iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046860

UUCD1 version

UUC-HoS-01269

Ensembl Protein ID

ENSP00000485772.1

UniProt Accession

O00303; A8K0S2; Q6IB45; Q8N978; EIF3F_HUMAN

Genbank Protein ID

AAD03467.1; BAC04577.1; BAF82326.1; BAF84043.1; AAP35540.1; CAG33240.1; AAH00490.1

Protein Name

Eukaryotic translation initiation factor 3 subunit F; Deubiquitinating enzyme eIF3f; Eukaryotic translation initiation factor 3 subunit 5; eIF-3-epsilon; eIF3 p47

Genbank Nucleotide ID

U94855; AK095574; AK289637; AK291354; BT006894; CR456959; BC000490

Gene Name

EIF3F; EIF3S5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000280606.2	ENST00000626223.2	ENSP00000485772.1
ENSG00000280606.2	ENST00000630137.2	ENSP00000487000.1
ENSG00000280606.2	ENST00000629098.1	ENSP00000487359.1

Annotation

Cancer Mutation
TCGA	COSMIC	CGAP	IntOGen
mRNA Expression
TCGA	ICGC	COSMIC	THPA
HPM
DNA & RNA Element
UTRdb	circRNADb	CircNet	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Protein 3D Structure
PDB
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	HPRD	Phospho.ELM	UniProt
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/JAMM	JAMM	21124883

Organism

Homo sapiens

Functional Description
(View)

Deubiquitinates activated NOTCH1, promoting its nuclear import, thereby acting as a positive regulator of Notch signaling.

Protein Sequence
(Fasta)

MATPAVPVSA PPATPTPVPA AAPASVPAPT PAPAAAPVPA AAPASSSDPA AAAAATAAPG 60
QTPASAQAPA QTPAPALPGP ALPGPFPGGR VVRLHPVILA SIVDSYERRN EGAARVIGTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAATCGCTTC TGGGTGCAGC CACAGGAGTG GGGTTGTTGG TCCAGGTGGA GCCATGGGTA 60
TGAGACATGC AAAAAAGTCT GGAAACATAT CTCAAAAGGC CAATCTACAA TAATGGTGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0396--Initiation factor
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0645--Protease
KW-0648--Protein biosynthesis
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR027531--eIF3f
IPR000555--JAMM/MPN+_dom
IPR024969--Rpn11/EIF3F_C

Pfam

PF01398--JAB
PF13012--MitMem_reg

SMART

SM00232--JAB_MPN

Gene Ontology

GO:0005829--C:cytosol
GO:0005852--C:eukaryotic translation initiation factor 3 complex
GO:0071541--C:eukaryotic translation initiation factor 3 complex, eIF3m
GO:0016020--C:membrane
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003743--F:translation initiation factor activity
GO:0031369--F:translation initiation factor binding
GO:0075522--P:IRES-dependent viral translational initiation
GO:0016579--P:protein deubiquitination
GO:0006413--P:translational initiation

KEGG

hsa:8665

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001150	Aegilops tauschii	35.81	6.00e-47	181.00
IUUC-Aml-001527	Ailuropoda melanoleuca	100.00	7.00e-162	563.00
IUUC-Atr-002686	Amborella trichopoda	41.06	8.00e-50	190.00
IUUC-Apl-003977	Anas platyrhynchos	91.07	4.00e-122	430.00
IUUC-Aca-004335	Anolis carolinensis	90.74	9.00e-149	519.00
IUUC-Aly-005945	Arabidopsis lyrata	38.78	6.00e-50	191.00
IUUC-Ath-007045	Arabidopsis thaliana	39.16	6.00e-50	191.00
IUUC-Acl-008365	Aspergillus clavatus	34.80	5.00e-41	161.00
IUUC-Afl-008742	Aspergillus flavus	35.53	4.00e-40	158.00
IUUC-Afu-009030	Aspergillus fumigatus	34.43	1.00e-40	160.00
IUUC-Ani-009212	Aspergillus nidulans	35.42	1.00e-41	163.00
IUUC-Ang-009712	Aspergillus niger	34.43	8.00e-40	157.00
IUUC-Aor-009885	Aspergillus oryzae	35.53	9.00e-42	164.00
IUUC-Ate-010315	Aspergillus terreus	35.53	1.00e-39	156.00
IUUC-Ame-010801	Astyanax mexicanus	54.07	6.00e-67	247.00
IUUC-Bgr-011982	Blumeria graminis	35.64	3.00e-40	159.00
IUUC-Bta-012804	Bos taurus	98.93	5.00e-168	583.00
IUUC-Bci-013891	Botrytis cinerea	34.91	5.00e-35	141.00
IUUC-Bdi-014328	Brachypodium distachyon	39.62	3.00e-48	185.00
IUUC-Bol-015446	Brassica oleracea	39.16	6.00e-51	194.00
IUUC-Bra-016862	Brassica rapa	39.54	2.00e-51	196.00
IUUC-Cel-018171	Caenorhabditis elegans	35.19	1.00e-46	179.00
IUUC-Cja-019335	Callithrix jacchus	100.00	1.00e-164	572.00
IUUC-Cfa-020138	Canis familiaris	99.63	1.00e-161	561.00
IUUC-Cpo-022109	Cavia porcellus	87.64	8.00e-137	479.00
IUUC-Cre-022664	Chlamydomonas reinhardtii	38.81	9.00e-58	216.00
IUUC-Csa-023994	Chlorocebus sabaeus	100.00	1.00e-164	572.00
IUUC-Cho-024351	Choloepus hoffmanni	76.84	3.00e-115	408.00
IUUC-Cin-025801	Ciona intestinalis	56.51	4.00e-88	318.00
IUUC-Csv-025805	Ciona savignyi	55.39	4.00e-86	311.00
IUUC-Cgl-026643	Colletotrichum gloeosporioides	31.87	3.00e-35	142.00
IUUC-Cne-026868	Cryptococcus neoformans	29.15	3.00e-28	119.00
IUUC-Cme-027328	Cyanidioschyzon merolae	27.22	2.00e-22	100.00
IUUC-Dre-028085	Danio rerio	80.30	2.00e-129	455.00
IUUC-Dno-030099	Dasypus novemcinctus	99.63	3.00e-161	561.00
IUUC-Dor-030324	Dipodomys ordii	91.04	7.00e-141	493.00
IUUC-Dse-031314	Dothistroma septosporum	35.74	2.00e-44	172.00
IUUC-Dme-031926	Drosophila melanogaster	49.26	8.00e-77	280.00
IUUC-Ete-032569	Echinops telfairi	93.17	5.00e-153	533.00
IUUC-Eca-033502	Equus caballus	94.66	1.00e-155	542.00
IUUC-Eeu-034883	Erinaceus europaeus	82.16	7.00e-83	299.00
IUUC-Fca-035873	Felis catus	100.00	6.00e-162	563.00
IUUC-Fal-036921	Ficedula albicollis	92.22	1.00e-149	522.00
IUUC-Fox-037765	Fusarium oxysporum	32.73	7.00e-30	124.00
IUUC-Fso-038240	Fusarium solani	33.09	3.00e-32	132.00
IUUC-Gmo-038864	Gadus morhua	78.44	2.00e-129	454.00
IUUC-Ggr-039862	Gaeumannomyces graminis	31.52	6.00e-30	125.00
IUUC-Gga-040952	Gallus gallus	92.28	4.00e-151	527.00
IUUC-Gac-041677	Gasterosteus aculeatus	79.55	1.00e-129	456.00
IUUC-Gma-043061	Glycine max	41.06	2.00e-49	189.00
IUUC-Ggo-045591	Gorilla gorilla	100.00	3.00e-165	574.00
IUUC-Hvu-047410	Hordeum vulgare	31.08	3.00e-20	90.50
IUUC-Itr-048211	Ictidomys tridecemlineatus	99.63	2.00e-161	561.00
IUUC-Lch-049410	Latimeria chalumnae	74.27	3.00e-87	314.00
IUUC-Lpe-051102	Leersia perrieri	40.00	4.00e-47	181.00
IUUC-Loc-052016	Lepisosteus oculatus	69.20	2.00e-114	405.00
IUUC-Lma-053157	Leptosphaeria maculans	34.26	5.00e-43	168.00
IUUC-Laf-054568	Loxodonta africana	99.26	3.00e-164	570.00
IUUC-Mcc-054613	Macaca mulatta	100.00	6.00e-165	573.00
IUUC-Meu-056832	Macropus eugenii	72.86	1.00e-82	298.00
IUUC-Mor-057104	Magnaporthe oryzae	31.32	5.00e-30	125.00
IUUC-Mtr-058445	Medicago truncatula	40.68	4.00e-58	218.00
IUUC-Mla-059038	Melampsora laricipopulina	31.12	3.00e-32	132.00
IUUC-Mga-059548	Meleagris gallopavo	91.95	1.00e-129	455.00
IUUC-Mvi-060520	Microbotryum violaceum	27.95	4.00e-22	98.60
IUUC-Mdo-062376	Monodelphis domestica	94.40	5.00e-151	526.00
IUUC-Mmu-063254	Mus musculus	99.25	1.00e-160	559.00
IUUC-Mac-065635	Musa acuminata	41.09	3.00e-52	198.00
IUUC-Mpu-066314	Mustela putorius furo	100.00	6.00e-162	563.00
IUUC-Mlu-067512	Myotis lucifugus	98.13	1.00e-159	555.00
IUUC-Nfi-068262	Neosartorya fischeri	34.43	1.00e-40	160.00
IUUC-Ncr-068872	Neurospora crassa	32.36	1.00e-32	134.00
IUUC-Nle-070118	Nomascus leucogenys	100.00	7.00e-162	563.00
IUUC-Opr-071228	Ochotona princeps	99.57	4.00e-141	493.00
IUUC-Ont-072600	Oreochromis niloticus	80.67	2.00e-132	464.00
IUUC-Oan-073584	Ornithorhynchus anatinus	93.64	3.00e-133	467.00
IUUC-Ocu-074542	Oryctolagus cuniculus	99.63	4.00e-161	560.00
IUUC-Oba-075923	Oryza barthii	38.93	2.00e-50	192.00
IUUC-Obr-076313	Oryza brachyantha	40.00	2.00e-48	186.00
IUUC-Ogl-076932	Oryza glaberrima	38.93	2.00e-50	192.00
IUUC-Ogu-078152	Oryza glumaepatula	38.93	2.00e-50	192.00
IUUC-Oin-079528	Oryza indica	38.93	2.00e-50	192.00
IUUC-Olo-080401	Oryza longistaminata	38.93	2.00e-50	192.00
IUUC-Ome-081553	Oryza meridionalis	38.57	4.00e-50	191.00
IUUC-Oni-082090	Oryza nivara	38.93	2.00e-50	192.00
IUUC-Opu-083583	Oryza punctata	40.00	5.00e-48	184.00
IUUC-Oru-084492	Oryza rufipogon	38.93	2.00e-50	192.00
IUUC-Osa-085383	Oryza sativa	38.93	2.00e-50	192.00
IUUC-Ola-086835	Oryzias latipes	79.55	3.00e-129	454.00
IUUC-Olu-087716	Ostreococcus lucimarinus	29.70	3.00e-28	119.00
IUUC-Oga-088886	Otolemur garnettii	99.25	8.00e-161	559.00
IUUC-Oar-090079	Ovis aries	98.58	2.00e-168	584.00
IUUC-Ptr-091457	Pan troglodytes	100.00	1.00e-164	572.00
IUUC-Pan-092317	Papio anubis	100.00	9.00e-109	385.00
IUUC-Psi-093129	Pelodiscus sinensis	85.71	3.00e-130	457.00
IUUC-Pma-094488	Petromyzon marinus	72.35	2.00e-124	438.00
IUUC-Pno-095049	Phaeosphaeria nodorum	34.26	3.00e-43	169.00
IUUC-Ppa-095341	Physcomitrella patens	41.57	3.00e-64	238.00
IUUC-Pfo-096286	Poecilia formosa	76.33	2.00e-130	457.00
IUUC-Pab-097765	Pongo abelii	100.00	1.00e-164	572.00
IUUC-Pop-099131	Populus trichocarpa	40.68	3.00e-54	205.00
IUUC-Pca-100524	Procavia capensis	82.91	2.00e-108	385.00
IUUC-Ppe-101934	Prunus persica	41.83	4.00e-59	221.00
IUUC-Pva-102577	Pteropus vampyrus	99.25	4.00e-161	560.00
IUUC-Pgr-103521	Puccinia graminis	30.19	2.00e-31	129.00
IUUC-Pte-104304	Pyrenophora teres	34.95	1.00e-43	170.00
IUUC-Pyt-104563	Pyrenophora triticirepentis	34.95	9.00e-44	171.00
IUUC-Rno-105717	Rattus norvegicus	99.63	3.00e-161	560.00
IUUC-Sha-107190	Sarcophilus harrisii	94.64	5.00e-147	513.00
IUUC-Sja-107918	Schizosaccharomyces japonicus	35.89	2.00e-45	176.00
IUUC-Spo-108355	Schizosaccharomyces pombe	35.84	1.00e-45	176.00
IUUC-Smo-109374	Selaginella moellendorffii	44.28	1.00e-68	252.00
IUUC-Sit-110119	Setaria italica	39.54	5.00e-49	187.00
IUUC-Sly-111570	Solanum lycopersicum	37.34	6.00e-46	177.00
IUUC-Stu-112308	Solanum tuberosum	39.66	4.00e-52	197.00
IUUC-Sar-113515	Sorex araneus	97.87	3.00e-52	197.00
IUUC-Sbi-114605	Sorghum bicolor	39.16	7.00e-49	188.00
IUUC-Sre-114906	Sporisorium reilianum	39.78	6.00e-52	197.00
IUUC-Tgu-117087	Taeniopygia guttata	90.25	4.00e-127	446.00
IUUC-Tru-117700	Takifugu rubripes	79.18	1.00e-129	455.00
IUUC-Tni-120470	Tetraodon nigroviridis	79.93	2.00e-130	458.00
IUUC-Tca-121109	Theobroma cacao	39.92	6.00e-48	184.00
IUUC-Tre-122095	Trichoderma reesei	33.94	4.00e-32	132.00
IUUC-Tvi-122580	Trichoderma virens	33.57	2.00e-31	129.00
IUUC-Tae-125129	Triticum aestivum	37.93	2.00e-51	196.00
IUUC-Tur-126658	Triticum urartu	36.43	1.00e-42	166.00
IUUC-Tme-127043	Tuber melanosporum	38.87	9.00e-48	184.00
IUUC-Tbe-127927	Tupaia belangeri	100.00	6.00e-162	563.00
IUUC-Ttr-129231	Tursiops truncatus	99.63	2.00e-161	561.00
IUUC-Uma-129578	Ustilago maydis	39.42	6.00e-51	194.00
IUUC-Vda-129730	Verticillium dahliae	32.36	7.00e-37	147.00
IUUC-Vpa-130677	Vicugna pacos	64.75	6.00e-42	164.00
IUUC-Vvi-130968	Vitis vinifera	41.44	1.00e-53	202.00
IUUC-Xtr-132203	Xenopus tropicalis	84.76	9.00e-137	479.00
IUUC-Xma-133972	Xiphophorus maculatus	78.81	9.00e-130	456.00
IUUC-Yli-134553	Yarrowia lipolytica	36.33	7.00e-40	157.00
IUUC-Zma-134941	Zea mays	38.78	2.00e-44	172.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence