iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000151835.14	ENST00000382292.7	ENSP00000371729.3
ENSG00000151835.14	ENST00000455470.5	ENSP00000406565.1
ENSG00000151835.14	ENST00000423156.1	ENSP00000390925.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	HPRD	Phospho.ELM	UniProt
PHOSIDA	BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UBQ/UBQ_Other	5.50e-06	27.8	26	67

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UBQ/UBQ_Other

   S: 18   npsdtVaeLKekiekklgippeqqrLiykGkiLeddktLady 59
             s+tV ++Ke+i+ ++g+p+ +qrL+  G++L d+ +++d+
   Q: 26   LASWTVRDVKERIFAETGFPVSEQRLWRGGRELSDWIKIGDL 67
           6799*******************************9999987 PP

Organism

Homo sapiens

Functional Description
(View)

Co-chaperone which acts as a regulator of the Hsp70 chaperone machinery and may be involved in the processing of other ataxia-linked proteins.

Protein Sequence
(Fasta)

METKENRWVP VTVLPGCVGC RTVAALASWT VRDVKERIFA ETGFPVSEQR LWRGGRELSD 60
WIKIGDLTSK NCHLFVNLQS KGLKGGGRFG QTTPPLVDFL KDILRRYPEG GQILKELIQN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TATCCTGAGA ACTTCCATGG GTCGCTGGAT CAGCAGGCAA CCATTATCAG ACTGGAGAGT 60
CATACTTTAA GGAATACAAA TGCAACACAC GACAATGTTT CCTGACATCA GATGATGAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0143--Chaperone
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0523--Neurodegeneration
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome

Interpro

IPR001623--DnaJ_domain
IPR003594--HATPase_C
IPR007842--HEPN_dom
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50076--DNAJ_2
PS50910--HEPN
PS50053--UBIQUITIN_2

Pfam

PF05168--HEPN
PF00240--ubiquitin

SMART

SM00748--HEPN

Gene Ontology

GO:0030424--C:axon
GO:0070852--C:cell body fiber
GO:0005737--C:cytoplasm
GO:0030425--C:dendrite
GO:0005739--C:mitochondrion
GO:0005634--C:nucleus
GO:0051087--F:chaperone binding
GO:0030544--F:Hsp70 protein binding
GO:0070628--F:proteasome binding
GO:0090084--P:negative regulation of inclusion body assembly
GO:0006457--P:protein folding

KEGG

hsa:26278

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-005273	Anolis carolinensis	82.85	0.00e+00	7712.00
IUUC-Ath-007365	Arabidopsis thaliana	27.95	1.00e-120	430.00
IUUC-Ago-007792	Ashbya gossypii	34.25	1.50e-01	31.60
IUUC-Bta-012474	Bos taurus	90.54	0.00e+00	8475.00
IUUC-Bci-013669	Botrytis cinerea	28.60	7.00e-45	177.00
IUUC-Bdi-014670	Brachypodium distachyon	27.83	8.00e-73	271.00
IUUC-Bol-015478	Brassica oleracea	28.07	2.00e-113	406.00
IUUC-Bra-017001	Brassica rapa	28.13	2.00e-114	409.00
IUUC-Cja-019784	Callithrix jacchus	96.39	0.00e+00	8884.00
IUUC-Cfa-020252	Canis familiaris	95.22	0.00e+00	8787.00
IUUC-Csa-023838	Chlorocebus sabaeus	98.71	0.00e+00	9174.00
IUUC-Dre-027695	Danio rerio	26.27	2.00e-08	57.00
IUUC-Dno-029927	Dasypus novemcinctus	92.77	0.00e+00	7544.00
IUUC-Fca-035566	Felis catus	94.73	0.00e+00	8777.00
IUUC-Fal-037286	Ficedula albicollis	84.65	0.00e+00	7889.00
IUUC-Gac-041756	Gasterosteus aculeatus	69.91	0.00e+00	6555.00
IUUC-Gma-043487	Glycine max	25.57	6.00e-122	434.00
IUUC-Ggo-044728	Gorilla gorilla	99.72	0.00e+00	9252.00
IUUC-Lpe-051271	Leersia perrieri	27.17	2.00e-121	432.00
IUUC-Meu-056405	Macropus eugenii	89.00	0.00e+00	3818.00
IUUC-Mtr-058211	Medicago truncatula	28.12	1.00e-119	427.00
IUUC-Mdo-061980	Monodelphis domestica	89.73	0.00e+00	8390.00
IUUC-Mpu-066108	Mustela putorius furo	94.90	0.00e+00	8814.00
IUUC-Nle-069952	Nomascus leucogenys	98.38	0.00e+00	9095.00
IUUC-Ont-071647	Oreochromis niloticus	70.52	0.00e+00	6672.00
IUUC-Oba-075143	Oryza barthii	26.45	5.00e-134	474.00
IUUC-Ogu-078339	Oryza glumaepatula	26.40	3.00e-133	472.00
IUUC-Ome-081491	Oryza meridionalis	26.32	2.00e-134	476.00
IUUC-Oni-082255	Oryza nivara	26.50	3.00e-134	475.00
IUUC-Oru-084921	Oryza rufipogon	26.50	2.00e-134	475.00
IUUC-Ola-087035	Oryzias latipes	69.66	0.00e+00	6606.00
IUUC-Oga-089127	Otolemur garnettii	95.80	0.00e+00	8827.00
IUUC-Pan-092313	Papio anubis	98.58	0.00e+00	9175.00
IUUC-Psi-093797	Pelodiscus sinensis	85.65	0.00e+00	7936.00
IUUC-Pab-098000	Pongo abelii	99.21	0.00e+00	9211.00
IUUC-Pop-099439	Populus trichocarpa	28.04	1.00e-119	426.00
IUUC-Ppe-101533	Prunus persica	28.29	1.00e-120	430.00
IUUC-Pva-102997	Pteropus vampyrus	89.50	0.00e+00	4489.00
IUUC-Ssl-108472	Sclerotinia sclerotiorum	28.74	4.00e-29	125.00
IUUC-Smo-109559	Selaginella moellendorffii	32.17	1.00e-06	50.10
IUUC-Sit-110764	Setaria italica	27.86	9.00e-78	287.00
IUUC-Sar-113078	Sorex araneus	91.09	0.00e+00	8411.00
IUUC-Sbi-114108	Sorghum bicolor	24.61	2.00e-91	333.00
IUUC-Tni-120464	Tetraodon nigroviridis	67.55	0.00e+00	6333.00
IUUC-Tca-120945	Theobroma cacao	26.61	4.00e-125	445.00
IUUC-Ttr-128833	Tursiops truncatus	91.47	0.00e+00	8431.00
IUUC-Vvi-131667	Vitis vinifera	26.47	1.00e-130	463.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence