iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	6.70e-94	314.8	563	887

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEfla 97
           tGlkNlgNtCYmNS+LQcLsn+p+l+e++ + k+k+ ++++  ++++g+++++++ l++elw+++ k v+ r+l  +++++++ f+g +qqD++Efl+
   Q: 563  TGLKNLGNTCYMNSILQCLSNTPQLTEYCISdKYKNYISRS--NKTNGQVIEEVAALIKELWNGQYKCVASRDLRYVVGQYQKIFRGVDQQDSHEFLT 658
           7*****************************95566666655..58***************************************************** PP
   S: 98   flldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesft 195
           +l+d l+++l+   + p++     + +++s++a+ + +k ++s+i +lF gq+ks++kc +c+++s ++e+f  lsl++p ++  +  +l++c+++++
   Q: 659  ILMDWLHSDLQT-LHVPRQ----REMISASEKAWLEFTKAKESMILHLFYGQMKSTVKCVACHKESATYESFSNLSLELPPNS--NVCQLNQCMDMYF 749
           **********33.333333....345677999************************************************999..567********** PP
   S: 196  keeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeq.ksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGsls 291
           + e+++g   ++c++ck k++a kkl+++klP+vL++hLkRf  + ++ +s  k ++++ fple Ld++p+ ++ e+   ++k+Y+L+av +H+G+++
   Q: 750  SGERIHG---WNCPSCKTKRDAIKKLDISKLPPVLVVHLKRFYADPSNsGSYMKKQNYLRFPLEnLDMNPYIARAESRAVTPKTYQLYAVSNHYGTME 844
           ******9...********************************8886651567899*******************9999999***************** PP
   S: 292  sGHYvayvkn.ekgkWllfdDskVtevkeeevleetgstaYvlfYk 336
           +GHY+a++k+ + gkW++fdD+ V++++ ++v++   s aY+lfY+
   Q: 845  GGHYTAFCKSaNYGKWFKFDDQVVSALDSSNVVS---SAAYILFYT 887
           **********44566*******************...********6 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MAKLKKLHMS SNLDDLEKMS IIPDLRSKGM KILLNTARKL YMTAEEYRLD GDEELAYITY 60
MKYFNMLTAI HKKSDYPSHK TTVRQMLGDT ESNRRIMDTL EEIINSLRHR YAQQHQAPEP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TATCGATAAA TTTCATGCAA AATAACAAAT GATTGTGTTG TTGCAGCCCA GCCCGCAGAT 60
TGAGAAATTC CTGCTATGAG AACAGGAAAA TCGGCGAGAT CCCGATTCCC AAATTCAACG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR001763--Rhodanese-like_dom
IPR015063--USP8_dimer
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50206--RHODANESE_3
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH
PF08969--USP8_dimer

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008587--P:imaginal disc-derived wing margin morphogenesis
GO:0016322--P:neuron remodeling
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0045880--P:positive regulation of smoothened signaling pathway
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001661	Ailuropoda melanoleuca	44.50	4.00e-85	308.00
IUUC-Apl-003226	Anas platyrhynchos	46.52	4.00e-84	305.00
IUUC-Aca-004936	Anolis carolinensis	45.67	6.00e-82	298.00
IUUC-Afu-009001	Aspergillus fumigatus	31.97	5.00e-50	192.00
IUUC-Ang-009844	Aspergillus niger	33.06	2.00e-50	193.00
IUUC-Ate-010585	Aspergillus terreus	32.88	8.00e-50	191.00
IUUC-Bta-013008	Bos taurus	44.50	4.00e-85	308.00
IUUC-Bol-015281	Brassica oleracea	37.24	2.00e-47	182.00
IUUC-Bra-016678	Brassica rapa	37.54	7.00e-47	180.00
IUUC-Cel-018482	Caenorhabditis elegans	31.71	2.00e-49	189.00
IUUC-Cja-019173	Callithrix jacchus	45.43	4.00e-84	305.00
IUUC-Cfa-021243	Canis familiaris	44.50	3.00e-85	309.00
IUUC-Cpo-021522	Cavia porcellus	44.82	1.00e-83	304.00
IUUC-Cre-022582	Chlamydomonas reinhardtii	37.68	2.00e-57	214.00
IUUC-Csa-023616	Chlorocebus sabaeus	45.43	2.00e-83	303.00
IUUC-Cho-024381	Choloepus hoffmanni	43.04	1.00e-44	174.00
IUUC-Cin-025287	Ciona intestinalis	37.95	6.00e-55	208.00
IUUC-Csv-026253	Ciona savignyi	37.65	2.00e-55	210.00
IUUC-Cne-026821	Cryptococcus neoformans	34.95	6.00e-61	229.00
IUUC-Dre-028440	Danio rerio	43.19	1.00e-81	297.00
IUUC-Dno-029039	Dasypus novemcinctus	45.17	6.00e-84	305.00
IUUC-Dse-031463	Dothistroma septosporum	31.13	6.00e-47	182.00
IUUC-Ete-033040	Echinops telfairi	43.68	1.00e-58	221.00
IUUC-Eca-033449	Equus caballus	44.99	3.00e-88	319.00
IUUC-Eeu-034693	Erinaceus europaeus	46.76	2.00e-48	187.00
IUUC-Fca-035794	Felis catus	44.50	9.00e-84	303.00
IUUC-Fal-037322	Ficedula albicollis	46.83	8.00e-83	301.00
IUUC-Gmo-038584	Gadus morhua	42.30	3.00e-81	295.00
IUUC-Gga-041188	Gallus gallus	45.91	1.00e-83	303.00
IUUC-Gac-041850	Gasterosteus aculeatus	43.75	6.00e-82	298.00
IUUC-Ggo-045565	Gorilla gorilla	45.43	4.00e-84	305.00
IUUC-Hsa-046438	Homo sapiens	45.43	3.00e-84	305.00
IUUC-Hvu-047686	Hordeum vulgare	45.64	7.00e-33	134.00
IUUC-Itr-048883	Ictidomys tridecemlineatus	45.43	2.00e-84	306.00
IUUC-Kpa-049321	Komagataella pastoris	33.80	6.00e-50	191.00
IUUC-Lch-050485	Latimeria chalumnae	45.41	1.00e-84	307.00
IUUC-Loc-052769	Lepisosteus oculatus	47.65	3.00e-84	306.00
IUUC-Lma-053021	Leptosphaeria maculans	33.16	2.00e-53	203.00
IUUC-Laf-053432	Loxodonta africana	46.28	1.00e-84	307.00
IUUC-Mcc-055823	Macaca mulatta	45.43	3.00e-84	306.00
IUUC-Meu-056099	Macropus eugenii	43.70	1.00e-59	224.00
IUUC-Mla-059089	Melampsora laricipopulina	37.88	1.00e-58	221.00
IUUC-Mga-059739	Meleagris gallopavo	46.52	4.00e-83	302.00
IUUC-Mvi-060559	Microbotryum violaceum	35.47	1.00e-57	217.00
IUUC-Mmr-061158	Microcebus murinus	45.69	1.00e-84	307.00
IUUC-Mdo-061801	Monodelphis domestica	45.98	3.00e-83	302.00
IUUC-Mmu-063665	Mus musculus	45.18	1.00e-82	300.00
IUUC-Mpu-066738	Mustela putorius furo	44.50	3.00e-85	309.00
IUUC-Mlu-067307	Myotis lucifugus	43.73	5.00e-83	301.00
IUUC-Nfi-068410	Neosartorya fischeri	32.51	7.00e-51	195.00
IUUC-Nle-069314	Nomascus leucogenys	45.43	2.00e-84	306.00
IUUC-Ont-071545	Oreochromis niloticus	43.64	1.00e-81	297.00
IUUC-Oan-073537	Ornithorhynchus anatinus	44.91	1.00e-82	300.00
IUUC-Ocu-074193	Oryctolagus cuniculus	45.17	1.00e-83	304.00
IUUC-Ola-086622	Oryzias latipes	45.21	5.00e-81	295.00
IUUC-Oga-088271	Otolemur garnettii	45.43	9.00e-85	308.00
IUUC-Oar-090431	Ovis aries	44.50	4.00e-85	309.00
IUUC-Ptr-091339	Pan troglodytes	44.25	3.00e-84	306.00
IUUC-Pan-092266	Papio anubis	46.99	1.00e-76	278.00
IUUC-Psi-093243	Pelodiscus sinensis	37.93	9.00e-54	202.00
IUUC-Pma-094626	Petromyzon marinus	43.86	2.00e-88	318.00
IUUC-Pno-094986	Phaeosphaeria nodorum	32.04	1.00e-41	164.00
IUUC-Ppa-095418	Physcomitrella patens	29.39	2.00e-33	137.00
IUUC-Pfo-096463	Poecilia formosa	43.63	6.00e-80	291.00
IUUC-Pab-097645	Pongo abelii	44.25	5.00e-84	305.00
IUUC-Pva-103222	Pteropus vampyrus	43.13	4.00e-78	285.00
IUUC-Pgr-103408	Puccinia graminis	34.02	3.00e-45	176.00
IUUC-Ptt-103699	Puccinia triticina	39.64	3.00e-51	196.00
IUUC-Pyt-104711	Pyrenophora triticirepentis	32.37	2.00e-51	197.00
IUUC-Rno-105510	Rattus norvegicus	45.60	4.00e-85	308.00
IUUC-Sha-106879	Sarcophilus harrisii	44.13	3.00e-83	303.00
IUUC-Smo-109542	Selaginella moellendorffii	32.82	2.00e-41	162.00
IUUC-Sar-113019	Sorex araneus	44.50	1.00e-83	304.00
IUUC-Sre-115031	Sporisorium reilianum	36.15	1.00e-61	231.00
IUUC-Ssc-116334	Sus scrofa	44.25	5.00e-84	305.00
IUUC-Tgu-117062	Taeniopygia guttata	46.83	3.00e-83	303.00
IUUC-Tru-117908	Takifugu rubripes	43.90	4.00e-82	298.00
IUUC-Tsy-118867	Tarsius syrichta	41.25	2.00e-74	273.00
IUUC-Tni-120206	Tetraodon nigroviridis	43.59	6.00e-81	295.00
IUUC-Tme-127144	Tuber melanosporum	36.83	2.00e-65	243.00
IUUC-Ttr-128580	Tursiops truncatus	44.82	3.00e-85	309.00
IUUC-Uma-129340	Ustilago maydis	37.02	8.00e-63	235.00
IUUC-Vpa-130541	Vicugna pacos	44.30	7.00e-82	298.00
IUUC-Xtr-132161	Xenopus tropicalis	43.90	4.00e-86	312.00
IUUC-Xma-134271	Xiphophorus maculatus	43.63	8.00e-80	291.00
IUUC-Yli-134561	Yarrowia lipolytica	32.51	3.00e-53	202.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence