iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000106346.11	ENST00000306177.9	ENSP00000301962.5
ENSG00000106346.11	ENST00000404008.6	ENSP00000385964.2
ENSG00000106346.11	ENST00000451154.5	ENSP00000416910.1
ENSG00000106346.11	ENST00000465073.6	ENSP00000430568.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	HPRD	Phospho.ELM	UniProt
PHOSIDA	BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	21319259; 19615732; 14715245

Classification

Family	E-value	Score	Start	End
DUB/USP	6.40e-81	273.8	112	411

Active Site

Position(s)	Description	Evidence
120	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
371	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDa 92
           Gl+NlgNtC+ N++LQcL+ +p+l++++l+ ++++++++     +  ++++++q  +++ +++   +++p  +++ ++++a++f+  +q+Da
   Q: 112  GLQNLGNTCFANAALQCLTYTPPLANYMLShEHSKTCHA-----EGFCMMCTMQAHITQALSNPGDVIKPMFVINEMRRIARHFRFGNQEDA 198
           9*****************************445555544.....578********************************************* PP
   S: 93   qEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkk 184
           +Efl++ +d++++++                  l+ +++ + +++ ++l+ ++F+g l+s++kcl+c+ vs +++p ld++l+++  +    
   Q: 199  HEFLQYTVDAMQKAC------------------LNGSNKLDRHTQATTLVCQIFGGYLRSRVKCLNCKGVSDTFDPYLDITLEIKAAQ---- 268
           ***************..................3344567789999******************************************.... PP
   S: 185  eslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqkekk 276
            s++++Le+f+k+e+l+gen y+c+kckk + a+k++++++ ++vL+l LkRf    ++    ki k v++p+ Ld++p++++p+ +   + 
   Q: 269  -SVNKALEQFVKPEQLDGENSYKCSKCKKMVPASKRFTIHRSSNVLTLSLKRF----ANFTGGKIAKDVKYPEYLDIRPYMSQPNGE---PI 352
           .9***************************************************....668889********************9977...8* PP
   S: 277  kYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
            Y L+av+vH+G +++ GHY++y+k ++g W++++Ds V++++  +vl+   ++aYvlfY r
   Q: 353  VYVLYAVLVHTGfNCHAGHYFCYIKASNGLWYQMNDSIVSTSDIRSVLS---QQAYVLFYIR 411
           *************************************************...********87 PP

Organism

Homo sapiens

Functional Description
(View)

Deubiquitinating enzyme which may play an important role during spermatogenesis.

Protein Sequence
(Fasta)

MTIVDKASES SDPSAYQNQP GSSEAVSPGD MDAGSASWGA VSSLNDVSNH TLSLGPVPGA 60
VVYSSSSVPD KSKPSPQKDQ ALGDGIAPPQ KVLFPSEKIC LKWQQTHRVG AGLQNLGNTC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGGGCGCGG CGGGCGCGGC GCTGACCCGG AGGCGGCGGC GGCGGTGCCC GGATGGAGGC 60
ACGTCATTGT CCCCCGCCGG GCGGCTGGGC TGTGTGCGGC GGCGGCGGCG GCGGCCGAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0221--Differentiation
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0744--Spermatogenesis
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0030154--P:cell differentiation
GO:0016579--P:protein deubiquitination
GO:0007283--P:spermatogenesis
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:84132

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000401	Aegilops tauschii	39.21	6.00e-71	262.00
IUUC-Aml-002303	Ailuropoda melanoleuca	73.91	0.00e+00	1412.00
IUUC-Atr-003102	Amborella trichopoda	46.91	1.00e-85	311.00
IUUC-Apl-003459	Anas platyrhynchos	44.74	0.00e+00	780.00
IUUC-Aca-004440	Anolis carolinensis	54.21	0.00e+00	989.00
IUUC-Aly-006389	Arabidopsis lyrata	42.36	2.00e-76	280.00
IUUC-Ath-006710	Arabidopsis thaliana	42.36	2.00e-76	280.00
IUUC-Ago-007836	Ashbya gossypii	26.44	2.00e-34	140.00
IUUC-Ame-011358	Astyanax mexicanus	67.92	0.00e+00	671.00
IUUC-Bta-012803	Bos taurus	72.44	0.00e+00	1610.00
IUUC-Bol-015996	Brassica oleracea	39.13	5.00e-82	299.00
IUUC-Bra-016634	Brassica rapa	43.31	2.00e-82	300.00
IUUC-Cja-019199	Callithrix jacchus	91.29	0.00e+00	2044.00
IUUC-Cfa-020597	Canis familiaris	76.66	0.00e+00	1662.00
IUUC-Cpo-021945	Cavia porcellus	70.66	0.00e+00	1580.00
IUUC-Csa-023485	Chlorocebus sabaeus	96.05	0.00e+00	2107.00
IUUC-Cho-024575	Choloepus hoffmanni	76.51	0.00e+00	1001.00
IUUC-Dre-028442	Danio rerio	55.41	0.00e+00	659.00
IUUC-Dno-029673	Dasypus novemcinctus	75.06	0.00e+00	1767.00
IUUC-Dor-030518	Dipodomys ordii	63.62	8.00e-131	461.00
IUUC-Ete-033088	Echinops telfairi	59.37	0.00e+00	961.00
IUUC-Eca-033579	Equus caballus	74.74	0.00e+00	1654.00
IUUC-Eeu-034511	Erinaceus europaeus	54.67	0.00e+00	950.00
IUUC-Fca-035792	Felis catus	74.66	0.00e+00	1540.00
IUUC-Fal-037075	Ficedula albicollis	54.94	0.00e+00	757.00
IUUC-Gga-040504	Gallus gallus	53.90	0.00e+00	729.00
IUUC-Gma-044075	Glycine max	47.88	5.00e-85	309.00
IUUC-Ggo-044798	Gorilla gorilla	95.05	0.00e+00	1925.00
IUUC-Hvu-047620	Hordeum vulgare	41.25	5.00e-74	273.00
IUUC-Itr-048078	Ictidomys tridecemlineatus	77.33	0.00e+00	1837.00
IUUC-Lch-049867	Latimeria chalumnae	67.77	0.00e+00	948.00
IUUC-Loc-052621	Lepisosteus oculatus	63.97	0.00e+00	699.00
IUUC-Laf-054330	Loxodonta africana	92.63	0.00e+00	1296.00
IUUC-Mcc-054900	Macaca mulatta	99.75	0.00e+00	800.00
IUUC-Mga-059501	Meleagris gallopavo	41.13	0.00e+00	727.00
IUUC-Mvi-060547	Microbotryum violaceum	45.62	9.00e-81	295.00
IUUC-Mmr-060864	Microcebus murinus	75.52	0.00e+00	1776.00
IUUC-Mdo-062395	Monodelphis domestica	61.36	0.00e+00	1462.00
IUUC-Mmu-064236	Mus musculus	68.85	0.00e+00	1513.00
IUUC-Mpu-065822	Mustela putorius furo	77.58	0.00e+00	1735.00
IUUC-Mlu-067091	Myotis lucifugus	73.64	0.00e+00	1593.00
IUUC-Nle-069004	Nomascus leucogenys	96.50	0.00e+00	2143.00
IUUC-Opr-071170	Ochotona princeps	63.24	0.00e+00	1148.00
IUUC-Ont-071832	Oreochromis niloticus	61.58	0.00e+00	650.00
IUUC-Oan-073711	Ornithorhynchus anatinus	57.46	0.00e+00	1264.00
IUUC-Ocu-074596	Oryctolagus cuniculus	96.82	0.00e+00	1056.00
IUUC-Oga-088641	Otolemur garnettii	75.19	0.00e+00	1721.00
IUUC-Oar-089760	Ovis aries	69.03	0.00e+00	1502.00
IUUC-Ptr-091445	Pan troglodytes	98.71	0.00e+00	2182.00
IUUC-Pan-092484	Papio anubis	96.05	0.00e+00	2030.00
IUUC-Psi-093277	Pelodiscus sinensis	53.73	0.00e+00	1091.00
IUUC-Pma-094651	Petromyzon marinus	37.93	2.00e-56	212.00
IUUC-Pfo-096469	Poecilia formosa	66.73	0.00e+00	655.00
IUUC-Pab-097794	Pongo abelii	96.84	0.00e+00	1983.00
IUUC-Ppe-101678	Prunus persica	46.25	2.00e-82	300.00
IUUC-Pva-103238	Pteropus vampyrus	69.44	0.00e+00	1464.00
IUUC-Rno-105068	Rattus norvegicus	69.49	0.00e+00	1527.00
IUUC-Sha-106713	Sarcophilus harrisii	62.69	0.00e+00	1493.00
IUUC-Smo-108763	Selaginella moellendorffii	48.05	1.00e-80	292.00
IUUC-Sit-109895	Setaria italica	44.30	2.00e-83	303.00
IUUC-Sar-113340	Sorex araneus	66.82	0.00e+00	1362.00
IUUC-Tgu-117149	Taeniopygia guttata	44.52	0.00e+00	838.00
IUUC-Tru-117776	Takifugu rubripes	64.88	6.00e-175	608.00
IUUC-Tsy-118974	Tarsius syrichta	76.08	0.00e+00	1751.00
IUUC-Tni-120774	Tetraodon nigroviridis	68.00	6.00e-173	600.00
IUUC-Tca-120936	Theobroma cacao	39.90	7.00e-85	308.00
IUUC-Tbe-128006	Tupaia belangeri	66.59	2.00e-123	437.00
IUUC-Ttr-128764	Tursiops truncatus	64.78	0.00e+00	1361.00
IUUC-Vvi-131535	Vitis vinifera	46.35	5.00e-87	316.00
IUUC-Xtr-132544	Xenopus tropicalis	57.61	0.00e+00	649.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence