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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045946
Ensembl Protein ID ENSP00000429900.1
UniProt Accession Q9ULH1; B2RNV3; ASAP1_HUMAN
Genbank Protein ID EAW92130.1; AAI37136.1; CAD97831.1; BAA86563.1
Protein Name Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1; 130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein; ADP-ribosylation factor-directed GTPase-activating protein 1; Development and differentiation-enhancing factor 1; PIP2-dependent ARF1 GAP
Genbank Nucleotide ID AC009682; BC137135; BX537768; AB033075
Gene Name ASAP1; DDEF1; KIAA1249
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000153317.14 ENST00000524124.5 ENSP00000429391.1
ENSG00000153317.14 ENST00000521075.5 ENSP00000428463.1
ENSG00000153317.14 ENST00000518721.5 ENSP00000429900.1
ENSG00000153317.14 ENST00000519483.5 ENSP00000429829.1
ENSG00000153317.14 ENST00000357668.2 ENSP00000350297.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
Phospho.ELMUniProtBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 1.50e-11 45.7 1070 1127
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvk.elegkrGlfPenFvekl 62
           ++v+++yd +a nddeLt+ +G+v+ v    e+d++W+ g      +++G+fP  Fv+ l
   Q: 1070 RRVKTIYDCQADNDDELTFIEGEVIIVT--GEEDQEWWIGHIeGQPERKGVFPVSFVHIL 1127
           789**********************996..999*******763455789*******9866 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types (By similarity). Plays a role in ciliogenesis.
 Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types (By similarity). Plays a role in ciliogenesis.
Protein Sequence
(Fasta)
MRSSASRLSS FSSRDSLWNR MPDQISVSEF IAETTEDYNS PTTSSFTTRL HNCRNTVTLL 60
EEALDQDRTA LQKVKKSVKA IYNSGQDHVQ NEENYAQVLD KFGSNFLSRD NPDLGTAFVK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045946|UBD,SH3|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCCTTCCTGC GCCGCGCTCG GCTCCCGCGC CTCGCCTGGC CTGGCCGCTG CCGCGGGCGA 60
GCACTGTGCG CTGGGCAGCC CCGGGCCCGC GCCTCCCGCC CAGCCGGCGC TTCCCGGTCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045946|UBD,SH3|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0040--ANK repeat
KW-0970--Cilium biogenesis/degradation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0343--GTPase activation
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR027267--AH/BAR-dom
IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR001164--ArfGAP
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR001452--SH3_domain
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50115--ARFGAP
PS50003--PH_DOMAIN
PS50002--SH3
Pfam

PF12796--Ank_2
PF01412--ArfGap
PF00169--PH
PF00018--SH3_1
PRINTS

PR00405--REVINTRACTNG
SMART

SM00248--ANK
SM00105--ArfGap
SM00233--PH
SM00326--SH3
Gene Ontology

GO:0031253--C:cell projection membrane
GO:0005829--C:cytosol
GO:0043197--C:dendritic spine
GO:0002102--C:podosome
GO:0045296--F:cadherin binding
GO:0005096--F:GTPase activator activity
GO:0046872--F:metal ion binding
GO:0005547--F:phosphatidylinositol-3,4,5-trisphosphate binding
GO:0005546--F:phosphatidylinositol-4,5-bisphosphate binding
GO:0001786--F:phosphatidylserine binding
GO:0060271--P:cilium assembly
GO:0061000--P:negative regulation of dendritic spine development
GO:1903527--P:positive regulation of membrane tubulation
GO:0071803--P:positive regulation of podosome assembly
KEGG hsa:50807
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001715 Ailuropoda melanoleuca 97.04 0.00e+00 1799.00
IUUC-Apl-004017 Anas platyrhynchos 90.11 0.00e+00 1598.00
IUUC-Aca-004813 Anolis carolinensis 86.02 0.00e+00 1768.00
IUUC-Afl-008446 Aspergillus flavus 32.79 1.00e-06 48.90
IUUC-Ani-009433 Aspergillus nidulans 37.63 1.00e-16 81.60
IUUC-Ang-009739 Aspergillus niger 36.56 2.00e-15 78.20
IUUC-Aor-010082 Aspergillus oryzae 39.33 1.00e-17 85.10
IUUC-Ame-011148 Astyanax mexicanus 66.23 0.00e+00 1319.00
IUUC-Bta-012845 Bos taurus 95.78 0.00e+00 1799.00
IUUC-Bci-013879 Botrytis cinerea 36.36 2.00e-15 77.80
IUUC-Cja-019378 Callithrix jacchus 99.28 0.00e+00 1792.00
IUUC-Cfa-020871 Canis familiaris 96.86 0.00e+00 1857.00
IUUC-Cpo-021882 Cavia porcellus 96.07 0.00e+00 1766.00
IUUC-Csa-023903 Chlorocebus sabaeus 99.28 0.00e+00 1808.00
IUUC-Cho-024955 Choloepus hoffmanni 98.67 0.00e+00 838.00
IUUC-Csv-026103 Ciona savignyi 51.85 0.00e+00 711.00
IUUC-Cgl-026399 Colletotrichum gloeosporioides 32.00 1.00e-17 85.10
IUUC-Dre-027777 Danio rerio 73.21 0.00e+00 1467.00
IUUC-Dno-029662 Dasypus novemcinctus 96.40 0.00e+00 1765.00
IUUC-Dse-031303 Dothistroma septosporum 33.33 2.00e-16 81.60
IUUC-Dme-032141 Drosophila melanogaster 50.14 0.00e+00 653.00
IUUC-Ete-032263 Echinops telfairi 91.75 0.00e+00 1308.00
IUUC-Eca-034304 Equus caballus 95.09 0.00e+00 1618.00
IUUC-Eeu-035275 Erinaceus europaeus 83.44 0.00e+00 777.00
IUUC-Fal-036825 Ficedula albicollis 89.37 0.00e+00 1644.00
IUUC-Fox-037687 Fusarium oxysporum 31.25 7.00e-18 85.90
IUUC-Gmo-039588 Gadus morhua 79.94 0.00e+00 1028.00
IUUC-Ggr-039997 Gaeumannomyces graminis 30.00 3.00e-13 70.90
IUUC-Gga-041168 Gallus gallus 90.07 0.00e+00 1690.00
IUUC-Gac-041493 Gasterosteus aculeatus 81.94 0.00e+00 1056.00
IUUC-Ggo-045273 Gorilla gorilla 97.21 0.00e+00 1721.00
IUUC-Itr-048570 Ictidomys tridecemlineatus 94.73 0.00e+00 1584.00
IUUC-Kpa-049331 Komagataella pastoris 45.76 2.00e-12 65.90
IUUC-Lch-050495 Latimeria chalumnae 58.73 0.00e+00 918.00
IUUC-Loc-052152 Lepisosteus oculatus 81.63 0.00e+00 1603.00
