iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cpo-022354

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AAKN02045123

Gene Name

USP22

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000001763.3	ENSCPOT00000001784.2	ENSCPOP00000001594.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	8.00e-93	311.2	177	520

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqq 90
           Gl NlgNtC+mN+++Q+L+++p lr+++l+ ++++++ +   +p+ +l++++ +lf+e+++++++   p +ll+ +++ a+++ gyeqq
   Q: 177  GLINLGNTCFMNCIVQALTHTPLLRDFFLS-DRHHCEMQ---SPSSCLVCEMSSLFQEFYSGHRSPHIPYKLLHLVWTHARHLAGYEQQ 261
           9*****************************.99999875...78********************************************* PP
   S: 91   DaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgk 179
           Da+Efl   ld l++++k                  ++ ++ +++++ +++i+++F g l+s+++c+ c+ vs++ +pf+d+sl++pg+
   Q: 262  DAHEFLIAALDVLHRHCKG----------------DDNGKKANNPNHCNCIIDQIFTGGLQSDVTCQVCHGVSTTIDPFWDISLDLPGS 334
           *****************22................22335677899999**************************************** PP
   S: 180  eetkke....................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrek 248
           ++   +                    +l+dcL+ ft++e+l ++ k++c+ c+++qe++k+l++kklP v ++hLkRf  +++ k r+k
   Q: 335  STPFWPlspgsegsvvngeshasgttTLTDCLRRFTRPEHLGSSAKIKCSGCHSYQESTKQLTMKKLPIVACFHLKRF--EHSAKLRRK 421
           *877779***********************************************************************..5666899** PP
   S: 249  inkkvefpleLdlspfcts............peekqkekkkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevlee 325
           i+++v+fpleLd++pf++s            p+++ ++++kY+L+avv+H+G+l+sGHY+++++++k++W+++dD  +t+ + ++vl  
   Q: 422  ITTYVSFPLELDMTPFMASskesrmngqyqqPTDSLNNDNKYSLFAVVNHQGTLESGHYTSFIRQHKDQWFKCDDAIITKASIKDVLD- 509
           *******************5555555555554445555**************************************************. PP
   S: 326  tgstaYvlfYkrr 338
             s++Y+lfY+++
   Q: 510  --SEGYLLFYHKQ 520
           ..********985 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

MVSRPESEGE AMDAELAVAP PGCSHLGSFK VDNWKQNLRA IYQCFVWSGT TEARKRKAKS 60
CVCHVCGVHL NRLHSCLYCV FFGCFTKKHI HEHAKAKRHN LAIDLTYGGI YCFLCQDYIY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTTTCCC GGCCGGAGTC GGAGGGCGAG GCCATGGACG CCGAGCTGGC GGTGGCGCCG 60
CCGGGCTGCT CACACCTGGG CAGCTTCAAG GTGGACAACT GGAAACAGAA CCTGCGGGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0000124--C:SAGA complex
GO:0010485--F:H4 histone acetyltransferase activity
GO:0030374--F:ligand-dependent nuclear receptor transcription coactivator activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016578--P:histone deubiquitination
GO:0016574--P:histone ubiquitination
GO:0045931--P:positive regulation of mitotic cell cycle
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000393	Aegilops tauschii	37.57	7.00e-65	241.00
IUUC-Aml-001343	Ailuropoda melanoleuca	95.43	0.00e+00	1055.00
IUUC-Atr-002653	Amborella trichopoda	37.43	2.00e-101	362.00
IUUC-Apl-003433	Anas platyrhynchos	92.98	0.00e+00	946.00
IUUC-Aca-005347	Anolis carolinensis	88.52	0.00e+00	999.00
IUUC-Ago-007811	Ashbya gossypii	30.60	2.00e-54	206.00
IUUC-Acl-008124	Aspergillus clavatus	32.06	7.00e-59	221.00
IUUC-Afl-008464	Aspergillus flavus	33.01	7.00e-55	207.00
IUUC-Afu-008912	Aspergillus fumigatus	31.16	7.00e-56	211.00
IUUC-Ani-009168	Aspergillus nidulans	32.33	3.00e-58	219.00
IUUC-Ang-009694	Aspergillus niger	31.19	2.00e-55	210.00
IUUC-Aor-010035	Aspergillus oryzae	35.21	9.00e-39	153.00
IUUC-Ate-010382	Aspergillus terreus	31.81	1.00e-52	200.00
IUUC-Ame-011253	Astyanax mexicanus	85.35	0.00e+00	829.00
IUUC-Bgr-012150	Blumeria graminis	31.15	1.00e-48	187.00
IUUC-Bta-013303	Bos taurus	96.50	0.00e+00	1050.00
IUUC-Bci-013604	Botrytis cinerea	33.12	1.00e-57	217.00
IUUC-Bdi-014171	Brachypodium distachyon	35.37	4.00e-77	282.00
IUUC-Bol-016509	Brassica oleracea	36.83	3.00e-73	270.00
IUUC-Cja-019283	Callithrix jacchus	98.11	0.00e+00	874.00
IUUC-Cfa-021239	Canis familiaris	97.24	0.00e+00	966.00
IUUC-Csa-023145	Chlorocebus sabaeus	97.90	0.00e+00	1083.00
IUUC-Cho-024938	Choloepus hoffmanni	94.83	3.00e-64	239.00
IUUC-Cin-025109	Ciona intestinalis	57.67	5.00e-123	434.00
IUUC-Csv-026214	Ciona savignyi	55.66	2.00e-174	605.00
IUUC-Cgl-026457	Colletotrichum gloeosporioides	32.81	6.00e-56	211.00
IUUC-Cne-027085	Cryptococcus neoformans	33.14	1.00e-64	241.00
IUUC-Dre-027433	Danio rerio	93.59	0.00e+00	922.00
IUUC-Dno-030095	Dasypus novemcinctus	97.23	0.00e+00	964.00
IUUC-Dor-030481	Dipodomys ordii	96.53	7.00e-99	354.00
IUUC-Dse-031415	Dothistroma septosporum	30.37	8.00e-60	224.00
IUUC-Dme-032074	Drosophila melanogaster	51.42	3.00e-139	488.00
IUUC-Ete-033175	Echinops telfairi	78.70	0.00e+00	729.00
IUUC-Eca-033736	Equus caballus	97.01	0.00e+00	957.00
IUUC-Eeu-034814	Erinaceus europaeus	91.30	2.00e-128	452.00
IUUC-Fca-035861	Felis catus	97.65	0.00e+00	965.00
IUUC-Fal-037645	Ficedula albicollis	93.28	0.00e+00	931.00
IUUC-Fox-038046	Fusarium oxysporum	32.29	2.00e-56	213.00
IUUC-Fso-038321	Fusarium solani	33.56	2.00e-57	216.00
IUUC-Gmo-038474	Gadus morhua	94.59	8.00e-172	596.00
IUUC-Gga-040624	Gallus gallus	91.43	0.00e+00	1010.00
IUUC-Gac-042197	Gasterosteus aculeatus	85.52	0.00e+00	922.00
IUUC-Gma-042897	Glycine max	33.16	8.00e-86	311.00
IUUC-Ggo-044409	Gorilla gorilla	97.90	0.00e+00	1083.00
IUUC-Hsa-046521	Homo sapiens	98.10	0.00e+00	1085.00
IUUC-Hvu-047739	Hordeum vulgare	38.95	2.00e-70	259.00
IUUC-Itr-048375	Ictidomys tridecemlineatus	97.86	0.00e+00	1061.00
IUUC-Kpa-049135	Komagataella pastoris	35.62	1.00e-68	254.00
IUUC-Lch-050537	Latimeria chalumnae	93.50	0.00e+00	1015.00
IUUC-Lpe-050969	Leersia perrieri	38.39	9.00e-73	267.00
IUUC-Loc-052765	Lepisosteus oculatus	82.89	0.00e+00	898.00
IUUC-Lma-053105	Leptosphaeria maculans	33.86	1.00e-67	250.00
IUUC-Laf-053571	Loxodonta africana	98.29	0.00e+00	970.00
IUUC-Mcc-055166	Macaca mulatta	97.90	0.00e+00	1083.00
IUUC-Mor-057103	Magnaporthe oryzae	32.74	1.00e-57	217.00
IUUC-Mpo-057621	Magnaporthe poae	32.53	3.00e-56	212.00
IUUC-Mtr-057894	Medicago truncatula	37.43	5.00e-87	315.00
IUUC-Mla-059185	Melampsora laricipopulina	30.41	3.00e-43	169.00
IUUC-Mga-059709	Meleagris gallopavo	92.98	0.00e+00	946.00
IUUC-Mvi-060530	Microbotryum violaceum	34.25	4.00e-59	222.00
IUUC-Mmr-060988	Microcebus murinus	97.14	0.00e+00	1073.00
IUUC-Mdo-063065	Monodelphis domestica	94.49	0.00e+00	1023.00
IUUC-Mmu-063829	Mus musculus	97.14	0.00e+00	1077.00
IUUC-Mac-065419	Musa acuminata	33.45	3.00e-76	279.00
IUUC-Mpu-066687	Mustela putorius furo	94.47	0.00e+00	1035.00
IUUC-Nfi-068423	Neosartorya fischeri	31.40	7.00e-56	211.00
IUUC-Ncr-068809	Neurospora crassa	29.77	9.00e-59	221.00
IUUC-Nle-069261	Nomascus leucogenys	93.71	0.00e+00	1027.00
IUUC-Opr-070469	Ochotona princeps	79.20	0.00e+00	680.00
IUUC-Ont-071961	Oreochromis niloticus	89.08	0.00e+00	966.00
IUUC-Oan-073565	Ornithorhynchus anatinus	86.35	0.00e+00	914.00
IUUC-Ocu-074435	Oryctolagus cuniculus	97.85	0.00e+00	1053.00
IUUC-Oba-075688	Oryza barthii	34.12	2.00e-77	283.00
IUUC-Obr-076652	Oryza brachyantha	41.69	2.00e-75	275.00
IUUC-Ogl-077910	Oryza glaberrima	34.05	4.00e-80	292.00
IUUC-Ogu-078479	Oryza glumaepatula	34.05	4.00e-80	292.00
IUUC-Oin-079697	Oryza indica	39.66	1.00e-76	280.00
IUUC-Olo-080811	Oryza longistaminata	41.38	2.00e-53	202.00
IUUC-Ome-081706	Oryza meridionalis	35.89	3.00e-79	290.00
IUUC-Oni-083070	Oryza nivara	33.69	5.00e-80	291.00
IUUC-Opu-083605	Oryza punctata	40.16	3.00e-68	252.00
IUUC-Oru-084522	Oryza rufipogon	34.05	4.00e-80	292.00
IUUC-Osa-085351	Oryza sativa	39.36	3.00e-77	282.00
IUUC-Ola-086743	Oryzias latipes	88.56	0.00e+00	753.00
IUUC-Olu-087695	Ostreococcus lucimarinus	31.81	2.00e-50	192.00
IUUC-Oga-089131	Otolemur garnettii	94.09	0.00e+00	1063.00
IUUC-Oar-089319	Ovis aries	97.22	0.00e+00	958.00
IUUC-Ptr-090783	Pan troglodytes	95.07	0.00e+00	970.00
IUUC-Pan-092927	Papio anubis	97.90	0.00e+00	1082.00
IUUC-Psi-093670	Pelodiscus sinensis	92.06	0.00e+00	946.00
IUUC-Pma-094323	Petromyzon marinus	69.71	0.00e+00	715.00
IUUC-Pno-095141	Phaeosphaeria nodorum	31.46	2.00e-57	216.00
IUUC-Pfo-096473	Poecilia formosa	90.75	0.00e+00	982.00
IUUC-Pab-097612	Pongo abelii	97.90	0.00e+00	1084.00
IUUC-Pop-099558	Populus trichocarpa	35.69	8.00e-90	324.00
IUUC-Ppe-102020	Prunus persica	35.69	2.00e-93	336.00
IUUC-Pva-102409	Pteropus vampyrus	79.24	0.00e+00	845.00
IUUC-Pgr-103657	Puccinia graminis	30.24	3.00e-38	152.00
IUUC-Pte-104340	Pyrenophora teres	32.22	1.00e-61	230.00
IUUC-Pyt-104782	Pyrenophora triticirepentis	33.86	6.00e-67	248.00
IUUC-Rno-105247	Rattus norvegicus	97.33	0.00e+00	1078.00
IUUC-Sce-106247	Saccharomyces cerevisiae	31.61	2.00e-52	200.00
IUUC-Sha-107538	Sarcophilus harrisii	96.31	6.00e-125	439.00
IUUC-Sja-107656	Schizosaccharomyces japonicus	33.91	3.00e-65	242.00
IUUC-Spo-108226	Schizosaccharomyces pombe	30.92	5.00e-60	224.00
IUUC-Ssl-108531	Sclerotinia sclerotiorum	32.35	1.00e-54	207.00
IUUC-Smo-109310	Selaginella moellendorffii	35.15	1.00e-87	317.00
IUUC-Sit-109716	Setaria italica	35.83	1.00e-80	293.00
IUUC-Sly-111077	Solanum lycopersicum	37.94	1.00e-83	303.00
IUUC-Sbi-114205	Sorghum bicolor	33.57	4.00e-81	295.00
IUUC-Tgu-116938	Taeniopygia guttata	95.95	0.00e+00	955.00
IUUC-Tru-117622	Takifugu rubripes	88.36	0.00e+00	981.00
IUUC-Tsy-119431	Tarsius syrichta	85.47	0.00e+00	810.00
IUUC-Tni-120661	Tetraodon nigroviridis	90.64	0.00e+00	993.00
IUUC-Tre-122139	Trichoderma reesei	32.12	1.00e-55	210.00
IUUC-Tvi-122599	Trichoderma virens	29.03	4.00e-58	218.00
IUUC-Tae-125608	Triticum aestivum	35.35	4.00e-86	312.00
IUUC-Tme-127115	Tuber melanosporum	37.33	6.00e-82	298.00
IUUC-Uma-129455	Ustilago maydis	32.31	6.00e-34	139.00
IUUC-Vda-129829	Verticillium dahliae	33.22	6.00e-36	144.00
IUUC-Vvi-131477	Vitis vinifera	36.21	4.00e-79	288.00
IUUC-Xtr-132444	Xenopus tropicalis	90.44	0.00e+00	1003.00
IUUC-Xma-133514	Xiphophorus maculatus	91.75	0.00e+00	997.00
IUUC-Yli-134357	Yarrowia lipolytica	30.81	7.00e-48	184.00
IUUC-Zma-134945	Zea mays	35.15	3.00e-77	282.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence