iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
Protein-protein Interaction
iRefIndex	PINA	HINT	Mentha
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_3-box	BTB_3-box	24840293

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	2.90e-14	54.1	59	128

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 4    ilvvggeeffahkivLaasSsvFyalflmeleesksklmveikd......vqpevfrallkFlYtgklde 67
           i++ +   +++h++vLaa+S++F +lf+++ ++s++k+++++kd      v  e+f ++l+++Ytg+l+ 
   Q: 59   IIEEEANPVSVHRCVLAARSKFFLDLFKKDKDSSEKKPKYQMKDllpygnVGREAFLHFLSYIYTGRLKP 128
           333448899***********************9999*******999999******************985 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Involved in the regulation of basal defense responses against pathogens, and may be implicated in the cross-talk between the SA- and JA-dependent signaling pathways.

Protein Sequence
(Fasta)

MAATAIEPSS SISFTSSHLS NPSPVVTTYH SAANLEELSS NLEQLLTNPD CDYTDAEIII 60
EEEANPVSVH RCVLAARSKF FLDLFKKDKD SSEKKPKYQM KDLLPYGNVG REAFLHFLSY 120

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Nucleotide Sequence
(Fasta)

CTGACGACAT TGCTTACGGT TTTTGAATCG TCGTCACAAA ATTTAGGAGA TTGGATTAGG 60
AATTGGCTCT TTCTTTACTA TTCTCCAAAG ACTTTACTAT TTGGTCAGTC TTCTTATTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0611--Plant defense
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR000210--BTB/POZ_dom
IPR021094--NPR1/NIM1-like_C
IPR024228--NPR_central_dom
IPR011333--SKP1/BTB/POZ

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50097--BTB

Pfam

PF00651--BTB
PF11900--DUF3420
PF12313--NPR1_like_C

SMART

SM00248--ANK
SM00225--BTB

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:1901149--F:salicylic acid binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0042742--P:defense response to bacterium
GO:0009816--P:defense response to bacterium, incompatible interaction
GO:0050832--P:defense response to fungus
GO:0009817--P:defense response to fungus, incompatible interaction
GO:0080185--P:effector dependent induction by symbiont of host immune response
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000022--P:regulation of jasmonic acid mediated signaling pathway
GO:0030162--P:regulation of proteolysis
GO:2000031--P:regulation of salicylic acid mediated signaling pathway
GO:0009617--P:response to bacterium
GO:0009620--P:response to fungus
GO:0009627--P:systemic acquired resistance

KEGG

ath:AT4G19660

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-005495	Arabidopsis lyrata	89.21	0.00e+00	950.00
IUUC-Bci-013976	Botrytis cinerea	45.45	1.40e-01	30.80
IUUC-Bol-016216	Brassica oleracea	77.12	0.00e+00	867.00
IUUC-Bra-017463	Brassica rapa	76.48	0.00e+00	857.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence