iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Sce-106365

UUCD1 version

UUC-SaC-00248

Ensembl Protein ID

YPL072W

UniProt Accession

Q02863; D6W3U3; UBP16_YEAST

Genbank Protein ID

AAB68265.1; DAA11359.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-specific-processing protease 16

Genbank Nucleotide ID

U41849; BK006949

Gene Name

UBP16; YPL072W; LPF12W

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
YPL072W	YPL072W	YPL072W

Annotation

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	Mentha
Post-translational Modifications (PTMs)
BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	12914939

Classification

Family	E-value	Score	Start	End
DUB/USP	4.40e-51	172.5	53	496

Active Site

Position(s)	Description	Evidence
62	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
407	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle..........kkkeklneenp..............kepkgellkslqklfeelw..kskkkavsprellka 76
           +Gl N gN C++ S LQ L+ ip + e+l++          k +++ + +np              +++ ++l +sl++l+  l   k++k+++sp+ ++++
   Q: 53   VGLINRGNDCFITSSLQGLAGIPRFVEYLKRirtvlleletKLSNNAKGDNPtvdnttrhsrlensSNSLAPLHESLTSLILDLIsvKDRKTSISPKIVINT 154
           6**********************************997666333333333335555555555555577777**********999989*************** PP
   S: 77   lkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvs.sreepfldlslpvp 177
           l+++ ++  +++q+Da+Ef+ +ll++l+ee                    s+  +++k+  n ++ +  F+g++++ ++cl+c+  s  ++++ +  +l+vp
   Q: 155  LESIFKSKISSKQNDAHEFTLILLQTLQEER-------------------SKLIDYSKQICNLNIPKFPFEGETSKFLVCLKCKGLSePSYKQTFIRELSVP 237
           ******9889********************9...................33567899*****************************99999999******* PP
   S: 178  gkeetkke.........................................slqdcLesftkeeelegenkyycekckkkqe............aekklklkkl 226
           ++++++++                                          + d L++++++  ++++  ++ e+  k+              + kk  + +l
   Q: 238  QQTSENLSnilahdeteiiddysclicqirailnheeyrnfkdctpdeiLMLDRLKNYATKAPINENLPFEVEQYVKRYSkgnlqvsnikgkVIKKDVVVQL 339
           ***9888899*************************************9999999***********999999999997777888999999999999999**** PP
   S: 227  PevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke..kkkYeLiavvvHsGslssGHYvayvkn......................... 301
           P++Li+hL+R +f+  ++sr+ +  +v+f ++++ls+++  ++ + +e  ++kY+L +vv H+Gs+ssGHY++y ++                         
   Q: 340  PDILIVHLSRSTFNGITYSRNPC--NVKFGERITLSEYTLAESGTITEnrQVKYNLKSVVKHTGSHSSGHYMCYRRKteirfgkedessfrrapvvnnevnk 439
           *************9998887655..578889999*9998887665544449*********************************************999999 PP
   S: 302  ..................ekgk......WllfdDskVtevkeeevleetgstaYvlfYkr 337
                                k      +++++D+ ++e++ ++vl+ +++ aY+l+Y+r
   Q: 440  nreqnvahndykksrykkV--KnalrypYWQISDTAIKESTASTVLN-EQKYAYMLYYER 496
           9999999988877776541..1456788*******************.66********98 PP

Organism

Saccharomyces cerevisiae

Protein Sequence
(Fasta)

MSWIKNVTES PTSLIKKVSC GLIIAASLYA IAPSLSALVF GDSKQSIGKY TTVGLINRGN 60
DCFITSSLQG LAGIPRFVEY LKRIRTVLLE LETKLSNNAK GDNPTVDNTT RHSRLENSSN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCTTGGA TAAAAAATGT AACAGAATCT CCGACTTCAC TGATTAAAAA AGTTTCATGT 60
GGTTTGATAA TTGCTGCTTC TCTATATGCC ATTGCACCCA GCCTAAGTGC GCTAGTCTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005741--C:mitochondrial outer membrane
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

sce:YPL072W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ath-007622	Arabidopsis thaliana	22.25	2.00e-11	62.00
IUUC-Ago-007955	Ashbya gossypii	33.95	3.00e-61	227.00
IUUC-Acl-008228	Aspergillus clavatus	26.33	2.00e-23	102.00
IUUC-Afl-008530	Aspergillus flavus	25.83	2.00e-19	89.00
IUUC-Ang-009829	Aspergillus niger	27.25	4.00e-23	100.00
IUUC-Aor-009934	Aspergillus oryzae	25.83	1.00e-19	89.00
IUUC-Ate-010439	Aspergillus terreus	26.03	2.00e-22	98.20
IUUC-Bgr-012072	Blumeria graminis	29.86	4.00e-15	74.30
IUUC-Bci-013641	Botrytis cinerea	31.67	1.00e-16	79.30
IUUC-Bol-015637	Brassica oleracea	22.88	8.00e-13	66.20
IUUC-Cgl-026463	Colletotrichum gloeosporioides	30.18	2.00e-14	71.60
IUUC-Fso-038234	Fusarium solani	28.08	4.00e-25	107.00
IUUC-Ggr-039945	Gaeumannomyces graminis	29.27	3.00e-12	64.70
IUUC-Kpa-049259	Komagataella pastoris	31.11	5.00e-35	140.00
IUUC-Lma-053197	Leptosphaeria maculans	24.51	1.00e-15	75.50
IUUC-Mor-057061	Magnaporthe oryzae	29.09	3.00e-14	71.60
IUUC-Mpo-057549	Magnaporthe poae	29.76	6.00e-13	67.40
IUUC-Mvi-060332	Microbotryum violaceum	28.96	6.00e-13	67.40
IUUC-Nfi-068557	Neosartorya fischeri	28.37	3.00e-23	101.00
IUUC-Pno-094802	Phaeosphaeria nodorum	27.85	1.00e-27	115.00
IUUC-Pgr-103686	Puccinia graminis	23.37	7.00e-16	77.00
IUUC-Ptt-103779	Puccinia triticina	21.74	7.00e-11	60.80
IUUC-Pte-104416	Pyrenophora teres	27.35	2.00e-27	115.00
IUUC-Pyt-104503	Pyrenophora triticirepentis	27.93	4.00e-27	114.00
IUUC-Sja-107903	Schizosaccharomyces japonicus	30.26	2.00e-12	65.10
IUUC-Tvi-122428	Trichoderma virens	31.33	1.00e-29	122.00
IUUC-Tme-126993	Tuber melanosporum	26.68	3.00e-26	111.00
IUUC-Vda-129757	Verticillium dahliae	28.57	2.00e-15	75.90
IUUC-Yli-134426	Yarrowia lipolytica	27.91	5.00e-32	130.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence