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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063918
Ensembl Protein ID ENSMUSP00000080325.2
UniProt Accession O89032; E9QKJ2; Q148Q8; SPD2A_MOUSE
Genbank Protein ID CAA07416.1; AAI18023.1
Protein Name SH3 and PX domain-containing protein 2A; Five SH3 domain-containing protein; SH3 multiple domains protein 1; Tyrosine kinase substrate with five SH3 domains
Genbank Nucleotide ID AJ007012; AC132268
Gene Name Sh3pxd2a; Fish; Sh3md1; Tks5
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000053617.11 ENSMUST00000081619.8 ENSMUSP00000080325.2
ENSMUSG00000053617.11 ENSMUST00000111800.2 ENSMUSP00000107430.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
miRTarBasemicroRNATRANSFACRepTar
miRNAMapRAID2
Protein-protein Interaction
IIDPINAHINTMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPhospho.ELM
UniProtPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 1.80e-25 89.8 172 221
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFve 60
            v  +y+ q++ eL+l++G+vv+vi  e+++ gW+     +++ +G +P+ + e
   Q: 172  VVVSNYKKQENSELSLQAGEVVDVI--EKNESGWWFV--STSEEQGWVPATYLE 221
           55668999*****************..9999****87..89********99976 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide (By similarity).
 Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide (By similarity).
Protein Sequence
(Fasta)
MLAYCVQDAT VVDVEKRRSP SKHYVYIINV TWSDSTSQTI YRRYSKFFDL QMQLLDKFPI 60
EGGQKDPKQR IIPFLPGKIL FRRSHIRDVA VKRLKPIDEY CRALVRLPPH ISQCDEVFRF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063918|UBD,SH3|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAGCGGGCAG GCGAGCGGAG CGCGGCGGCG CGGGAGGGAA GGGGCGCGCG GCAGGCCCAC 60
GGGAGCAGCC TGGGACGCAC GGAGCCCTCG TGCCCTCCGG GACAGTCGCC TGCCCCGGAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063918|UBD,SH3|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0965--Cell junction
KW-0966--Cell projection
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
Interpro

IPR001683--Phox
IPR001452--SH3_domain
PROSITE

PS50195--PX
PS50002--SH3
Pfam

PF00787--PX
PF00018--SH3_1
SMART

SM00312--PX
SM00326--SH3
Gene Ontology

GO:0030054--C:cell junction
GO:0042995--C:cell projection
GO:0005737--C:cytoplasm
GO:0002102--C:podosome
GO:0035091--F:phosphatidylinositol binding
GO:0016176--F:superoxide-generating NADPH oxidase activator activity
GO:0072675--P:osteoclast fusion
GO:0055114--P:oxidation-reduction process
GO:0071800--P:podosome assembly
GO:0072593--P:reactive oxygen species metabolic process
GO:0006801--P:superoxide metabolic process
KEGG mmu:14218
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002151 Ailuropoda melanoleuca 85.64 0.00e+00 1409.00
IUUC-Apl-003703 Anas platyrhynchos 73.72 0.00e+00 1259.00
IUUC-Aca-004457 Anolis carolinensis 81.02 7.00e-180 624.00
IUUC-Ago-007743 Ashbya gossypii 32.06 5.00e-12 66.20
IUUC-Acl-008171 Aspergillus clavatus 34.17 2.00e-14 73.90
IUUC-Afl-008719 Aspergillus flavus 35.00 3.00e-14 73.60
IUUC-Afu-008915 Aspergillus fumigatus 35.00 3.00e-15 77.00
IUUC-Ani-009427 Aspergillus nidulans 35.00 5.00e-15 76.30
IUUC-Ang-009708 Aspergillus niger 33.33 1.00e-13 71.60
IUUC-Aor-010013 Aspergillus oryzae 35.00 3.00e-14 73.60
IUUC-Ate-010261 Aspergillus terreus 33.33 1.00e-13 71.60
IUUC-Ame-011457 Astyanax mexicanus 64.52 0.00e+00 766.00
IUUC-Bta-013479 Bos taurus 83.60 0.00e+00 1416.00
IUUC-Cja-019155 Callithrix jacchus 87.86 0.00e+00 944.00
IUUC-Cfa-020490 Canis familiaris 89.54 0.00e+00 1669.00
IUUC-Cpo-021684 Cavia porcellus 88.32 0.00e+00 1770.00
IUUC-Csa-023923 Chlorocebus sabaeus 87.29 0.00e+00 1500.00
IUUC-Dre-028235 Danio rerio 65.26 0.00e+00 764.00
IUUC-Dno-029730 Dasypus novemcinctus 88.95 0.00e+00 1332.00
IUUC-Dor-030418 Dipodomys ordii 84.42 0.00e+00 1585.00
IUUC-Dse-031199 Dothistroma septosporum 32.79 2.00e-13 70.90
IUUC-Eca-034227 Equus caballus 90.28 0.00e+00 1705.00
IUUC-Eeu-034576 Erinaceus europaeus 82.56 0.00e+00 784.00
IUUC-Fca-036401 Felis catus 86.43 0.00e+00 1259.00
IUUC-Fal-037241 Ficedula albicollis 73.99 0.00e+00 1367.00
IUUC-Gmo-038635 Gadus morhua 64.89 0.00e+00 715.00
IUUC-Gga-040247 Gallus gallus 75.24 0.00e+00 1514.00
IUUC-Gac-042274 Gasterosteus aculeatus 67.66 0.00e+00 817.00
IUUC-Ggo-044416 Gorilla gorilla 90.47 0.00e+00 1843.00
IUUC-Hsa-045688 Homo sapiens 90.38 0.00e+00 1841.00
IUUC-Itr-048267 Ictidomys tridecemlineatus 88.36 0.00e+00 1501.00
IUUC-Lch-049929 Latimeria chalumnae 66.93 0.00e+00 1355.00
IUUC-Loc-052462 Lepisosteus oculatus 63.75 0.00e+00 1223.00
IUUC-Lma-053176 Leptosphaeria maculans 33.65 1.00e-13 72.00
IUUC-Laf-053739 Loxodonta africana 90.68 0.00e+00 1782.00
IUUC-Mcc-055016 Macaca mulatta 90.73 0.00e+00 1845.00
IUUC-Meu-056030 Macropus eugenii 81.53 0.00e+00 1696.00
IUUC-Mga-059413 Meleagris gallopavo 74.52 0.00e+00 1245.00
IUUC-Mvi-060253 Microbotryum violaceum 29.13 3.00e-11 63.90
IUUC-Mmr-061087 Microcebus murinus 90.72 0.00e+00 1836.00
IUUC-Mdo-062381 Monodelphis domestica 81.02 0.00e+00 1674.00
IUUC-Mpu-065765 Mustela putorius furo 88.86 0.00e+00 1755.00
IUUC-Mlu-067569 Myotis lucifugus 88.96 0.00e+00 1630.00
IUUC-Nfi-068447 Neosartorya fischeri 35.00 4.00e-15 76.60
IUUC-Ncr-068701 Neurospora crassa 34.62 1.00e-14 75.10
IUUC-Nle-069525 Nomascus leucogenys 90.20 0.00e+00 1776.00
IUUC-Opr-070295 Ochotona princeps 87.21 0.00e+00 1755.00
IUUC-Oan-073433 Ornithorhynchus anatinus 67.97 0.00e+00 1132.00
IUUC-Ocu-074937 Oryctolagus cuniculus 88.02 0.00e+00 1664.00
IUUC-Ola-087466 Oryzias latipes 63.93 0.00e+00 752.00
IUUC-Oga-088137 Otolemur garnettii 90.83 0.00e+00 1642.00
IUUC-Oar-089419 Ovis aries 84.66 0.00e+00 1483.00
IUUC-Pan-092312 Papio anubis 89.31 0.00e+00 1355.00
IUUC-Psi-093083 Pelodiscus sinensis 78.06 0.00e+00 675.00
IUUC-Pma-094308 Petromyzon marinus 54.83 1.00e-149 523.00
IUUC-Pno-095129 Phaeosphaeria nodorum 31.73 6.00e-12 66.20
IUUC-Pfo-096570 Poecilia formosa 65.45 0.00e+00 772.00
IUUC-Pab-098178 Pongo abelii 87.82 0.00e+00 1775.00
IUUC-Pca-100175 Procavia capensis 86.00 0.00e+00 901.00
IUUC-Pva-102477 Pteropus vampyrus 87.47 0.00e+00 1764.00
IUUC-Pgr-103429 Puccinia graminis 29.90 1.00e-06 48.90
IUUC-Ptt-103749 Puccinia triticina 30.43 2.00e-06 48.50
IUUC-Pte-104254 Pyrenophora teres 34.31 1.00e-13 71.60
IUUC-Pyt-104756 Pyrenophora triticirepentis 33.65 1.00e-13 72.00
IUUC-Rno-105320 Rattus norvegicus 94.93 0.00e+00 1937.00
IUUC-Sha-106782 Sarcophilus harrisii 80.25 0.00e+00 1610.00
IUUC-Sja-107854 Schizosaccharomyces japonicus 32.54 9.00e-12 65.10
IUUC-Ssc-116136 Sus scrofa 88.90 0.00e+00 1536.00
IUUC-Tgu-116879 Taeniopygia guttata 72.77 0.00e+00 1204.00
IUUC-Tru-117609 Takifugu rubripes 66.00 0.00e+00 785.00
IUUC-Tni-119718 Tetraodon nigroviridis 64.29 0.00e+00 729.00
IUUC-Tbe-128042 Tupaia belangeri 85.73 0.00e+00 1046.00
IUUC-Ttr-129158 Tursiops truncatus 83.21 0.00e+00 942.00
IUUC-Xtr-132901 Xenopus tropicalis 68.22 0.00e+00 1291.00
IUUC-Xma-133284 Xiphophorus maculatus 66.41 0.00e+00 795.00
IUUC-Yli-134532 Yarrowia lipolytica 32.17 5.00e-12 66.20
Created Date 25-Jun-2017

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