IUUC-Laf-053716 Loxodonta africana 94.85 0.00e+00 1691.00
IUUC-Mcc-054921 Macaca mulatta 99.28 0.00e+00 1796.00
IUUC-Meu-056172 Macropus eugenii 74.42 0.00e+00 957.00
IUUC-Mor-057115 Magnaporthe oryzae 41.25 1.00e-17 85.10
IUUC-Mpo-057623 Magnaporthe poae 36.49 3.00e-13 70.50
IUUC-Mla-059095 Melampsora laricipopulina 45.78 5.00e-19 89.40
IUUC-Mga-059751 Meleagris gallopavo 88.34 0.00e+00 1616.00
IUUC-Mvi-060310 Microbotryum violaceum 38.96 2.00e-14 74.70
IUUC-Mmr-060919 Microcebus murinus 98.29 0.00e+00 1783.00
IUUC-Mdo-062814 Monodelphis domestica 90.35 0.00e+00 1757.00
IUUC-Mmu-063683 Mus musculus 92.07 0.00e+00 1774.00
IUUC-Mpu-066167 Mustela putorius furo 97.04 0.00e+00 1823.00
IUUC-Mlu-067593 Myotis lucifugus 92.45 0.00e+00 1646.00
IUUC-Nle-069303 Nomascus leucogenys 99.16 0.00e+00 1726.00
IUUC-Opr-070730 Ochotona princeps 88.63 0.00e+00 841.00
IUUC-Ont-071978 Oreochromis niloticus 75.17 0.00e+00 1457.00
IUUC-Oan-073362 Ornithorhynchus anatinus 83.33 2.00e-68 250.00
IUUC-Ocu-074259 Oryctolagus cuniculus 95.43 0.00e+00 1779.00
IUUC-Oga-088179 Otolemur garnettii 96.61 0.00e+00 1610.00
IUUC-Oar-090066 Ovis aries 81.86 0.00e+00 1540.00
IUUC-Ptr-091408 Pan troglodytes 99.82 0.00e+00 1798.00
IUUC-Pan-092196 Papio anubis 99.37 0.00e+00 1808.00
IUUC-Psi-093612 Pelodiscus sinensis 85.55 0.00e+00 1726.00
IUUC-Pma-094175 Petromyzon marinus 52.00 0.00e+00 732.00
IUUC-Ppa-095411 Physcomitrella patens 40.54 2.00e-14 72.80
IUUC-Pfo-096707 Poecilia formosa 74.55 0.00e+00 1453.00
IUUC-Pab-098254 Pongo abelii 94.44 0.00e+00 1696.00
IUUC-Pca-100662 Procavia capensis 89.08 0.00e+00 1685.00
IUUC-Pva-102540 Pteropus vampyrus 91.60 0.00e+00 1657.00
IUUC-Pte-104047 Pyrenophora teres 40.23 8.00e-18 84.70
IUUC-Pyt-104690 Pyrenophora triticirepentis 33.33 6.00e-14 72.80
IUUC-Rno-105530 Rattus norvegicus 92.11 0.00e+00 1684.00
IUUC-Sce-106322 Saccharomyces cerevisiae 25.00 8.00e-08 51.60
IUUC-Sha-106473 Sarcophilus harrisii 92.28 0.00e+00 1737.00
IUUC-Sja-107965 Schizosaccharomyces japonicus 32.73 2.00e-15 77.80
IUUC-Spo-108088 Schizosaccharomyces pombe 36.07 2.00e-16 80.90
IUUC-Ssl-108437 Sclerotinia sclerotiorum 29.79 4.00e-12 66.60
IUUC-Tgu-117155 Taeniopygia guttata 86.04 0.00e+00 1306.00
IUUC-Tru-117958 Takifugu rubripes 74.29 0.00e+00 1477.00
IUUC-Tni-119805 Tetraodon nigroviridis 79.47 0.00e+00 1329.00
IUUC-Tre-122184 Trichoderma reesei 32.74 2.00e-16 81.30
IUUC-Tvi-122676 Trichoderma virens 31.45 4.00e-17 83.60
IUUC-Tme-127201 Tuber melanosporum 32.58 2.00e-17 84.70
IUUC-Ttr-128174 Tursiops truncatus 87.49 0.00e+00 1567.00
IUUC-Uma-129415 Ustilago maydis 45.00 6.00e-20 92.40
IUUC-Vda-129911 Verticillium dahliae 37.63 3.00e-17 84.00
IUUC-Xtr-131957 Xenopus tropicalis 73.69 0.00e+00 1348.00
IUUC-Xma-133604 Xiphophorus maculatus 60.33 0.00e+00 824.00
Created Date 25-Jun-2017

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