00
IUUC-Mor-057143	Magnaporthe oryzae	20.21	7.00e-08	52.80
IUUC-Mtr-057976	Medicago truncatula	25.38	4.00e-33	135.00
IUUC-Mla-058970	Melampsora laricipopulina	23.77	7.00e-19	88.60
IUUC-Mga-059543	Meleagris gallopavo	75.82	0.00e+00	659.00
IUUC-Mmr-061534	Microcebus murinus	81.04	0.00e+00	750.00
IUUC-Mdo-062140	Monodelphis domestica	77.29	0.00e+00	652.00
IUUC-Mmu-063673	Mus musculus	78.64	0.00e+00	716.00
IUUC-Mpu-066328	Mustela putorius furo	79.24	0.00e+00	733.00
IUUC-Mlu-067938	Myotis lucifugus	81.64	0.00e+00	761.00
IUUC-Nle-069426	Nomascus leucogenys	81.70	0.00e+00	709.00
IUUC-Opr-070796	Ochotona princeps	75.97	6.00e-107	380.00
IUUC-Ont-072248	Oreochromis niloticus	61.99	1.00e-153	536.00
IUUC-Oan-072916	Ornithorhynchus anatinus	80.68	0.00e+00	737.00
IUUC-Ocu-074459	Oryctolagus cuniculus	75.06	3.00e-168	584.00
IUUC-Oba-075765	Oryza barthii	27.77	6.00e-29	122.00
IUUC-Obr-076005	Oryza brachyantha	26.41	2.00e-29	123.00
IUUC-Ogl-077916	Oryza glaberrima	26.52	3.00e-31	129.00
IUUC-Ogu-078263	Oryza glumaepatula	26.80	8.00e-30	124.00
IUUC-Oin-080096	Oryza indica	28.28	3.00e-23	102.00
IUUC-Ome-081928	Oryza meridionalis	25.49	3.00e-28	119.00
IUUC-Oni-082424	Oryza nivara	26.80	7.00e-30	125.00
IUUC-Oru-085117	Oryza rufipogon	26.80	7.00e-30	125.00
IUUC-Ola-087429	Oryzias latipes	56.63	9.00e-145	506.00
IUUC-Oga-087981	Otolemur garnettii	82.04	0.00e+00	757.00
IUUC-Oar-089927	Ovis aries	80.24	0.00e+00	732.00
IUUC-Ptr-090878	Pan troglodytes	82.07	0.00e+00	775.00
IUUC-Pan-092698	Papio anubis	82.27	0.00e+00	780.00
IUUC-Psi-093451	Pelodiscus sinensis	76.52	0.00e+00	703.00
IUUC-Ppa-096015	Physcomitrella patens	26.07	1.00e-13	71.20
IUUC-Pfo-096096	Poecilia formosa	62.35	5.00e-154	537.00
IUUC-Pab-098676	Pongo abelii	80.88	0.00e+00	760.00
IUUC-Pca-100418	Procavia capensis	82.95	2.00e-112	399.00
IUUC-Ppe-101898	Prunus persica	25.05	7.00e-24	105.00
IUUC-Pva-103018	Pteropus vampyrus	79.84	0.00e+00	728.00
IUUC-Pgr-103423	Puccinia graminis	25.51	3.00e-10	60.80
IUUC-Pte-104330	Pyrenophora teres	21.99	1.00e-13	71.60
IUUC-Pyt-104518	Pyrenophora triticirepentis	22.07	3.00e-16	80.50
IUUC-Rno-105708	Rattus norvegicus	78.24	0.00e+00	720.00
IUUC-Ssl-108648	Sclerotinia sclerotiorum	22.33	1.00e-13	71.60
IUUC-Sit-110442	Setaria italica	26.82	7.00e-27	115.00
IUUC-Sly-110928	Solanum lycopersicum	25.71	3.00e-15	76.30
IUUC-Stu-112223	Solanum tuberosum	26.35	5.00e-17	82.00
IUUC-Ssc-116397	Sus scrofa	80.04	0.00e+00	729.00
IUUC-Tgu-117446	Taeniopygia guttata	69.71	0.00e+00	631.00
IUUC-Tru-118268	Takifugu rubripes	60.16	1.00e-141	496.00
IUUC-Tsy-119484	Tarsius syrichta	77.12	1.00e-43	170.00
IUUC-Tni-119735	Tetraodon nigroviridis	55.92	7.00e-124	437.00
IUUC-Tca-121660	Theobroma cacao	25.14	6.00e-26	112.00
IUUC-Tae-125203	Triticum aestivum	27.42	5.00e-27	115.00
IUUC-Tur-126458	Triticum urartu	27.59	7.00e-16	78.60
IUUC-Tbe-127740	Tupaia belangeri	74.65	0.00e+00	664.00
IUUC-Ttr-129273	Tursiops truncatus	80.24	0.00e+00	724.00
IUUC-Vvi-131177	Vitis vinifera	25.71	4.00e-26	112.00
IUUC-Xtr-132374	Xenopus tropicalis	63.95	1.00e-168	586.00
IUUC-Xma-133267	Xiphophorus maculatus	62.09	1.00e-154	539.00
IUUC-Yli-134571	Yarrowia lipolytica	25.00	5.00e-12	65.90
IUUC-Zma-135796	Zea mays	27.12	2.00e-27	117.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence